AutismKB 2.0

Annotation Detail for TYR


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Basic Information Top
Gene Symbol:TYR ( OCA1A,OCAIA,SHEP3 )
Gene Full Name: tyrosinase (oculocutaneous albinism IA)
Band: 11q14.3
Quick LinksEntrez ID:7299; OMIM: 606933; Uniprot ID:TYRO_HUMAN; ENSEMBL ID: ENSG00000077498; HGNC ID: 12442
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6481L-dopachrome biosynthesis
Pathway IDPathway Name
hsa04916Melanogenesis
hsa00740Riboflavin metabolism
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00168Oculocutaneous albinism
Inherited disorders of amino acid metabolism
Genetic disorders
Desease IDDesease Name
1709Parkinson disease
1785Uveomeningoencephalitic syndrome
1832Congenital abnormality
2060Glaucoma
2068Skin disease
2237Neoplasm metastasis
Desease Name
ocular albinism
NORMALVARIATION
tanning
melanoma
temperature-sensitive enzymatic activity
CANCER
freckles
type I-A (tyrosinase-negative) oculocutaneous albinism
type IB (yellow) oculocutaneous albinism
skin sensitivity to sun
VISION
full-length deletion of the tyrosinase gene
Blue vs green eyes
DEVELOPMENTAL
skin pigmentation
Desease Name
Skin sensitivity to sun
Tanning
Melanoma
Freckles
Eye color
Skin pigmentation
Vitiligo
Blue vs. green eyes
Desease Name
Waardenburg syndrome/albinism, digenic
Albinism, oculocutaneous, type IA
Albinism, oculocutaneous, type IB
Skin/hair/eye pigmentation 3, freckling
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C050642 1,2-dihydroxynaphthalene TYR protein results in increased oxidation of 1,2-dihydroxynaphthaleneincreases oxidation 17224140
C523393 4-(6-hydroxy-2-naphthyl)-1,3-benzenediol 4-(6-hydroxy-2-naphthyl)-1,3-benzenediol results in decreased activity of TYR proteindecreases activity 17827726
C011164 amentoflavone amentoflavone analog results in decreased activity of TYR proteindecreases activity 17473463
D003513 Cycloheximide Cycloheximide inhibits the reaction [Quercetin results in increased activity of TYR protein]decreases reaction|increases activity 14717847
D003609 Dactinomycin Dactinomycin inhibits the reaction [Quercetin results in increased activity of TYR protein]decreases reaction|increases activity 14717847
D003609 Dactinomycin Dactinomycin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]decreases reaction|increases activity 15278367
D004112 Dimercaprol Dimercaprol results in decreased activity of TYR proteindecreases activity 16928136
D004298 Dopamine TYR protein affects the metabolism of Dopamineaffects metabolic processing 8131222
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of TYR geneincreases mutagenesis 16180137
17174358
9475716
D005054 Eugenol TYR protein results in increased oxidation of Eugenolincreases oxidation 8620581
D005576 Forskolin Forskolin results in increased activity of TYR proteinincreases activity 17460731
D005576 Forskolin [resveratrol co-treated with Forskolin] results in decreased activity of TYR proteinaffects cotreatment|decreases activity 17460731
D006861 Hydrogen Peroxide CAT protein inhibits the reaction [TYR protein results in increased abundance of Hydrogen Peroxide]decreases reaction|increases abundance 15885091
D006861 Hydrogen Peroxide resveratrol inhibits the reaction [TYR protein results in increased abundance of Hydrogen Peroxide]decreases reaction|increases abundance 15885091
D006861 Hydrogen Peroxide TYR protein results in increased abundance of Hydrogen Peroxideincreases abundance 15885091
D007550 Isothiuronium Isothiuronium analog results in decreased expression of TYR mRNAdecreases expression 8043013
D008543 Melanins [TYR protein results in decreased expression of and results in decreased activity of PLD1 protein] which results in decreased abundance of Melaninsdecreases abundance|decreases activity|decreases expression 14615486
D008750 Methyldopa TYR protein affects the metabolism of Methyldopaaffects metabolic processing 8131222
D008770 Methylnitrosourea Methylnitrosourea results in increased mutagenesis of TYR geneincreases mutagenesis 17174358
