AutismKB 2.0

Annotation Detail for TYK2


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Basic Information Top
Gene Symbol:TYK2 ( JTK1 )
Gene Full Name: tyrosine kinase 2
Band: 19p13.2
Quick LinksEntrez ID:7297; OMIM: 176941; Uniprot ID:TYK2_HUMAN; ENSEMBL ID: ENSG00000105397; HGNC ID: 12440
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa05145Toxoplasmosis
hsa04630Jak-STAT signaling pathway
No data
Pathway IDPathway Name
200034IL12-mediated signaling events
200033Signaling events mediated by PTP1B
200131IL23-mediated signaling events
200124IL6-mediated signaling events
200023IL27-mediated signaling events
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Immune system diseases
Primary immunodeficiency
H00107Other well-defined immunodeficiency syndromes
Desease IDDesease Name
1807Autoimmune disease
1831Prostate cancer
1834Sarcoidosis
2217Thrombocythemia, Hemorrhagic
2146Lupus erythematosus
Desease Name
type 1 diabetes
IMMUNE
lupus erythematosus
Desease Name
Type 1 diabetes
Desease Name
Tyrosine kinase 2 deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D003687 Dehydroepiandrosterone Dehydroepiandrosterone results in increased expression of TYK2 mRNAincreases expression 18709148
D004958 Estradiol Estradiol results in increased expression of TYK2 mRNAincreases expression 18709148
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TYK2 mRNAaffects cotreatment|increases expression 17942748
D008727 Methotrexate TYK2 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D037742 Nanotubes, Carbon Nanotubes, Carbon results in decreased expression of TYK2 mRNAdecreases expression 15585362
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of TYK2 mRNAincreases expression 18709148
C017947 sodium arsenite sodium arsenite results in decreased expression of TYK2 mRNAdecreases expression 12760830
D013654 Taurine Taurine results in decreased expression of TYK2 mRNAdecreases expression 16579726
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TYK2 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 9.5612039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.5614514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Estradiol 4.3711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3714692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0215276417
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 6.0217302879
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2217306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1417286800
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Estradiol 1.9317289903 18497071 17261762 16675129 17018787 14630087 19861407 12948864
MESH:D001943 Breast Neoplasms Methotrexate 1.9316978400
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1216924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.1215276417 17306315 16507464
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4318572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.2018566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.2019524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0211677210 17681005 16919318 17110522 17333356 15861022 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1816354765 8697196 15340226 12621046 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.809562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8015322242 20055451 10048152
MESH:D003424 Crohn Disease marker/mechanism 21102463
MESH:D003550 Cystic Fibrosis Methotrexate 4.4319747007
MESH:D003882 Dermatomyositis Methotrexate 5.3620191521
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 3.7516616286
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D058065 Diabetic Cardiomyopathies Taurine 6.3416025228
MESH:D003928 Diabetic Nephropathies Estradiol 3.5919279558
MESH:D056486 Drug-Induced Liver Injury Taurine 4.459328219
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.4520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema perfluorooctanoic acid 7.6317259670 12083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.6312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.1111473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0215345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9616452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006086 Graft vs Host Disease Methotrexate 5.4116518429
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly perfluorooctanoic acid 9.543609246
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.5412621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.3312676792
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia perfluorooctanoic acid 4.0112083418
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0817937319
MESH:D007248 Infertility, Male sodium arsenite 7.0812646999 15346721
MESH:D007249 Inflammation perfluorooctanoic acid 5.4712083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4712200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.0916393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Estradiol 6.4715618244
MESH:D007674 Kidney Diseases sodium arsenite 6.4720008137
MESH:D007680 Kidney Neoplasms Estradiol 3.1515610895
MESH:D007805 Language Development Disorders Methotrexate 5.329562676
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.518812269
MESH:D008103 Liver Cirrhosis Methotrexate 3.8014986274
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.7514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Taurine 3.7515893842 15931870
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.7512878042
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 11.3718709148
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 11.3714757943 18709148
MESH:D008113 Liver Neoplasms sodium arsenite 11.3715276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.3716984957
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 6.628603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.6212151625
MESH:D008171 Lung Diseases sodium arsenite 3.3019095001
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.3418516814
MESH:D008175 Lung Neoplasms sodium arsenite 2.3517306315 19931552 15276417 16712894 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3511884234 19555203
MESH:D008223 Lymphoma Methotrexate 4.0917352296
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 6.8516457693
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.8516891317 17203775 11408345 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D052016 Mucositis Methotrexate 5.5717488658
MESH:D009103 Multiple Sclerosis marker/mechanism 19525955
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4416810080
MESH:D009369 Neoplasms sodium arsenite 2.5811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9220056578
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009421 Nervous System Malformations Estradiol 10.2711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.2714600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.2712854658
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.219802331
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 5.2516397352
MESH:D010051 Ovarian Neoplasms Estradiol 5.0219401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.0215276417 17306315
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 10.6417132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.6411222880 11896295 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1816740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.1816039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D011565 Psoriasis marker/mechanism 20953190
MESH:D011565 Psoriasis Methotrexate 3.4917410198
MESH:D051437 Renal Insufficiency Methotrexate 4.9717352296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012878 Skin Neoplasms sodium arsenite 5.8819524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9512854658
MESH:D013576 Syndactyly Methotrexate 5.279562676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
OMIM:611521 TYROSINE KINASE 2 DEFICIENCY marker/mechanism
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5711723127 17306315 16712894 16452187
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9611813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014652 Vascular Diseases sodium arsenite 4.7117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
KEGG:05160 Hepatitis C
KEGG:04630 Jak-STAT signaling pathway
KEGG:05162 Measles
KEGG:04380 Osteoclast differentiation
REACT:6900 Signaling in Immune system
KEGG:05145 Toxoplasmosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37094
    • No data
    Releated disease ID Related disease Name
    PA443815Crohn Disease
    PA153627493Autoimmune Thyroid Disease
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB04716 - 2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE
    DB08183 - 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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