AutismKB 2.0

Annotation Detail for TRAF1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TRAF1 ( EBI6,MGC:10353 )
Gene Full Name: TNF receptor-associated factor 1
Band: 9q33.2
Quick LinksEntrez ID:7185; OMIM: 601711; Uniprot ID:TRAF1_HUMAN; ENSEMBL ID: ENSG00000056558; HGNC ID: 12031
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200031CD40/CD40L signaling
200133HIV-1 Nef: Negative effector of Fas and TNF-alpha
200086TNF receptor signaling pathway
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1848Embryoma
1860Brain tumor
2051Leukemia
2053Colon cancer
2146Lupus erythematosus
2239Lymphoma
Desease Name
rheumatoid arthritis
IMMUNE
multiple autoimmune diseases
Arthritis, Rheumatoid
REPRODUCTION
patent ductus arteriosus
Desease Name
Rheumatoid arthritis
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C047948 1'-acetoxychavicol acetate 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]decreases reaction|increases expression 15905586
C501474 4-OH-2',3,3',4',5'-pentachlorobiphenyl 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]decreases reaction|increases expression 14761676
C006632 arsenic trioxide arsenic trioxide results in increased expression of TRAF1 mRNAincreases expression 20458559
C006632 arsenic trioxide arsenic trioxide results in increased expression of TRAF1 mRNAincreases expression 19730151
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TRAF1 mRNAincreases expression 20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of TRAF1 mRNAincreases expression 15003993
D002330 Carmustine Carmustine results in decreased expression of TRAF1 mRNAdecreases expression 15980968
D002784 Cholesterol Cholesterol analog results in increased expression of TRAF1 mRNAincreases expression 19477266
D003474 Curcumin Curcumin inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA]decreases reaction|increases expression 16219905
D003474 Curcumin Curcumin results in decreased expression of TRAF1 proteindecreases expression 16023083
19372569
D016572 Cyclosporine Cyclosporine results in increased expression of TRAF1 mRNAincreases expression 20106945
D004052 Diethylnitrosamine CTNNB1 protein promotes the reaction [Diethylnitrosamine results in increased expression of TRAF1 protein]increases expression|increases reaction 20583210
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TRAF1 proteinincreases expression 20583210
D004391 Dust Dust results in increased expression of TRAF1 mRNAincreases expression 17805423
D004958 Estradiol Estradiol affects the expression of TRAF1 mRNAaffects expression 14699072
D005492 Folic Acid Folic Acid affects the expression of TRAF1 mRNAaffects expression 16361273
C056507 gemcitabine gemcitabine affects the expression of TRAF1 mRNAaffects expression 17039268
D017313 Fenretinide Fenretinide inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]decreases reaction|increases expression 16230421
D017313 Fenretinide Fenretinide inhibits the reaction TRAF1 proteindecreases reaction 16230421
C016517 indole-3-carbinol indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]decreases reaction|increases expression 15811958
C051890 irinotecan irinotecan metabolite results in decreased expression of TRAF1 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan metabolite results in increased expression of TRAF1 mRNAincreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of TRAF1 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in increased expression of TRAF1 mRNAincreases expression 15956246
C115354 lonafarnib lonafarnib inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]decreases reaction|increases expression 15090542
C029938 nickel sulfate nickel sulfate results in increased expression of TRAF1 mRNAincreases expression 16780908
C002669 parthenolide parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF1 mRNA]decreases reaction|increases expression 16921510
C002669 parthenolide parthenolide inhibits the reaction [VEGFA protein results in increased expression of TRAF1 mRNA]decreases reaction|increases expression 16921510
C002669 parthenolide parthenolide results in decreased expression of TRAF1 mRNAdecreases expression 16921510
C002669 parthenolide parthenolide results in decreased expression of TRAF1 proteindecreases expression 16921510
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]decreases reaction|increases expression 14761676
C023617 pregna-4,17-diene-3,16-dione pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA]decreases reaction|increases expression 15322087
C017947 sodium arsenite sodium arsenite results in decreased expression of TRAF1 proteindecreases expression 12676792
D014284 Triiodothyronine 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]decreases reaction|increases expression 14761676
D014284 Triiodothyronine Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]decreases reaction|increases expression 14761676
D014284 Triiodothyronine Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]increases expression|increases reaction 14761676