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [scoparone results in increased expression of TYR protein]decreases reaction|increases expression 17049123
D010656 Phenylephrine Dactinomycin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]decreases reaction|increases activity 15278367
D010656 Phenylephrine Phenylephrine results in increased activity of TYR proteinincreases activity 15278367
D010656 Phenylephrine Prazosin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]decreases reaction|increases activity 15278367
C121565 pifithrin pifithrin results in decreased expression of TYR mRNAdecreases expression 19098008
C121565 pifithrin pifithrin results in decreased expression of TYR proteindecreases expression 19098008
D010936 Plant Extracts Plant Extracts results in decreased activity of TYR proteindecreases activity 17473463
C025299 polyphenols polyphenols results in decreased expression of TYR mRNAdecreases expression 16293270
D011224 Prazosin Prazosin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]decreases reaction|increases activity 15278367
D011794 Quercetin Cycloheximide inhibits the reaction [Quercetin results in increased activity of TYR protein]decreases reaction|increases activity 14717847
D011794 Quercetin Dactinomycin inhibits the reaction [Quercetin results in increased activity of TYR protein]decreases reaction|increases activity 14717847
D011794 Quercetin Quercetin results in increased activity of TYR proteinincreases activity 14717847
D011794 Quercetin TYR protein results in increased metabolism of Quercetinincreases metabolic processing 18001220
D011794 Quercetin TYR protein results in increased susceptibility to Quercetinincreases response to substance 18001220
C059514 resveratrol resveratrol affects the localization of TYR protein modified formaffects localization 17460731
C059514 resveratrol [resveratrol co-treated with Forskolin] results in decreased activity of TYR proteinaffects cotreatment|decreases activity 17460731
C059514 resveratrol resveratrol results in decreased activity of TYR proteindecreases activity 17460731
C059514 resveratrol resveratrol results in decreased expression of TYR proteindecreases expression 17460731
C059514 resveratrol resveratrol inhibits the reaction [TYR protein results in increased abundance of Hydrogen Peroxide]decreases reaction|increases abundance 15885091
C018145 scoparone N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [scoparone results in increased expression of TYR protein]decreases reaction|increases expression 17049123
C018145 scoparone scoparone results in increased expression of and results in increased activity of TYR proteinincreases activity|increases expression 17049123
C018145 scoparone scoparone results in increased expression of TYR mRNAincreases expression 17049123
D013481 Superoxides TYR protein results in increased abundance of Superoxidesincreases abundance 15885091
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury pifithrin 13.8117670903
MESH:D058186 Acute Kidney Injury resveratrol 13.8116538975
MESH:D058186 Acute Kidney Injury Superoxides 13.8118460982
MESH:D000230 Adenocarcinoma Methylnitrosourea 3.0815113128 15688392
MESH:D000236 Adenoma Ethylnitrosourea 6.836695378
MESH:D000236 Adenoma resveratrol 6.8315688382
MESH:D016117 Albinism, Ocular marker/mechanism
OMIM:103470 ALBINISM, OCULAR, WITH SENSORINEURAL DEAFNESS marker/mechanism
OMIM:203100 ALBINISM, OCULOCUTANEOUS, TYPE IA marker/mechanism
MESH:D000544 Alzheimer Disease Plant Extracts 4.4516962711
MESH:D000544 Alzheimer Disease resveratrol 4.4516162502 16183991
MESH:D000743 Anemia, Hemolytic Quercetin 4.0717084956
MESH:D000756 Anemia, Sideroblastic Superoxides 5.4516910769
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9517460149
MESH:D001169 Arthritis, Experimental Plant Extracts 7.4514686799
MESH:D001169 Arthritis, Experimental resveratrol 7.4517115116
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7815336622
MESH:D050197 Atherosclerosis resveratrol 3.1616873680 17967414
MESH:D001327 Autoimmune Diseases Quercetin 4.2219761891
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 5.3414601052
