AutismKB 2.0

Annotation Detail for TSC2


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Basic Information Top
Gene Symbol:TSC2 ( FLJ43106,LAM,TSC4 )
Gene Full Name: tuberous sclerosis 2
Band: 16p13.3
Quick LinksEntrez ID:7249; OMIM: 191092; Uniprot ID:TSC2_HUMAN; ENSEMBL ID: ENSG00000103197; HGNC ID: 12363
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa04150mTOR signaling pathway
hsa04115p53 signaling pathway
Pathway IDPathway Name
Signalling by NGF
Signaling by Insulin receptor
Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
200135p38 signaling mediated by MAPKAP kinases
200080mTOR signaling pathway
200061LKB1 signaling events
200101Direct p53 effectors
Pathway IDPathway Name
P00033Insulin/IGF pathway-protein kinase B signaling cascade
P04397p53 pathway by glucose deprivation
Pathway IDPathway Name
500906Inhibition of TSC complex formation by PKB
500503Regulation of Rheb GTPase activity by AMPK
500640AKT phosphorylates targets in the cytosol
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1709Parkinson disease
1740Alzheimer's disease
1824Bone disease
1860Brain tumor
1883Polycystic kidney
1886Angiomyolipoma
1910Infantile spasms
1911Intestinal disease
1944Breast cancer
1976Squamous cell cancer
1988PEComa
2031Endometrial cancer
2106Pancreas cancer
2124Autistic disorder
2176Tuberous sclerosis
2237Neoplasm metastasis
Desease Name
gangliogliomas
CANCER
No data
Desease Name
Lymphangioleiomyomatosis, somatic
Tuberous sclerosis-2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TSC2 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of TSC2 mRNAincreases expression 16788091
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of TSC2 mRNAdecreases expression 12419474
C075773 4-phenylbutyric acid 4-phenylbutyric acid results in increased expression of TSC2 mRNAincreases expression 14583596
D000082 Acetaminophen Acetaminophen affects the expression of TSC2 mRNAaffects expression 17562736
D013196 Dihydrotestosterone Dihydrotestosterone inhibits the reaction [FSHB protein results in increased phosphorylation of TSC2 protein]decreases reaction|increases phosphorylation 17510244
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TSC2 mRNAaffects expression 16483693
D001374 Azacitidine [Azacitidine affects the methylation of TSC2 promoter] which affects the expression of TSC2 mRNAaffects expression|affects methylation 18538015
D001374 Azacitidine Azacitidine results in decreased methylation of TSC2 promoterdecreases methylation 19250671
D001374 Azacitidine Azacitidine results in increased expression of TSC2 mRNAincreases expression 19250671
D001554 Benzene Benzene results in increased expression of TSC2 mRNAincreases expression 12928149
D001554 Benzene TRP53 protein affects the reaction [Benzene results in increased expression of TSC2 mRNA]affects reaction|increases expression 12928149
D003474 Curcumin Curcumin results in decreased phosphorylation of TSC2 proteindecreases phosphorylation 18790744
D004054 Diethylstilbestrol TSC2 gene mutant form results in increased susceptibility to Diethylstilbestrolincreases response to substance 15937110
D005472 Fluorouracil Fluorouracil results in increased expression of TSC2 mRNAincreases expression 16584549
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of TSC2 mRNAdecreases expression 12419474
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of TSC2 mRNAincreases expression 12057914
C044361 M-VAC protocol TSC2 protein results in decreased susceptibility to M-VAC protocoldecreases response to substance 15814643
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FSHB protein results in increased phosphorylation of TSC2 protein]decreases reaction|increases phosphorylation 17510244
C093973 PD 98059 PD 98059 inhibits the reaction [FSHB protein results in increased phosphorylation of TSC2 protein]decreases reaction|increases phosphorylation 17510244
D010656 Phenylephrine Phenylephrine results in increased phosphorylation of TSC2 proteinincreases phosphorylation 15795328
15757502
D010656 Phenylephrine SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]increases phosphorylation|increases reaction 15795328
D010656 Phenylephrine U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]decreases reaction|increases phosphorylation 15757502
D011794 Quercetin Quercetin results in increased expression of TSC2 mRNAincreases expression 14715546
