AutismKB 2.0

Annotation Detail for UBE2D3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:UBE2D3 ( E2(17)KB3,MGC43926,MGC5416,UBC4/5,UBCH5C )
Gene Full Name: ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
Band: 4q24
Quick LinksEntrez ID:7323; OMIM: 602963; Uniprot ID:UB2D3_HUMAN; ENSEMBL ID: ENSG00000109332; HGNC ID: 12476
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-11BMP Signalling Pathway
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
hsa04120Ubiquitin mediated proteolysis
Pathway IDPathway Name
Signaling by TGF beta
Signaling by BMP
Pathway IDPathway Name
200146Internalization of ErbB1
200174BARD1 signaling events
200026Canonical NF-kappaB pathway
Pathway IDPathway Name
P00060Ubiquitin proteasome pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2011Leukoencephalopathy
2151Neuroblastoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of UBE2D3 mRNAaffects expression 21346803
C017906 3-dinitrobenzene 3-dinitrobenzene affects the expression of UBE2D3 mRNAaffects expression 16988215
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of UBE2D3 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of UBE2D3 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of UBE2D3 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of UBE2D3 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of UBE2D3 mRNAincreases expression 20382639
D002101 Cacodylic Acid Cacodylic Acid results in increased expression of UBE2D3 mRNAincreases expression 17720352
C459604 candoxin candoxin results in increased expression of UBE2D3 mRNAincreases expression 16309724
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of UBE2D3 mRNAincreases expression 17555576
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UBE2D3 mRNAaffects cotreatment|increases expression 17942748
D019833 Genistein Genistein results in increased expression of UBE2D3 mRNAincreases expression 17341692
D016627 Oxidopamine Oxidopamine results in increased expression of UBE2D3 mRNAincreases expression 12486162
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of UBE2D3 mRNAincreases expression 17616710
D010634 Phenobarbital Phenobarbital results in decreased expression of UBE2D3 mRNAdecreases expression 19363144
D010634 Phenobarbital Phenobarbital results in increased expression of UBE2D3 mRNAincreases expression 19363144
C059514 resveratrol resveratrol results in decreased expression of UBE2D3 mRNAdecreases expression 17804521
D012402 Rotenone Rotenone results in increased expression of UBE2D3 mRNAincreases expression 19013527
D013629 Tamoxifen Tamoxifen affects the expression of UBE2D3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UBE2D3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of UBE2D3 mRNAincreases expression 17942748
D013806 Theophylline Theophylline affects the expression of UBE2D3 mRNAaffects expression 16988215
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4914745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.096195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.0915322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D058186 Acute Kidney Injury resveratrol 3.7916538975
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3014692618
MESH:D000230 Adenocarcinoma Genistein 4.3011473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.713712494
MESH:D000236 Adenoma resveratrol 6.7115688382
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.8817620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.8816835633
MESH:D000544 Alzheimer Disease resveratrol 2.5516183991 16162502
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7420041841 18218290 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.2215885639
MESH:D001169 Arthritis, Experimental resveratrol 7.2217115116
MESH:D001249 Asthma Theophylline 3.8412113382 9701106
MESH:D050197 Atherosclerosis resveratrol 3.2316873680 17967414
MESH:D001281 Atrial Fibrillation Amiodarone 3.8519698954 18651412
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 4.6114699433
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.961440618 11289319
MESH:D001778 Blood Coagulation Disorders Amiodarone 8.8419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.8412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D002545 Brain Ischemia resveratrol 4.2217600658
MESH:D001943 Breast Neoplasms Cacodylic Acid 2.3417474063
MESH:D001943 Breast Neoplasms Genistein 2.3417200150 16873071 16541309
MESH:D001943 Breast Neoplasms resveratrol 2.3417534123 16393696 17651959
MESH:D001943 Breast Neoplasms Tamoxifen 2.3416202921 17049068 18629630 19221464 18855134 19288272 16273361 15668708 19103187 19244106 19059307 19189210 19155303 19289846 19142967 20544844 20135344 19084267 18351453 18821012 11161223 18997820 21152245 20859285 19066611 18425577 15565566 19487384 17242785 16818667 19200415 18984771 17893378 19189212 16873071 20005174 20390343 21138602 17440819 19011961 17261762 19115204 20065188 19410462 18815881
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3420435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4419066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.9416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.947296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.943084413
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.9416924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.9420935162 17173139 20007298 1701930 6705139
MESH:D006528 Carcinoma, Hepatocellular resveratrol 13.9419321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.9416924424
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.5316675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.647296757
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.7016227395
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3318670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8719225199 15710769
MESH:D002318 Cardiovascular Diseases Genistein 7.3616332659
MESH:D002318 Cardiovascular Diseases resveratrol 7.3615458977
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.0218974383
MESH:D002386 Cataract Acetaminophen 2.5410977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.497505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.4920889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.194080065
MESH:D002637 Chest Pain Theophylline 5.8215238202
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.699022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6911677210 17333356 17681005 16105132 16919318 15861022 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815340226 8697196 15668235 16354765 12621046
MESH:D003092 Colitis resveratrol 4.0616474422
MESH:D003110 Colonic Neoplasms Genistein 3.8917182828
MESH:D003110 Colonic Neoplasms resveratrol 3.8916338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0017141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.7116507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9518551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3019031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7411906362 14531868 12868966 18759878 8156756 2524372 11298694 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.433621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.7116873680
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.2716647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2717107852
MESH:D003928 Diabetic Nephropathies resveratrol 8.8516286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.8519279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.8018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.8011289319 16192314 18648102 9328219 9653073 18692083 18289764 1440618 8291058 7440962 6482804 6679447 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.8011421492 18071297 16177239 19164858 16109766 18713872 19370779 19416960 14986274 10774834 16393943 11743745 19085960 12705907 15968718 11287661 17522070 19739265 12958197 12594235 16485898 11461765 16081117 11739529 17562736 16227642 19923254 10663392 2444490 16781746 12392966 19420014 12153990 14550746 12540782 10915739 15619225 14725611 11834606 17906064 11529661
MESH:D056486 Drug-Induced Liver Injury Amiodarone 11.8018218290 15265979
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.8020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D004421 Dystonia Phenobarbital 3.941851702
MESH:D004487 Edema resveratrol 6.668985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8515322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.9912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 14.9917872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.9919031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.5316402032
MESH:D016889 Endometrial Neoplasms Genistein 7.3811473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.3816202921 17893378 19155303 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9610568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.7817923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.043659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.823922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.486401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.197750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.963659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.193581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1920426865
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.1915150132 15547733 16805852 15878914 15264214 15547721 16704527 16510608 15623463
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver Amiodarone 12.7914986274
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.7915345470
MESH:D005234 Fatty Liver Tamoxifen 12.7919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.966705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8920067830
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D005909 Glioblastoma Genistein 3.2216598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.977505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3011294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.456705139
MESH:D006529 Hepatomegaly Amiodarone 14.1215265979
MESH:D006529 Hepatomegaly Phenobarbital 14.1216109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.1212621046 16120746 15340226
MESH:D006561 Herpes Simplex resveratrol 4.1216876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9916959395 16354765 8697196 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.6516870215
MESH:D006937 Hypercholesterolemia Amiodarone 9.118137927 9751232
MESH:D006937 Hypercholesterolemia resveratrol 9.1117188708
MESH:D006949 Hyperlipidemias resveratrol 3.9616873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8815034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8818850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.2417488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 4.4517991464 18020914
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.5817600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male 3-dinitrobenzene 11.4016988215
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.4017937319
MESH:D007248 Infertility, Male Theophylline 11.4016988215
MESH:D007249 Inflammation resveratrol 8.1316366677
MESH:D007249 Inflammation Tamoxifen 8.1319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.1312878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.4916624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.968074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007674 Kidney Diseases Acetaminophen 2.1615629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.0816705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.086582329
MESH:D007680 Kidney Neoplasms Tamoxifen 12.0818625569
MESH:D007938 Leukemia Genistein 2.9918980019 17468513
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.5316087638
MESH:D008064 Lipidoses Amiodarone 7.7515342952 17567588
MESH:D008064 Lipidoses Tamoxifen 7.7515342952 17567588
MESH:D008103 Liver Cirrhosis Phenobarbital 2.8621047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1515034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.4417823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4412878042
MESH:D008107 Liver Diseases Acetaminophen 3.8712969438 19014921 16611625 11587558 12587719 19460945 19784758 16610002
MESH:D008107 Liver Diseases Phenobarbital 3.8719363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1817185352 16871587
MESH:D008113 Liver Neoplasms Phenobarbital 10.518742319 19073162 19812893 15975961 19482888 21047994
MESH:D008113 Liver Neoplasms resveratrol 10.5120405173 19812893 19073162 19321006
MESH:D008113 Liver Neoplasms Tamoxifen 10.5116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.5116984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.553712494 1399818 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.5517172636 18308698 2563599 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.5512151625
MESH:D008133 Long QT Syndrome Amiodarone 3.5311989578 17391786 15350150
MESH:D008171 Lung Diseases Amiodarone 3.3312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.4218516814
MESH:D008175 Lung Neoplasms Tamoxifen 2.2318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2319555203 11884234
MESH:D016393 Lymphoma, B-Cell resveratrol 4.2417088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8114749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 9.8015688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.8019428831
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.8112929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 9.8111606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.8116827153 11731420 19196723 19196722 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.4919453300
MESH:D008545 Melanoma resveratrol 3.4017992120
MESH:D008545 Melanoma Tamoxifen 3.4012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008659 Metabolic Diseases resveratrol 4.3117112576
MESH:D009101 Multiple Myeloma resveratrol 3.4217049120 16490592 17935668 14749477 16267019 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.8117962980
MESH:D009181 Mycoses Amiodarone 4.8512754197 17974566
MESH:D009203 Myocardial Infarction Genistein 5.9117141266
MESH:D009203 Myocardial Infarction resveratrol 5.9116456233 16317513 16525036 17188708 17015251 17125593
MESH:D017202 Myocardial Ischemia resveratrol 8.8317125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.8312213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.6117141266
MESH:D009205 Myocarditis resveratrol 4.7017322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4117484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8018551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.613581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009374 Neoplasms, Experimental resveratrol 3.948985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9419189210 19200415 19196722
MESH:D009410 Nerve Degeneration 3-dinitrobenzene 9.0811301198
MESH:D009410 Nerve Degeneration Rotenone 9.0815790535 18619942 17356569
MESH:D009421 Nervous System Malformations Genistein 9.3916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.3914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.876679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 13.9218514411
MESH:D019636 Neurodegenerative Diseases Oxidopamine 13.9218514411
MESH:D019636 Neurodegenerative Diseases resveratrol 13.9217652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.3417929310
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.6812819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.686482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.963988306
MESH:D010018 Osteomalacia Phenobarbital 4.3017016548
MESH:D010024 Osteoporosis Genistein 3.2119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.9416169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 9.9417513867
MESH:D010051 Ovarian Neoplasms Genistein 2.5819005980
MESH:D010146 Pain Acetaminophen 2.3416870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.4716965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.427296757
MESH:D010300 Parkinson Disease Rotenone 2.9519114014 18619942 15451049 16412576 11445065 19232380 18191903 16140633 11535288
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 5.4011771942 15893579
MESH:D020734 Parkinsonian Disorders Rotenone 4.0218197244 15795934 15927086 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.416228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.562563599
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.3916679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.3911222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Genistein 2.6615256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms resveratrol 2.6617804756 17636462 17718901 15767336 17675339 16731767
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6615067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.2516919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.4412752131
MESH:D029424 Pulmonary Disease, Chronic Obstructive Theophylline 5.0818983928
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8312490602 12832656 11597910
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.5316325855
MESH:D015427 Reperfusion Injury resveratrol 3.2416317513 17520802 15827377 17058453 16314181
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.323692021
MESH:D012640 Seizures 2,4-dinitrotoluene 5.7718551238
MESH:D012640 Seizures Phenobarbital 5.7716876388 3137016 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.766407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.0218724381
MESH:D012878 Skin Neoplasms resveratrol 5.6115837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.3716709447
MESH:D013088 Spermatocele Tamoxifen 11.3716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9819457130
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3212958204 17575124
MESH:D013276 Stomach Ulcer Amiodarone 3.2618087811
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.4216321402
MESH:D013610 Tachycardia Amiodarone 4.2211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.1319225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0915669648
MESH:D013959 Thyroid Diseases Amiodarone 11.8719731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.8712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.976582329 3712494 1399818 7505956 6587162
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.971399818
MESH:D013971 Thyrotoxicosis Amiodarone 4.8018020914 19584973
MESH:D014062 Tongue Neoplasms resveratrol 4.1516227395
MESH:D016171 Torsades de Pointes Amiodarone 4.1317467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.7716049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.778074119
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 11.7715537745
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.778653321 17572228 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2510091137
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.0417473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.2914692618
MESH:D014594 Uterine Neoplasms resveratrol 9.2917044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4814671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.2417488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
Pathway ID Pathway Name
KEGG:04141 Protein processing in endoplasmic reticulum
REACT:25177 RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1
REACT:12034 Signaling by BMP
REACT:6844 Signaling by TGF beta
REACT:6900 Signaling in Immune system
KEGG:04120 Ubiquitin mediated proteolysis
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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