AutismKB 2.0

Annotation Detail for UBA7


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Basic Information Top
Gene Symbol:UBA7 ( D8,MGC12713,UBA1B,UBE1L,UBE2 )
Gene Full Name: ubiquitin-like modifier activating enzyme 7
Band: 3p21.31
Quick LinksEntrez ID:7318; OMIM: 191325; Uniprot ID:UBA7_HUMAN; ENSEMBL ID: ENSG00000182179; HGNC ID: 12471
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05012Parkinson's disease
hsa04120Ubiquitin mediated proteolysis
No data
No data
Pathway IDPathway Name
P00060Ubiquitin proteasome pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
2011Leukoencephalopathy
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016572 Cyclosporine Cyclosporine results in decreased expression of UBA7 mRNAdecreases expression 20106945
C006253 pirinixic acid pirinixic acid results in decreased expression of UBA7 mRNAdecreases expression 17426115
C025462 sulindac sulfide sulindac sulfide results in decreased expression of UBA7 mRNAdecreases expression 16184548
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.6418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.2216434500
MESH:D000544 Alzheimer Disease sulindac sulfide 3.1618759972
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.6319483382
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.5612391285
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.8212371664
MESH:D002779 Cholestasis Cyclosporine 8.8619486331
MESH:D002779 Cholestasis pirinixic acid 8.8619176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5918249437
MESH:D004487 Edema pirinixic acid 2.9612083418
MESH:D005234 Fatty Liver Cyclosporine 9.2119224547
MESH:D005234 Fatty Liver pirinixic acid 9.2120131406 19236843
MESH:D005355 Fibrosis Cyclosporine 3.7912168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.968708960
MESH:D006333 Heart Failure pirinixic acid 2.7820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.1615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.6418467677 16221962 19176532 19772884
MESH:D006943 Hyperglycemia pirinixic acid 3.6320558911
MESH:D006973 Hypertension Cyclosporine 2.2310903974
MESH:D007333 Insulin Resistance pirinixic acid 2.9016306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.3115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.568314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 3.1212371664
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9416377806 20007298 15890375
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.6516801185
MESH:D009135 Muscular Diseases pirinixic acid 4.1616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2916411023
MESH:D009369 Neoplasms pirinixic acid 2.1217405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.7019348381 18481113
MESH:D009765 Obesity pirinixic acid 1.8920558911
MESH:D011230 Precancerous Conditions Cyclosporine 3.6412371664
MESH:D011565 Psoriasis Cyclosporine 2.3416882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5619058328
MESH:D014594 Uterine Neoplasms sulindac sulfide 5.2418645019
MESH:D014605 Uveitis Cyclosporine 4.851336536
MESH:D014985 Xerophthalmia Cyclosporine 5.3117120751
Pathway ID Pathway Name
KEGG:05012 Parkinson's disease
REACT:6900 Signaling in Immune system
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162407761
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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