AutismKB 2.0

Annotation Detail for TULP3


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Basic Information Top
Gene Symbol:TULP3 ( MGC45295,TUBL3 )
Gene Full Name: tubby like protein 3
Band: 12p13.33
Quick LinksEntrez ID:7289; OMIM: 604730; Uniprot ID:TULP3_HUMAN; ENSEMBL ID: ENSG00000078246; HGNC ID: 12425
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TULP3 mRNAaffects expression 17562736
D001104 Arbutin Arbutin results in decreased expression of TULP3 mRNAdecreases expression 17103032
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of TULP3 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of TULP3 mRNAincreases expression 20106945
D019833 Genistein Genistein results in decreased expression of TULP3 mRNAdecreases expression 16705744
C011890 kojic acid kojic acid results in decreased expression of TULP3 mRNAdecreases expression 16595896
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of TULP3 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of TULP3 mRNAdecreases expression 19244175
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of TULP3 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of TULP3 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Genistein 2.5211473722
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Genistein 2.5017200150 16541309 16873071
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2416050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.053084413
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.0516924424
MESH:D002318 Cardiovascular Diseases Genistein 3.4616332659
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6812371664
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5316647724
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9911834606 11743745 17562736 11739529 16227642 12153990 16177239 14725611 19923254 12392966 14986274 11461765 19370779 10915739 16393943 19416960 16081117 18071297 15968718 15619225 16109766 14550746 16485898 19420014 11421492 19739265 19085960 12540782 19164858 17906064 12594235 16781746 17522070 12705907 12958197 2444490 11529661 18713872 10774834 10663392 11287661
MESH:D056486 Drug-Induced Liver Injury Selenium 3.9915131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:C538011 Eales disease Vitamin E 5.089068938
MESH:D004714 Endometrial Hyperplasia Genistein 4.9316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.5111473722
MESH:D005234 Fatty Liver Cyclosporine 3.1019224547
MESH:D005355 Fibrosis Cyclosporine 3.4512168785 12639820
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005909 Glioblastoma Genistein 3.4016598420
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1016080930
MESH:D006333 Heart Failure Selenium 3.2117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7716490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.3514716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007251 Influenza, Human Selenium 12.2516624496
MESH:D007251 Influenza, Human Vitamin E 12.2516624496
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 10.7512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.758314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 10.7512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D007938 Leukemia Genistein 3.1318980019 17468513
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.7017823541
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.7016169303
MESH:D008107 Liver Diseases Acetaminophen 1.6719784758 12969438 12587719 11587558 19460945 16611625 19014921 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008114 Liver Neoplasms, Experimental kojic acid 3.4718544905
MESH:D008171 Lung Diseases Vitamin E 3.3316863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.6512929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.6515318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009203 Myocardial Infarction Genistein 2.9417141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.8417141266
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations Genistein 4.3116427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D010024 Osteoporosis Genistein 3.3919401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3516169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6619005980
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011471 Prostatic Neoplasms Genistein 3.3215378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3215084515
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012871 Skin Diseases Vitamin E 2.4918709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.798532709
MESH:D020521 Stroke Vitamin E 3.7116517955
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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