AutismKB 2.0

Annotation Detail for TSNAX


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Basic Information Top
Gene Symbol:TSNAX ( DISC1,TRAX )
Gene Full Name: translin-associated factor X
Band: 1q42.2
Quick LinksEntrez ID:7257; OMIM: 602964; Uniprot ID:TSNAX_HUMAN; ENSEMBL ID: ENSG00000116918; HGNC ID: 12380
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2045Bipolar disorder
No data
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001241 Aspirin Aspirin results in increased expression of TSNAX mRNAincreases expression 11906190
D017239 Paclitaxel Paclitaxel analog results in increased expression of TSNAX mRNAincreases expression 15585946
D017239 Paclitaxel Paclitaxel results in increased expression of TSNAX mRNAincreases expression 15585946
D013467 Sulindac Sulindac results in decreased expression of TSNAX mRNAdecreases expression 11906190
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TSNAX mRNAdecreases expression 16962184
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 6.2214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4711752688 14514962 15322242
MESH:D058186 Acute Kidney Injury Sulindac 4.747897758
MESH:D000230 Adenocarcinoma Sulindac 3.1811910360
MESH:D000236 Adenoma Sulindac 3.9810223192
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.9912394442 11874996 17611924 15623613 16460482 19003578 11535846
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D055963 Asthma, Aspirin-Induced Aspirin 5.0420485159 12372130
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001859 Bone Neoplasms Paclitaxel 5.0315867366
MESH:D001913 Bowen's Disease Sulindac 6.0811207687
MESH:D001932 Brain Neoplasms Aspirin 4.8115481559
MESH:D001943 Breast Neoplasms Aspirin 2.1015161893
MESH:D001943 Breast Neoplasms Paclitaxel 2.1015136595 11325840 16273361 18234424 16244791 16115903 18323546 18223236
MESH:D001943 Breast Neoplasms Sulindac 2.1016642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 2.5616313753
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5616120746 18850075 18670907
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.248697196 15340226 16354765 12621046 15668235
MESH:D003110 Colonic Neoplasms Aspirin 4.5512411196
MESH:D003110 Colonic Neoplasms Sulindac 4.5512458338 12902858
MESH:D015179 Colorectal Neoplasms Aspirin 3.8817047198
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.8818802399
MESH:D015179 Colorectal Neoplasms Sulindac 3.8811076880 10666051 11197048 18059344
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D003930 Diabetic Retinopathy Sulindac 5.6917621415 12861449
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004487 Edema Aspirin 8.4917259670
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.4912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6216714409 15322242 18230668
MESH:D004715 Endometriosis Sulindac 10.5315652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 10.539294722 10568697
MESH:D004938 Esophageal Neoplasms Paclitaxel 5.3316481741
MESH:D004938 Esophageal Neoplasms Sulindac 5.3312235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 6.1114745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.7619069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.5120067830
MESH:D005764 Gastroesophageal Reflux Sulindac 5.5211910360
MESH:D005909 Glioblastoma Aspirin 4.1912870263
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006261 Headache Aspirin 5.6815240983
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5110048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7716354765 15340226 16959395 18606429 8697196
MESH:D012001 Hyperacusis Aspirin 6.4915240983
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0218670907 18850075
MESH:D007249 Inflammation Sulindac 5.843291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.8412878042 12200463
MESH:D007414 Intestinal Neoplasms Sulindac 5.0312351151 12663524 10223192 12628509 12584176 10213222
MESH:D007417 Intestinal Polyps Sulindac 5.4511245490 12394442
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D008080 Liposarcoma Paclitaxel 5.2817353645
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.4512468960
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Sulindac 3.1014986274 16867024
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D008175 Lung Neoplasms Sulindac 2.6919359593 15713900
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.6911884234 19555203
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.4314749477
MESH:D008545 Melanoma Paclitaxel 4.0412025231 16342250 12040289
MESH:D008545 Melanoma Sulindac 4.0416642371
MESH:D008881 Migraine Disorders Aspirin 4.3415240983
MESH:D009101 Multiple Myeloma Paclitaxel 3.9614749477
MESH:D009203 Myocardial Infarction Aspirin 3.6812692751
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009325 Nausea Aspirin 5.9415240983
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.3815867366
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D019636 Neurodegenerative Diseases Sulindac 4.6116850258 17266991
MESH:D010003 Osteoarthritis Aspirin 4.277009135
MESH:D010014 Osteolysis Paclitaxel 5.6115867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.0811161223
MESH:D010146 Pain Aspirin 8.616363464 6995502
MESH:D010146 Pain Sulindac 8.613291741
MESH:D010190 Pancreatic Neoplasms Sulindac 3.4611504793 16820089
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 6.1711156591
MESH:D020795 Photophobia Aspirin 6.4915240983
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.7916356831 16729912 17172428 17136230
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012220 Rhinitis Aspirin 4.7712372130
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.8212269725
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D013274 Stomach Neoplasms Paclitaxel 2.4518396642 18506536
MESH:D020521 Stroke Aspirin 4.7016403987
MESH:D024801 Tauopathies Paclitaxel 5.4416930453
MESH:D013927 Thrombosis Aspirin 4.8817672075
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D014581 Urticaria Aspirin 4.9020485159 10982225
MESH:D014594 Uterine Neoplasms Sulindac 5.1018645019
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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