D014284 Triiodothyronine Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TRAF1 protein]increases expression|increases reaction 14761676
D014284 Triiodothyronine Triiodothyronine results in increased expression of TRAF1 mRNAincreases expression 14761676
D014284 Triiodothyronine Triiodothyronine results in increased expression of TRAF1 proteinincreases expression 14761676
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]increases expression|increases reaction 14761676
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TRAF1 protein]increases expression|increases reaction 14761676
C403304 zerumbone zerumbone results in decreased expression of TRAF1 mRNAdecreases expression 16007145
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6415322242 14514962 11752688
MESH:D058186 Acute Kidney Injury Folic Acid 4.1416595132 16316344 17003819
MESH:D055371 Acute Lung Injury nickel sulfate 4.1119131640 11954676 12718980 16100012
MESH:D000230 Adenocarcinoma arsenic trioxide 9.7619825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.7620464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 9.7611473722
MESH:D000230 Adenocarcinoma Fenretinide 9.7610697514
MESH:D000236 Adenoma Benzo(a)pyrene 10.576695378
MESH:D000236 Adenoma Diethylnitrosamine 10.576695378 10737359
MESH:D000236 Adenoma Folic Acid 10.5716963246
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.3518056438 19052882 17620307 16434500 17162532 19061943
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4915276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6917306315 16712894
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8717887948
MESH:D000544 Alzheimer Disease Curcumin 4.4615590663
MESH:D000544 Alzheimer Disease Folic Acid 4.4617116317
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8719183758
MESH:D001172 Arthritis, Rheumatoid marker/mechanism 18794853
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6916807698
MESH:D050197 Atherosclerosis Cholesterol 6.8616632123
MESH:D050197 Atherosclerosis Curcumin 6.8618704882
MESH:D001321 Autistic Disorder Folic Acid 2.8521388746
MESH:D001327 Autoimmune Diseases Curcumin 4.2819761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.3316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D002545 Brain Ischemia Curcumin 4.1216770732
MESH:D001932 Brain Neoplasms Carmustine 13.8116187019
MESH:D001932 Brain Neoplasms Curcumin 13.8117596214
MESH:D001932 Brain Neoplasms Fenretinide 13.8116187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.8020146248 17474063
MESH:D001943 Breast Neoplasms Curcumin 6.8018593918 19250217 16243823 18462866
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.8017474063
MESH:D001943 Breast Neoplasms Estradiol 6.8017261762 12948864 19861407 16675129 18497071 14630087 17289903 17018787
MESH:D001943 Breast Neoplasms Fenretinide 6.8016601279
MESH:D001943 Breast Neoplasms Folic Acid 6.8016777985
MESH:D001943 Breast Neoplasms gemcitabine 6.8018382427 17039268
MESH:D001943 Breast Neoplasms indole-3-carbinol 6.8016082211
MESH:D001943 Breast Neoplasms parthenolide 6.8016873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.8020435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1311589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002277 Carcinoma Curcumin 7.7418593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.7416835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.5116217749 15073043 14691202 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.5118691550 19539802 16502159 21159647 17761372 19394651 20432363 19335982 18971187 3084413 16569478 20524982 18494052 19822196 16328049 18210153 20727157 16779866 18978308 3581430 19107877 18785209 18665156 18393292 16878318 20935162 18788625 16807293 16935385 10737359 19383236 19052882 19208518 20084675 16830150 20007298 19701751 17428255 17162532 19519916 20214788 11831363 19919837 20101231 16288022 17173139 16681979 16540662 19418558 20514400 17978847 10672840 16698587 17138121 19171122 18506893 18056438 20512989 17055752
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.5116924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 8.5116270382 17159502
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.5115276417 17306315 16507464
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9118414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6619014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9312490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.3320419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 10.3318462866
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 10.3316274795
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.3318572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2518670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Folic Acid 3.8116755160
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.8412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.8421159647 7505956 17174075 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.8418566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.8420056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.2616154183