MESH:D001919 Bradycardia Phenylephrine 4.3515306635
MESH:D001927 Brain Diseases Ethylnitrosourea 4.7114991843
MESH:D002545 Brain Ischemia Plant Extracts 9.8316041641
MESH:D002545 Brain Ischemia resveratrol 9.8317600658
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.1216651633 15144691 16357521 16436596 18412241
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.1511306469 14633655 16253758
MESH:D001943 Breast Neoplasms Quercetin 2.1518628248
MESH:D001943 Breast Neoplasms resveratrol 2.1516393696 17534123 17651959
MESH:D002057 Burns, Chemical Plant Extracts 5.149625245
MESH:D002105 Cadmium Poisoning Quercetin 5.3516962696
MESH:D002280 Carcinoma, Basal Cell marker/mechanism 18488027
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 4.6618834353
MESH:D006528 Carcinoma, Hepatocellular Quercetin 4.6619519916 12508355
MESH:D006528 Carcinoma, Hepatocellular resveratrol 4.6616227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4016675471
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7717234771
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.6616227395
MESH:D006332 Cardiomegaly Phenylephrine 11.0616170337 11754973 17287366 17124262 11179087 15728586
MESH:D006332 Cardiomegaly Plant Extracts 11.0617645561
MESH:D006332 Cardiomegaly Quercetin 11.0619794523
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 7.1516936243
MESH:D002318 Cardiovascular Diseases resveratrol 7.1515458977
MESH:D002386 Cataract Methylnitrosourea 3.8812484553
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 6.9616003739
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 6.967505956 2727394
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.7917160924
MESH:D003092 Colitis resveratrol 3.9416474422
MESH:D003110 Colonic Neoplasms polyphenols 5.7616293270
MESH:D003110 Colonic Neoplasms Quercetin 5.7617148506 11134977 19440933 19056647 16640504 17191121 15741050
MESH:D003110 Colonic Neoplasms resveratrol 5.7616338953
MESH:D015179 Colorectal Neoplasms Quercetin 2.7018095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 2.7016550006
MESH:D003327 Coronary Disease resveratrol 3.6316507316
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 8.0419496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 8.0416873680
MESH:D003928 Diabetic Nephropathies Plant Extracts 8.8519706694
MESH:D003928 Diabetic Nephropathies resveratrol 8.8516286809
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.6119370779
MESH:D056486 Drug-Induced Liver Injury Prazosin 4.6118071297
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.7918357618
MESH:D004487 Edema Plant Extracts 6.8212787963
MESH:D004487 Edema resveratrol 6.828985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.8417872969
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.4915268973
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.6617923197
MESH:D004827 Epilepsy Plant Extracts 3.6319439326 19700373
MESH:D005234 Fatty Liver Plant Extracts 3.9315975614
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.0411555667
MESH:D005355 Fibrosis Quercetin 3.7119474275
MESH:D005909 Glioblastoma Ethylnitrosourea 7.1516436596
MESH:D005909 Glioblastoma Quercetin 7.1519804834
MESH:D005910 Glioma Ethylnitrosourea 9.6916357521 16651633 18412241
MESH:D005910 Glioma Methylnitrosourea 9.699825942
MESH:D005910 Glioma Quercetin 9.6917643826
MESH:D006331 Heart Diseases pifithrin 4.4614766674
MESH:D006333 Heart Failure Plant Extracts 3.7518097624
MESH:D006521 Hepatitis, Chronic Methyldopa 6.4714986274
MESH:D006561 Herpes Simplex Plant Extracts 9.4810715843
MESH:D006561 Herpes Simplex resveratrol 9.4816876885
MESH:D015658 HIV Infections Plant Extracts 3.5812878215
MESH:D019584 Hot Flashes Plant Extracts 4.5614716179 16566672 17454163
MESH:D006930 Hyperalgesia Prazosin 4.7212727271
MESH:D006937 Hypercholesterolemia resveratrol 3.8317188708
MESH:D006943 Hyperglycemia Quercetin 3.8618262572 11834736
MESH:D020138 Hyperhomocysteinemia Plant Extracts 9.4916484555
MESH:D020138 Hyperhomocysteinemia Superoxides 9.4912615666
MESH:D006949 Hyperlipidemias Plant Extracts 9.0115975614 15268973
