AutismKB 2.0

Annotation Detail for PLIN4


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Basic Information Top
Gene Symbol:PLIN4 ( KIAA1881,S3-12 )
Gene Full Name: perilipin 4
Band: 19p13.3
Quick LinksEntrez ID:729359; OMIM: 613247; Uniprot ID:PLIN4_HUMAN; ENSEMBL ID: ENSG00000167676; HGNC ID: 29393
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PLIN4 mRNAaffects expression 17562736
C015001 arsenite arsenite results in increased expression of PLIN4 mRNAincreases expression 18929588
D004041 Dietary Fats Dietary Fats results in decreased expression of PLIN4 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of PLIN4 mRNAdecreases expression 18042831
D010269 Paraquat Paraquat results in increased expression of PLIN4 mRNAincreases expression 12595580
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PLIN4 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of PLIN4 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000382 Agricultural Workers' Diseases Paraquat 4.2211874814
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.2520435547
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003110 Colonic Neoplasms arsenite 2.6215037631
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6516393943 19085960 11743745 17522070 11529661 15968718 12392966 12705907 19416960 16227642 12540782 10915739 16485898 18071297 11739529 16081117 17562736 19420014 19739265 12594235 12153990 16109766 10663392 11421492 14725611 15619225 16781746 17906064 19164858 19923254 10774834 2444490 14550746 12958197 19370779 11287661 11461765 14986274 18713872 16177239 11834606
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D005234 Fatty Liver arsenite 15.1518296743
MESH:D005234 Fatty Liver Dietary Fats 15.1519004024 17967931 19551842 18296743
MESH:D005234 Fatty Liver pirinixic acid 15.1520131406 19236843
MESH:D005355 Fibrosis arsenite 10.4618296743
MESH:D005355 Fibrosis Dietary Fats 10.4618296743
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005911 Gliosis Paraquat 5.6811124998
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4119772884 16221962 19176532 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D007248 Infertility, Male Paraquat 3.454850670
MESH:D007249 Inflammation Dietary Fats 2.5720412841
MESH:D007333 Insulin Resistance Dietary Fats 7.8918457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.8916306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D008103 Liver Cirrhosis arsenite 7.3718296743
MESH:D008103 Liver Cirrhosis Dietary Fats 7.3718296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6919014921 12969438 11587558 16611625 12587719 19784758 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.9115890375 20007298 16377806
MESH:D008175 Lung Neoplasms arsenite 2.3616809336
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009389 Neovascularization, Pathologic arsenite 4.8715738583
MESH:D009410 Nerve Degeneration Paraquat 3.9616893418
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity Dietary Fats 4.6417217161 20518802 18457598 11836018 16723640 18674790 21332399 19632207 20132043
MESH:D009765 Obesity pirinixic acid 4.6420558911
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010300 Parkinson Disease Paraquat 2.9111181820 15451049 15824117 11445065 11124998 16140633 16510128 12911755
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.8516190885
MESH:D011014 Pneumonia Paraquat 4.9112504350
MESH:D011658 Pulmonary Fibrosis Paraquat 3.0117997886 16324872
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 4.2611700416
MESH:D012135 Respiratory Sounds Paraquat 4.4711874814
MESH:D012162 Retinal Degeneration Paraquat 4.1016458197
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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