AutismKB 2.0

Annotation Detail for TLCD2


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Basic Information Top
Gene Symbol:TLCD2 ( - )
Gene Full Name: TLC domain containing 2
Band: 17p13.3
Quick LinksEntrez ID:727910; OMIM: NA; Uniprot ID:TLCD2_HUMAN; ENSEMBL ID: ENSG00000185561; HGNC ID: 33522
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TLCD2 mRNAaffects expression 17562736
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TLCD2 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of TLCD2 mRNAdecreases expression 19482888
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 4.326195326
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.8617620307
MESH:D000799 Angioedema Acetaminophen 4.9110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.043084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.0420007298 1701930 17173139 6705139 20935162
MESH:D002386 Cataract Acetaminophen 2.8310977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 5.024080065
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6817906064 18071297 14986274 14550746 17522070 16393943 12958197 19416960 16177239 19739265 16227642 17562736 16081117 10915739 19085960 12594235 16109766 10663392 10774834 11529661 11421492 19370779 19420014 19164858 11834606 12705907 15619225 11739529 15968718 12392966 11461765 16781746 19923254 2444490 12540782 12153990 14725611 11287661 18713872 16485898 11743745
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 5.1719426721
MESH:D004421 Dystonia Phenobarbital 4.611851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.873659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.943922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.1020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 4.016401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 5.027750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.903659116
MESH:D005756 Gastritis Acetaminophen 4.7416983495
MESH:D006529 Hepatomegaly Phenobarbital 4.2516109766
MESH:D006930 Hyperalgesia Acetaminophen 3.1116870215
MESH:D007674 Kidney Diseases Acetaminophen 2.4415629191 12587719
MESH:D008103 Liver Cirrhosis Phenobarbital 3.1221047994
MESH:D008107 Liver Diseases Acetaminophen 4.2516611625 12969438 19460945 19784758 19014921 16610002 12587719 11587558
MESH:D008107 Liver Diseases Phenobarbital 4.2519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.7416871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 2.458742319 19073162 19812893 15975961 21047994 19482888
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.972563599 6150874 18308698 17172636 1399818
MESH:D008546 Melanoma, Experimental Acetaminophen 4.3319513568
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.3617484760
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.3118514411
MESH:D010018 Osteomalacia Phenobarbital 5.2517016548
MESH:D010146 Pain Acetaminophen 2.8216870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.6216965848
MESH:D011230 Precancerous Conditions Phenobarbital 4.092563599
MESH:D019310 Pseudolymphoma Phenobarbital 5.5612752131
MESH:D012640 Seizures Phenobarbital 3.014039156 3137016 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.716407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.431399818
MESH:D014581 Urticaria Acetaminophen 3.5810982225
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018