AutismKB 2.0

Annotation Detail for TTK


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TTK ( CT96,ESK,FLJ38280,MPS1,MPS1L1,PYT )
Gene Full Name: TTK protein kinase
Band: 6q14.1
Quick LinksEntrez ID:7272; OMIM: 604092; Uniprot ID:TTK_HUMAN; ENSEMBL ID: ENSG00000112742; HGNC ID: 12401
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
1848Embryoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TTK proteinaffects expression 20106945
D006710 Homocysteine Homocysteine results in decreased expression of TTK mRNAdecreases expression 17326132
D001374 Azacitidine [Azacitidine co-treated with Thalidomide] affects the expression of TTK mRNAaffects cotreatment|affects expression 18720364
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TTK mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TTK mRNAdecreases expression 20382639
20018196
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TTK mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of TTK mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TTK mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TTK mRNA]decreases reaction|increases expression 17854601
D004317 Doxorubicin TTK protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004958 Estradiol Estradiol results in increased expression of TTK mRNAincreases expression 20106945
D019833 Genistein Genistein affects the expression of TTK mRNAaffects expression 18847459
C051890 irinotecan irinotecan metabolite results in decreased expression of TTK mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of TTK mRNAdecreases expression 15956246
C011890 kojic acid kojic acid results in decreased expression of TTK mRNAdecreases expression 16595896
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of TTK mRNAincreases expression 20713471
C008493 methylselenic acid methylselenic acid results in decreased expression of TTK mRNAdecreases expression 18548127
D009151 Mustard Gas Mustard Gas results in decreased expression of TTK mRNAdecreases expression 18955075
D009151 Mustard Gas Mustard Gas results in increased expression of TTK mRNAincreases expression 15674844
D037742 Nanotubes, Carbon Nanotubes, Carbon results in decreased expression of TTK mRNAdecreases expression 15585362
C059514 resveratrol resveratrol results in decreased expression of TTK mRNAdecreases expression 15767336
C017947 sodium arsenite sodium arsenite results in decreased expression of TTK mRNAdecreases expression 17998272
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TTK mRNAdecreases expression 16714409
D013792 Thalidomide [Azacitidine co-treated with Thalidomide] affects the expression of TTK mRNAaffects cotreatment|affects expression 18720364
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of TTK mRNAdecreases expression 17951470
D014747 Vinblastine TTK protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2011752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Thalidomide 8.208333272
MESH:D058186 Acute Kidney Injury resveratrol 3.7116538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.8820127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 9.8817418594
MESH:D000230 Adenocarcinoma Estradiol 9.8811473722
MESH:D000230 Adenocarcinoma Genistein 9.8811473722
MESH:D000236 Adenoma Benzo(a)pyrene 15.306695378
MESH:D000236 Adenoma Diethylnitrosamine 15.306695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 15.3010545420 6695378
MESH:D000236 Adenoma resveratrol 15.3015688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.5517620307 17162532 19061943 18056438 16434500 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.5516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7517306315 16712894
MESH:D000419 Albuminuria Doxorubicin 4.4021441931
MESH:D000544 Alzheimer Disease resveratrol 2.5416162502 16183991
MESH:D000690 Amyotrophic Lateral Sclerosis Thalidomide 4.2616510725
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9219183758
MESH:D001169 Arthritis, Experimental resveratrol 7.6317115116
MESH:D001169 Arthritis, Experimental Thalidomide 7.639598899
MESH:D001249 Asthma Mustard Gas 2.6710378619
MESH:D050197 Atherosclerosis Methylcholanthrene 6.6711922910
MESH:D050197 Atherosclerosis resveratrol 6.6717967414 16873680
MESH:D001321 Autistic Disorder Homocysteine 3.0520468076 16297937
MESH:D001768 Blister Mustard Gas 5.0119167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.5514601052
MESH:D002545 Brain Ischemia resveratrol 4.1317600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.6817150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.6220146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.6217474063
MESH:D001943 Breast Neoplasms Doxorubicin 4.6215567936 15994142 15136595 16935488 16264153 19526202 18695136 15668708 17426702 15634643 18382427 15939500 16826403 16322301 17983394 16595493 16096432 15692762 18234424 16115903 17369602 15993339 11325840 18628466
MESH:D001943 Breast Neoplasms Estradiol 4.6212948864 18497071 17289903 14630087 17018787 17261762 19861407 16675129
MESH:D001943 Breast Neoplasms Genistein 4.6216873071 17200150 16541309
MESH:D001943 Breast Neoplasms Methylcholanthrene 4.6217474063
MESH:D001943 Breast Neoplasms resveratrol 4.6216393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6220435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.0115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.8317687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6316227642 18705752 15721981 16011737 15700767 16124888 16192424 16097048 16050911 10355542 15673190 3786805
MESH:D002276 Carcinoid Tumor Doxorubicin 4.6616051944
