AutismKB 2.0

Annotation Detail for C4B


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Basic Information Top
Gene Symbol:C4B ( C4B1,C4B12,C4B2,C4B3,C4B5,C4F,CH,CO4,CPAMD3,FLJ60561,MGC164979 )
Gene Full Name: complement component 4B (Chido blood group)
Band: 6p21.33
Quick LinksEntrez ID:721; OMIM: 120820; Uniprot ID:CO4B_HUMAN; ENSEMBL ID: ENSG00000224389; HGNC ID: 1324
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05322Systemic lupus erythematosus
hsa05150Staphylococcus aureus infection
hsa04610Complement and coagulation cascades
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1782Henoch-Schoenlein purpura
1807Autoimmune disease
2025Polyarthritis
2052Infection
2124Autistic disorder
2146Lupus erythematosus
No data
No data
Desease Name
C4 deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of C4B mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of C4B mRNAincreases expression 17484886
C055162 clopidogrel clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of C4B mRNA]decreases reaction|increases expression 19172522
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C4B mRNA]decreases reaction|increases expression 18200517
C010176 halofuginone halofuginone results in decreased expression of C4B mRNAdecreases expression 17180598
D008070 Lipopolysaccharides clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of C4B mRNA]decreases reaction|increases expression 19172522
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of C4B mRNAdecreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of C4B mRNA]decreases expression|increases reaction 18467677
C006253 pirinixic acid pirinixic acid results in decreased expression of C4B mRNAdecreases expression 18467677
17426115
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of C4B mRNA]decreases expression|increases reaction 18467677
C017947 sodium arsenite sodium arsenite affects the expression of C4B mRNAaffects expression 19590694
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C4B mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of C4B mRNAincreases expression 18200517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D054058 Acute Coronary Syndrome clopidogrel 6.2419106084
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.6611850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 9.6618653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1717306315 16712894
MESH:D019973 Alcohol-Related Disorders Curcumin 5.3517887948
MESH:D000544 Alzheimer Disease Curcumin 2.6515590663
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7716807698
MESH:D050197 Atherosclerosis Curcumin 3.4118704882
MESH:D001321 Autistic Disorder marker/mechanism 15694999 20452682
MESH:D001327 Autoimmune Diseases marker/mechanism 20452682
MESH:D001327 Autoimmune Diseases Curcumin 4.7119761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D002545 Brain Ischemia Curcumin 4.5716770732
MESH:D001932 Brain Neoplasms Curcumin 4.1017596214
MESH:D001943 Breast Neoplasms Curcumin 2.7319250217 18462866 18593918 16243823
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9915673190 16011737 15721981 16124888 18705752 16097048 16227642 15700767 10355542 3786805 16050911 16192424
MESH:D002277 Carcinoma Curcumin 3.9718593918
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1318788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.1315276417 17306315 16507464
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0318414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 5.0118462866
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.0118572023
MESH:D002318 Cardiovascular Diseases clopidogrel 4.7220180610
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1019524636 20056578
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D003092 Colitis Curcumin 10.6818200517 16782535 16804969
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 10.6816474422 18023891 16804969 17991707 16782535 17936198 11698051 16867261 18200517
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.4917276891
MESH:D003103 Coloboma Curcumin 4.7218809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5316340194 19359593
MESH:D016510 Corneal Neovascularization Curcumin 5.1118497527
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7418403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.1618204486
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.083786805 15027814 10092053 21278145 6884620 2869522 7120509 7179309 4309450 16177239 9327722 15968718 3732212 19085960 19336974 10915739 15998439 7440962 16227642 6623471 17522070 11566570
MESH:D004381 Duodenal Ulcer Curcumin 4.2517351913
MESH:D004487 Edema perfluorooctanoic acid 7.5517259670 12083418
MESH:D004487 Edema pirinixic acid 7.5512083418
MESH:D019446 Endotoxemia Lipopolysaccharides 4.6315821434 15328337 17637181
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.1916239168 12631006 17595544 12795759 61145 16045604 19224547 15959796
MESH:D005234 Fatty Liver Curcumin 14.1919297423
MESH:D005234 Fatty Liver pirinixic acid 14.1919236843 20131406
MESH:D005334 Fever Lipopolysaccharides 4.179205823 11852909
MESH:D005355 Fibrosis Carbon Tetrachloride 16.3218705752
MESH:D005355 Fibrosis Curcumin 16.3218705752
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 16.3217994277
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.9118462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9216452187
MESH:D005909 Glioblastoma Curcumin 3.5817596214
MESH:D006258 Head and Neck Neoplasms Curcumin 3.7718462866 18829502
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.5516366002
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919900420 19110552
MESH:D006529 Hepatomegaly perfluorooctanoic acid 9.433609246
MESH:D006529 Hepatomegaly pirinixic acid 9.4319772884 16221962 19176532 18467677
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.2617701891
MESH:D006689 Hodgkin Disease sodium arsenite 3.3012676792
MESH:D006930 Hyperalgesia perfluorooctanoic acid 3.9912083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006937 Hypercholesterolemia Curcumin 4.2218704882
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006965 Hyperplasia halofuginone 5.4611874485
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007248 Infertility, Male sodium arsenite 3.1015346721 12646999