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of TSC2 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of TSC2 mRNAincreases expression 19244175
D020123 Sirolimus Sirolimus inhibits the reaction [TSC2 gene mutant form results in increased expression of DDIT3 protein]decreases reaction|increases expression 19420259
D020123 Sirolimus Sirolimus inhibits the reaction [TSC2 gene mutant form results in increased expression of ERO1L mRNA]decreases reaction|increases expression 19420259
D020123 Sirolimus Sirolimus inhibits the reaction [TSC2 gene mutant form results in increased expression of HMOX1 protein]decreases reaction|increases expression 19420259
C017947 sodium arsenite sodium arsenite results in decreased expression of TSC2 mRNAdecreases expression 12760830
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased phosphorylation of TSC2 proteinincreases phosphorylation 15757502
D013755 Tetradecanoylphorbol Acetate U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of TSC2 protein]decreases reaction|increases phosphorylation 15757502
C113580 U 0126 U 0126 inhibits the reaction [FSHB protein results in increased phosphorylation of TSC2 protein]decreases reaction|increases phosphorylation 17510244
C113580 U 0126 U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]decreases reaction|increases phosphorylation 15757502
C113580 U 0126 U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of TSC2 protein]decreases reaction|increases phosphorylation 15757502
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of TSC2 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of TSC2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D000168 Acrocephalosyndactylia U 0126 5.2817694057
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.8511850527 18653653
MESH:D000230 Adenocarcinoma Fluorouracil 2.3817638652
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7116712894 17306315
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8917887948
MESH:D000544 Alzheimer Disease Curcumin 2.5815590663
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3015469931
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.9810965797
MESH:D000740 Anemia Fluorouracil 3.5516511603 15504547 17963324
MESH:D000741 Anemia, Aplastic Benzene 4.2217661222 11369114 14761424
MESH:D000743 Anemia, Hemolytic Quercetin 4.0717084956
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9517460149
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6916807698
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7815336622
MESH:D050197 Atherosclerosis Curcumin 3.2118704882
MESH:D001321 Autistic Disorder marker/mechanism 14627686
MESH:D001321 Autistic Disorder Acetaminophen 2.2918445737
MESH:D001321 Autistic Disorder Sirolimus 2.2921115397
MESH:D001327 Autoimmune Diseases Curcumin 10.2419761891
MESH:D001327 Autoimmune Diseases Quercetin 10.2419761891
MESH:D001855 Bone Marrow Diseases Benzene 5.0416183116
MESH:D001919 Bradycardia Phenylephrine 4.3515306635
MESH:D001927 Brain Diseases marker/mechanism 21062901
MESH:D002545 Brain Ischemia Curcumin 4.1416770732
MESH:D001932 Brain Neoplasms Curcumin 3.7717596214
MESH:D001943 Breast Neoplasms Benzene 2.3117162533 11921183
MESH:D001943 Breast Neoplasms Curcumin 2.3116243823 19250217 18593918 18462866
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.3117129689 15324884
MESH:D001943 Breast Neoplasms Fluorouracil 2.3118357371 19217205 16110121 15136595 16557594 16595493 18608205
MESH:D001943 Breast Neoplasms Quercetin 2.3118628248
MESH:D002105 Cadmium Poisoning Quercetin 5.3516962696
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.7416050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4816051944
MESH:D002277 Carcinoma Curcumin 8.0718593918
MESH:D002277 Carcinoma Fluorouracil 8.0717121937
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.6116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.613084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 13.6116924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.6116332177 18930000 17045692 17088986 16799960 17971768
MESH:D006528 Carcinoma, Hepatocellular Quercetin 13.6119519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 13.6119335982
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.6116507464 15276417 17306315
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9118414057
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7717234771
