AutismKB 2.0

Annotation Detail for TYROBP


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TYROBP ( DAP12,KARAP,PLOSL )
Gene Full Name: TYRO protein tyrosine kinase binding protein
Band: 19q13.12
Quick LinksEntrez ID:7305; OMIM: 604142; Uniprot ID:TYOBP_HUMAN; ENSEMBL ID: ENSG00000011600; HGNC ID: 12449
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04650Natural killer cell mediated cytotoxicity
Pathway IDPathway Name
Axon guidance
Interactions of the immunoglobulin superfamily (IgSF) member proteins
Cell junction organization
Signaling in Immune system
No data
No data
Pathway IDPathway Name
500477Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1832Congenital abnormality
No data
No data
Desease Name
Nasu-Hakola disease
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TYROBP mRNAaffects expression 17562736
D001966 Bromine Bromine results in increased expression of TYROBP mRNAincreases expression 18790026
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TYROBP mRNA]decreases reaction|increases expression 18200517
C014347 decitabine [decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TYROBP mRNAaffects cotreatment|decreases expression 15251184
C014347 decitabine decitabine results in decreased expression of TYROBP mRNAdecreases expression 15251184
C121718 dicyclanil dicyclanil results in increased expression of TYROBP mRNAincreases expression 15664270
D004041 Dietary Fats Dietary Fats results in decreased expression of TYROBP mRNAdecreases expression 18042831
D002117 Calcitriol Calcitriol results in increased expression of TYROBP mRNAincreases expression 12875902
16322758
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TYROBP mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TYROBP mRNAaffects cotreatment|increases expression 17942748
C041786 palm oil palm oil results in decreased expression of TYROBP mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of TYROBP mRNAdecreases expression 17426115
D013749 Tetrachlorodibenzodioxin [decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TYROBP mRNAaffects cotreatment|decreases expression 15251184
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TYROBP mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TYROBP mRNAdecreases expression 15251184
D014212 Tretinoin Tretinoin results in increased expression of TYROBP mRNAincreases expression 16322758
16054129
12875902
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TYROBP mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of TYROBP mRNAincreases expression 17982090
18200517
C025643 vinclozolin vinclozolin affects the expression of TYROBP mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9314514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8214692618
MESH:D018248 Adenoma, Liver Cell dicyclanil 17.9517162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.9516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.9516835633
MESH:D019973 Alcohol-Related Disorders Curcumin 5.1817887948
MESH:D000505 Alopecia Tretinoin 3.6615955085
MESH:D000544 Alzheimer Disease Curcumin 2.6315590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6819015723
MESH:D001161 Arteriosclerosis Dietary Fats 10.1515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.1511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3115885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.3116412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.7716807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.7716292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D050197 Atherosclerosis Curcumin 3.3518704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001327 Autoimmune Diseases Curcumin 4.5619761891
MESH:D001471 Barrett Esophagus Tretinoin 4.4716935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.6019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.6012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.6016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D002545 Brain Ischemia Curcumin 4.4116770732
MESH:D001932 Brain Neoplasms Curcumin 3.9917596214
MESH:D001943 Breast Neoplasms Calcitriol 2.9911237771
MESH:D001943 Breast Neoplasms Curcumin 2.9919250217 18593918 16243823 18462866
MESH:D001943 Breast Neoplasms decitabine 2.9919208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 2.9920435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9920435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9916443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6716813970
MESH:D002277 Carcinoma Curcumin 8.4318593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2616168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.743084413
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 4.7417162532
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.741917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9918414057
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.9811237771
MESH:D002294 Carcinoma, Squamous Cell Curcumin 10.9818462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.9819215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.9816051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 7.3310977129
MESH:D002386 Cataract Tretinoin 7.3317460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6716129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8816105132 17333356 17110522 16919318 15861022 11677210 17681005
MESH:D002779 Cholestasis pirinixic acid 7.8819176532
MESH:D002822 Choriocarcinoma Tretinoin 5.2616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8315340226 8697196 15668235 16354765 12621046
MESH:D002972 Cleft Palate Tretinoin 5.839407595
MESH:D003092 Colitis Curcumin 16.5918200517 16782535 16804969
MESH:D003092 Colitis Tretinoin 16.5917035595
