AutismKB 2.0

Annotation Detail for C6


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Basic Information Top
Gene Symbol:C6 ( - )
Gene Full Name: complement component 6
Band: 5p13.1
Quick LinksEntrez ID:729; OMIM: 217050; Uniprot ID:CO6_HUMAN; ENSEMBL ID: ENSG00000039537; HGNC ID: 1339
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05322Systemic lupus erythematosus
hsa04610Complement and coagulation cascades
hsa05020Prion diseases
Pathway IDPathway Name
Signaling in Immune system
No data
No data
Pathway IDPathway Name
500475Terminal pathway of complement
Related Diseases/Disorders Top
Desease IDDesease Name
H00103Late complement pathway defects
Immune system diseases
Primary immunodeficiency
Desease IDDesease Name
2225Gram-Negative bacterial infection
Desease Name
deficiencies of C6
No data
Desease Name
C6 deficiency
Combined C6/C7 deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of C6 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of C6 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of C6 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of C6 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of C6 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of C6 mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of C6 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of C6 mRNAdecreases expression 19638242
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of C6 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of C6 mRNAaffects cotreatment|increases expression 17942748
C004925 methylmercuric chloride methylmercuric chloride results in increased expression of C6 mRNAincreases expression 17961207
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of C6 mRNAincreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein inhibits the reaction [perfluorooctanoic acid results in increased expression of C6 mRNA]decreases reaction|increases expression 18467677
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of C6 mRNAdecreases expression 16221955
C006253 pirinixic acid pirinixic acid results in decreased expression of C6 mRNAdecreases expression 18467677
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of C6 mRNA]decreases expression|increases reaction 18467677
C045950 propiconazole propiconazole results in increased expression of C6 mRNAincreases expression 19363144
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of C6 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of C6 mRNAaffects cotreatment|increases expression 17942748
D014303 Trinitrotoluene Trinitrotoluene affects the expression of C6 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced methylmercuric chloride 14.786734493
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 14.7811752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 14.787525203
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8214692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.723712494
MESH:D000236 Adenoma Diethylnitrosamine 6.726695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.5916434500 19052882 17620307 19061943 17162532 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.5916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.5916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.0811289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.8619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.8612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9717474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8216192424 16097048 18705752 16011737 3786805 16124888 16050911 16227642 15721981 10355542 15673190 15700767
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.4616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.463581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.463084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.4621507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.4618788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.4616288022 11831363 17173139 19335982 20214788 21159647 16935385 20101231 20514400 20084675 17138121 19418558 17055752 20935162 19171122 18785209 17978847 18393292 19208518 16807293 19539802 17761372 19919837 18971187 16569478 10737359 18506893 19052882 19701751 19107877 10672840 18210153 16698587 20524982 16681979 17162532 16878318 20512989 16502159 19519916 18978308 16779866 18691550 20007298 20432363 19394651 18494052 18665156 16830150 3084413 16540662 19383236 18788625 3581430 16328049 17428255 18056438 19822196 20727157
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.697296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 7.5610977129
MESH:D002386 Cataract Trinitrotoluene 7.5615817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.176135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.177505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.1712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.172727394 7505956 17174075 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 19.3919486331 9022650
MESH:D002779 Cholestasis Cyclosporine 19.3919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 19.3917333356 15861022 17110522 16919318 17681005 16105132 11677210
MESH:D002779 Cholestasis pirinixic acid 19.3919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.118697196 15340226 15668235 12621046 16354765
OMIM:612446 COMPLEMENT COMPONENT 6 DEFICIENCY marker/mechanism
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.3617141729 14669216
MESH:D000013 Congenital Abnormalities Trinitrotoluene 9.3615095906
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 20055451 10048152
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3718551238
MESH:D003490 Cyanosis Trinitrotoluene 11.3718551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8412868966 2524372 11906362 14531868 8156756 18759878 11298694 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.523621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2417107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 18.8418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 18.8418648102 1440618 8291058 6679447 18289764 9328219 9022650 18692083 6482804 7440962 16192314 11289319 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.8410663392 16393943 12153990 19370779 19420014 19085960 11739529 16109766 11743745 16177239 12594235 17562736 19164858 11834606 15619225 11461765 18713872 12392966 2444490 14725611 19923254 11421492 14550746 16227642 12705907 16485898 10915739 18071297 17906064 10774834 12540782 19416960 11287661 15968718 19739265 16781746 11529661 12958197 14986274 16081117 17522070
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 18.843732212 10915739 16227642 15968718 3786805 21278145 7120509 19085960 4309450 7440962 9327722 16177239 17522070 2869522 10092053 7179309 15027814 15998439 11566570 6623471 19336974 6884620
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 18.8419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.8420420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 18.8418551238 21346803
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004487 Edema perfluorooctanoic acid 11.6317259670 12083418
MESH:D004487 Edema pirinixic acid 11.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9616714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.059294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1816302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.113581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 24.9812795759 19224547 12631006 16045604 15959796 61145 16239168 17595544
MESH:D005234 Fatty Liver Cyclosporine 24.9819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 24.9820387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.9815345470
MESH:D005234 Fatty Liver pirinixic acid 24.9819236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.086705139
