Annotation Detail for D2HGDH
Basic Information Top
| Gene Symbol: | D2HGDH ( D2HGD,FLJ42195,MGC25181 ) |
|---|---|
| Gene Full Name: | D-2-hydroxyglutarate dehydrogenase |
| Band: | 2q37.3 |
| Quick Links | Entrez ID:728294; OMIM: 609186; Uniprot ID:D2HDH_HUMAN; ENSEMBL ID: ENSG00000180902; HGNC ID: 28358 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Pathway Information| No data |
| No data |
| No data |
| No data |
| Desease Name |
|---|
| D-2-hydroxyglutaric aciduria |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000082 | Acetaminophen | Acetaminophen affects the expression of D2HGDH mRNA | affects expression | 17562736 |
| C019417 | alpha-hydroxyglutarate | D2HGDH protein results in increased metabolism of alpha-hydroxyglutarate | increases metabolic processing | 15609246 |
| C029743 | alpha-ketoglutaric acid | D2HGDH protein results in increased chemical synthesis of alpha-ketoglutaric acid | increases chemical synthesis | 15609246 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000592 | Amino Acid Metabolism, Inborn Errors | marker/mechanism | 15609246 | ||
| MESH:D000799 | Angioedema | Acetaminophen | 4.71 | 10982225 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 1.39 | 18445737 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 1.41 | 3084413 | |
| MESH:D002386 | Cataract | Acetaminophen | 2.81 | 10977129 | |
| OMIM:600721 | D-2-HYDROXYGLUTARIC ACIDURIA 1 | marker/mechanism | |||
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 1.68 | 12594235 15968718 19164858 12705907 12540782 17522070 2444490 11421492 19923254 14725611 17562736 16781746 16485898 17906064 11743745 18071297 11529661 11461765 10915739 19416960 14550746 12958197 11287661 16081117 19420014 14986274 19370779 10774834 10663392 11834606 12153990 16227642 18713872 16109766 15619225 12392966 19739265 16177239 11739529 16393943 19085960 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 4.96 | 19426721 | |
| MESH:D005756 | Gastritis | Acetaminophen | 4.54 | 16983495 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 3.06 | 16870215 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 2.42 | 12587719 15629191 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 1.71 | 19784758 12587719 19460945 16610002 19014921 11587558 12969438 16611625 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 3.68 | 17185352 16871587 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 4.22 | 19513568 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 3.26 | 18514411 | |
| MESH:D010146 | Pain | Acetaminophen | 2.77 | 16870215 | |
| MESH:D014581 | Urticaria | Acetaminophen | 3.50 | 10982225 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:00650 | Butanoate metabolism |
| KEGG:00051 | Fructose and mannose metabolism |
| KEGG:00591 | Linoleic acid metabolism |
| KEGG:01100 | Metabolic pathways |
| REACT:1046 | Pyruvate metabolism and Citric Acid (TCA) cycle |