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 16.5911698051 16782535 17936198 16474422 17991707 16804969 18200517 18023891 16867261
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.4617276891
MESH:D003103 Coloboma Curcumin 4.6018809619
MESH:D003110 Colonic Neoplasms Curcumin 4.0016340194 19359593
MESH:D003110 Colonic Neoplasms decitabine 4.0017616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.9718497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4620055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.469211117 9664655 9142499 10589399 9224671 9125849 16925845 14991402 17551590 8800419
MESH:D003456 Cryptorchidism vinclozolin 4.4114966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.4518403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4517107852
MESH:D003928 Diabetic Nephropathies Curcumin 4.0618204486
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.6016227642 19923254 19164858 16485898 17906064 2444490 12705907 19370779 19739265 16081117 10774834 16393943 12594235 19085960 11834606 11421492 10915739 15968718 11287661 17522070 16781746 14986274 12392966 16109766 19420014 12958197 10663392 16177239 12153990 17562736 12540782 18071297 11461765 18713872 15619225 19416960 11529661 14725611 11739529 11743745 14550746
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.6020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004381 Duodenal Ulcer Curcumin 4.1117351913
MESH:D050171 Dyslipidemias Dietary Fats 3.4918367378
MESH:D004487 Edema pirinixic acid 6.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.2715322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.2718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.3115138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3112538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2119294695
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.9711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.979664655 16938888
MESH:D005234 Fatty Liver Curcumin 19.2519297423
MESH:D005234 Fatty Liver Dietary Fats 19.2517967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.2515345470
MESH:D005234 Fatty Liver pirinixic acid 19.2519236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Curcumin 28.6318705752
MESH:D005355 Fibrosis Dietary Fats 28.6318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 28.6320067830
MESH:D005355 Fibrosis Tretinoin 28.6317994277
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 28.6317994277
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.7718462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4016417039
MESH:D005909 Glioblastoma Curcumin 7.4017596214
MESH:D005909 Glioblastoma Tretinoin 7.4017312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Curcumin 13.2218829502 18462866
MESH:D006258 Head and Neck Neoplasms decitabine 13.2219215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 13.2216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.629664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly pirinixic acid 8.5018467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.5012621046 15340226 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.1117701891
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.148697196 18606429 16959395 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 7.7716870215
MESH:D006930 Hyperalgesia Tretinoin 7.7716870215
MESH:D006937 Hypercholesterolemia Curcumin 9.4218704882
MESH:D006937 Hypercholesterolemia Dietary Fats 9.4221332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6416778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6721332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male decitabine 11.4517581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.4517937319
MESH:D007248 Infertility, Male vinclozolin 11.4516467254
MESH:D007249 Inflammation Curcumin 8.5116956363 17151092 18403477
MESH:D007249 Inflammation Dietary Fats 8.5120412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5112200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.7518596194 18200517
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.7518200517
MESH:D007333 Insulin Resistance Dietary Fats 7.3611836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.3616306350
MESH:D007410 Intestinal Diseases Tretinoin 10.2317994277
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 10.2317994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.2710783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.1216580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.1217551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.2315629191 12587719
MESH:D007889 Leiomyoma Curcumin 4.6318555241
MESH:D007938 Leukemia Curcumin 10.7118462866
MESH:D007938 Leukemia decitabine 10.7119235587 18980019
MESH:D007938 Leukemia Tretinoin 10.7117143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.2616106398
MESH:D007951 Leukemia, Myeloid decitabine 9.7517236224 19117987 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 9.7516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0017679729 19010910 18460780 19387464 18704418 18206229
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0019850784 16294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.5618055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1917368321 16935935 9834237 17301526 17339181 12679006 17712046 19029980 17217047 19225113 19642359 17294898 17107899 17506722 19035177 16788101 15748426 19075265 16331271 16823087 16140955 16766008 17361223 17649720 16891316
MESH:D015458 Leukemia, T-Cell Curcumin 4.8316106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8116417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.349224671
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9018296743