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D002779 Cholestasis Cyclosporine 2.7619486331
MESH:D002971 Cleft Lip Folic Acid 3.8721254359
MESH:D002972 Cleft Palate Folic Acid 5.8121254359 8946559
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8115340226 16354765 15668235 12621046 8697196
MESH:D003092 Colitis Curcumin 3.9716782535 16804969 18200517
MESH:D003103 Coloboma Curcumin 4.3618809619
MESH:D003110 Colonic Neoplasms Curcumin 3.9316340194 19359593
MESH:D003110 Colonic Neoplasms irinotecan 3.9317725105 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 6.2920501625
MESH:D015179 Colorectal Neoplasms Fenretinide 6.2917273769
MESH:D015179 Colorectal Neoplasms Folic Acid 6.2916985020 16963246 17116713 17087956 17245555
MESH:D015179 Colorectal Neoplasms irinotecan 6.2918509181 18259882 15273666 16391804 17159606 17454858 16303861
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 6.2915531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8817141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.6918497527
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4020055451 10048152 15322242
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9015213294
MESH:D003704 Dementia Polychlorinated Biphenyls 4.5116140633
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.4811298694 16823706 16780908
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 9.8518403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.8520387270
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 9.8516886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.8517107852
MESH:D003928 Diabetic Nephropathies Curcumin 8.4518204486
MESH:D003928 Diabetic Nephropathies Estradiol 8.4519279558
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.5319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D004381 Duodenal Ulcer Curcumin 3.8517351913
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6916714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 7.2911473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Folic Acid 7.2917301261
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.849294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.2512903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2516530937
MESH:D017889 Exfoliation Syndrome Folic Acid 5.2816504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8611564622
MESH:D005234 Fatty Liver arsenic trioxide 17.2415073043
MESH:D005234 Fatty Liver Curcumin 17.2419297423
MESH:D005234 Fatty Liver Cyclosporine 17.2419224547
MESH:D005234 Fatty Liver Diethylnitrosamine 17.2420387270 21071580
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005355 Fibrosis Curcumin 13.5818705752
MESH:D005355 Fibrosis Cyclosporine 13.5812639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.5820067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0616904648
MESH:D005756 Gastritis Folic Acid 4.8817171786
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.4918462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4716452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D005901 Glaucoma Folic Acid 4.8816504073
MESH:D005909 Glioblastoma Carmustine 11.3816187019
MESH:D005909 Glioblastoma Curcumin 11.3817596214
MESH:D005909 Glioblastoma Fenretinide 11.3816187019
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.5218829502 18462866
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.5820471113
MESH:D006330 Heart Defects, Congenital Folic Acid 10.5817286298 16524890
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.5810048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6915340226 16120746 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.8317701891
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D006679 HIV Seropositivity Folic Acid 5.2817209195
MESH:D006689 Hodgkin Disease sodium arsenite 2.9812676792
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.838697196 18606429 16354765 15340226 16959395
MESH:D006937 Hypercholesterolemia Cholesterol 9.1116933029
MESH:D006937 Hypercholesterolemia Curcumin 9.1118704882
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.3216755160 16865747 16433478 16395265 16397167
MESH:D006973 Hypertension Cyclosporine 4.6810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6818670907 18850075
MESH:D007248 Infertility, Male sodium arsenite 2.8515346721 12646999
MESH:D007249 Inflammation Curcumin 7.7116956363 18403477 17151092
MESH:D007249 Inflammation Diethylnitrosamine 7.7118785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.7112878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1318200517 18596194
MESH:D007333 Insulin Resistance Estradiol 2.8316627594 16393666
MESH:D007414 Intestinal Neoplasms Curcumin 4.0410783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007674 Kidney Diseases Cyclosporine 9.368314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.3615618244
MESH:D007674 Kidney Diseases sodium arsenite 9.3620008137
MESH:D007680 Kidney Neoplasms Cyclosporine 6.7112371664