MESH:D006949 Hyperlipidemias resveratrol 9.0116873680
MESH:D006973 Hypertension Phenylephrine 5.418949925 12717712
MESH:D006973 Hypertension Quercetin 5.4118356687
MESH:D006984 Hypertrophy Phenylephrine 4.3818502941 12791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1317488730
MESH:D007022 Hypotension Dopamine 4.846740701
MESH:D020244 Infarction, Middle Cerebral Artery pifithrin 11.3219475672
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 11.3217600658
MESH:D007248 Infertility, Male Methylnitrosourea 3.677193160
MESH:D007249 Inflammation Plant Extracts 8.0516366677 12787963 19332304 15997105
MESH:D007249 Inflammation polyphenols 8.0516366677
MESH:D007249 Inflammation resveratrol 8.0516366677
MESH:D007251 Influenza, Human Quercetin 10.5516624496
MESH:D007251 Influenza, Human resveratrol 10.5516624496
MESH:D007410 Intestinal Diseases Superoxides 5.2510210152
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.4512584176 12628509 12351151
MESH:D007627 Keloid Quercetin 4.7717086741
MESH:D007674 Kidney Diseases Quercetin 2.9916962696
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.1016518626
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 3.7817379185
MESH:D007938 Leukemia Quercetin 3.0617468513
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.4516087638
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.0715526292
MESH:D008103 Liver Cirrhosis Plant Extracts 3.6317157831
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 2.9115479170
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.9112741479
MESH:D008107 Liver Diseases Plant Extracts 4.5017034775
MESH:D008107 Liver Diseases polyphenols 4.5016698588
MESH:D008113 Liver Neoplasms Plant Extracts 7.2919168119
MESH:D008113 Liver Neoplasms Quercetin 7.2918980244
MESH:D008113 Liver Neoplasms resveratrol 7.2919073162 19321006 20405173 19812893
MESH:D008114 Liver Neoplasms, Experimental Quercetin 2.9419519916
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.2716080182
MESH:D008175 Lung Neoplasms Ethylnitrosourea 4.8216271038 6695378 16019985 17703301
MESH:D008175 Lung Neoplasms Methylnitrosourea 4.8218062963
MESH:D008175 Lung Neoplasms Plant Extracts 4.8220869020
MESH:D008175 Lung Neoplasms Quercetin 4.8216280456
MESH:D008223 Lymphoma Ethylnitrosourea 7.6715790496
MESH:D008223 Lymphoma Methylnitrosourea 7.6711418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 9.9414633661
MESH:D016393 Lymphoma, B-Cell resveratrol 9.9417088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.7114749477
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.8615375218
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.0615688416
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 9.5618041768 10767621 10838139
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 9.5614999141 16827153 12931682 14633655 11751437 11807958 16619500 15688392 16944150 16051031 10767621 19196723 17020996 15313902 10838139 17131329 15113128
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 9.568985016 11606380
MESH:D008545 Melanoma marker/mechanism 18488027 19578364
MESH:D008545 Melanoma resveratrol 2.3417992120
MESH:D008579 Meningioma Ethylnitrosourea 5.7917943659
MESH:D008659 Metabolic Diseases resveratrol 4.2017112576
MESH:D009101 Multiple Myeloma resveratrol 3.3314749477 16267019 17935668 16490592 17164350 17049120
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.6817962980
MESH:D009203 Myocardial Infarction Quercetin 5.7919595682
MESH:D009203 Myocardial Infarction resveratrol 5.7916525036 17125593 17015251 16456233 16317513 17188708
MESH:D017202 Myocardial Ischemia resveratrol 3.8617125593 17015251
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.6519207477
MESH:D009205 Myocarditis resveratrol 4.5717322642
MESH:D009369 Neoplasms Methylnitrosourea 5.2415533788
MESH:D009369 Neoplasms Quercetin 5.2415185748
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 14.4116707424
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 14.4112696579
MESH:D009374 Neoplasms, Experimental resveratrol 14.418985016
MESH:D009442 Neurilemmoma Ethylnitrosourea 12.6416003739 17160924 16651423