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 5.0018705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0018397230 16248980
MESH:D008107 Liver Diseases marker/mechanism 12651611
MESH:D008107 Liver Diseases Acetaminophen 4.1412969438 11587558 16611625 19014921 19460945 12587719 19784758 16610002
MESH:D008107 Liver Diseases Curcumin 4.1416956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2917185352 16871587
MESH:D008113 Liver Neoplasms dicyclanil 7.6120118626
MESH:D008113 Liver Neoplasms pirinixic acid 7.6120007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1412151625
MESH:D008175 Lung Neoplasms Curcumin 2.4616243823 19359593 18462866
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4619555203 11884234
MESH:D008223 Lymphoma Curcumin 7.9018462866
MESH:D008223 Lymphoma decitabine 7.9019470736
MESH:D016399 Lymphoma, T-Cell Curcumin 4.7716173963
MESH:D008527 Medulloblastoma Tretinoin 2.8017453147
MESH:D008545 Melanoma Curcumin 5.2518462866 17885582
MESH:D008545 Melanoma decitabine 5.2516505122 17785578
MESH:D008545 Melanoma Tretinoin 5.2516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008569 Memory Disorders Curcumin 4.2217263510
MESH:D008591 Meningomyelocele Tretinoin 4.5016940565
MESH:D009101 Multiple Myeloma Curcumin 7.6619372569
MESH:D009101 Multiple Myeloma decitabine 7.6618172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.0017962980
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009190 Myelodysplastic Syndromes decitabine 7.5819010910 16882708 18608210 19157545
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.5817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009361 Neoplasm Invasiveness Curcumin 4.4318495463
MESH:D009369 Neoplasms decitabine 8.4119116145 19470736 17925555
MESH:D009369 Neoplasms pirinixic acid 8.4117405874
MESH:D009369 Neoplasms Tretinoin 8.4116946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.6312497104
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.739125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.7318462866
MESH:D009436 Neural Tube Defects Tretinoin 3.099142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009765 Obesity Curcumin 7.5119297423
MESH:D009765 Obesity Dietary Fats 7.5119632207 18457598 18674790 11836018 21332399 16723640 20518802 20132043 17217161
MESH:D009765 Obesity pirinixic acid 7.5120558911
MESH:D010024 Osteoporosis Curcumin 3.5018719352
MESH:D010051 Ovarian Neoplasms Curcumin 8.0818462866 19020741
MESH:D010051 Ovarian Neoplasms decitabine 8.0819331143 19259094
MESH:D010051 Ovarian Neoplasms Tretinoin 8.0816936753
MESH:D010146 Pain Acetaminophen 6.7416870215
MESH:D010146 Pain Tretinoin 6.7416870215
MESH:D010190 Pancreatic Neoplasms Curcumin 8.8219196508 19401701 17440100
MESH:D010190 Pancreatic Neoplasms decitabine 8.8219294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.8215976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.2617698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:C536329 Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy marker/mechanism
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.7711118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.7718042343 18220299 19015723
MESH:D055728 Primary Myelofibrosis decitabine 4.8017616702
MESH:D011469 Prostatic Diseases vinclozolin 5.0218220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8615572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.5315754350 16644109 18247401 16289102 12479363
MESH:D011471 Prostatic Neoplasms Curcumin 3.5315129424 11398177 18156803 18226269 10851300 18769126 12497104
MESH:D011472 Prostatitis vinclozolin 5.0218629315
MESH:D011507 Proteinuria Tretinoin 3.6616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D011625 Pterygium Tretinoin 4.8816723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.5819168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.0818379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012208 Rhabdomyosarcoma decitabine 11.1519155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.1516116481 16283617
MESH:D012509 Sarcoma Curcumin 4.1718462866
MESH:D018805 Sepsis Curcumin 4.1218389075
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6416192470
MESH:D012878 Skin Neoplasms Tretinoin 5.6416467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013274 Stomach Neoplasms decitabine 2.5619037991
MESH:D013274 Stomach Neoplasms Tretinoin 2.5617261132
MESH:D013276 Stomach Ulcer Curcumin 3.5519188055 16631530
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms decitabine 7.4317967635
MESH:D013964 Thyroid Neoplasms Tretinoin 7.4317045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.8416051514
MESH:D014376 Tuberculosis Tretinoin 3.2616040207
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.4618593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.4619087683 17616700
MESH:D014565 Urogenital Neoplasms Curcumin 5.3518462866
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7316129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D014604 Uveal Neoplasms decitabine 13.1617785578
MESH:D014604 Uveal Neoplasms Tretinoin 13.1616752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.1216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D015430 Weight Gain Dietary Fats 3.7916723640
MESH:D009396 Wilms Tumor Tretinoin 4.0216287080
Pathway ID Pathway Name
REACT:18266 Axon guidance
REACT:20676 Cell junction organization
REACT:23853 Interactions of the immunoglobulin superfamily (IgSF) member proteins
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04380 Osteoclast differentiation
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37100
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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