AutismKB 2.0

Annotation Detail for TRPC6


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Basic Information Top
Gene Symbol:TRPC6 ( FLJ11098,FLJ14863,FSGS2,TRP6 )
Gene Full Name: transient receptor potential cation channel, subfamily C, member 6
Band: 11q22.1
Quick LinksEntrez ID:7225; OMIM: 603652; Uniprot ID:TRPC6_HUMAN; ENSEMBL ID: ENSG00000137672; HGNC ID: 12338
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
Axon guidance
Hemostasis
Pathway IDPathway Name
200004Endothelins
200132Nephrin/Neph1 signaling in the kidney podocyte
200157EPO signaling pathway
Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1746Hypertension, Pulmonary
1848Embryoma
1904Diabetes mellitus
2040Hyperglycemia
No data
No data
Desease Name
Glomerulosclerosis, focal segmental, 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063159 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole results in decreased activity of TRPC6 proteindecreases activity 11179201
C044295 1,2-dioctanoylglycerol 1,2-dioctanoylglycerol results in increased activity of TRPC6 proteinincreases activity 11179201
C060229 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased activity of TRPC6 proteindecreases activity 11179201
C036535 1,6-bis(cyclohexyloximinocarbonyl)hexane 1,6-bis(cyclohexyloximinocarbonyl)hexane results in increased activity of TRPC6 proteinincreases activity 11179201
C520323 1-oleoyl-2-acetoyl-sn-glycerol 1-oleoyl-2-acetoyl-sn-glycerol affects the reaction [TRPC6 protein affects the transport of Barium]affects reaction|affects transport 16055711
C520323 1-oleoyl-2-acetoyl-sn-glycerol 1-oleoyl-2-acetoyl-sn-glycerol results in increased activity of TRPC6 proteinincreases activity 11179201
C520323 1-oleoyl-2-acetoyl-sn-glycerol TRPC6 protein promotes the reaction [1-oleoyl-2-acetoyl-sn-glycerol results in increased transport of Calcium]increases reaction|increases transport 15672411
D000584 Amiloride Amiloride results in decreased activity of TRPC6 proteindecreases activity 11179201
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TRPC6 mRNAaffects expression 16483693
D001464 Barium 1-oleoyl-2-acetoyl-sn-glycerol affects the reaction [TRPC6 protein affects the transport of Barium]affects reaction|affects transport 16055711
D001464 Barium ADRA1A protein promotes the reaction [TRPC6 protein results in increased transport of Barium]increases reaction|increases transport 11179201
D001464 Barium TRPC6 protein affects the transport of Bariumaffects transport 16055711
D001464 Barium TRPC6 protein results in increased transport of Bariumincreases transport 11179201
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TRPC6 mRNAincreases expression 17879257
D002104 Cadmium Cadmium results in decreased activity of TRPC6 proteindecreases activity 11179201
D002118 Calcium TRPC6 protein affects the transport of Calciumaffects transport 18209485
D002118 Calcium TRPC6 protein affects the transport of Calciumaffects transport 18209485
D002118 Calcium TRPC6 protein results in increased transport of Calciumincreases transport 11179201
D002118 Calcium TRPC6 protein affects the transport of Calciumaffects transport 15672411
D002118 Calcium TRPC6 protein promotes the reaction [1-oleoyl-2-acetoyl-sn-glycerol results in increased transport of Calcium]increases reaction|increases transport 15672411
D002118 Calcium TRPC6 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]increases reaction|increases transport 15672411
D002118 Calcium TRPC6 protein results in increased transport of Calciumincreases transport 18822394
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of TRPC6 mRNAincreases expression 16644059
D002586 Cesium TRPC6 protein results in increased transport of Cesiumincreases transport 11179201
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TRPC6 mRNAincreases expression 17351261
D005419 Flavonoids Flavonoids results in increased expression of TRPC6 mRNAincreases expression 18035473
D005682 Gadolinium Gadolinium results in decreased activity of TRPC6 proteindecreases activity 11179201
C023427 guanosine 5'-O-(2-thiodiphosphate) guanosine 5'-O-(2-thiodiphosphate) results in decreased activity of TRPC6 proteindecreases activity 11179201
D016244 Guanosine 5'-O-(3-Thiotriphosphate) Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of TRPC6 proteinincreases activity 11179201