MESH:D007680 Kidney Neoplasms Estradiol 6.7115610895
MESH:D007859 Learning Disorders Cholesterol 4.8917134702
MESH:D007889 Leiomyoma Curcumin 4.3818555241
MESH:D007938 Leukemia arsenic trioxide 6.1715070760
MESH:D007938 Leukemia Curcumin 6.1718462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.1317077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.1316106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.5719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1016467208 16968895 17050201 20471514 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0812712474 19075265 16331271 11161223 15336539 19225113 16112521 16966277 15748426 15213294 11468182 15622746 17712046 16891316 19642359 17649720 17107899 17869043 17217047 12018890 19035177 16330433 9834237 16823087 12679006
MESH:D015458 Leukemia, T-Cell arsenic trioxide 11.0416882451
MESH:D015458 Leukemia, T-Cell Curcumin 11.0416106398
MESH:D007972 Leukoplakia, Oral Fenretinide 5.8316707609
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7120032147 18522880 19638242 18665156 18407596
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.3618705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3612878042
MESH:D008107 Liver Diseases Curcumin 6.4116956363
MESH:D008107 Liver Diseases Diethylnitrosamine 6.4117034775
MESH:D008107 Liver Diseases Folic Acid 6.4116877991
MESH:D008113 Liver Neoplasms arsenic trioxide 16.9514682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.9520195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 16.9519833225 19426721 19256749 19090486 9163691 20583210 19427195 21278145 20492335 15175105 18754104 20452335 20405173 18977376 16942905 19551842 10737359 20434301 21047994 19294768 18644402 19642983 19073162 18648771 19690152 2422723 19254457 20101389 19638242 21071580 19499222 12771043 20137499 15885732 12112319 19812893 20501860 19850985 20118626 19996281 19255062 2862719 21167192 18978307
MESH:D008113 Liver Neoplasms sodium arsenite 16.9515276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.9516984957
MESH:D008113 Liver Neoplasms zerumbone 16.9520452335
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 13.0920377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.093124819 19539802 19126423 19009564 18253720 17174075 17942915 16842330 18093689 18079962 18164116 2563599 21159647 17854601 18775883 18308698 9362446 18544905 16267830 19004024 19519916 18282651
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 13.091423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.0912151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1915213294
MESH:D008171 Lung Diseases sodium arsenite 3.0319095001
MESH:D008175 Lung Neoplasms arsenic trioxide 8.2011798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.2018520028 6695378 20464547 20869020 18569708 18816296 20064080 20135361 17053015
MESH:D008175 Lung Neoplasms Curcumin 8.2016243823 18462866 19359593
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.206695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms sodium arsenite 8.2016712894 17306315 19931552 17077188 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.2019555203 11884234
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.2817718048
MESH:D008223 Lymphoma Curcumin 3.4418462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.4916173963
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.8816891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 5.8810697514
MESH:D020149 Manganese Poisoning Estradiol 4.2719453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.4816832597
MESH:D008545 Melanoma Carmustine 7.0812393984
MESH:D008545 Melanoma Curcumin 7.0818462866 17885582
MESH:D008545 Melanoma Fenretinide 7.0816270382
MESH:D008545 Melanoma sodium arsenite 7.0816487513 19082730
MESH:D008569 Memory Disorders Curcumin 3.9517263510
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.2516381670
MESH:D009062 Mouth Neoplasms Fenretinide 8.2516274795
MESH:D052016 Mucositis irinotecan 4.8017159606
MESH:D009101 Multiple Myeloma arsenic trioxide 11.5614977855 11468182 15949261 19417148 19549372
MESH:D009101 Multiple Myeloma Curcumin 11.5619372569
MESH:D009101 Multiple Myeloma lonafarnib 11.5616996129
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.7117962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0216882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1216810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 9.6516624393
MESH:D009361 Neoplasm Invasiveness Curcumin 9.6518495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.683581430 9029167
MESH:D009362 Neoplasm Metastasis irinotecan 5.6818259882
MESH:D009369 Neoplasms Benzo(a)pyrene 7.7811141357
MESH:D009369 Neoplasms Fenretinide 7.7817353921 15958647
MESH:D009369 Neoplasms sodium arsenite 7.7811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4620056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.3212497104
MESH:D009389 Neovascularization, Pathologic Estradiol 9.8617289903
MESH:D009389 Neovascularization, Pathologic parthenolide 9.8616921510
