Annotation Detail for TTC1
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene affects the expression of TTC1 mRNA | affects expression | 21346803
|
| D016572 |
Cyclosporine |
Cyclosporine results in increased expression of TTC1 mRNA | increases expression | 20106945
|
| C014707 |
nitrosobenzylmethylamine |
nitrosobenzylmethylamine results in increased expression of TTC1 mRNA | increases expression | 17616710
|
| D013752 |
Tetracycline |
Tetracycline results in increased expression of TTC1 mRNA | increases expression | 16917069
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
1.79 | 16705839 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
7.46 | 6135515 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
Cyclosporine |
7.46 | 12371664 |
| MESH:D002779 |
Cholestasis |
|
Cyclosporine |
3.21 | 19486331 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
4.58 | 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
4.51 | 21346803 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Tetracycline |
4.51 | 17522070 |
| MESH:D004938 |
Esophageal Neoplasms |
|
nitrosobenzylmethylamine |
2.85 | 15547733 15547721 15878914 16805852 16704527 15150132 16510608 15623463 15264214 |
| MESH:D005234 |
Fatty Liver |
|
Cyclosporine |
9.48 | 19224547 |
| MESH:D005234 |
Fatty Liver |
|
Tetracycline |
9.48 | 19224547 16917069 |
| MESH:D005355 |
Fibrosis |
|
Cyclosporine |
3.70 | 12639820 12168785 |
| MESH:D005885 |
Gingival Hyperplasia |
|
Cyclosporine |
4.85 | 8708960 |
| MESH:D006457 |
Hemoglobinuria, Paroxysmal |
|
Cyclosporine |
5.05 | 15720958 |
| MESH:D006973 |
Hypertension |
|
Cyclosporine |
2.21 | 10903974 |
| MESH:D007638 |
Keratoconjunctivitis Sicca |
|
Cyclosporine |
5.16 | 15604871 |
| MESH:D007674 |
Kidney Diseases |
|
Cyclosporine |
2.54 | 10903974 8314463 18776723 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
8.44 | 16705839 |
| MESH:D007680 |
Kidney Neoplasms |
|
Cyclosporine |
8.44 | 12371664 |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
2.27 | 7678174 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.77 | 2876786 6135515 2876784 |
| MESH:D008664 |
Metal Metabolism, Inborn Errors |
|
Cyclosporine |
5.51 | 16801185 |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
4.49 | 18551238 7678174 |
| MESH:D009395 |
Nephritis, Interstitial |
|
Tetracycline |
5.51 | 9884423 |
| MESH:D009402 |
Nephrosis, Lipoid |
|
Cyclosporine |
5.16 | 17954296 |
| MESH:D009404 |
Nephrotic Syndrome |
|
Cyclosporine |
3.65 | 19348381 18481113 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
3.83 | 16049721 |
| MESH:D010391 |
Pemphigoid, Bullous |
|
Tetracycline |
6.16 | 11026799 |
| MESH:D011230 |
Precancerous Conditions |
|
Cyclosporine |
3.59 | 12371664 |
| MESH:D017096 |
Prion Diseases |
|
Tetracycline |
6.04 | 10903871 |
| MESH:D011565 |
Psoriasis |
|
Cyclosporine |
2.33 | 16882103 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
2.79 | 18551238 |
| MESH:D013274 |
Stomach Neoplasms |
|
nitrosobenzylmethylamine |
2.33 | 12958204 17575124 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
2.41 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
4.95 | 10091137 |
| MESH:D014605 |
Uveitis |
|
Cyclosporine |
4.71 | 1336536 |
| MESH:D014985 |
Xerophthalmia |
|
Cyclosporine |
5.16 | 17120751 |
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