AutismKB 2.0

Annotation Detail for TUFM


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Basic Information Top
Gene Symbol:TUFM ( COXPD4,EF-TuMT,EFTU,P43 )
Gene Full Name: Tu translation elongation factor, mitochondrial
Band: 16p11.2
Quick LinksEntrez ID:7284; OMIM: 602389; Uniprot ID:EFTU_HUMAN; ENSEMBL ID: ENSG00000178952; HGNC ID: 12420
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Combined oxidative phosphorylation deficiency 4
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TUFM mRNAaffects expression 17562736
D000171 Acrolein Acrolein results in increased metabolism of TUFM proteinincreases metabolic processing 17570602
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TUFM proteinincreases expression 17292933
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TUFM mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of TUFM mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TUFM mRNAaffects cotreatment|affects expression 17602206
D004317 Doxorubicin Doxorubicin results in increased expression of TUFM proteinincreases expression 16144979
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TUFM mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUFM mRNAaffects cotreatment|increases expression 17942748
C006253 pirinixic acid pirinixic acid results in increased expression of TUFM mRNAincreases expression 18301758
15375163
D011794 Quercetin Quercetin results in increased expression of TUFM proteinincreases expression 17292933
D018038 Sodium Selenite Sodium Selenite results in increased expression of TUFM mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUFM mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in decreased expression of TUFM mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9611752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury Acrolein 9.5820525806 21297076
MESH:D055371 Acute Lung Injury pirinixic acid 9.5818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1820127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 7.1817418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1814692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.786695378
MESH:D000236 Adenoma Diethylnitrosamine 6.7810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.9918056438 16434500 17620307 19052882 17162532 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.9916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.9916835633
MESH:D000419 Albuminuria Doxorubicin 4.6421441931
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D000544 Alzheimer Disease Acrolein 3.2914715435 15207723 17570602
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.3217084956
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001161 Arteriosclerosis Acrolein 10.6715014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.6711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.3716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2816292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D001260 Ataxia Telangiectasia Quercetin 5.0915336622
MESH:D050197 Atherosclerosis Acrolein 4.0217363696 16037261 16126721
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001327 Autoimmune Diseases Quercetin 4.5119761891
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.7619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.7612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.7616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8314601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.8817150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9917474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.9917474063
MESH:D001943 Breast Neoplasms Doxorubicin 2.9911325840 18695136 18382427 15994142 15668708 16826403 16115903 15692762 18234424 15993339 17426702 16595493 16096432 16264153 18628466 15939500 16935488 15136595 17369602 15634643 19526202 15567936 16322301 17983394
MESH:D001943 Breast Neoplasms Quercetin 2.9918628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9920435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9916166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D002105 Cadmium Poisoning Quercetin 5.6816962696
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9416051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.013084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.0119539802 19383236 18210153 3581430 20084675 20007298 18785209 16698587 19171122 20727157 17761372 16935385 18506893 19919837 19519916 16830150 19701751 17428255 11831363 19822196 19394651 16540662 18393292 10737359 17173139 16681979 16807293 18056438 17138121 18788625 17978847 19052882 20524982 20514400 3084413 19208518 16288022 20214788 19107877 16779866 20101231 19418558 18665156 16328049 20432363 18691550 19335982 16502159 21159647 18978308 18971187 18494052 20512989 16878318 17055752 10672840 20935162 17162532 16569478
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 9.0117876044 18059187 16234567 16023760
MESH:D006528 Carcinoma, Hepatocellular Quercetin 9.0112508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.011917145
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.0617234771
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.191485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.6720419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.676189445
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.6716096774 16051514
MESH:D006332 Cardiomegaly Quercetin 6.9419794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9418670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.5816455267 17382496 17308081 18627295 17007740 17351982 16242529 16731534 16612575 16364871 15476868 15792986 17329180 16952015 16109756 17131338 17928571 17519947 15811867 16278810 16269455 17974986 15505089 17924179 16651473
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9716243910 17334414
MESH:D002386 Cataract Acetaminophen 7.3810977129
MESH:D002386 Cataract Tretinoin 7.3817460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.792727394 7505956 17174075 21159647
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.5719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5716835633
MESH:D002779 Cholestasis Cyclosporine 13.7019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.7017333356 16105132 15861022 11677210 17110522 17681005 16919318
MESH:D002779 Cholestasis pirinixic acid 13.7019176532
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8712621046 16354765 15668235 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 5.879407595
MESH:D003092 Colitis Tretinoin 3.8117035595
MESH:D003110 Colonic Neoplasms Quercetin 2.4317148506 19056647 15741050 17191121 16640504 11134977 19440933
