AutismKB 2.0

Annotation Detail for TYRO3


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Basic Information Top
Gene Symbol:TYRO3 ( BYK,Dtk,FLJ16467,RSE,Sky,Tif )
Gene Full Name: TYRO3 protein tyrosine kinase
Band: 15q15.1
Quick LinksEntrez ID:7301; OMIM: 600341; Uniprot ID:TYRO3_HUMAN; ENSEMBL ID: ENSG00000092445; HGNC ID: 12446
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
2202Kidney tubular necrosis, acute
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TYRO3 mRNAincreases expression 19933214
C113043 2-methylthio-ADP TYRO3 protein results in increased susceptibility to 2-methylthio-ADPincreases response to substance 15733062
D000244 Adenosine Diphosphate TYRO3 protein results in increased susceptibility to Adenosine Diphosphateincreases response to substance 15733062
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TYRO3 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TYRO3 mRNAaffects cotreatment|increases expression 18164116
D001966 Bromine Bromine results in decreased expression of TYRO3 mRNAdecreases expression 18790026
D016572 Cyclosporine Cyclosporine results in increased expression of TYRO3 mRNAincreases expression 20106945
D003907 Dexamethasone Dexamethasone results in decreased expression of TYRO3 mRNAdecreases expression 12782123
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TYRO3 mRNAaffects cotreatment|increases expression 18164116
C045651 epigallocatechin gallate epigallocatechin gallate results in decreased expression of TYRO3 mRNAdecreases expression 12628509
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of TYRO3 mRNAdecreases expression 17606305
C010176 halofuginone halofuginone results in increased expression of TYRO3 mRNAincreases expression 17180598
D001556 Lindane Lindane affects the expression of TYRO3 mRNAaffects expression 17785943
D009151 Mustard Gas Mustard Gas results in decreased expression of TYRO3 mRNAdecreases expression 18988085
C009166 retinol acetate retinol acetate results in increased expression of TYRO3 mRNAincreases expression 16772331
D018038 Sodium Selenite Sodium Selenite results in decreased expression of TYRO3 mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TYRO3 mRNAincreases expression 19933214
D014859 Warfarin Warfarin results in decreased expression of TYRO3 mRNAdecreases expression 18772604
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8115322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8014692618
MESH:D000236 Adenoma beta-Naphthoflavone 6.8019389873
MESH:D000236 Adenoma Diethylnitrosamine 6.806695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.9417162532 18056438 17620307 16434500 19061943 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.9416835633
MESH:D000382 Agricultural Workers' Diseases Lindane 4.3412661182
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Dexamethasone 7.2817659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.2815885639
MESH:D001249 Asthma epigallocatechin gallate 5.3216516891
MESH:D001249 Asthma Mustard Gas 5.3210378619
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 5.0319761891
MESH:D001768 Blister Mustard Gas 5.1219167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9617474063
MESH:D001943 Breast Neoplasms Lindane 1.9614688026
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.1215286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.9517687719 10378619
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8416935385 20084675 19418558 21159647 10672840 20524982 17761372 19822196 18393292 20935162 17162532 19052882 19208518 19394651 20512989 3084413 17055752 16779866 20514400 19335982 17978847 19701751 18056438 20007298 20432363 18785209 18691550 19519916 20101231 18210153 10737359 17428255 16540662 19539802 16328049 16807293 16288022 3581430 16681979 11831363 19107877 17173139 16878318 16698587 16830150 19383236 18978308 16569478 17138121 18506893 19919837 18665156 20727157 18494052 18971187 18788625 16502159 20214788 19171122
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3416120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.5012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.5017174075 7505956 2727394 21159647
MESH:D002543 Cerebral Hemorrhage Warfarin 5.8011061249
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2019052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2016835633
MESH:D002779 Cholestasis Cyclosporine 7.6619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6617333356 16105132 17110522 16919318 11677210 15861022 17681005
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7115894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815668235 15340226 8697196 12621046 16354765
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4915824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0214669216 17141729
MESH:D023903 Coronary Restenosis Warfarin 5.6412872399
OMIM:122700 COUMARIN RESISTANCE Warfarin 5.7820579077 20497562
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.6017728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6010048152 20055451 15322242
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.3712438553
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7416285004
MESH:D003922 Diabetes Mellitus, Type 1 Warfarin 4.0418772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.1520387270
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 7.1516988119
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.1517107852
MESH:D003928 Diabetic Nephropathies Warfarin 5.0512644472
MESH:D003967 Diarrhea Dexamethasone 3.667237001
MESH:D003875 Drug Eruptions Warfarin 5.9414723717
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.1519107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.1515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D004485 Eczema Dexamethasone 4.4212438553
MESH:D004487 Edema Dexamethasone 11.3219703484
MESH:D004487 Edema Mustard Gas 11.3211428647 11428631 11402378 9260866
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.3211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.989294722 10568697
MESH:D004890 Erythema Mustard Gas 5.129357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0916302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver Cyclosporine 12.8219224547
MESH:D005234 Fatty Liver Diethylnitrosamine 12.8221071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.8215345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005355 Fibrosis Cyclosporine 8.3512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.3520067830
MESH:D006471 Gastrointestinal Hemorrhage Warfarin 6.6911794436
MESH:D005776 Gaucher Disease Warfarin 5.9212359135
