AutismKB 2.0

Annotation Detail for UBC


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Basic Information Top
Gene Symbol:UBC ( HMG20 )
Gene Full Name: ubiquitin C
Band: 12q24.3
Quick LinksEntrez ID:7316; OMIM: 191340; Uniprot ID:UBC_HUMAN; ENSEMBL ID: ENSG00000150991; HGNC ID: 12468
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03320PPAR signaling pathway
Pathway IDPathway Name
APC-Cdc20 mediated degradation of Nek2A
Signaling by Wnt
Cell Cycle, Mitotic
DNA Replication
Signalling by NGF
Apoptosis
DNA Repair
Signaling by EGFR
Signaling in Immune system
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
HIV Infection
Cell Cycle Checkpoints
Regulation of activated PAK-2p34 by proteasome mediated degradation
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1855Prostatic hypertrophy, Benign
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C015802 2,6-dichloro-4-nitrophenol 2,6-dichloro-4-nitrophenol results in increased expression of UBC mRNAincreases expression 11227219
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in decreased expression of UBC mRNAdecreases expression 12734338
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of UBC mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of UBC mRNAaffects expression 15606129
D000082 Acetaminophen Acetaminophen results in increased expression of UBC mRNAincreases expression 11264010
C040534 alpha-hexachlorocyclohexane alpha-hexachlorocyclohexane results in increased expression of UBC mRNAincreases expression 16940010
D000643 Ammonium Chloride Ammonium Chloride affects the expression of UBC mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of UBC proteindecreases expression 19364129
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of UBC mRNAincreases expression 19737606
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of UBC mRNAincreases expression 20127859
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of UBC mRNAaffects expression 15963342
D003474 Curcumin Curcumin results in increased expression of UBC mRNAincreases expression 16101141
D016572 Cyclosporine Cyclosporine results in increased expression of UBC mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of UBC mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of UBC mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of UBC mRNA]decreases reaction|increases expression 17942915
D004958 Estradiol Estradiol results in increased expression of UBC mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of UBC mRNAincreases expression 17942748
17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UBC mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of UBC mRNAdecreases expression 18035473
D016627 Oxidopamine Oxidopamine results in increased expression of UBC mRNAincreases expression 12486162
C017557 nickel subsulfide nickel subsulfide results in increased expression of UBC mRNAincreases expression 12760830
C041786 palm oil palm oil results in decreased expression of UBC mRNAdecreases expression 18042831
D010269 Paraquat Paraquat results in increased expression of UBC mRNAincreases expression 12595580
D011794 Quercetin Quercetin results in decreased expression of UBC mRNAdecreases expression 19496084
C017947 sodium arsenite sodium arsenite results in increased expression of UBC mRNAincreases expression 12760830
C016104 sodium bichromate sodium bichromate results in increased expression of UBC mRNAincreases expression 12760830
D013629 Tamoxifen Tamoxifen affects the expression of UBC mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UBC mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of UBC mRNAincreases expression 18465118
16466705
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3414745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6411752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D000230 Adenocarcinoma arsenic trioxide 9.7019825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.7020127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.7011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.7014692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 14.993712494
MESH:D000236 Adenoma Benzo(a)pyrene 14.996695378
MESH:D000236 Adenoma beta-Naphthoflavone 14.9919389873
MESH:D000236 Adenoma Diethylnitrosamine 14.996695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.3517162532 19052882 16434500 19061943 18056438 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4915276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6917306315 16712894
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.5611874814
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8717887948
MESH:D000544 Alzheimer Disease Curcumin 2.5715590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.0517084956
MESH:D000799 Angioedema Acetaminophen 3.6310982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8719183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.2215238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5415885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6916807698
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7715336622
MESH:D050197 Atherosclerosis Curcumin 3.2018704882
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 4.5114699433
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Curcumin 10.1819761891
MESH:D001327 Autoimmune Diseases Quercetin 10.1819761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.811440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.3316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D002545 Brain Ischemia Curcumin 4.1216770732
MESH:D001932 Brain Neoplasms Curcumin 3.7617596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.5617474063 20146248
MESH:D001943 Breast Neoplasms Curcumin 4.5619250217 18462866 18593918 16243823
MESH:D001943 Breast Neoplasms Dietary Fats 4.5620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.5617474063
MESH:D001943 Breast Neoplasms Estradiol 4.5617018787 16675129 17289903 17261762 19861407 12948864 18497071 14630087
MESH:D001943 Breast Neoplasms Quercetin 4.5618628248