MESH:D015179 Colorectal Neoplasms Acrolein 3.6917597105
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.6918259882 18802399
MESH:D015179 Colorectal Neoplasms Quercetin 3.6918852136 18095365
OMIM:610678 COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 4 marker/mechanism
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4720055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4716925845 9664655 17551590 9142499 9211117 9125849 9224671 14991402 10589399 8800419
MESH:D003556 Cystitis Acrolein 5.5312161096
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8516285004
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8019496084
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2817107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.2719420014 11834606 12594235 19416960 16393943 16781746 12392966 17906064 16485898 16227642 17562736 10663392 15619225 18071297 2444490 11739529 10774834 12705907 17522070 11743745 11421492 14725611 19164858 11529661 19923254 18713872 19370779 14986274 19085960 12540782 16177239 16081117 10915739 12153990 11461765 12958197 15968718 11287661 19739265 16109766 14550746
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.2719107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 12.2717416283
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.2715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.2720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Doxorubicin 8.3118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.3111462148
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.4018230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 12.4018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.7617359293
MESH:D016889 Endometrial Neoplasms Tretinoin 7.7616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.2918037988
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.0411564622
MESH:D005124 Eye Abnormalities Tretinoin 9.0416938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 19.4419224547
MESH:D005234 Fatty Liver Diethylnitrosamine 19.4420387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.4415345470
MESH:D005234 Fatty Liver pirinixic acid 19.4419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7019069698
MESH:D005355 Fibrosis Cyclosporine 22.0812639820 12168785
MESH:D005355 Fibrosis Quercetin 22.0819474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.0820067830
MESH:D005355 Fibrosis Tretinoin 22.0817994277
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005909 Glioblastoma Doxorubicin 12.2517150277
MESH:D005909 Glioblastoma Quercetin 12.2519804834
MESH:D005909 Glioblastoma Tretinoin 12.2517312396
MESH:D005910 Glioma Quercetin 3.0817643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.0215692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.0216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.3320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.3310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.3314991402 9664655
MESH:D006331 Heart Diseases Doxorubicin 3.5416244371 16244372 16707910 17875725 16144979 16495754 12587719 14766674 16330681 18006777 16879835 17888722 18674790
MESH:D006333 Heart Failure Doxorubicin 7.2117481944
MESH:D006333 Heart Failure pirinixic acid 7.2120558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9815692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.6116221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6112621046 16120746 15340226
MESH:D006689 Hodgkin Disease Doxorubicin 3.4815147373 17606976 18501091
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816354765 15340226 16959395 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 7.8416870215
MESH:D006930 Hyperalgesia Tretinoin 7.8416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D006943 Hyperglycemia pirinixic acid 9.5020558911
MESH:D006943 Hyperglycemia Quercetin 9.5018262572 11834736
MESH:D006973 Hypertension Cyclosporine 8.7510903974
MESH:D006973 Hypertension Quercetin 8.7518356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.7518850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Diethylnitrosamine 5.0318785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0312200463 12878042
MESH:D007251 Influenza, Human Quercetin 4.6416624496
MESH:D007333 Insulin Resistance pirinixic acid 7.4816306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.4814714311
MESH:D007410 Intestinal Diseases Tretinoin 3.8717994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.2116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.2117551590 15992940
MESH:D007627 Keloid Quercetin 5.0617086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 19.5712587719 15629191
MESH:D007674 Kidney Diseases Acrolein 19.5712488133
MESH:D007674 Kidney Diseases Cyclosporine 19.578314463 18776723 10903974
MESH:D007674 Kidney Diseases Doxorubicin 19.5715369732 16775033 15699352
MESH:D007674 Kidney Diseases Quercetin 19.5716962696
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2316707910
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8012371664
MESH:D007938 Leukemia Quercetin 6.5917468513
MESH:D007938 Leukemia Tretinoin 6.5917143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.2916085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7819285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0919850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2017217047 16788101 16766008 9834237 17712046 19035177 16331271 17506722 17107899 12679006 17339181 16823087 17368321 16891316 16140955 19225113 15748426 17649720 19642359 16935935 19029980 19075265 17361223 17301526 17294898
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8718522880 18407596 20032147 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.8416595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.8415474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.8412741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.8412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.8418397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 3.9716610002 16611625 19784758 12587719 11587558 19014921 12969438 19460945
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.3821137059 20195826
MESH:D008113 Liver Neoplasms Clofibric Acid 18.3817602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.3821278145 18648771 20492335 21071580 12771043 21167192 19426721 19996281 20405173 19255062 12112319 9163691 19499222 20434301 10737359 19427195 19690152 19833225 19812893 18754104 19638242 15175105 20452335 18978307 20137499 18977376 18644402 20118626 20583210 20501860 19254457 19073162 19090486 19294768 2862719 15885732 2422723 20101389 21047994 19551842 16942905 19850985 19256749 19642983
