AutismKB 2.0

Annotation Detail for TRPM2


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Basic Information Top
Gene Symbol:TRPM2 ( EREG1,KNP3,LTRPC2,MGC133383,NUDT9H,NUDT9L1,TRPC7 )
Gene Full Name: transient receptor potential cation channel, subfamily M, member 2
Band: 21q22.3
Quick LinksEntrez ID:7226; OMIM: 603749; Uniprot ID:TRPM2_HUMAN; ENSEMBL ID: ENSG00000142185; HGNC ID: 12339
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2045Bipolar disorder
Desease Name
bipolar disorder
PSYCH
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TRPM2 mRNAaffects expression 21346803
D002118 Calcium TRPM2 protein affects the transport of Calciumaffects transport 16933200
D002118 Calcium TRPM2 protein results in increased transport of Calciumincreases transport 12529379
C014347 decitabine decitabine results in decreased expression of TRPM2 mRNAdecreases expression 19194470
D004052 Diethylnitrosamine [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TRPM2 mRNAaffects cotreatment|increases expression 16158176
D005439 Flufenamic Acid Flufenamic Acid inhibits the reaction [Hydrogen Peroxide results in increased activity of TRPM2 protein]decreases reaction|increases activity 16933200
D005439 Flufenamic Acid Flufenamic Acid results in decreased activity of TRPM2 proteindecreases activity 16933200
D015073 2-Acetylaminofluorene [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TRPM2 mRNAaffects cotreatment|increases expression 16158176
D006861 Hydrogen Peroxide Flufenamic Acid inhibits the reaction [Hydrogen Peroxide results in increased activity of TRPM2 protein]decreases reaction|increases activity 16933200
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased activity of TRPM2 proteinincreases activity 16933200
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 2-Acetylaminofluorene 7.5210737359
MESH:D000236 Adenoma Diethylnitrosamine 7.5210737359 6695378
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 6.456705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3019052882 17162532 19061943 18056438 16434500 17620307
MESH:D001943 Breast Neoplasms decitabine 2.2618320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2617474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.9016705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 4.9017761372 3581430 6705139 10737359 3084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.9019418558 17162532 10672840 20084675 16328049 19394651 16878318 20101231 16935385 20935162 17055752 17978847 20514400 21159647 20432363 11831363 18971187 18785209 18665156 3084413 20727157 16288022 10737359 20512989 18788625 19822196 16681979 19539802 16502159 16807293 19919837 19383236 16569478 18978308 18691550 19107877 20214788 18506893 18056438 18210153 19208518 19701751 16698587 17173139 17138121 18494052 16540662 19171122 19335982 16779866 3581430 16830150 20524982 20007298 19052882 17428255 18393292 17761372 19519916
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6519215824
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.6916936243
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.047505956 17174075 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9319052882
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3718551238
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2420387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.1118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.1119107877
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.5619294695
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D005234 Fatty Liver Diethylnitrosamine 3.4621071580 20387270
MESH:D006258 Head and Neck Neoplasms decitabine 3.6619215824
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.766705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.696705139
MESH:D007248 Infertility, Male decitabine 3.3817581917
MESH:D007249 Inflammation Diethylnitrosamine 2.5018785209
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.5616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2116705839
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.4916316344
MESH:D007938 Leukemia decitabine 3.1919235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.2817236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4117679729 18206229 18704418 19387464 18460780 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9118055864
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9619638242 20032147 18665156 18407596 18522880
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1517034775
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 5.2214678523 10672840 11376686 10737359 16273603 18001218
MESH:D008113 Liver Neoplasms Diethylnitrosamine 5.2219254457 19256749 2422723 20434301 18648771 19812893 19294768 12112319 18978307 21047994 19090486 20405173 20501860 19073162 15175105 19426721 20118626 10737359 18977376 20492335 20101389 19499222 19551842 18754104 2862719 20583210 21278145 19427195 20452335 20137499 18644402 15885732 19850985 19255062 12771043 19996281 16942905 19833225 19690152 19638242 21167192 9163691 21071580 19642983
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 6.826150874 534488 1399818
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.8219519916 18164116 19004024 18308698 16267830 17854601 19539802 3124819 17174075 18775883 2563599 18544905 19009564 19126423 18253720 21159647 18282651 9362446 16842330 17942915 18093689 18079962
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 2.8411376686
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.8420970405 6695378 21163286 20512841
MESH:D008223 Lymphoma decitabine 3.6119470736
MESH:D008545 Melanoma decitabine 2.2717785578 16505122
MESH:D009101 Multiple Myeloma decitabine 3.5418172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5219157545 19010910 16882708 18608210
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2518551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.669029167 3581430
MESH:D009369 Neoplasms decitabine 2.8319116145 17925555 19470736
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6912819281 16049721
MESH:D010024 Osteoporosis Calcium 3.9317882678
MESH:D010051 Ovarian Neoplasms decitabine 2.7219259094 19331143
MESH:D010190 Pancreatic Neoplasms decitabine 5.6419294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.6416540662
MESH:D010212 Papilloma Hydrogen Peroxide 4.4412065085
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.802563599
MESH:D055728 Primary Myelofibrosis decitabine 5.0917616702
MESH:D012208 Rhabdomyosarcoma decitabine 4.7119155313
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7118551238
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 3.1812065085
MESH:D013274 Stomach Neoplasms decitabine 2.5819037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.5818456281
MESH:D013964 Thyroid Neoplasms decitabine 7.9917967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.997505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 9.0116049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 9.0115867355 15289314 1399818
MESH:D001749 Urinary Bladder Neoplasms decitabine 9.0119087683 17616700
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
MESH:D014604 Uveal Neoplasms decitabine 5.3617785578
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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