MESH:D001943 Breast Neoplasms Tamoxifen 4.5619115204 21152245 16273361 20859285 15565566 19011961 20065188 20390343 18855134 19410462 19189210 17440819 19142967 17049068 17242785 16873071 19066611 17261762 18629630 15668708 16818667 19288272 19155303 19487384 20135344 21138602 20005174 19084267 18997820 19200415 16202921 18815881 19244106 17893378 19289846 18821012 20544844 19059307 18351453 18984771 19221464 19189212 11161223 19103187 18425577
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.5620435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1311589617
MESH:D002105 Cadmium Poisoning Quercetin 5.3316962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5716227642 15700767 15673190 16097048 16050911 16011737 16192424 15721981 3786805 18705752 10355542 16124888
MESH:D002277 Carcinoma Curcumin 7.7418593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.7416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3019066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 19.237296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 19.233084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 19.2315073043 16217749 14691202 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 19.2318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 19.2316935385 17428255 16502159 11831363 19208518 18393292 16569478 19383236 18691550 19107877 18665156 21159647 20432363 19171122 19919837 19335982 18971187 16807293 20727157 17162532 17055752 18785209 18788625 19701751 19418558 16779866 16878318 20101231 10737359 18506893 18056438 3581430 10672840 19394651 20214788 18978308 16681979 19822196 20514400 17761372 3084413 20512989 17138121 18210153 20084675 19052882 20524982 19539802 16698587 16288022 16830150 20007298 17173139 16540662 18494052 17978847 20935162 16328049 19519916
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.2316924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 19.2312508355 19519916
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 19.2317306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 19.2316924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9118414057
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7517234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6619014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.587296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9312490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.2120419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.2118462866
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.2118572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4317572228
MESH:D006332 Cardiomegaly Quercetin 6.4219794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4218670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.4610977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 19.577505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.5712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 19.5717174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 19.5718566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 19.5719524636 20056578
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.4919486331 9022650
MESH:D002779 Cholestasis Cyclosporine 12.4919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.4916919318 11677210 17110522 16105132 17333356 17681005 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0216354765 12621046 15340226 8697196 15668235
MESH:D003092 Colitis Curcumin 3.9718200517 16804969 16782535
MESH:D003103 Coloboma Curcumin 4.3618809619
MESH:D003110 Colonic Neoplasms Curcumin 3.8619359593 16340194
MESH:D003110 Colonic Neoplasms Quercetin 3.8617148506 19056647 19440933 11134977 16640504 15741050 17191121
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5620501625
MESH:D015179 Colorectal Neoplasms Quercetin 2.5618095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8817141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.6918497527
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4020055451 15322242 10048152
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9015213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1519031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6112868966 8970840 2524372 11298694 11906362 18759878 8156756 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.303621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5619496084
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.8218403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8217107852
MESH:D003928 Diabetic Nephropathies Curcumin 14.0118204486
MESH:D003928 Diabetic Nephropathies Estradiol 14.0119279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.0119279558
MESH:D003967 Diarrhea 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 4.6910611417
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.329022650 7440962 18648102 6679447 11289319 16192314 6482804 1440618 9653073 18692083 18289764 8291058 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.3219416960 11421492 11529661 14986274 11743745 12392966 12540782 18071297 12153990 16109766 18713872 19420014 16781746 10774834 14725611 17522070 11461765 10663392 14550746 19370779 11739529 19739265 11287661 2444490 15968718 19085960 17906064 16177239 12705907 19923254 10915739 17562736 16081117 19164858 16485898 15619225 11834606 16227642 16393943 12594235 12958197
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.324309450 9327722 6623471 10915739 15998439 16177239 17522070 10092053 11566570 2869522 15968718 16227642 19336974 21278145 7120509 15027814 3786805 7179309 3732212 6884620 19085960 7440962
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.3219107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.3220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D004381 Duodenal Ulcer Curcumin 3.8517351913
