AutismKB 2.0

Annotation Detail for TUBG1


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Basic Information Top
Gene Symbol:TUBG1 ( GCP-1,TUBG,TUBGCP1 )
Gene Full Name: tubulin, gamma 1
Band: 17q21.31
Quick LinksEntrez ID:7283; OMIM: 191135; Uniprot ID:TBG1_HUMAN; ENSEMBL ID: ENSG00000131462; HGNC ID: 12417
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
Pathway IDPathway Name
200087PLK1 signaling events
No data
Pathway IDPathway Name
500383Loss of proteins required for interphase microtubule organization from the centrosome
500380Centrosome maturation
500381Recruitment of mitotic centrosome proteins and complexes
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TUBG1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TUBG1 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TUBG1 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of TUBG1 proteinincreases expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of TUBG1 mRNAdecreases expression 20458559
D002330 Carmustine Carmustine results in decreased expression of TUBG1 mRNAdecreases expression 15980968
D016572 Cyclosporine Cyclosporine results in decreased expression of TUBG1 mRNAdecreases expression 20106945
D004391 Dust Dust results in decreased expression of TUBG1 mRNAdecreases expression 17805423
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3419825857 11798837
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.9516206674
MESH:D001932 Brain Neoplasms Carmustine 4.6516187019
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7916705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7916217749 14691202 15553829 11135700 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.196135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1912371664
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.1218551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.0818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.0821346803 18551238
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005234 Fatty Liver arsenic trioxide 8.7115073043
MESH:D005234 Fatty Liver Cyclosporine 8.7119224547
MESH:D005355 Fibrosis Cyclosporine 3.5012168785 12639820
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D005909 Glioblastoma Carmustine 4.1016187019
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 2.488314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.7616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.7616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.7612371664
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1720471514 19850784 17050201 16467208 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3819225113 19075265 16966277 19642359 12679006 16112521 16823087 16330433 17869043 17107899 11161223 11468182 15622746 15748426 17649720 15336539 12712474 17712046 15213294 16891316 12018890 16331271 9834237 17217047 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.897678174
MESH:D008113 Liver Neoplasms arsenic trioxide 4.8914682389
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.502876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.5020377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8719825857 11798837
MESH:D008545 Melanoma Carmustine 2.8912393984
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2915949261 11468182 14977855 19549372 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2816105982 16882451
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.7018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.7018551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2810525206
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.7812819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.7816049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4719769630 12452020 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6015580305
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2319131511
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012640 Seizures 2,4-dinitrotoluene 6.4718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8516049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.8511780464 12973940 12845720 20435036
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.3510091137
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00570 adduct Vinblastine Antineoplastic Agents, Phytogenic;Tubulin Modulators
No data
No data
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Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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