AutismKB 2.0

Annotation Detail for C7


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Basic Information Top
Gene Symbol:C7 ( - )
Gene Full Name: complement component 7
Band: 5p13.1
Quick LinksEntrez ID:730; OMIM: 217070; Uniprot ID:CO7_HUMAN; ENSEMBL ID: ENSG00000112936; HGNC ID: 1346
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05322Systemic lupus erythematosus
hsa04610Complement and coagulation cascades
hsa05020Prion diseases
Pathway IDPathway Name
Signaling in Immune system
No data
No data
Pathway IDPathway Name
500475Terminal pathway of complement
Related Diseases/Disorders Top
Desease IDDesease Name
H00103Late complement pathway defects
Immune system diseases
Primary immunodeficiency
No data
Desease Name
Macular Degeneration
deficiencies of C6
VISION
No data
Desease Name
C7 deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C012277 1,2-diamino-4-nitrobenzene 1,2-diamino-4-nitrobenzene results in decreased expression of C7 mRNAdecreases expression 17070881
C035314 1-nitropropane 1-nitropropane results in decreased expression of C7 mRNAdecreases expression 17070881
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of C7 mRNAincreases expression 17070881
C025235 2,6-diaminotoluene 2,6-diaminotoluene results in decreased expression of C7 mRNAdecreases expression 17070881
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of C7 mRNAdecreases expression 20406850
C014706 2-nitro-4-phenylenediamine 2-nitro-4-phenylenediamine results in decreased expression of C7 mRNAdecreases expression 17070881
C016617 2-nitropropane 2-nitropropane results in increased expression of C7 mRNAincreases expression 17070881
C028676 4-acetylaminofluorene 4-acetylaminofluorene results in decreased expression of C7 mRNAdecreases expression 17070881
D000638 Amiodarone Amiodarone affects the expression of C7 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of C7 mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of C7 mRNAaffects expression 19483382
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of C7 mRNAincreases expression 17961207
D002994 Clofibrate Clofibrate affects the expression of C7 mRNAaffects expression 19483382
D005001 Ethionine Ethionine affects the expression of C7 mRNAaffects expression 19483382
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of C7 mRNAincreases expression 17070881
C004925 methylmercuric chloride methylmercuric chloride results in increased expression of C7 mRNAincreases expression 17961207
D009151 Mustard Gas Mustard Gas results in increased expression of C7 mRNAincreases expression 18988085
D009853 Omeprazole Omeprazole affects the expression of C7 mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid affects the expression of C7 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of C7 mRNAaffects expression 19483382
D013853 Thioacetamide Thioacetamide affects the expression of C7 mRNAaffects expression 19483382
C025643 vinclozolin vinclozolin affects the expression of C7 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced methylmercuric chloride 4.606734493
MESH:D000138 Acidosis Ammonium Chloride 3.4318287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000236 Adenoma 2-Acetylaminofluorene 3.6710737359
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.886705139
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.3516434500
MESH:D001008 Anxiety Disorders vinclozolin 3.5319015723
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6918218290 18057881 20041841
MESH:D001249 Asthma Mustard Gas 2.6710378619
MESH:D001281 Atrial Fibrillation Amiodarone 3.8018651412 19698954
MESH:D001768 Blister Mustard Gas 5.0319167455
MESH:D001778 Blood Coagulation Disorders Amiodarone 48.5819483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 48.5819483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 48.5819483382
MESH:D001778 Blood Coagulation Disorders Ethionine 48.5819483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 48.5819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 48.5819483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 48.5819483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 48.5819483382
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 3.1911921183
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.0315286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.8517687719 10378619
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.5216705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 6.526705139 3581430 10737359 17761372 3084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 6.521701930
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 6.5217997003
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8519225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.9518974383
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.646135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 6.641399818
MESH:D002637 Chest Pain Omeprazole 4.9815447763
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.1818291259
MESH:D002779 Cholestasis pirinixic acid 2.7319176532
OMIM:610102 COMPLEMENT COMPONENT 7 DEFICIENCY marker/mechanism
MESH:D003456 Cryptorchidism vinclozolin 4.2114966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.8018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2-nitropropane 8.8020517888 15804453 16445897
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.8015265979 18218290
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 8.8012963478
MESH:D004381 Duodenal Ulcer Omeprazole 4.2015991576 17151854 21218061 16613094