MESH:D050171 Dyslipidemias Dietary Fats 3.3018367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6916714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.2812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.2819031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.9411473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.9416202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.849294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.893581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.8912903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.8916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8611564622
MESH:D005234 Fatty Liver arsenic trioxide 40.0715073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 40.0761145 15959796 19224547 16239168 12795759 17595544 16045604 12631006
MESH:D005234 Fatty Liver Curcumin 40.0719297423
MESH:D005234 Fatty Liver Cyclosporine 40.0719224547
MESH:D005234 Fatty Liver Dietary Fats 40.0718296743 19551842 19004024 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 40.0721071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 40.0715345470
MESH:D005234 Fatty Liver Tamoxifen 40.0719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.816705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9719069698
MESH:D005355 Fibrosis Carbon Tetrachloride 31.8218705752
MESH:D005355 Fibrosis Curcumin 31.8218705752
MESH:D005355 Fibrosis Cyclosporine 31.8212639820 12168785
MESH:D005355 Fibrosis Dietary Fats 31.8218296743
MESH:D005355 Fibrosis Quercetin 31.8219474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 31.8220067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0616904648
MESH:D005756 Gastritis Acetaminophen 3.4616983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.4918462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4716452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D005909 Glioblastoma Curcumin 6.9817596214
MESH:D005909 Glioblastoma Quercetin 6.9819804834
MESH:D005910 Glioma Quercetin 2.9717643826
MESH:D005911 Gliosis Paraquat 4.9511124998
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.847505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.5218829502 18462866
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.0820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0810048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.556705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.5519110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6912621046 15340226 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.8317701891
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.9812676792
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8316354765 18606429 8697196 16959395 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.5416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3216899240
MESH:D006937 Hypercholesterolemia Curcumin 8.6018704882
MESH:D006937 Hypercholesterolemia Dietary Fats 8.6021332399
MESH:D006943 Hyperglycemia Quercetin 3.8518262572 11834736
MESH:D006949 Hyperlipidemias Dietary Fats 3.4221332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7315034207
MESH:D006973 Hypertension Cyclosporine 8.1110903974
MESH:D006973 Hypertension Quercetin 8.1118356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1118850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8815338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.4317937319
MESH:D007248 Infertility, Male Paraquat 10.434850670
MESH:D007248 Infertility, Male sodium arsenite 10.4312646999 15346721
MESH:D007249 Inflammation Curcumin 18.5617151092 16956363 18403477
MESH:D007249 Inflammation Dietary Fats 18.5620412841
MESH:D007249 Inflammation Diethylnitrosamine 18.5618785209
MESH:D007249 Inflammation Flavonoids 18.5617296493
MESH:D007249 Inflammation Tamoxifen 18.5619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.5612200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1318596194 18200517
MESH:D007251 Influenza, Human Quercetin 4.3016624496
MESH:D007333 Insulin Resistance Dietary Fats 6.9218457598 11836018
MESH:D007333 Insulin Resistance Estradiol 6.9216627594 16393666
MESH:D007414 Intestinal Neoplasms Curcumin 4.0410783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.818074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1516580747
MESH:D007627 Keloid Quercetin 4.7517086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007674 Kidney Diseases Acetaminophen 17.7812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 17.788314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 17.7815618244
MESH:D007674 Kidney Diseases Quercetin 17.7816962696
MESH:D007674 Kidney Diseases sodium arsenite 17.7820008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.346582329
MESH:D007680 Kidney Neoplasms Cyclosporine 16.3412371664
MESH:D007680 Kidney Neoplasms Estradiol 16.3415610895
MESH:D007680 Kidney Neoplasms Tamoxifen 16.3418625569
MESH:D007889 Leiomyoma Curcumin 4.3818555241
MESH:D007938 Leukemia arsenic trioxide 9.9815070760
MESH:D007938 Leukemia Curcumin 9.9818462866
MESH:D007938 Leukemia Quercetin 9.9817468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.1317077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.1316106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.5719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1017050201 16467208 20471514 16968895 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0816966277 16330433 19225113 12712474 12679006 17217047 15622746 16112521 19075265 19642359 17869043 11468182 16891316 9834237 12018890 15748426 19035177 15336539 11161223 16823087 17107899 15213294 17712046 17649720 16331271
MESH:D015458 Leukemia, T-Cell arsenic trioxide 11.0416882451
MESH:D015458 Leukemia, T-Cell Curcumin 11.0416106398