D007501 Iron TRPC6 protein results in increased uptake of Ironincreases uptake 14640978
D007811 Lanthanum Lanthanum results in decreased activity of TRPC6 proteindecreases activity 11179201
D008094 Lithium TRPC6 protein results in increased transport of Lithiumincreases transport 11179201
D008345 Manganese TRPC6 protein results in increased transport of Manganeseincreases transport 11179201
D009151 Mustard Gas Mustard Gas results in increased expression of TRPC6 mRNAincreases expression 15674844
D010656 Phenylephrine TRPC6 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]increases reaction|increases transport 15672411
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TRPC6 mRNAaffects binding|increases activity|increases expression 19710929
D011188 Potassium TRPC6 protein results in increased transport of Potassiumincreases transport 11179201
D012413 Rubidium TRPC6 protein results in increased transport of Rubidiumincreases transport 11179201
D012964 Sodium TRPC6 protein results in increased transport of Sodiumincreases transport 11179201
D013324 Strontium TRPC6 protein results in increased transport of Strontiumincreases transport 11179201
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.3018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6817505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 3.9520127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.9514692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.506695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.2216434500
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.3916640825
MESH:D000544 Alzheimer Disease Iron 4.7116563566 16640825
MESH:D000544 Alzheimer Disease Lithium 4.7119621015
MESH:D000740 Anemia Iron 4.1416566752 16434484
MESH:D018798 Anemia, Iron-Deficiency Iron 4.4217147795 16569441 17375513 17162259 17163184
MESH:D000756 Anemia, Sideroblastic Iron 10.1916910769
MESH:D000756 Anemia, Sideroblastic Manganese 10.1916910769
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8219183758
MESH:D001145 Arrhythmias, Cardiac Iron 8.6016604332
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 8.6017460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5015885639
MESH:D001249 Asthma Mustard Gas 2.6310378619
MESH:D001260 Ataxia Telangiectasia Iron 5.1915336622
MESH:D050197 Atherosclerosis Cadmium 6.6815687053
MESH:D050197 Atherosclerosis Iron 6.6816640825 16632123
MESH:D001321 Autistic Disorder Iron 2.8117352947
MESH:D001424 Bacterial Infections Iron 4.9316640825
MESH:D001714 Bipolar Disorder Lithium 4.1917594078 20046352 19153942 20338123
MESH:D001768 Blister Mustard Gas 4.9019167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.9119483382
MESH:D001919 Bradycardia Phenylephrine 4.2815306635
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0920146248 17474063
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7117687719 10378619
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5216124888 15700767 16011737 18705752 3786805 16192424 15673190 16227642 16050911 10355542 15721981 16097048
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8018788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 1.9820419170
MESH:D002295 Carcinoma, Transitional Cell Amiloride 4.8514644129
MESH:D006332 Cardiomegaly Phenylephrine 3.3917124262 15728586 16170337 11754973 17287366 11179087
MESH:D009202 Cardiomyopathies Iron 3.8716640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.3716604332
MESH:D002471 Cell Transformation, Neoplastic Cadmium 3.5217332340
MESH:D002779 Cholestasis Ethinyl Estradiol 7.1017110522 17681005 11677210 16919318 16105132 17333356 15861022
MESH:D002779 Cholestasis pirinixic acid 7.1019176532
MESH:D003092 Colitis Amiloride 4.8512065299
MESH:D003110 Colonic Neoplasms Iron 2.8516640825
MESH:D007644 Darier Disease Lithium 5.6520338123
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.4919244398
MESH:D003920 Diabetes Mellitus Iron 4.2316604332 16640825
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.2816506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 3.0316506275
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 1.9815027814 6623471 21278145 11566570 2869522 15998439 10915739 7120509 3732212 16227642 15968718 4309450 17522070 10092053 19085960 3786805 7179309 6884620 16177239 7440962 19336974 9327722