MESH:D002277 Carcinoma Methylcholanthrene 7.9310545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.9316835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 19.4521507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 19.4518788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 19.4518971187 19052882 18978308 16288022 16540662 19539802 16502159 17173139 20524982 19822196 17162532 18210153 18665156 17761372 18785209 19701751 16569478 17138121 20214788 21159647 20727157 3084413 20084675 20007298 20432363 18506893 20101231 18393292 19208518 19171122 19383236 17978847 19107877 16779866 19919837 19335982 18494052 18056438 19519916 11831363 19394651 17055752 20512989 20935162 16698587 16328049 16878318 18691550 10672840 17428255 19418558 16935385 16807293 16830150 3581430 18788625 20514400 10737359 16681979
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 19.4516234567 17876044 18059187 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.4516924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 19.4516924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 19.4516227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 19.4515276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Thalidomide 19.4516313753
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4416675471
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.721485588 16201981
MESH:D002292 Carcinoma, Renal Cell Vinblastine 6.721485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.4520419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.456189445
MESH:D002294 Carcinoma, Squamous Cell resveratrol 10.4516227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.4518572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.4316612575 17974986 16364871 16269455 16242529 15792986 17007740 16651473 17131338 15505089 16455267 17308081 17928571 17351982 16952015 18627295 17519947 15476868 16278810 17382496 17329180 15811867 16731534 16109756 17924179
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8916243910 17334414
MESH:D002318 Cardiovascular Diseases Genistein 7.1716332659
MESH:D002318 Cardiovascular Diseases resveratrol 7.1715458977
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 25.0120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 25.0112371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 25.012727394 17174075 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 25.0118566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 25.0116192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 25.0120056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 15.4519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 15.4516835633
MESH:D018281 Cholangiocarcinoma Thalidomide 15.4518291259
MESH:D002779 Cholestasis Cyclosporine 2.8019486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0415668235 16354765 12621046 8697196 15340226
MESH:D003092 Colitis resveratrol 9.5416474422
MESH:D003092 Colitis Thalidomide 9.5416680017
MESH:D003110 Colonic Neoplasms Genistein 5.7817182828
MESH:D003110 Colonic Neoplasms irinotecan 5.7817725105 17287894
MESH:D003110 Colonic Neoplasms resveratrol 5.7816338953
MESH:D015179 Colorectal Neoplasms Azacitidine 6.3619934284
MESH:D015179 Colorectal Neoplasms Doxorubicin 6.3618802399 18259882
MESH:D015179 Colorectal Neoplasms irinotecan 6.3617454858 17159606 16303861 18259882 15273666 18509181 16391804
MESH:D015179 Colorectal Neoplasms resveratrol 6.3616550006
MESH:D015179 Colorectal Neoplasms Vinblastine 6.3618802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9317141729 14669216
MESH:D016510 Corneal Neovascularization Thalidomide 5.429301478
MESH:D003324 Coronary Artery Disease Homocysteine 3.7016379339
MESH:D003327 Coronary Disease resveratrol 3.6616507316
MESH:D003389 Cranial Nerve Diseases Thalidomide 6.159200351
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8220055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Thalidomide 2.829200351
MESH:D003424 Crohn Disease Thalidomide 4.0916078585
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.6416873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8820387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.8816647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8817107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.5919279558
MESH:D003928 Diabetic Nephropathies resveratrol 8.5916286809
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.616884620 9327722 10092053 2869522 7179309 19085960 10915739 15968718 15027814 7440962 19336974 11566570 7120509 3786805 17522070 3732212 15998439 16227642 21278145 16177239 4309450 6623471
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.6119107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 8.6117416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.6120420201
MESH:D004362 Drug Toxicity Doxorubicin 7.7418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.7411462148
MESH:D004487 Edema Mustard Gas 10.759260866 11402378 11428647 11428631
MESH:D004487 Edema resveratrol 10.758985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.7511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.8817872969
MESH:D004714 Endometrial Hyperplasia Genistein 4.4416402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 11.9517359293
MESH:D016889 Endometrial Neoplasms Estradiol 11.9519148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 11.9511473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8910568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0118037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.7017923197
MESH:D004890 Erythema Mustard Gas 5.019357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9716302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.2220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2216530937