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9318695887
MESH:D002294 Carcinoma, Squamous Cell marker/mechanism 18538015
MESH:D002294 Carcinoma, Squamous Cell Curcumin 13.7818462866
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 13.7817066447 18986760 16757204 16280240
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 13.7819435901
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 13.7818572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 13.7818922899
MESH:D006332 Cardiomegaly Phenylephrine 6.8815728586 11179087 11754973 16170337 17287366 17124262
MESH:D006332 Cardiomegaly Quercetin 6.8819794523
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.3816936243
MESH:D002386 Cataract Acetaminophen 2.4710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.316135515
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.3120056578 19524636
MESH:D003092 Colitis Curcumin 9.0416782535 16804969 18200517
MESH:D003092 Colitis Selenium 9.0417936198
MESH:D003103 Coloboma Curcumin 4.3818809619
MESH:D003110 Colonic Neoplasms Curcumin 5.7119359593 16340194
MESH:D003110 Colonic Neoplasms Fluorouracil 5.7117172411 17018589 16340194 16510598 17287894 17725105 17016597 15001691 17169374 18772588
MESH:D003110 Colonic Neoplasms Quercetin 5.7117148506 16640504 11134977 19440933 19056647 17191121 15741050
MESH:D015179 Colorectal Neoplasms Azacitidine 3.5019934284
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.5020501625 17454858 18448328 17094418 16391804 17594712 17401013 18802399 16331619 18383874 17255274 15148649 15289873 18949393 17695437 16282729 14970324 17016601 16524972 16303861 18509181 18288408
MESH:D015179 Colorectal Neoplasms Quercetin 3.5018095365 18852136
MESH:D016510 Corneal Neovascularization Curcumin 4.7118497527
MESH:D019465 Craniofacial Abnormalities Benzene 2.8615643154
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.8619769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3716002989 12952375
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8318551238
MESH:D007644 Darier Disease Fluorouracil 4.6016733453
MESH:D003872 Dermatitis Benzene 4.5815902427
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5819496084
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.6618403477
MESH:D003928 Diabetic Nephropathies Curcumin 3.8518204486
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 5.8721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.8717522070 16781746 19370779 19739265 12540782 11743745 12594235 14725611 10774834 11461765 11834606 19416960 18713872 11287661 14550746 10915739 11421492 17906064 12958197 12705907 15619225 18071297 14986274 11529661 16177239 11739529 19164858 19420014 19923254 16109766 16393943 12153990 15968718 12392966 10663392 16485898 16227642 17562736 19085960 2444490 16081117
MESH:D056486 Drug-Induced Liver Injury Selenium 5.8715131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004381 Duodenal Ulcer Curcumin 3.8717351913
MESH:C538011 Eales disease Vitamin E 4.519068938
MESH:D004487 Edema Tetradecanoylphorbol Acetate 3.4515177302 8113982 8273558 16716910 11698051 9599246 7812673
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.5016402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.3416804899 15700306
MESH:D019446 Endotoxemia Lipopolysaccharides 4.2017637181 15328337 15821434
MESH:D004827 Epilepsy marker/mechanism 21062901
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4016337965 15173087 17638652 16785472 16481741
MESH:D005234 Fatty Liver Curcumin 3.5319297423
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5416534752 16513791 16002989 15751030 16611131
MESH:D005334 Fever Lipopolysaccharides 3.859205823 11852909
MESH:D005355 Fibrosis Curcumin 8.5118705752
MESH:D005355 Fibrosis Quercetin 8.5119474275
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.5018462866
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 12.1716452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 12.1716452187
MESH:D005909 Glioblastoma Curcumin 7.0217596214
MESH:D005909 Glioblastoma Quercetin 7.0219804834
MESH:D005910 Glioma Fluorouracil 5.9416145905
MESH:D005910 Glioma Quercetin 5.9417643826
MESH:D006258 Head and Neck Neoplasms Curcumin 12.4318462866 18829502
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.4318337622 15102660 15162350
MESH:D006258 Head and Neck Neoplasms Sirolimus 12.4319435901