MESH:D004487 Edema Mustard Gas 6.119260866 11402378 11428631 11428647
MESH:D004487 Edema pirinixic acid 6.1112083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9412538720
MESH:D004890 Erythema Mustard Gas 4.909357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9416530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 16.8612795759 19224547 12631006 15959796 17595544 61145 16239168 16045604
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.8615345470
MESH:D005234 Fatty Liver Iron 16.8616640825
MESH:D005234 Fatty Liver pirinixic acid 16.8620131406 19236843
MESH:D005355 Fibrosis Carbon Tetrachloride 3.2018705752
MESH:D005621 Friedreich Ataxia Iron 5.1716640825 16604332
MESH:D005909 Glioblastoma Manganese 3.7517043766
MESH:D005923 Glomerulosclerosis, Focal Segmental marker/mechanism
MESH:D006130 Growth Disorders Amiloride 4.5919703807
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6820471113
MESH:D006330 Heart Defects, Congenital Lithium 6.6819638421
MESH:D006333 Heart Failure pirinixic acid 2.3820558911
MESH:D006432 Hemochromatosis Iron 4.3016604332 16574947 16640825 17053826 17255318 17236123
MESH:D006486 Hemosiderosis Iron 4.9516604332
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3519900420 19110552
MESH:D006525 Hepatitis, Viral, Human Iron 5.2016640825
MESH:D006527 Hepatolenticular Degeneration Iron 4.6817182432
MESH:D006529 Hepatomegaly Iron 7.9316890145
MESH:D006529 Hepatomegaly pirinixic acid 7.9318467677 19176532 16221962 19772884
MESH:D015658 HIV Infections Iron 3.5416597321
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2716899240
MESH:D006943 Hyperglycemia pirinixic acid 2.9620558911
MESH:D006973 Hypertension Amiloride 5.6918524855 19344079 15174897
MESH:D006973 Hypertension Phenylephrine 5.6912717712 8949925
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8315338365
MESH:D006984 Hypertrophy Phenylephrine 4.3212791704 18502941
MESH:D007006 Hypogonadism Iron 4.2216640825
MESH:D020514 Hypokalemic Periodic Paralysis Amiloride 12.2419822448
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 12.2419822448
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5516945680 16569931
MESH:D007037 Hypothyroidism Iron 4.8216640825
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3217937319
MESH:D007249 Inflammation Amiloride 7.8317237260
MESH:D007249 Inflammation Flavonoids 7.8317296493
MESH:D007249 Inflammation Mustard Gas 7.8311428631 9357497 11402378 11428620 11428647 8975870 16001271 17524151 9260866
MESH:D007333 Insulin Resistance pirinixic acid 2.4616306350
MESH:D019189 Iron Metabolism Disorders Iron 4.7917163184
MESH:D007674 Kidney Diseases Cadmium 3.3616322080 16226777 16962696
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.7816316344
MESH:D020961 Lewy Body Disease Iron 5.1716563566
MESH:D056929 Liddle Syndrome Amiloride 5.7119344079
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.4616943688 17334410 17157831 11408273 16221502 17174718 11903743 21278145 16239168
MESH:D008103 Liver Cirrhosis Iron 6.4616640825
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.2415370692 17557913 16136751 17631135 16097048 17922224 15959796 18187930 17565644 12667390 17944888 18412020 20821823 15362042 14512876 15338365 17698563 16015684 16033810 12445421 18317297 18376398 12649538 15996030 18395095 12586293 17869086 18339082 12389079 16192424 18705752 17805973 12445418 18395914 15057751 10355542 15650968 15931870 14724832 18418968 12609069 15818738 11481614 12632512 16116963 16027843 18481824 17714472 15925388 13678700 17900296 16248980 14716833 18279442 18054572 17766677 18472094 18277467 18006644 12666154 17976157 17823541 15893842 15673190 18263696 12546737 16011737 15123356 18420326 14716496 18166357 14748882 15052691 17761835 17481882 18429990 16638106 17525996 14620537 18251166 15730626 18210741 18472332 12632514 12898905 18156304 15876570 12741479 17640975 12958196 17721639 18205269 17708605
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2415474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0215830285 15720792 17285989 16246199 16964402
MESH:D008108 Liver Diseases, Alcoholic Iron 4.7517207112 16737972
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9115123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4616899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 9.8920195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 9.8919294768
