AutismKB 2.0

Annotation Detail for TRPC4


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Basic Information Top
Gene Symbol:TRPC4 ( HTRP4,MGC119570,MGC119571,MGC119572,MGC119573,TRP4 )
Gene Full Name: transient receptor potential cation channel, subfamily C, member 4
Band: 13q13.3
Quick LinksEntrez ID:7223; OMIM: 603651; Uniprot ID:TRPC4_HUMAN; ENSEMBL ID: ENSG00000133107; HGNC ID: 12336
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Axon guidance
No data
Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1746Hypertension, Pulmonary
1766Renal Cell cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C038237 1-oleoyl-2-acetylglycerol TRPC4 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Strontium]affects reaction|increases transport 11830588
D016718 Arachidonic Acid TRPC4 protein affects the reaction [Arachidonic Acid results in increased transport of Calcium]affects reaction|increases transport 11830588
D001464 Barium TRPC4 protein affects the reaction [Carbachol results in increased transport of Barium]affects reaction|increases transport 11830588
D001464 Barium TRPC4 protein results in increased transport of Bariumincreases transport 11042129
D002118 Calcium TRPC4 protein affects the reaction [Arachidonic Acid results in increased transport of Calcium]affects reaction|increases transport 11830588
D002118 Calcium TRPC4 protein affects the reaction [Carbachol results in increased transport of Calcium]affects reaction|increases transport 11830588
D002217 Carbachol TRPC4 protein affects the reaction [Carbachol results in increased transport of Barium]affects reaction|increases transport 11830588
D002217 Carbachol TRPC4 protein affects the reaction [Carbachol results in increased transport of Calcium]affects reaction|increases transport 11830588
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TRPC4 mRNAincreases expression 12075121
D011374 Progesterone Progesterone results in increased expression of TRPC4 mRNAincreases expression 18070364
D012643 Selenium Selenium results in decreased expression of TRPC4 mRNAdecreases expression 19244175
D013324 Strontium TRPC4 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Strontium]affects reaction|increases transport 11830588
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Arachidonic Acid 3.0118582451
MESH:D001919 Bradycardia Carbachol 6.1912411408
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6617868700
MESH:D001930 Brain Injuries Progesterone 4.5215665606 15845082 15380490
MESH:D001943 Breast Neoplasms Progesterone 2.4317614352 16175315 15562024
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0217110522 17681005 15861022 17333356 16919318 11677210 16105132
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D003929 Diabetic Neuropathies Progesterone 4.7517187935
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2215131321
MESH:D004487 Edema Arachidonic Acid 4.2411698051 15177302 9831321 7990266 16716910 9599246
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.8412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.8417692515
MESH:D004715 Endometriosis Progesterone 3.9616134523
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0215345470
MESH:D005334 Fever Arachidonic Acid 4.8511852909
MESH:D006333 Heart Failure Selenium 3.1917162251
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Arachidonic Acid 5.919831321 15177302 17371808
MESH:D007249 Inflammation Progesterone 5.9115869954
MESH:D007251 Influenza, Human Selenium 4.5116624496
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.3616316344
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.5517203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.5515318939
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D010018 Osteomalacia Strontium 7.0416815919
MESH:D010024 Osteoporosis Calcium 3.9017882678
MESH:D010051 Ovarian Neoplasms Progesterone 2.5817393432 16525653
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.5615862959 16503802
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
Pathway ID Pathway Name
REACT:18266 Axon guidance
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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