MESH:D006330 Heart Defects, Congenital Vitamin E 2.8916080930
MESH:D006333 Heart Failure Selenium 2.9617162251
MESH:D006402 Hematologic Diseases Benzene 4.4816183116
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2216366002
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.8517701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6416863852 16490937
MESH:D006689 Hodgkin Disease sodium arsenite 3.0012676792
MESH:D019584 Hot Flashes Vitamin E 3.7814716179
MESH:D006930 Hyperalgesia Acetaminophen 2.5516870215
MESH:D006937 Hypercholesterolemia Curcumin 3.8818704882
MESH:D006943 Hyperglycemia Quercetin 3.8618262572 11834736
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2512960047 14722030
MESH:D006973 Hypertension Benzene 8.4517940673
MESH:D006973 Hypertension Phenylephrine 8.458949925 12717712
MESH:D006973 Hypertension Quercetin 8.4518356687
MESH:D006984 Hypertrophy Phenylephrine 10.4418502941 12791704
MESH:D006984 Hypertrophy Sirolimus 10.4419211884
MESH:D007021 Hypospadias Diethylstilbestrol 4.3916002989
MESH:D007246 Infertility Diethylstilbestrol 4.1715036965
MESH:D007248 Infertility, Male sodium arsenite 2.8612646999 15346721
MESH:D007249 Inflammation Curcumin 8.0018403477 16956363 17151092
MESH:D007249 Inflammation Lipopolysaccharides 8.0012878042 17963957 9205823 17255318 17237260
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 8.008273558 15177302 7562506 7812673 11698051
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1318596194 18200517
MESH:D007251 Influenza, Human Quercetin 17.5016624496
MESH:D007251 Influenza, Human Selenium 17.5016624496
MESH:D007251 Influenza, Human Vitamin E 17.5016624496
MESH:D007414 Intestinal Neoplasms Curcumin 4.0510783313
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4517255318
MESH:D007627 Keloid Quercetin 4.7717086741
MESH:D007674 Kidney Diseases Acetaminophen 13.5615629191 12587719
MESH:D007674 Kidney Diseases Quercetin 13.5616962696
MESH:D007674 Kidney Diseases sodium arsenite 13.5620008137
MESH:D007674 Kidney Diseases Vitamin E 13.5612488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.4516518626
MESH:D007676 Kidney Failure, Chronic Selenium 9.4516518626
MESH:D007680 Kidney Neoplasms marker/mechanism 11170505
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.6116705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.6116762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Fluorouracil 11.6116985049
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8717184923
MESH:D007889 Leiomyoma marker/mechanism 15937110
MESH:D007889 Leiomyoma Curcumin 4.3918555241
MESH:D007938 Leukemia Azacitidine 14.2919148494
MESH:D007938 Leukemia Benzene 14.2914694614 18335105 15935818 17119257
MESH:D007938 Leukemia Curcumin 14.2918462866
MESH:D007938 Leukemia Quercetin 14.2917468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.0316106398
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 11.4516972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 11.4516972261
MESH:D007951 Leukemia, Myeloid Azacitidine 9.4419077051
MESH:D007951 Leukemia, Myeloid Benzene 9.4417506065
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 19250671
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 4.3118720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.3119478238
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.0119299654
MESH:D015458 Leukemia, T-Cell Curcumin 4.5816106398
MESH:D007970 Leukopenia Lipopolysaccharides 4.5115821434
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.5317355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.5312878042
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.5312741479
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 6.5317050028
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.5316169303
MESH:D008107 Liver Diseases Acetaminophen 3.9319460945 12587719 19784758 16610002 19014921 16611625 12969438 11587558
MESH:D008107 Liver Diseases Curcumin 3.9316956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0717185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.497678174
MESH:D008113 Liver Neoplasms Diethylstilbestrol 13.4916712894 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 13.4916603448 15113037 17045692 18383874
MESH:D008113 Liver Neoplasms Quercetin 13.4918980244
MESH:D008113 Liver Neoplasms sodium arsenite 13.4915276417 16712894
