AutismKB 2.0

Annotation Detail for TTF1


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Basic Information Top
Gene Symbol:TTF1 ( - )
Gene Full Name: transcription termination factor, RNA polymerase I
Band: 9q34.13
Quick LinksEntrez ID:7270; OMIM: 600777; Uniprot ID:TTF1_HUMAN; ENSEMBL ID: ENSG00000125482; HGNC ID: 12397
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Transcription
No data
Pathway IDPathway Name
P00023General transcription regulation
P00022General transcription by RNA polymerase I
P00055Transcription regulation by bZIP transcription factor
Pathway IDPathway Name
500577RNA Polymerase I Transcription Termination
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TTF1 mRNAincreases expression 19933214
D006710 Homocysteine Homocysteine results in decreased expression of TTF1 mRNAdecreases expression 17326132
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TTF1 mRNAincreases expression 17879257
D004958 Estradiol Estradiol promotes the reaction [CREBBP protein binds to TTF1 promoter]affects binding|increases reaction 19698761
D004958 Estradiol Estradiol promotes the reaction [ESR1 protein binds to TTF1 promoter]affects binding|increases reaction 19698761
D009151 Mustard Gas Mustard Gas results in increased expression of TTF1 mRNAincreases expression 15674843
D014212 Tretinoin Tretinoin results in increased expression of TTF1 mRNAincreases expression 15328022
D014212 Tretinoin Tretinoin results in increased expression of TTF1 mRNAincreases expression 15328022
D014810 Vitamin E Vitamin E results in decreased expression of TTF1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4720127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.4711473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Mustard Gas 5.2210378619
MESH:D001249 Asthma Tretinoin 5.2216456186
MESH:D001321 Autistic Disorder Homocysteine 3.0216297937 20468076
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001768 Blister Mustard Gas 5.5619167455
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8916197459 16206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8620146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 1.8612948864 14630087 18497071 19861407 17289903 16675129 17018787 17261762
MESH:D001943 Breast Neoplasms Tretinoin 1.8616873071 16443354 16166294
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5615286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.4217687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2916050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.111917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7920419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.7916096774 16051514
MESH:D002386 Cataract Tretinoin 3.2417460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9518566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tretinoin 2.769407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D003324 Coronary Artery Disease Homocysteine 3.8316379339
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.7516925845 9142499 9211117 17551590 9125849 9224671 14991402 10589399 9664655 8800419
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7519769572
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:C538011 Eales disease Vitamin E 5.159068938
MESH:D004487 Edema Mustard Gas 3.599260866 11402378 11428647 11428631
MESH:D004489 Edema, Cardiac Tretinoin 4.9118230668
MESH:D016889 Endometrial Neoplasms Estradiol 7.9811473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 7.9816569247
MESH:D004890 Erythema Mustard Gas 5.569357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D017889 Exfoliation Syndrome Homocysteine 6.1016504073
MESH:D005124 Eye Abnormalities Tretinoin 3.789664655 16938888
MESH:D005355 Fibrosis Tretinoin 3.8717994277
MESH:D005901 Glaucoma Homocysteine 5.5916504073
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 17.1220471113
MESH:D006330 Heart Defects, Congenital Homocysteine 17.1219638421
MESH:D006330 Heart Defects, Congenital Tretinoin 17.1214991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 17.1216080930
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7816490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 11.5717088409
MESH:D019584 Hot Flashes Vitamin E 11.5714716179
MESH:D006930 Hyperalgesia Tretinoin 3.4316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.9517369066 17292331 18234410
MESH:D007249 Inflammation Mustard Gas 2.9111428631 11428647 9260866 17524151 11428620 16001271 11402378 9357497 8975870
MESH:D007251 Influenza, Human Vitamin E 4.6616624496
MESH:D007333 Insulin Resistance Estradiol 3.1316627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1815992940 17551590
MESH:D007674 Kidney Diseases Estradiol 6.5915618244
MESH:D007674 Kidney Diseases Vitamin E 6.5912488133
MESH:D007680 Kidney Neoplasms Estradiol 3.2115610895
MESH:D007938 Leukemia Tretinoin 2.8917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9816932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1116294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3215748426 17712046 16140955 16788101 9834237 17301526 17368321 19225113 16331271 16891316 16766008 17294898 17217047 17361223 17649720 19642359 16823087 16935935 19075265 19029980 17107899 17506722 17339181 12679006 19035177
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.6718397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.6716169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1220195826 21137059
MESH:D008171 Lung Diseases Mustard Gas 8.1418161513 18702808
MESH:D008171 Lung Diseases Vitamin E 8.1416863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6317053015 6695378 18520028 20064080 20869020 20464547 18569708 20135361 18816296
MESH:D008175 Lung Neoplasms Mustard Gas 3.633148597 8781369
MESH:D008175 Lung Neoplasms Vitamin E 3.6311062179
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7211807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Homocysteine 13.6516602021
MESH:D008591 Meningomyelocele Tretinoin 13.6516940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2217596541
MESH:D009203 Myocardial Infarction Homocysteine 3.8117412321
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3911141357
MESH:D009369 Neoplasms Tretinoin 5.3916946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Estradiol 10.7911399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 10.799125849
MESH:D009436 Neural Tube Defects Tretinoin 3.229142499
MESH:D009503 Neutropenia Mustard Gas 4.2716761898 7688884
MESH:D010051 Ovarian Neoplasms Estradiol 5.0419401270
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0416936753
MESH:D010146 Pain Tretinoin 3.1316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5415976015
MESH:D010300 Parkinson Disease Homocysteine 3.6516275827
MESH:D011041 Poisoning Mustard Gas 4.1015727166
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4817292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.4816740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.4815084515
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011537 Pruritus Mustard Gas 4.4918058305
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0117266442 17894541 17720292 10334151 17620002
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016116481 16283617
MESH:D012559 Schizophrenia Homocysteine 3.1316641680
MESH:D012871 Skin Diseases Mustard Gas 5.2215451306 16961503 12880345
MESH:D012871 Skin Diseases Vitamin E 5.2218709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0619755658 10029692
MESH:D012878 Skin Neoplasms Tretinoin 6.0616467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4020155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.4017261132
MESH:D020521 Stroke Vitamin E 3.7416517955
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2316026305 17045167
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2617053015
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
Pathway ID Pathway Name
REACT:1788 Transcription
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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