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3111294989 10048152
MESH:D006406 Hematoma Warfarin 6.6917493413
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 10.3711000095
MESH:D006470 Hemorrhage Warfarin 10.3718429757
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8516120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.057520565
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0216354765 18606429 8697196 15340226 16959395
MESH:D006965 Hyperplasia halofuginone 5.2111874485
MESH:D006973 Hypertension Cyclosporine 8.4910903974
MESH:D006973 Hypertension Dexamethasone 8.4917042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.4918670907 18850075
MESH:D006976 Hypertension, Pulmonary Warfarin 4.7712359135
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4617937319
MESH:D007249 Inflammation Dexamethasone 11.808960868 11099482
MESH:D007249 Inflammation Diethylnitrosamine 11.8018785209
MESH:D007249 Inflammation Mustard Gas 11.8011428631 8975870 11402378 17524151 11428647 9357497 16001271 11428620 9260866
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.8012878042 12200463
MESH:D007333 Insulin Resistance Sodium Selenite 3.2514714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.318314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7012371664
MESH:D054068 Livedo Reticularis Warfarin 6.6918280355
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9818665156 18407596 18522880 19638242 20032147
MESH:D008103 Liver Cirrhosis halofuginone 6.9817180598
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 5.0416718785
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 5.0417481882
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 5.0416489207 11172339 12175628 14739098 18458672
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0412878042
MESH:D008107 Liver Diseases Diethylnitrosamine 4.4117034775
MESH:D008107 Liver Diseases Lindane 4.411715830
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.3621295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.3619073162 19551842 19256749 19499222 19427195 12112319 18754104 15885732 9163691 20452335 19833225 19254457 16942905 19090486 18644402 20501860 19690152 18648771 19426721 19850985 21047994 20434301 19638242 19812893 15175105 19642983 20405173 21071580 18978307 2422723 20137499 20583210 18977376 10737359 19996281 20118626 20101389 20492335 21278145 12771043 2862719 19255062 19294768 21167192
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.3616984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 9.7018164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.7019004024 18164116 19519916 3124819 16267830 17942915 18544905 19126423 19539802 18253720 18308698 18093689 19009564 2563599 18775883 18282651 9362446 17174075 18079962 16842330 21159647 17854601
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7012151625
MESH:D008171 Lung Diseases Mustard Gas 3.4218161513 18702808
MESH:D008175 Lung Neoplasms Dexamethasone 4.8315824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.8320970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Mustard Gas 4.833148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8311884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0214737004
MESH:D008545 Melanoma epigallocatechin gallate 2.9811746506 17992120
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D009101 Multiple Myeloma Dexamethasone 3.4715867202 16118317 15744524
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 5.4617962980
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.529809623
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D009336 Necrosis Warfarin 5.5114723717
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.559029167 3581430
MESH:D009369 Neoplasms Lindane 3.3516818664 12807735
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2419348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1714600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3020387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0920387270
MESH:D009503 Neutropenia Mustard Gas 3.937688884 16761898
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4116540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D011041 Poisoning Mustard Gas 3.7615727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.8212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.822563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.5221297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1611896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Lindane 3.6812661182 14688026
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.6818760546
MESH:D020151 Protein C Deficiency Warfarin 6.3118376272
MESH:D011537 Pruritus Ethinyl Estradiol 9.4115861022 16919318
MESH:D011537 Pruritus Mustard Gas 9.4118058305
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011655 Pulmonary Embolism Warfarin 6.3119300499
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9117620002 17894541 17720292 17266442 10334151
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.9718379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012640 Seizures Lindane 3.5912842176 7539098 15475178
MESH:D012851 Sinus Thrombosis, Intracranial Warfarin 5.8312269725
MESH:D012871 Skin Diseases halofuginone 5.3811874485
MESH:D012871 Skin Diseases Mustard Gas 5.3812880345 15451306 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9116709447
MESH:D013272 Stomach Diseases Dexamethasone 4.2915472012
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013276 Stomach Ulcer Dexamethasone 3.4515138204
MESH:D020521 Stroke Warfarin 4.9419300499
MESH:D013923 Thromboembolism Warfarin 6.1416960144 18698879
MESH:D019851 Thrombophilia Ethinyl Estradiol 10.8911994571
MESH:D019851 Thrombophilia Warfarin 10.8917493413
MESH:D013927 Thrombosis marker/mechanism 15733062
MESH:D013927 Thrombosis Ethinyl Estradiol 9.2915669648
MESH:D013927 Thrombosis Warfarin 9.2915720958 17245631 11518727 11307788 17672075 19300499
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.957505956
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D014605 Uveitis Cyclosporine 11.671336536
MESH:D014605 Uveitis Dexamethasone 11.671336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D014657 Vasculitis Warfarin 5.8320337814
MESH:D054556 Venous Thromboembolism Warfarin 6.3418776969
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 10.6115869587 14671159
MESH:D020246 Venous Thrombosis Warfarin 10.6114723717 15733061
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB04184 - Acetate Ion Indicators and Reagents
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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