AutismKB 2.0

Annotation Detail for UBE2E2


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Basic Information Top
Gene Symbol:UBE2E2 ( FLJ25157,UBCH8 )
Gene Full Name: ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)
Band: 3p24.3
Quick LinksEntrez ID:7325; OMIM: 602163; Uniprot ID:UB2E2_HUMAN; ENSEMBL ID: ENSG00000182247; HGNC ID: 12478
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
hsa04120Ubiquitin mediated proteolysis
No data
No data
Pathway IDPathway Name
P00060Ubiquitin proteasome pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of UBE2E2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of UBE2E2 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of UBE2E2 mRNAdecreases expression 20106945
20064835
D016572 Cyclosporine Cyclosporine results in increased expression of UBE2E2 mRNAincreases expression 20106945
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of UBE2E2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of UBE2E2 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of UBE2E2 mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of UBE2E2 mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of UBE2E2 mRNAincreases expression 18796159
18172886
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.656195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6514514962 15322242 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 19.7517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.7516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.7516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.7319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8717474063 20146248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.733084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.731701930 20935162 17173139 20007298 6705139
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7112371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Cyclosporine 8.4419486331
MESH:D002779 Cholestasis pirinixic acid 8.4419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.208697196 15668235 16354765 12621046 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3718551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 marker/mechanism 20818381
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5217562736 11461765 19739265 19416960 16227642 18071297 16393943 14725611 19420014 10915739 11743745 18713872 19085960 16781746 11529661 12705907 11287661 12153990 12392966 17906064 12594235 11739529 2444490 16109766 19370779 15968718 19164858 19923254 16081117 14550746 10663392 15619225 17522070 11421492 16485898 12540782 10774834 12958197 14986274 11834606 16177239
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Cyclosporine 8.5119224547
MESH:D005234 Fatty Liver pirinixic acid 8.5120131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Cyclosporine 9.7012639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.7020067830
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Phenobarbital 16.5816109766
MESH:D006529 Hepatomegaly pirinixic acid 16.5818467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.5816120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4918606429 15340226 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Cyclosporine 5.2410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2418670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2815629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.2818776723 8314463 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.0616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 8.0612371664
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0321047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2012878042
MESH:D008107 Liver Diseases Acetaminophen 4.1319460945 16611625 16610002 12969438 12587719 19784758 19014921 11587558
MESH:D008107 Liver Diseases Phenobarbital 4.1319363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.4121137059 20195826
MESH:D008113 Liver Neoplasms Phenobarbital 11.4119073162 8742319 19482888 21047994 15975961 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 11.4115890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4116984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.3317172636 1399818 2563599 18308698 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3312151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2517053015 20135361 18520028 18569708 20464547 18816296 6695378 20869020 20064080
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2511884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2518551238
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2211141357
MESH:D009369 Neoplasms pirinixic acid 5.2217405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6916049721 12819281
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.8112371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.812563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5318551238
MESH:D012640 Seizures Phenobarbital 6.5316876388 4039156 3137016 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8519755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8516192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.261399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2816049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2817053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
Pathway ID Pathway Name
KEGG:04141 Protein processing in endoplasmic reticulum
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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