MESH:D050171 Dyslipidemias Clofibrate 3.9716707586
MESH:D004487 Edema Mustard Gas 6.4911428647 9260866 11428631 11402378
MESH:D004487 Edema pirinixic acid 6.4912083418
MESH:D004890 Erythema Mustard Gas 5.039357497
MESH:D005218 Fat Necrosis Thioacetamide 5.5916456712
MESH:D005234 Fatty Liver Amiodarone 12.5314986274
MESH:D005234 Fatty Liver Clofibrate 12.5319224547
MESH:D005234 Fatty Liver pirinixic acid 12.5320131406 19236843
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1716417039
MESH:D006333 Heart Failure pirinixic acid 2.4620558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.196705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.296705139
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.4515929193 18665440 17276928
MESH:D006505 Hepatitis Thioacetamide 4.0916456712
MESH:D006529 Hepatomegaly Amiodarone 8.1415265979
MESH:D006529 Hepatomegaly pirinixic acid 8.1419772884 16221962 19176532 18467677
MESH:D006937 Hypercholesterolemia Amiodarone 3.758137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.0720558911
MESH:D007037 Hypothyroidism Amiodarone 11.1818020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 11.188137927 18031379
MESH:D007248 Infertility, Male vinclozolin 2.9516467254
MESH:D007249 Inflammation Mustard Gas 2.729357497 11402378 17524151 11428647 8975870 11428620 11428631 9260866 16001271
MESH:D007333 Insulin Resistance pirinixic acid 2.5516306350
MESH:D007674 Kidney Diseases Cadmium Chloride 3.3916962696
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.8716705839
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.9919248655
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6016417039
MESH:D008064 Lipidoses Amiodarone 3.4215342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5115474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 2.5116097051 17127702 17355460 11682029 15716488 16098781 17292413 15095483 15288472 18032466 18031379 17629604 18615449 15334695 16126171 15474484 16511523 18263696 11172339 18295389 18606216 15288473 12085344 12175628 15158331 15362042 16248980 14739098 16343077 18416461 18380797 11481614 12557150 12679928 18458672 18395095 10677585 15465738 15078482 12531686 16489207 17050028 12891558 15075984 15316131
MESH:D008107 Liver Diseases Thioacetamide 2.6716337175 18374380 15158337
MESH:D017114 Liver Failure, Acute Thioacetamide 4.1915313186 12479984 17276928 15633222
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.237678174
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 7.2316273603 10672840 11376686 10737359 14678523 18001218
MESH:D008113 Liver Neoplasms pirinixic acid 7.2320007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.982876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 5.98534488 1399818 6150874
MESH:D008133 Long QT Syndrome Amiodarone 3.4817391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 7.3312587719
MESH:D008171 Lung Diseases Mustard Gas 7.3318161513 18702808
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.3518516814
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 2.8911376686
MESH:D008175 Lung Neoplasms Mustard Gas 2.893148597 8781369
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 3.5011921183
MESH:D009135 Muscular Diseases pirinixic acid 3.3816239165
MESH:D009181 Mycoses Amiodarone 4.7717974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.0919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8416411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.5418551238 7678174
MESH:D009336 Necrosis 2-nitropropane 10.5412195237
MESH:D009369 Neoplasms pirinixic acid 1.8917405874
MESH:D009503 Neutropenia Mustard Gas 3.8516761898 7688884
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.819802331
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3216049721
MESH:D011041 Poisoning Mustard Gas 3.6715727166
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.7718220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.8018220299
MESH:D011472 Prostatitis vinclozolin 4.8018629315
MESH:D011537 Pruritus Mustard Gas 3.9618058305
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.6812490602 11597910 12832656
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.6817894541 17266442 17620002 17720292 10334151
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4518551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.9518724381
MESH:D012871 Skin Diseases Mustard Gas 2.6815451306 16961503 12880345
MESH:D013272 Stomach Diseases Omeprazole 4.4818545984
MESH:D013276 Stomach Ulcer Amiodarone 7.1818087811
MESH:D013276 Stomach Ulcer Omeprazole 7.1810750652 11906479 16755016 17977527 15991576 18237397
MESH:D013610 Tachycardia Amiodarone 4.1611238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0619225199
MESH:D013959 Thyroid Diseases Amiodarone 4.6319731979
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.5815710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.7319584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.0617467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2016049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 5.201399818 15289314 15867355
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1910091137
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
KEGG:05020 Prion diseases
REACT:6900 Signaling in Immune system
KEGG:05322 Systemic lupus erythematosus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25941
    • No data
    No data
    Releated drug ID Related drug Name
    PA450287magnesium
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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