MESH:D008113 Liver Neoplasms pirinixic acid 18.3820007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 18.3818980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.3816984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.5618544905 17174075 18164116 19009564 18079962 19519916 18253720 17854601 18775883 18282651 17942915 16842330 19539802 18093689 9362446 21159647 19126423 19004024 3124819 2563599 16267830 18308698
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 14.5617085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Quercetin 14.5619519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.5612151625
MESH:D008171 Lung Diseases Acrolein 4.2611504702
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.6917053015 20064080 18520028 18569708 20869020 20464547 20135361 6695378 18816296
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.6920970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 6.696189445 17418594
MESH:D008175 Lung Neoplasms Quercetin 6.6916280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6919555203 11884234
MESH:D008223 Lymphoma Doxorubicin 3.5216098063
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1514737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.8617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.6715621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.0815458769
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Doxorubicin 3.4716827129
MESH:D008545 Melanoma Tretinoin 3.4716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 11.3319513568
MESH:D008546 Melanoma, Experimental Acrolein 11.3310803710
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D008654 Mesothelioma Doxorubicin 3.0917638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5815792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D052016 Mucositis Doxorubicin 4.9117415656
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1217596541
MESH:D009203 Myocardial Infarction Doxorubicin 9.6919429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 9.6919151258
MESH:D009203 Myocardial Infarction Quercetin 9.6919595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6516411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.6519207477
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.983581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.9818259882
MESH:D009369 Neoplasms Acrolein 16.1717329238
MESH:D009369 Neoplasms Benzo(a)pyrene 16.1711141357
MESH:D009369 Neoplasms pirinixic acid 16.1717405874
MESH:D009369 Neoplasms Quercetin 16.1715185748
MESH:D009369 Neoplasms Tretinoin 16.1716594593 16946489
MESH:D009393 Nephritis Acrolein 6.4212653641
MESH:D009401 Nephrosis Doxorubicin 4.8716636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.5419348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.5416889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.839125849
MESH:D009436 Neural Tube Defects Tretinoin 3.109142499
MESH:D009447 Neuroblastoma Doxorubicin 3.3015555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 14.5618514411
MESH:D019636 Neurodegenerative Diseases Acrolein 14.5611342003
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 14.5620387270
MESH:D020078 Neurogenic Inflammation Quercetin 4.4517929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.3119495926
MESH:D012516 Osteosarcoma Doxorubicin 4.1815930896
MESH:D010051 Ovarian Neoplasms Quercetin 5.0719005980
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0716936753
MESH:D010146 Pain Acetaminophen 6.8116870215
MESH:D010146 Pain Tretinoin 6.8116870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.8216540662
MESH:D010190 Pancreatic Neoplasms Quercetin 8.8216965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.8215976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010300 Parkinson Disease Acrolein 3.6217690948
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010787 Photosensitivity Disorders Acrolein 5.8711550810
MESH:D003557 Phyllodes Tumor Doxorubicin 5.2917983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.2917638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 15.7512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 15.752563599
MESH:D011230 Precancerous Conditions Quercetin 15.7519056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111399792 11222880 11896295 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0917292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.0915897917 15749863 16868541 18437689 16729912 16888761
MESH:D011471 Prostatic Neoplasms Quercetin 2.0917292933 14715546
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.0918760546
MESH:D011507 Proteinuria Tretinoin 3.6916636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D051437 Renal Insufficiency Acrolein 10.9512732208
MESH:D051437 Renal Insufficiency Doxorubicin 10.9517922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1916116481 16283617
MESH:D012509 Sarcoma Doxorubicin 4.0615675481 16767912 17203757 17710206 18313854 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.3416326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9117846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.6816862918
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.8619755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 13.8615692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.8616192470
MESH:D012878 Skin Neoplasms Tretinoin 13.8616467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.6715625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.372093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3718456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.3717261132
MESH:D020521 Stroke Acrolein 4.6216269634
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.387505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 12.3816010429 17909728
MESH:D013964 Thyroid Neoplasms Tretinoin 12.3816026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8616051514
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5717053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.5717653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.5716720314
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7516129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.3317678736 16364871 17638931 17334414
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37082
    • No data
    Releated disease ID Related disease Name
    PA152241953Encephalopathy, Infantile
    PA444736Leigh Disease
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB04315 - Guanosine-5'-Diphosphate
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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