MESH:D007249 Inflammation Curcumin 9.0616956363 18403477 17151092
MESH:D007249 Inflammation Lipopolysaccharides 9.0617963957 12878042 17255318 9205823 17237260
MESH:D007249 Inflammation perfluorooctanoic acid 9.0612083418
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.8918596194 18200517
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.8918200517
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.8217994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.3810783313
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.8117255318
MESH:D007674 Kidney Diseases sodium arsenite 2.8920008137
MESH:D007889 Leiomyoma Curcumin 4.7618555241
MESH:D007938 Leukemia Curcumin 3.3218462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.3816106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.9616106398
MESH:D007970 Leukopenia Lipopolysaccharides 4.9315821434
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.478812269
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.3516943688 17157831 17174718 11903743 21278145 16239168 17334410 11408273 16221502
MESH:D008103 Liver Cirrhosis halofuginone 7.3517180598
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.9717565644 16136751 15052691 18376398 18317297 17557913 18263696 12586293 18472094 15730626 16015684 15818738 12389079 18251166 12649538 18472332 16116963 17805973 15925388 15338365 12445418 17714472 15893842 12898905 14512876 17766677 17698563 16192424 14620537 15362042 18006644 18412020 15650968 17631135 17823541 18339082 15959796 14748882 12666154 18187930 16011737 17761835 14716496 12632512 18054572 16638106 17976157 18210741 18277467 15931870 15370692 12741479 17944888 16248980 18156304 17869086 18429990 12632514 11481614 18395914 15057751 12546737 18705752 17708605 14724832 17922224 18279442 15123356 20821823 17481882 17721639 15673190 10355542 16097048 13678700 18205269 18166357 17900296 18481824 18420326 16033810 18395095 12609069 12667390 17525996 15996030 18418968 12958196 15876570 14716833 12445421 17640975 16027843
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.9717355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 6.9714739098 11172339 12175628 18458672 16489207
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.9712878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.9715474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.3917285989 15720792 16964402 15830285 16246199
MESH:D008107 Liver Diseases Curcumin 4.3916956363
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.2219294768
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 11.2218709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 11.2220007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 11.2216712894 15276417
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7115583823 12014681
MESH:D008171 Lung Diseases sodium arsenite 3.2819095001
MESH:D055370 Lung Injury Lipopolysaccharides 4.2221114838
MESH:D008175 Lung Neoplasms Curcumin 2.7319359593 18462866 16243823
MESH:D008175 Lung Neoplasms sodium arsenite 2.7317077188 19931552 15276417 17306315 16712894
MESH:D008223 Lymphoma Curcumin 3.7118462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.9116173963
MESH:D008545 Melanoma Curcumin 3.6017885582 18462866
MESH:D008545 Melanoma sodium arsenite 3.6019082730 16487513
MESH:D008569 Memory Disorders Curcumin 4.3517263510
MESH:D009101 Multiple Myeloma Curcumin 3.6319372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.1617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009361 Neoplasm Invasiveness Curcumin 4.5718495463
MESH:D009362 Neoplasm Metastasis clopidogrel 4.2211875746
MESH:D009369 Neoplasms pirinixic acid 5.2017405874
MESH:D009369 Neoplasms sodium arsenite 5.2011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8820056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.8012497104
MESH:D009423 Nervous System Neoplasms Curcumin 5.9018462866
MESH:D009436 Neural Tube Defects sodium arsenite 3.2512854658
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.179802331
MESH:D009765 Obesity Curcumin 4.7319297423
MESH:D009765 Obesity pirinixic acid 4.7320558911
MESH:D010024 Osteoporosis Curcumin 3.5718719352
MESH:D010051 Ovarian Neoplasms Curcumin 5.2118462866 19020741
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.2115276417 17306315
MESH:D010190 Pancreatic Neoplasms Curcumin 2.9917440100 19401701 19196508
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.3817698068
MESH:D011014 Pneumonia Lipopolysaccharides 4.7912224865 11605937
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.6317132714
MESH:D011471 Prostatic Neoplasms Curcumin 3.4118226269 18769126 11398177 10851300 12497104 18156803 15129424
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.4116039940
MESH:D011656 Pulmonary Emphysema Curcumin 4.6919168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.2110666014 18379247
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8410835634
MESH:D012170 Retinal Vein Occlusion clopidogrel 6.3419371211
MESH:D012509 Sarcoma Curcumin 4.2818462866
MESH:D018805 Sepsis Curcumin 4.2218389075
MESH:D012871 Skin Diseases halofuginone 3.5511874485
MESH:D012878 Skin Neoplasms sodium arsenite 2.7718572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9312854658
MESH:D013276 Stomach Ulcer Curcumin 3.6619188055 16631530
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3315821434
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.5118593936
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.5117306315 16452187 16712894 11723127
MESH:D014565 Urogenital Neoplasms Curcumin 5.5018462866
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9311813266
MESH:D014652 Vascular Diseases sodium arsenite 4.6617056641
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
REACT:6900 Signaling in Immune system
KEGG:05150 Staphylococcus aureus infection
KEGG:05322 Systemic lupus erythematosus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25904
    • No data
    Releated disease ID Related disease Name
    PA444822Lupus Erythematosus, Systemic
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00028 binder Intravenous Immunoglobulin Immunomodulatory Agents;Anti-Infectives
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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