AutismKB 2.0

Annotation Detail for C5


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Basic Information Top
Gene Symbol:C5 ( CPAMD4,FLJ17816,FLJ17822,MGC142298 )
Gene Full Name: complement component 5
Band: 9q33.2
Quick LinksEntrez ID:727; OMIM: 120900; Uniprot ID:CO5_HUMAN; ENSEMBL ID: ENSG00000106804; HGNC ID: 1331
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05322Systemic lupus erythematosus
hsa05150Staphylococcus aureus infection
hsa04610Complement and coagulation cascades
hsa05020Prion diseases
Pathway IDPathway Name
Signaling by GPCR
Signaling in Immune system
No data
No data
Pathway IDPathway Name
500405Peptide ligand-binding receptors
500476Activation of C3 and C5
Related Diseases/Disorders Top
Desease IDDesease Name
H00103Late complement pathway defects
Immune system diseases
Primary immunodeficiency
Desease IDDesease Name
1781Rheumatoid arthritis
1901Endometriosis
1907Depression
1954Stroke
1992Aortic valve disease
2241Infertility
Desease Name
rheumatoid arthritis
IMMUNE
multiple autoimmune diseases
No data
Desease Name
Liver fibrosis, susceptibility to
C5 deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of C5 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of C5 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of C5 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of C5 mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of C5 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of C5 mRNAdecreases expression 20106945
D003687 Dehydroepiandrosterone Dehydroepiandrosterone results in decreased expression of C5 mRNAdecreases expression 18709148
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of C5 mRNAdecreases expression 19638242
C093973 PD 98059 PD 98059 inhibits the reaction [C5 protein results in increased phosphorylation of MAPK1 protein]decreases reaction|increases phosphorylation 16116186
C093973 PD 98059 PD 98059 inhibits the reaction [C5 protein results in increased phosphorylation of MAPK3 protein]decreases reaction|increases phosphorylation 16116186
D037342 Pertussis Toxin Pertussis Toxin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]affects binding|decreases expression|decreases reaction 16116186
D037342 Pertussis Toxin Pertussis Toxin inhibits the reaction [C5 protein results in increased phosphorylation of AKT1 protein]decreases reaction|increases phosphorylation 16116186
D037342 Pertussis Toxin Pertussis Toxin inhibits the reaction [C5 protein results in increased phosphorylation of MAPK1 protein]decreases reaction|increases phosphorylation 16116186
D037342 Pertussis Toxin Pertussis Toxin inhibits the reaction [C5 protein results in increased phosphorylation of MAPK3 protein]decreases reaction|increases phosphorylation 16116186
D010656 Phenylephrine C5 protein affects the susceptibility to Phenylephrineaffects response to substance 10750764
C539676 rEV576 protein, tick rEV576 protein, tick binds to and results in decreased activity of C5 proteinaffects binding|decreases activity 15699138
17445829
C539676 rEV576 protein, tick rEV576 protein, tick binds to and results in increased stability of and results in decreased activity of C5 proteinaffects binding|decreases activity|increases stability 18536718
C539676 rEV576 protein, tick rEV576 protein, tick binds to and results in decreased activity of C5 proteinaffects binding|decreases activity 17215252
C539676 rEV576 protein, tick rEV576 protein, tick results in decreased activity of C5 proteindecreases activity 18844789
C539676 rEV576 protein, tick rEV576 protein, tick results in decreased activity of C5 proteindecreases activity 19194881
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of C5 mRNAdecreases expression 20106945
15056799
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of C5 mRNAincreases expression 11489354
C009687 wortmannin wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12A mRNA]decreases expression|decreases reaction 16116186
C009687 wortmannin wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]affects binding|decreases expression|decreases reaction 16116186
C009687 wortmannin wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12B mRNA]decreases expression|decreases reaction 16116186
C009687 wortmannin wortmannin inhibits the reaction [C5 protein results in decreased expression of IL23A mRNA]decreases expression|decreases reaction 16116186
C009687 wortmannin wortmannin inhibits the reaction [C5 protein results in increased phosphorylation of AKT1 protein]decreases reaction|increases phosphorylation 16116186
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9315322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000236 Adenoma Diethylnitrosamine 2.886695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.3319061943 17162532 16434500 19052882 18056438 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3316835633
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 5.8417302879
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1617460149
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001919 Bradycardia Phenylephrine 4.6315306635
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9617474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6416705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.6412907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.6420432363 19519916 16779866 19052882 11831363 16878318 18056438 17428255 18978308 17978847 16681979 18785209 18691550 17138121 16830150 19394651 20007298 18506893 17162532 19539802 20524982 16807293 19107877 19171122 19383236 19701751 20512989 18210153 19822196 17173139 16540662 3581430 16698587 20084675 20101231 20935162 21159647 19919837 18494052 19335982 19208518 18393292 18971187 3084413 16569478 17055752 16935385 16288022 20214788 17761372 16502159 18788625 19418558 16328049 20514400 10672840 20727157 18665156 10737359
MESH:D006332 Cardiomegaly Phenylephrine 6.9815728586 11179087 11754973 17124262 16170337 17287366
