AutismKB 2.0

Annotation Detail for TUB


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Basic Information Top
Gene Symbol:TUB ( rd5 )
Gene Full Name: tubby homolog (mouse)
Band: 11p15.4
Quick LinksEntrez ID:7275; OMIM: 601197; Uniprot ID:TUB_HUMAN; ENSEMBL ID: ENSG00000166402; HGNC ID: 12406
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TUB mRNAaffects expression 16483693
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of TUB mRNAdecreases expression 12057914
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of TUB mRNAincreases expression 12057914
D018038 Sodium Selenite Sodium Selenite results in decreased expression of TUB mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TUB mRNAdecreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4715322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 4.1918287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.4918653653 11850527
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5618850075 18670907 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D019457 Chromosome Breakage Sodium Selenite 5.3115894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2416354765 12621046 8697196 15668235 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.1516285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.1215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.1220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6215322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.429294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 5.0317637181 15821434 15328337
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005334 Fever Lipopolysaccharides 4.4111852909 9205823
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.5120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5110048152 11294989
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.7816366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4515340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7718606429 15340226 16354765 16959395 8697196
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0218850075 18670907
MESH:D007249 Inflammation Lipopolysaccharides 5.689205823 17963957 17255318 17237260 12878042
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.6812200463 12878042
MESH:D007333 Insulin Resistance Sodium Selenite 3.5214714311
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 5.0917255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007970 Leukopenia Lipopolysaccharides 5.3315821434
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.5612878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5612878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D055370 Lung Injury Lipopolysaccharides 4.5721114838
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.5214737004
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D011014 Pneumonia Lipopolysaccharides 5.1812224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3318760546
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.9710835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.5615821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02028 - L-Alpha-Glycerophospho-D-Myo-Inositol-4,5-Bis-Phosphate
No data
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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