MESH:D009442 Neurilemmoma Methylnitrosourea 12.6411555667
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.9917168769
MESH:D019636 Neurodegenerative Diseases resveratrol 3.6517652729
MESH:D020078 Neurogenic Inflammation Quercetin 10.1017929310
MESH:D020078 Neurogenic Inflammation resveratrol 10.1017929310
MESH:D009765 Obesity Plant Extracts 3.1019056576 20132043
MESH:C537729 Oculocutaneous albinism type 1B marker/mechanism
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.7917160924
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.6119495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 9.6117513867
MESH:D010051 Ovarian Neoplasms Quercetin 2.6819005980
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 5.5116965848
MESH:D010190 Pancreatic Neoplasms Quercetin 5.5116965848
MESH:D010195 Pancreatitis Methyldopa 5.6710484002
MESH:D010212 Papilloma Hydrogen Peroxide 9.0612065085
MESH:D010212 Papilloma Plant Extracts 9.0616517061 15173996
MESH:D010300 Parkinson Disease Eugenol 4.3317329831
MESH:D011230 Precancerous Conditions Quercetin 3.8219056647
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 3.9916679765
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.2315682402 12376480
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.2314666653 17804756
MESH:D011471 Prostatic Neoplasms Quercetin 2.2314715546 17292933
MESH:D011471 Prostatic Neoplasms resveratrol 2.2317675339 17636462 16731767 17804756 17718901 15767336
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3916325855
MESH:D015427 Reperfusion Injury resveratrol 7.0516314181 15827377 16317513 17058453 17520802
MESH:D015427 Reperfusion Injury Superoxides 7.0518460982
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.2718155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 5.2911555667
MESH:D012512 Sarcoma, Ewing's Dactinomycin 4.9014601052
MESH:D012554 Schistosomiasis japonica Quercetin 5.3516862918
MESH:D012852 Sinusitis Phenylephrine 4.517327846
MESH:D012878 Skin Neoplasms marker/mechanism 18488027
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.2112065085
MESH:D012878 Skin Neoplasms Plant Extracts 9.2115173996 16517061
MESH:D012878 Skin Neoplasms resveratrol 9.2115837718 8985016
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.6915930296 16257854 18593901
MESH:D013276 Stomach Ulcer Eugenol 7.6618543354
MESH:D013276 Stomach Ulcer Plant Extracts 7.6618193104 18237397 12787963 15255614 17135157
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3116321402
MESH:D013345 Subarachnoid Hemorrhage pifithrin 5.8718364113
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 12.6317997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 12.6317997062
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 11.6615790496
MESH:D013953 Thymus Neoplasms Methylnitrosourea 11.6611418001
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 3.783078959 7505956
MESH:D014062 Tongue Neoplasms resveratrol 4.0416227395
MESH:D001749 Urinary Bladder Neoplasms Quercetin 2.7316720314
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.9317473185
MESH:D014594 Uterine Neoplasms resveratrol 3.9517044934
MESH:D020301 Vasospasm, Intracranial pifithrin 5.4218364113
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 9.9018097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 9.9017488730
MESH:D020257 Ventricular Remodeling Plant Extracts 5.1218097624
MESH:D014947 Wounds and Injuries Plant Extracts 4.1019894650 20213670
Pathway ID Pathway Name
KEGG:04916 Melanogenesis
KEGG:01100 Metabolic pathways
KEGG:00740 Riboflavin metabolism
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37095
    • No data
    Releated disease ID Related disease Name
    PA446047Vitiligo
    PA443613Carcinoma, Basal Cell
    PA444903Melanoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB00548 inhibitor Azelaic Acid Antineoplastic Agents;Dermatologic Agents
    DB00600 antagonist Monobenzone Dermatologicals
    DB01055 antagonist Mimosine Antineoplastic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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