MESH:D005355 Fibrosis Carbon Tetrachloride 14.9718705752
MESH:D005355 Fibrosis Cyclosporine 14.9712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.9720067830
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.077505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.356705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.3519110552 19900420
MESH:D006529 Hepatomegaly perfluorooctanoic acid 27.693609246
MESH:D006529 Hepatomegaly pirinixic acid 27.6916221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly propiconazole 27.6917178688 17178689
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 27.6912621046 16120746 15340226
MESH:D006529 Hepatomegaly Trinitrotoluene 27.6915817613
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1118606429 16959395 15340226 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.9316870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.9312083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5816899240
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9815034207
MESH:D006973 Hypertension Cyclosporine 4.9810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1315338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9617937319
MESH:D007248 Infertility, Male Trinitrotoluene 6.9612150543
MESH:D007249 Inflammation Diethylnitrosamine 8.4518785209
MESH:D007249 Inflammation perfluorooctanoic acid 8.4512083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.4512200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.6516306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.088074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.8518776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.5016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.506582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.5012371664
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.288812269
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.6616239168 17157831 11903743 16943688 21278145 17174718 17334410 11408273 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.6618407596 20032147 18522880 19638242 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.219327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4012546737 15925388 15931870 16097048 18277467 12445421 18472094 15650968 15673190 16027843 12649538 15876570 17869086 18205269 18472332 16116963 17557913 18418968 17481882 18705752 17805973 18054572 14748882 18420326 16136751 14512876 15338365 12609069 17761835 14620537 12632514 15893842 12898905 18166357 16248980 18395095 18210741 15052691 17922224 18481824 16638106 17640975 15730626 12666154 17708605 17823541 15818738 15370692 18187930 17944888 18251166 16033810 15996030 17525996 18339082 18317297 12958196 18156304 18395914 17976157 12632512 17698563 15362042 18263696 15123356 15057751 10355542 14716496 18279442 12389079 18412020 16015684 17714472 12445418 17631135 20821823 18376398 15959796 12741479 12667390 17766677 14724832 12586293 17900296 17721639 18006644 16192424 11481614 13678700 16011737 17565644 18429990 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4012878042
MESH:D008107 Liver Diseases Acetaminophen 9.4919014921 11587558 12969438 16611625 19460945 12587719 19784758 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 9.4916246199 17285989 15720792 16964402 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 9.4917034775
MESH:D008107 Liver Diseases propiconazole 9.4919363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5016899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 26.217678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 26.2115890375 18177683 9163691 2125692
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 26.2119294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 26.2119073162 2862719 19850985 21071580 19812893 19642983 9163691 15885732 19256749 21167192 20118626 19255062 19427195 20583210 20492335 19996281 10737359 19294768 20434301 19638242 21047994 20101389 20452335 12771043 16942905 20137499 2422723 19254457 19551842 19690152 19833225 12112319 20501860 15175105 19090486 18977376 18978307 18648771 20405173 19426721 18754104 21278145 18644402 19499222
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 26.2114757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 26.2116377806 15890375 20007298
MESH:D008113 Liver Neoplasms propiconazole 26.2119028983
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 26.2116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 28.592876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 28.596587162 3712494 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 28.598603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 28.5915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 28.5918308698 18775883 19539802 19126423 16842330 17174075 9362446 21159647 19009564 18093689 19004024 18544905 18282651 17854601 16267830 18164116 19519916 2563599 17942915 3124819 18253720 18079962
MESH:D008114 Liver Neoplasms, Experimental propiconazole 28.5917178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 28.5912151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4014755239
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4020970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4019555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9716411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.8518551238 7678174
MESH:D009336 Necrosis Trinitrotoluene 10.8518551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.743581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.743581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.9617405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.936679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.2618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.2620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1820387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.999802331
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.3516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.356482804 4026338
MESH:D009784 Occupational Diseases Trinitrotoluene 15.3514694615 17852074 12819281
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.083988306
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4316540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.527296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.536228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.0312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.032563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 9.8417132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.8411222880 11896295 11399792 11118676
MESH:D011537 Pruritus Ethinyl Estradiol 3.3616919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.393692021
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2618551238
MESH:D012640 Seizures Trinitrotoluene 6.2618551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0016709447
MESH:D013163 Splenomegaly Trinitrotoluene 5.2415817613
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.196582329 6587162 7505956 1399818 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.197505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.0416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.048074119
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3710091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
KEGG:05020 Prion diseases
REACT:6900 Signaling in Immune system
KEGG:05322 Systemic lupus erythematosus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25921
    • No data
    No data
    Releated drug ID Related drug Name
    PA450287magnesium
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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