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9818850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.376135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.3712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.3717174075 2727394 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4916835633
MESH:D002779 Cholestasis Cyclosporine 2.9519486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1215668235 8697196 15340226 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.1418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.1418551238
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 3.7116616286
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2617107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.0918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.0918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.0919107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.0920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0018230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Cyclosporine 7.9019224547
MESH:D005234 Fatty Liver Diethylnitrosamine 7.9021071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Cyclosporine 8.7212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3610048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9612621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416959395 18606429 16354765 15340226 8697196
MESH:D006973 Hypertension Cyclosporine 8.7210903974
MESH:D006973 Hypertension Phenylephrine 8.728949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.7218850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.6118502941 12791704
MESH:D007105 Immune Complex Diseases marker/mechanism
MESH:D007249 Inflammation Diethylnitrosamine 4.9818785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9812878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Cyclosporine 2.378314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.6316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.6316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.6312371664
MESH:C537005 Leiner disease marker/mechanism
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 5.3116972261
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8518665156 18407596 20032147 19638242 18522880
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1117034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.477678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.4718177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 14.4718709148
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.4721071580 19690152 18648771 19833225 19090486 21047994 2422723 20492335 15175105 18754104 19551842 12771043 19254457 19256749 2862719 19638242 19294768 19812893 19642983 10737359 18977376 18644402 20101389 19499222 19073162 9163691 19427195 20405173 15885732 21278145 19255062 19426721 20583210 20452335 19996281 20137499 16942905 12112319 20434301 20501860 21167192 19850985 18978307 20118626
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.4716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 19.032876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 19.038603461
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 19.038603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 19.0318253720 18079962 18164116 18544905 19004024 17942915 16842330 18093689 17854601 18775883 19126423 16267830 21159647 3124819 18282651 19009564 17174075 19539802 18308698 9362446 19519916 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.0312151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4214755239
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4221163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4211884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 3.9116457693
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D019846 Miller Fisher Syndrome rEV576 protein, tick 7.9018844789
MESH:D020720 Myasthenia Gravis, Autoimmune, Experimental rEV576 protein, tick 7.9017215252 19194881
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.6318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.6318551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.599029167 3581430
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3318481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.0612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.0616049721
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 5.0916397352
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4416540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.1012371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.102563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711222880 11896295 11399792 11118676
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9918551238
MESH:D012852 Sinusitis Phenylephrine 4.787327846
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.678532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.027505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.0816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.0816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.2710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.2710091137
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
KEGG:05020 Prion diseases
REACT:14797 Signaling by GPCR
REACT:6900 Signaling in Immune system
KEGG:05150 Staphylococcus aureus infection
KEGG:05322 Systemic lupus erythematosus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25911
    • No data
    Releated disease ID Related disease Name
    PA444801Liver Diseases
    PA134850558Macular Degeneration
    PA443434Arthritis, Rheumatoid
    Releated drug ID Related drug Name
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    PA450287magnesium
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00028 binder Intravenous Immunoglobulin Immunomodulatory Agents;Anti-Infectives
    DB01257 antibody Eculizumab
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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