MESH:D017889 Exfoliation Syndrome Homocysteine 5.5516504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 12.3016239168 16045604 15959796 61145 12631006 19224547 12795759 17595544
MESH:D005234 Fatty Liver Cyclosporine 12.3019224547
MESH:D005234 Fatty Liver Diethylnitrosamine 12.3020387270 21071580
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4419069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.7914633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 13.8418705752
MESH:D005355 Fibrosis Cyclosporine 13.8412639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.8420067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5316452187
MESH:D005871 Giant Lymph Node Hyperplasia Thalidomide 6.1512701121
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D005901 Glaucoma Homocysteine 5.1416504073
MESH:D005909 Glioblastoma Doxorubicin 7.0117150277
MESH:D005909 Glioblastoma Genistein 7.0116598420
MESH:D005910 Glioma Thalidomide 3.7616327979
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.4315692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.7820471113
MESH:D006330 Heart Defects, Congenital Homocysteine 10.7819638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.7811294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.3816707910 16495754 12587719 17875725 16144979 16879835 16244371 16244372 17888722 18006777 14766674 16330681 18674790
MESH:D006333 Heart Failure Doxorubicin 3.2517481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7615692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4519900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7416120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.8815709030
MESH:D006561 Herpes Simplex resveratrol 4.0316876885
MESH:D006689 Hodgkin Disease Doxorubicin 11.6517606976 18501091 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 11.6512676792
MESH:D006689 Hodgkin Disease Vinblastine 11.6518501091 18180244
MESH:D019584 Hot Flashes Estradiol 3.6017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8916354765 18606429 8697196 15340226 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3816899240
MESH:D006937 Hypercholesterolemia resveratrol 3.8717188708
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.5817369066 17292331 18234410
MESH:D006949 Hyperlipidemias resveratrol 3.8916873680
MESH:D006973 Hypertension Cyclosporine 4.7510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9415338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1717488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.5017600658
MESH:D007248 Infertility, Male sodium arsenite 2.8915346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 15.0618785209
MESH:D007249 Inflammation Mustard Gas 15.0611428620 11428647 11428631 8975870 9260866 17524151 11402378 16001271 9357497
MESH:D007249 Inflammation resveratrol 15.0616366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.0612878042 12200463
MESH:D007249 Inflammation Thalidomide 15.0616134734
MESH:D007251 Influenza, Human resveratrol 4.3916624496
MESH:D007333 Insulin Resistance Estradiol 2.8716627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007674 Kidney Diseases Cyclosporine 13.748314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 13.7415369732 16775033 15699352
MESH:D007674 Kidney Diseases Estradiol 13.7415618244
MESH:D007674 Kidney Diseases sodium arsenite 13.7420008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0116707910
MESH:D007680 Kidney Neoplasms Cyclosporine 6.8612371664
MESH:D007680 Kidney Neoplasms Estradiol 6.8615610895
MESH:D007898 Leishmaniasis, Visceral Thalidomide 4.2216514283
MESH:D007938 Leukemia Azacitidine 6.5019148494
MESH:D007938 Leukemia Genistein 6.5018980019 17468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0116085563
MESH:D007951 Leukemia, Myeloid Azacitidine 4.4819077051
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 4.5318720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute Thalidomide 4.5318720364
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.0519299654
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.4816087638
MESH:D017880 Limb Deformities, Congenital Thalidomide 4.3510473037
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.6921278145 17157831 16221502 11903743 11408273 16943688 17174718 16239168 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.6919638242 20032147 18522880 18665156 18407596
MESH:D008103 Liver Cirrhosis Thalidomide 10.6916943688 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.5012586293 18395095 18156304 18006644 18481824 12389079 15818738 20821823 18210741 12445418 15362042 16097048 18187930 18472332 18339082 17869086 18166357 12649538 17640975 17481882 16011737 14716496 15123356 17922224 13678700 16136751 16248980 18277467 17766677 14748882 17721639 12666154 15925388 16033810 18412020 14724832 16027843 14620537 18429990 17698563 12445421 16015684 18418968 18420326 18279442 16638106 12546737 18054572 18317297 14512876 17944888 12609069 18251166 14716833 17557913 11481614 17714472 15931870 18705752 15370692 15057751 17900296 16116963 17823541 15650968 18472094 18205269 12632512 15893842 15730626 12898905 12667390 15673190 17631135 15996030 17805973 17525996 15052691 12958196 18263696 18376398 17565644 15338365 15959796 10355542 17761835 18395914 16192424 12741479 17976157 17708605 12632514 15876570
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.5016439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.5014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.5017823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.5012878042
MESH:D008106 Liver Cirrhosis, Experimental Thalidomide 8.5015465738
