AutismKB 2.0

Annotation Detail for TSSC1


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Basic Information Top
Gene Symbol:TSSC1 ( - )
Gene Full Name: tumor suppressing subtransferable candidate 1
Band: 2p25.3
Quick LinksEntrez ID:7260; OMIM: 608998; Uniprot ID:TSSC1_HUMAN; ENSEMBL ID: ENSG00000032389; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TSSC1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of TSSC1 mRNAincreases expression 20406850
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TSSC1 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TSSC1 mRNAdecreases expression 20064835
20106945
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of TSSC1 mRNA]affects reaction|decreases expression 15016801
D014303 Trinitrotoluene Trinitrotoluene affects the expression of TSSC1 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 4.657525203
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.6220464547 20127859
MESH:D000230 Adenocarcinoma Fluorouracil 4.6217638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D000740 Anemia Fluorouracil 4.0215504547 16511603 17963324
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1517474063 20146248
MESH:D001943 Breast Neoplasms Fluorouracil 2.1516110121 16557594 18357371 15136595 16595493 18608205 19217205
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1916051944
MESH:D002277 Carcinoma Fluorouracil 3.8217121937
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.9216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.9216705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.9212619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.9217045692 17088986 16799960 17971768 18930000 16332177
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1418695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8920419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8918986760 16280240 17066447 16757204
MESH:D002386 Cataract Trinitrotoluene 4.0314694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.986135515
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2717172411 16510598 17016597 15001691 17169374 17725105 16340194 18772588 17018589 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0014970324 16524972 18383874 18448328 17094418 20501625 15148649 16282729 18509181 17695437 18949393 18802399 17454858 16303861 17594712 15289873 17401013 17016601 18288408 16391804 17255274 16331619
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.6915095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 21.4018551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 21.4018551238
MESH:D003490 Cyanosis Trinitrotoluene 21.4018551238
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.8018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.8021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 6.8018551238 21346803
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7116530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7116785472 16481741 17638652 15173087 16337965
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5915162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D006529 Hepatomegaly Trinitrotoluene 4.6515817613
MESH:D007248 Infertility, Male Trinitrotoluene 3.8712150543
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.0516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.0516705839
MESH:D007680 Kidney Neoplasms Fluorouracil 14.0516985049
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.567678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.5618177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.5620195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 11.5616603448 18383874 17045692 15113037
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.582876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.588603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.6214755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6218569708 17053015 20135361 18816296 20869020 18520028 6695378 20464547 20064080
MESH:D008175 Lung Neoplasms Fluorouracil 3.6215246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.3416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.3418986760 16757204
MESH:D009336 Necrosis 2,4-dinitrotoluene 20.6918551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 20.6918551238 7678174
MESH:D009336 Necrosis Trinitrotoluene 20.6918551238
MESH:D009369 Neoplasms Benzo(a)pyrene 5.5211141357
MESH:D009369 Neoplasms Fluorouracil 5.5218600527 16928823 18239605
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 17.0316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 17.0316049721
MESH:D009784 Occupational Diseases Trinitrotoluene 17.0312819281 17852074 14694615
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7516500647 16929163 15113037 19003803
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1617292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.1618626508 19082440
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3018722050 18286688 15538739 16160472
MESH:D012640 Seizures 2,4-dinitrotoluene 11.1418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 11.1418551238
MESH:D012640 Seizures Trinitrotoluene 11.1418551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4910029692 19755658
MESH:D013163 Splenomegaly Trinitrotoluene 5.6215817613
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4820155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4819015929 18567086 18396642 17498489 16951190 19084572 17172411 17522103 15786421 16424979
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2916280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.8717053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.5810091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1816803524
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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