MESH:D008113 Liver Neoplasms Iron 9.8916640825 20302851
MESH:D008113 Liver Neoplasms pirinixic acid 9.8915890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.4612014681 15583823
MESH:D008171 Lung Diseases Mustard Gas 3.2818702808 18161513
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.426695378 20464547 17053015 20869020 20064080 18520028 18816296 20135361 18569708
MESH:D008175 Lung Neoplasms Iron 3.4216640825
MESH:D008175 Lung Neoplasms Mustard Gas 3.428781369 3148597
MESH:D008268 Macular Degeneration Iron 3.8416640825
MESH:D020149 Manganese Poisoning Manganese 5.2516551646 19453300 16568477
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9916381670
MESH:D009069 Movement Disorders Manganese 4.7716551646
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.4017086897
MESH:D009135 Muscular Diseases pirinixic acid 3.2516239165
MESH:D009181 Mycoses Iron 5.2016640825
MESH:D009203 Myocardial Infarction Lithium 5.7016288908
MESH:D009203 Myocardial Infarction pirinixic acid 5.7019151258
MESH:D017202 Myocardial Ischemia Iron 4.2416604332
MESH:D015428 Myocardial Reperfusion Injury Iron 7.9516604332
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9516411023
MESH:D009361 Neoplasm Invasiveness Amiloride 5.0514644129
MESH:D009369 Neoplasms Benzo(a)pyrene 4.3911141357
MESH:D009369 Neoplasms pirinixic acid 4.3917405874
MESH:D009404 Nephrotic Syndrome Iron 4.3017178036
MESH:D009410 Nerve Degeneration Manganese 4.0816551646
MESH:D009436 Neural Tube Defects 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole 5.5317326132
MESH:D019636 Neurodegenerative Diseases Iron 4.0317296847 16604332
MESH:D009503 Neutropenia Mustard Gas 3.7316761898 7688884
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D010003 Osteoarthritis Iron 3.8116640825
MESH:D010018 Osteomalacia Strontium 6.4916815919
MESH:D010024 Osteoporosis Calcium 7.1617882678
MESH:D010024 Osteoporosis Iron 7.1616648989 16640825
MESH:D010146 Pain 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 4.6018987195
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4411578682
MESH:D010212 Papilloma Iron 4.2312065085
MESH:D020447 Parasomnias Iron 5.7517352947
MESH:D010300 Parkinson Disease Iron 5.5816640825 16563566
MESH:D010300 Parkinson Disease Manganese 5.5811181820
MESH:D020734 Parkinsonian Disorders Manganese 4.2416140633
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.1215687053
MESH:D010900 Pituitary Diseases Iron 5.4016604332
MESH:D011041 Poisoning Iron 8.1916604332
MESH:D011041 Poisoning Mustard Gas 8.1915727166
MESH:D017119 Porphyria Cutanea Tarda Iron 4.7316640825
MESH:D011225 Pre-Eclampsia Iron 4.2216640825
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.5417292933
MESH:D011471 Prostatic Neoplasms Cadmium 3.5417075824
MESH:D011528 Protozoan Infections Iron 5.7516640825
MESH:D011537 Pruritus Ethinyl Estradiol 8.6516919318 15861022
MESH:D011537 Pruritus Mustard Gas 8.6518058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8317720292 17266442 10334151 17894541 17620002
MESH:D015427 Reperfusion Injury pirinixic acid 2.2619058328
MESH:D012148 Restless Legs Syndrome Iron 4.3516930377
MESH:D012640 Seizures Lithium 3.8119660546
MESH:D012852 Sinusitis Phenylephrine 4.447327846
MESH:D012871 Skin Diseases Mustard Gas 2.6515451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5810029692 19755658
MESH:D012878 Skin Neoplasms Iron 5.5812065085
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6816709447
MESH:D013226 Status Epilepticus Lithium 5.5219430551 19951488 19570321
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5520155912 2093021
MESH:D013398 Sudden Infant Death Iron 5.1916640825
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9315669648
MESH:D014376 Tuberculosis Iron 3.9216597321
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.0817053015
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0514692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3015869587 14671159
Pathway ID Pathway Name
REACT:18266 Axon guidance
REACT:604 Hemostasis
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37011
    • No data
    Releated disease ID Related disease Name
    PA444289Glomerulosclerosis, Focal Segmental
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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