MESH:D008064 Lipidoses Tamoxifen 3.0115342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.3516239168 17157831 17174718 16943688 21278145 11408273 17334410 11903743 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 10.3518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.3519638242 20032147 18665156 18407596 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0715034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.3912632514 17721639 18251166 14716833 15876570 12445418 18418968 14716496 18156304 17944888 12898905 17766677 12546737 17976157 17761835 12632512 17708605 15057751 18376398 12609069 16248980 12649538 12445421 18705752 15730626 15959796 15673190 16027843 13678700 18395095 17557913 18205269 17525996 16136751 12667390 15123356 18210741 18263696 12958196 18166357 15818738 18054572 17805973 18481824 18412020 16638106 17714472 17698563 18395914 18420326 15338365 16097048 17640975 16192424 17631135 10355542 17900296 14620537 12666154 15052691 18472094 15370692 17869086 18006644 15996030 17823541 14748882 18279442 12741479 14724832 18429990 17565644 15893842 16011737 16116963 15650968 15931870 15925388 18317297 17922224 16015684 12586293 18472332 20821823 14512876 17481882 18277467 18339082 12389079 18187930 11481614 15362042 16033810
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 8.3917355460 18006644 18705752
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.3914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 8.3912741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.3918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.3912878042
MESH:D008107 Liver Diseases Acetaminophen 8.9219014921 12969438 16610002 16611625 12587719 19784758 19460945 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.9216964402 16246199 15830285 17285989 15720792
MESH:D008107 Liver Diseases Curcumin 8.9216956363
MESH:D008107 Liver Diseases Diethylnitrosamine 8.9217034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9615123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.8016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.8016899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 28.6114682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 28.6121137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 28.6121295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 28.6119294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 28.619163691 19090486 21167192 19294768 19812893 19254457 19638242 18648771 19850985 2422723 21071580 18978307 20137499 19551842 19642983 15175105 21047994 18977376 19499222 20501860 18644402 20118626 20492335 2862719 16942905 15885732 10737359 20583210 19690152 21278145 19255062 19996281 19073162 12112319 20434301 20405173 19427195 18754104 19256749 20452335 19426721 20101389 19833225 12771043
MESH:D008113 Liver Neoplasms Quercetin 28.6118980244
MESH:D008113 Liver Neoplasms sodium arsenite 28.6115276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 28.6116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 28.6116984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 26.293712494 598648 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 26.2920377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 26.2918164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 26.2915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 26.2919539802 21159647 17174075 18544905 19004024 19126423 16267830 18164116 19009564 3124819 19519916 18308698 2563599 17942915 18079962 18282651 16842330 18775883 18093689 17854601 9362446 18253720
MESH:D008114 Liver Neoplasms, Experimental Quercetin 26.2919519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 26.2912151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1915213294
MESH:D008171 Lung Diseases sodium arsenite 3.0319095001
MESH:D008175 Lung Neoplasms arsenic trioxide 12.5319825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.5320869020 20464547 20064080 18520028 6695378 17053015 20135361 18569708 18816296
MESH:D008175 Lung Neoplasms Curcumin 12.5319359593 16243823 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.536695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Quercetin 12.5316280456
MESH:D008175 Lung Neoplasms sodium arsenite 12.5317077188 17306315 16712894 15276417 19931552
MESH:D008175 Lung Neoplasms Tamoxifen 12.5318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.5311884234 19555203
MESH:D008223 Lymphoma Curcumin 3.4418462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.4916173963
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.5317203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.5319196723 16827153 14580682 11731420 19196722
MESH:D020149 Manganese Poisoning Estradiol 11.9419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.9419453300
MESH:D008545 Melanoma Curcumin 4.9317885582 18462866
MESH:D008545 Melanoma sodium arsenite 4.9316487513 19082730
MESH:D008545 Melanoma Tamoxifen 4.9319393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3619513568
MESH:D008569 Memory Disorders Curcumin 3.9517263510
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0316381670
MESH:D009101 Multiple Myeloma arsenic trioxide 6.9515949261 19417148 14977855 19549372 11468182
MESH:D009101 Multiple Myeloma Curcumin 6.9519372569
MESH:D009128 Muscle Spasticity 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 5.8917220914
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.7117962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0216105982 16882451
MESH:D009203 Myocardial Infarction Quercetin 2.9119595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.0316810080
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.0319207477
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 9.6516624393
MESH:D009361 Neoplasm Invasiveness Curcumin 9.6518495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.973581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.973581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.9719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.7211141357
MESH:D009369 Neoplasms Quercetin 7.7215185748
MESH:D009369 Neoplasms sodium arsenite 7.7211559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4620056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 10.1312497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.1319189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1118481113 19348381
MESH:D009410 Nerve Degeneration Paraquat 3.5616893418
MESH:D009421 Nervous System Malformations Estradiol 8.7911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.7914600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.4218462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.356679447