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.326135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Benzene 9.3212562636
MESH:D008114 Liver Neoplasms, Experimental Quercetin 9.3219519916
MESH:D008171 Lung Diseases sodium arsenite 7.0219095001
MESH:D008171 Lung Diseases Vitamin E 7.0216863852
MESH:D017563 Lung Diseases, Interstitial Benzene 4.6214698565
MESH:D055370 Lung Injury Lipopolysaccharides 3.8221114838
MESH:D008175 Lung Neoplasms Azacitidine 12.5821224363
MESH:D008175 Lung Neoplasms Benzene 12.5812562636
MESH:D008175 Lung Neoplasms Curcumin 12.5819359593 18462866 16243823
MESH:D008175 Lung Neoplasms Fluorouracil 12.5815246190
MESH:D008175 Lung Neoplasms Quercetin 12.5816280456
MESH:D008175 Lung Neoplasms sodium arsenite 12.5817077188 16712894 17306315 15276417 19931552
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 12.5811807781
MESH:D008175 Lung Neoplasms Vitamin E 12.5811062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6015086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9615166399
MESH:D018192 Lymphangioleiomyomatosis marker/mechanism
MESH:D008223 Lymphoma Benzene 11.9117119257 17584886
MESH:D008223 Lymphoma Curcumin 11.9118462866
MESH:D008223 Lymphoma Diethylstilbestrol 11.9115700306
MESH:D016399 Lymphoma, T-Cell Curcumin 4.5016173963
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3216002989
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.2512562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 9.4511921183
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.4515318939
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 9.458985016
MESH:D008545 Melanoma Curcumin 5.1418462866 17885582
MESH:D008545 Melanoma Sirolimus 5.1419282848
MESH:D008545 Melanoma sodium arsenite 5.1419082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D008569 Memory Disorders Curcumin 3.9717263510
MESH:D008654 Mesothelioma Selenium 2.7215107826
MESH:D009006 Monosomy Azacitidine 5.8919299654
MESH:D009062 Mouth Neoplasms marker/mechanism 18538015
MESH:D009062 Mouth Neoplasms Fluorouracil 8.6016757204 18986760
MESH:D009062 Mouth Neoplasms Sirolimus 8.6019435901
MESH:D009101 Multiple Myeloma Azacitidine 11.5619549372 18443271
MESH:D009101 Multiple Myeloma Benzene 11.5617119195
MESH:D009101 Multiple Myeloma Curcumin 11.5619372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.7317962980
MESH:D009190 Myelodysplastic Syndromes Azacitidine 3.9017611569 19805378 17596541 18720364
MESH:D009203 Myocardial Infarction Quercetin 2.9119595682
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.6519207477
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.6718551238 7678174
MESH:D009361 Neoplasm Invasiveness Curcumin 4.1918495463
MESH:D009369 Neoplasms 4-phenylbutyric acid 14.7719116145
MESH:D009369 Neoplasms Diethylstilbestrol 14.7715313581
MESH:D009369 Neoplasms Fluorouracil 14.7718239605 18600527 16928823
MESH:D009369 Neoplasms Quercetin 14.7715185748
MESH:D009369 Neoplasms sodium arsenite 14.7711559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4820056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.3412497104
MESH:D009410 Nerve Degeneration marker/mechanism 21419848
MESH:D009421 Nervous System Malformations Diethylstilbestrol 3.9511399458
MESH:D009423 Nervous System Neoplasms Curcumin 5.4418462866
MESH:D009436 Neural Tube Defects Benzene 7.1315643154
MESH:D009436 Neural Tube Defects sodium arsenite 7.1312854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7218514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.1817929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3116436463
MESH:D009765 Obesity Curcumin 2.7019297423
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.6116049721
MESH:D009784 Occupational Diseases Benzene 8.6115576619 15612468 17178637 17119257 15913788 15727169 15935809 16737584 17479406
MESH:D010024 Osteoporosis Curcumin 3.3518719352
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.0419495926
MESH:D010051 Ovarian Neoplasms Benzene 14.3712562636
MESH:D010051 Ovarian Neoplasms Curcumin 14.3719020741 18462866
MESH:D010051 Ovarian Neoplasms Quercetin 14.3719005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 14.3715276417 17306315
MESH:D010051 Ovarian Neoplasms U 0126 14.3716211241
MESH:D010146 Pain Acetaminophen 2.2416870215
MESH:D010190 Pancreatic Neoplasms Curcumin 11.8419401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.8419003803 15113037 16929163 16500647