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9416246199 17285989 15830285 16964402 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9417034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0115123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5614706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 21.0315890375 9163691 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.0320195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 21.0319294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.0319427195 21047994 19073162 18977376 12112319 2422723 21278145 19642983 19426721 18648771 16942905 21071580 19638242 19254457 19690152 21167192 18754104 19090486 20452335 20434301 20137499 15175105 12771043 19551842 19499222 15885732 19833225 20405173 18644402 19294768 19812893 10737359 20492335 19850985 20118626 20501860 19256749 18978307 20583210 9163691 19996281 19255062 20101389 2862719
MESH:D008113 Liver Neoplasms resveratrol 21.0319321006 19812893 20405173 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 21.0316712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.0316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 26.858603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 26.8515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 26.8517174075 19126423 17854601 18544905 3124819 18079962 18308698 18093689 9362446 18775883 16842330 19004024 21159647 2563599 19009564 18164116 18253720 18282651 17942915 19539802 16267830 19519916
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 26.8517085340 16842330
MESH:D008114 Liver Neoplasms, Experimental kojic acid 26.8518544905
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 26.851399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 26.8512151625
MESH:D008171 Lung Diseases Mustard Gas 7.2118161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 7.2119095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 15.0714755239
MESH:D008175 Lung Neoplasms Azacitidine 15.0721224363
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 15.0717053015 20135361 18520028 18816296 20464547 20064080 18569708 6695378 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 15.0721163286 6695378 20970405 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 15.076189445 17418594
MESH:D008175 Lung Neoplasms Methylcholanthrene 15.0716271038 17909032 6695378 7750092 21163286 9230183 20970405 15390079 11893704 16337739 10545420 20512841 1399818
MESH:D008175 Lung Neoplasms Mustard Gas 15.073148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 15.0716712894 17306315 19931552 15276417 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 15.0711884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.3516098063
MESH:D016393 Lymphoma, B-Cell resveratrol 4.1617088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.4617654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 8.4614749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4215621674
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.0915688416
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 13.5115458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.5111408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 13.5114578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 13.5111606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 4.3319453300
MESH:D008545 Melanoma Doxorubicin 9.5516827129
MESH:D008545 Melanoma resveratrol 9.5517992120
MESH:D008545 Melanoma sodium arsenite 9.5516487513 19082730
MESH:D008545 Melanoma Thalidomide 9.5512829675 16098027 17089043
MESH:D008545 Melanoma Vinblastine 9.5518505091 17761969 16809738 18332650 16432458 15577320 15577323 16248763 18176117 12374674
MESH:D008591 Meningomyelocele Homocysteine 5.3816602021
MESH:D008654 Mesothelioma Doxorubicin 3.0017638057
MESH:D008659 Metabolic Diseases resveratrol 4.2417112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3615792986
MESH:D009006 Monosomy Azacitidine 5.9319299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0716381670
MESH:D052016 Mucositis Doxorubicin 11.9117415656
MESH:D052016 Mucositis irinotecan 11.9117159606
MESH:D009101 Multiple Myeloma Azacitidine 11.7919549372 18443271
MESH:D009101 Multiple Myeloma resveratrol 11.7916267019 17935668 17164350 16490592 14749477 17049120
MESH:D009101 Multiple Myeloma Thalidomide 11.7919112817 17168659 15867202 15744524 19372569 19112201 15741222 15920492 16445831 15939924
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.7217962980
MESH:D009190 Myelodysplastic Syndromes Azacitidine 7.8419805378 18720364 17611569 17596541
MESH:D009190 Myelodysplastic Syndromes Thalidomide 7.8418720364
MESH:D009203 Myocardial Infarction Doxorubicin 13.1315857846 19429709
MESH:D009203 Myocardial Infarction Genistein 13.1317141266
MESH:D009203 Myocardial Infarction Homocysteine 13.1317412321
MESH:D009203 Myocardial Infarction resveratrol 13.1317188708 17015251 16525036 16317513 17125593 16456233
MESH:D017202 Myocardial Ischemia resveratrol 8.6117125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.6112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.1317141266
MESH:D009205 Myocarditis resveratrol 4.6117322642
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.263581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.2618259882
MESH:D009362 Neoplasm Metastasis irinotecan 9.2618259882
MESH:D009369 Neoplasms Benzo(a)pyrene 4.7811141357
MESH:D009369 Neoplasms sodium arsenite 4.7811559025
MESH:D009374 Neoplasms, Experimental resveratrol 8.738985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.7320056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5817289903
MESH:D009401 Nephrosis Doxorubicin 4.6216899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.8718481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.8715640375 16889571