MESH:D009436 Neural Tube Defects arsenic trioxide 11.3510525206
MESH:D009436 Neural Tube Defects sodium arsenite 11.3512854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 13.2018514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 13.2020387270
MESH:D019636 Neurodegenerative Diseases Oxidopamine 13.2018514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.1717929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
MESH:D009765 Obesity Curcumin 4.6019297423
MESH:D009765 Obesity Dietary Fats 4.6016723640 18674790 18457598 20132043 17217161 20518802 19632207 21332399 11836018
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.244026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.813988306
MESH:D010024 Osteoporosis Curcumin 3.3418719352
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.0219495926
MESH:D010051 Ovarian Neoplasms arsenic trioxide 14.2712452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Curcumin 14.2718462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 14.2719401270
MESH:D010051 Ovarian Neoplasms Quercetin 14.2719005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 14.2717306315 15276417
MESH:D010146 Pain Acetaminophen 2.2316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.7415580305
MESH:D010190 Pancreatic Neoplasms Curcumin 11.7419401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.7416540662
MESH:D010190 Pancreatic Neoplasms Quercetin 11.7416965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.287296757
MESH:D010235 Paraganglioma arsenic trioxide 3.9719927285
MESH:D010300 Parkinson Disease Paraquat 2.7415451049 15824117 16140633 16510128 12911755 11124998 11181820 11445065
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 10.7011771942 15893579
MESH:D010302 Parkinson Disease, Secondary Paraquat 10.7016190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.266228378
MESH:D011014 Pneumonia Paraquat 4.2412504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.3012371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.302563599
MESH:D011230 Precancerous Conditions Quercetin 14.3019056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9811896295 11118676 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6920887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0719131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms Curcumin 2.0711398177 18156803 12497104 15129424 18769126 18226269 10851300
MESH:D011471 Prostatic Neoplasms Estradiol 2.0716740699
MESH:D011471 Prostatic Neoplasms Quercetin 2.0714715546 17292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0716039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0715067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.1016919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011656 Pulmonary Emphysema Curcumin 4.3419168576
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8317997886 16324872
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 8.6210666014 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 8.6211700416
MESH:D012135 Respiratory Sounds Paraquat 3.8511874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.403692021
MESH:D012162 Retinal Degeneration Paraquat 8.4016458197
MESH:D012509 Sarcoma Curcumin 3.9318462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7616646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.3316862918
MESH:D018805 Sepsis Curcumin 3.9018389075
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.8210029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 8.8219524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.8216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.8516709447
MESH:D013088 Spermatocele Tamoxifen 10.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8319457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6412854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.2217007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.222093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2218456281
MESH:D013276 Stomach Ulcer Curcumin 3.3116631530 19188055
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.041399818 7505956 3712494 6587162 6582329
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.0419014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.047505956
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7515213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 22.888074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 22.8812845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 22.8817053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 22.8818593936
MESH:D001749 Urinary Bladder Neoplasms Quercetin 22.8816720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 22.8811723127 16452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 22.8817572228 8653321 16712894
MESH:D014565 Urogenital Neoplasms Curcumin 5.0518462866
MESH:D014581 Urticaria Acetaminophen 2.7810982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.5811813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1014692618
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3515869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D015430 Weight Gain Dietary Fats 3.5616723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
Pathway ID Pathway Name
REACT:8017 APC-Cdc20 mediated degradation of Nek2A
REACT:578 Apoptosis
REACT:6850 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
REACT:24941 Circadian Clock
REACT:216 DNA Repair
REACT:383 DNA Replication
REACT:6185 HIV Infection
REACT:11123 Membrane Trafficking
REACT:21257 Metabolism of RNA
KEGG:03320 PPAR signaling pathway
REACT:13505 Proteasome mediated degradation of PAK-2p34
REACT:25177 RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1
REACT:9417 Signaling by EGFR
REACT:11045 Signaling by Wnt
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB04464 - N-Formylmethionine
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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