MESH:D010190 Pancreatic Neoplasms Quercetin 11.8416965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 11.8415976015
MESH:D010212 Papilloma Hydrogen Peroxide 8.9912065085
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 8.9918922899 8330346 12065085 18404319
MESH:D010300 Parkinson Disease Sirolimus 3.6719682553
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.3111550810
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9814722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4816977796 15687265
MESH:D010954 Plasmacytoma Selenium 4.7015087411
MESH:D011014 Pneumonia Lipopolysaccharides 4.3612224865 11605937
MESH:D011230 Precancerous Conditions Quercetin 3.8219056647
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 3.9217184923
MESH:D011471 Prostatic Neoplasms Azacitidine 2.0818324645
MESH:D011471 Prostatic Neoplasms Curcumin 2.0815129424 18226269 12497104 18769126 18156803 11398177 10851300
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0815846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0819082440 18626508
MESH:D011471 Prostatic Neoplasms Quercetin 2.0814715546 17292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0816039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0815084515
MESH:D011656 Pulmonary Emphysema Curcumin 4.3619168576
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8518286688 18722050 16160472 15538739
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.8518379247 10666014
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6110835634
MESH:D012509 Sarcoma Curcumin 3.9518462866
MESH:D012554 Schistosomiasis japonica Quercetin 5.3516862918
MESH:D012640 Seizures marker/mechanism 21062901
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4118551238
MESH:D018805 Sepsis Curcumin 3.9218389075
MESH:D012852 Sinusitis Phenylephrine 4.517327846
MESH:D012871 Skin Diseases Vitamin E 2.3918709164
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.1412065085
MESH:D012878 Skin Neoplasms sodium arsenite 9.1418572023 19524636
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 9.1412065085 8330346 11807781 8985016 18404319
MESH:D013088 Spermatocele Diethylstilbestrol 4.5216709447 16002989
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6512854658
MESH:D013274 Stomach Neoplasms Benzene 2.6912562636
MESH:D013274 Stomach Neoplasms Fluorouracil 2.6919015929 16951190 18567086 17172411 17498489 18396642 16424979 17522103 15786421 19084572
MESH:D013276 Stomach Ulcer Curcumin 3.3316631530 19188055
MESH:D020521 Stroke Vitamin E 3.3716517955
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0015821434
MESH:D013953 Thymus Neoplasms Benzene 4.7610850423
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8216280240
MESH:D014402 Tuberous Sclerosis marker/mechanism 21345208 21062901
MESH:D014402 Tuberous Sclerosis Sirolimus 5.3821115397 18495876
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.0316049721
MESH:D001749 Urinary Bladder Neoplasms Curcumin 15.0318593936
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 15.0317306315 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Quercetin 15.0316720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 15.0316712894 17306315 11723127 16452187
MESH:D014565 Urogenital Neoplasms Curcumin 5.0718462866
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.0010091137
MESH:D014571 Urologic Neoplasms M-VAC protocol 12.0017933135
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 14.9416175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.9416803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.9411813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.9814652134
MESH:D014594 Uterine Neoplasms Benzene 9.2412562636
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.2415809267 16690809
MESH:D014605 Uveitis Sirolimus 5.441336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2516002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.2317056641
Pathway ID Pathway Name
KEGG:04910 Insulin signaling pathway
KEGG:04150 mTOR signaling pathway
KEGG:04115 p53 signaling pathway
REACT:498 Signaling by Insulin receptor
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37035
    • No data
    No data
    Releated drug ID Related drug Name
    PA451365sirolimus
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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