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1119348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.7911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.7914600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.4218462866
MESH:D009436 Neural Tube Defects arsenic trioxide 11.4910525206
MESH:D009436 Neural Tube Defects Folic Acid 11.4917438019
MESH:D009436 Neural Tube Defects sodium arsenite 11.4912854658
MESH:D009447 Neuroblastoma irinotecan 3.378761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1720387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.528761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.4716303764
MESH:D009503 Neutropenia Folic Acid 4.3116322990
MESH:D052556 Niemann-Pick Disease, Type C Cholesterol 5.5020557099 9802331
MESH:D009765 Obesity Curcumin 2.7019297423
MESH:D010024 Osteoporosis Curcumin 3.3418719352
MESH:D010051 Ovarian Neoplasms arsenic trioxide 14.2816624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Curcumin 14.2818462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 14.2819401270
MESH:D010051 Ovarian Neoplasms Fenretinide 14.2816133793
MESH:D010051 Ovarian Neoplasms sodium arsenite 14.2817306315 15276417
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 15.5515580305
MESH:D010190 Pancreatic Neoplasms Curcumin 15.5519401701 19196508 17440100
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 15.5516540662
MESH:D010190 Pancreatic Neoplasms Fenretinide 15.5515580305
MESH:D010190 Pancreatic Neoplasms gemcitabine 15.5511504793 18383843 18992248 16929163 17440100
MESH:D010235 Paraganglioma arsenic trioxide 3.9719927285
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.3216702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.3612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.362563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9811399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6920887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.4119131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4117292933
MESH:D011471 Prostatic Neoplasms Curcumin 2.4118226269 11398177 15129424 18769126 18156803 12497104 10851300
MESH:D011471 Prostatic Neoplasms Estradiol 2.4116740699
MESH:D011471 Prostatic Neoplasms Fenretinide 2.4117024972
MESH:D011471 Prostatic Neoplasms parthenolide 2.4116921510
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.4115721890
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.4116039940
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011656 Pulmonary Emphysema Curcumin 4.3419168576
MESH:D051437 Renal Insufficiency Folic Acid 4.5715728788
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.8318379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012162 Retinal Degeneration Fenretinide 4.2516303925
MESH:D012509 Sarcoma Curcumin 3.9318462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7616646077
MESH:D012559 Schizophrenia Folic Acid 2.8716641680
MESH:D018805 Sepsis Curcumin 3.9018389075
MESH:D012871 Skin Diseases Folic Acid 3.2018709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 16.8910029692 19755658
MESH:D012878 Skin Neoplasms Fenretinide 16.8916467112
MESH:D012878 Skin Neoplasms sodium arsenite 16.8918572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 16.898532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.8916192470
MESH:D013118 Spinal Cord Diseases Folic Acid 5.2816361298
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6412854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 6.1817007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 6.1820155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.1818456281
MESH:D013274 Stomach Neoplasms Folic Acid 6.1817171786
MESH:D013274 Stomach Neoplasms irinotecan 6.1815723263
MESH:D013276 Stomach Ulcer Curcumin 3.3119188055 16631530
MESH:D020521 Stroke Folic Acid 4.1616517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.6719014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.677505956
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7515213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 14.9512845720 12973940 20435036 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.9517053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 14.9518593936
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 14.9516720286
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.9516712894 17306315 11723127 16452187
MESH:D014565 Urogenital Neoplasms Curcumin 5.0518462866
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 15.0816154183
MESH:D002583 Uterine Cervical Neoplasms indole-3-carbinol 15.0816082211
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 15.0811813266
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
Pathway ID Pathway Name
KEGG:05200 Pathways in cancer
KEGG:05222 Small cell lung cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36708
  • No data
    Releated disease ID Related disease Name
    PA443434Arthritis, Rheumatoid
    PA443434Arthritis, Rheumatoid
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018