MESH:D009421 Nervous System Malformations Estradiol 22.2816427766 11399458
MESH:D009421 Nervous System Malformations Genistein 22.2816427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 22.2814600291
MESH:D009421 Nervous System Malformations Thalidomide 22.2816859833
MESH:D009436 Neural Tube Defects sodium arsenite 3.0512854658
MESH:D009447 Neuroblastoma Doxorubicin 6.9015555623
MESH:D009447 Neuroblastoma irinotecan 6.908761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.1120387270
MESH:D019636 Neurodegenerative Diseases resveratrol 8.1117652729
MESH:D017599 Neuroectodermal Tumors irinotecan 4.588761367
MESH:D020078 Neurogenic Inflammation resveratrol 4.2617929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9720387270
MESH:D009503 Neutropenia Mustard Gas 9.1416761898 7688884
MESH:D009503 Neutropenia Vinblastine 9.1417378895
MESH:D010024 Osteoporosis Genistein 3.1619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.6816169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 9.6817513867
MESH:D012516 Osteosarcoma Doxorubicin 3.9915930896
MESH:D010051 Ovarian Neoplasms Estradiol 10.9619401270
MESH:D010051 Ovarian Neoplasms Genistein 10.9619005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.9615276417 17306315
MESH:D010051 Ovarian Neoplasms Thalidomide 10.9616288038
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3716540662
MESH:D010291 Paresis Thalidomide 6.159200351
MESH:D010300 Parkinson Disease Homocysteine 3.5216275827
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0117983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0117638057
MESH:D011041 Poisoning Mustard Gas 3.6615727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.5112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.512563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Thalidomide 4.1517031469
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.0816679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.0811896295 11118676 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7520887781
MESH:D011471 Prostatic Neoplasms Azacitidine 2.9118324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.9116888761 15897917 16729912 18437689 15749863 16868541
MESH:D011471 Prostatic Neoplasms Estradiol 2.9116740699
MESH:D011471 Prostatic Neoplasms Genistein 2.9115256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.9116205645
MESH:D011471 Prostatic Neoplasms resveratrol 2.9117636462 17718901 17804756 15767336 16731767 17675339
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.9116039940
MESH:D011471 Prostatic Neoplasms Thalidomide 2.9116729912
MESH:D011536 Prurigo Thalidomide 6.1512755975
MESH:D011537 Pruritus Mustard Gas 3.9418058305
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8710334151 17894541 17266442 17620002 17720292
MESH:D051437 Renal Insufficiency Doxorubicin 4.0717922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.4316325855
MESH:D015427 Reperfusion Injury resveratrol 3.2016317513 17058453 16314181 17520802 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012509 Sarcoma Doxorubicin 3.8617710206 16767912 18313854 15625365 17203757 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.0914601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6417846226
MESH:D012559 Schizophrenia Homocysteine 3.0916641680
MESH:D019873 Schnitzler Syndrome Thalidomide 5.7916096327
MESH:D012871 Skin Diseases Mustard Gas 2.6816961503 15451306 12880345
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 17.1819755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 17.1815692506
MESH:D012878 Skin Neoplasms resveratrol 17.1815837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 17.1819524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 17.1816192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4217203757 16767912 15625365
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6812854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.322093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3218456281
MESH:D013274 Stomach Neoplasms irinotecan 3.3215723263
MESH:D013276 Stomach Ulcer Thalidomide 4.0415138204
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3516321402
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.917505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 6.9116010429 17909728
MESH:D013978 Tibial Fractures Estradiol 4.5319048282
MESH:D014062 Tongue Neoplasms resveratrol 4.0816227395
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.0117053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.0117653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.0117306315 11723127 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.1217473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.1211813266
MESH:D014594 Uterine Neoplasms resveratrol 3.9917044934
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D014625 Vaginal Neoplasms Vinblastine 4.8915577323
MESH:D014652 Vascular Diseases sodium arsenite 11.6117056641
MESH:D014652 Vascular Diseases Thalidomide 11.6115741222
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 9.8417638931 17334414 17678736 16364871
MESH:D018487 Ventricular Dysfunction, Left resveratrol 9.8417488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
Pathway ID Pathway Name
KEGG:04110 Cell cycle
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37066
    • No data
    Releated disease ID Related disease Name
    PA444987Multiple Sclerosis
    Releated drug ID Related drug Name
    PA450037interferon beta-1a
    PA450039interferon beta-1b
    PA451999interferons
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01782 - 2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved