AutismKB 2.0

Annotation Detail for UBE2I


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Basic Information Top
Gene Symbol:UBE2I ( C358B7.1,P18,UBC9 )
Gene Full Name: ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
Band: 16p13.3
Quick LinksEntrez ID:7329; OMIM: 601661; Uniprot ID:UBC9_HUMAN; ENSEMBL ID: ENSG00000103275; HGNC ID: 12485
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
No data
Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
200070Signaling events mediated by HDAC Class I
200130C-MYB transcription factor network
200152Regulation of cytoplasmic and nuclear SMAD2/3 signaling
200019Signaling events mediated by HDAC Class II
200097Sumoylation by RanBP2 regulates transcriptional repression
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of UBE2I mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of UBE2I mRNAincreases expression 16788091
C041594 4-nonylphenol 4-nonylphenol results in increased expression of UBE2I mRNAincreases expression 12735107
D000082 Acetaminophen Acetaminophen affects the expression of UBE2I mRNAaffects expression 17562736
D015081 2-Naphthylamine 2-Naphthylamine results in increased expression of UBE2I mRNAincreases expression 18247414
D000643 Ammonium Chloride Ammonium Chloride affects the expression of UBE2I mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of UBE2I mRNAdecreases expression 18247414
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of UBE2I mRNAincreases expression 20504355
D002118 Calcium Calcium affects the expression of UBE2I mRNAaffects expression 15913539
D003840 Deoxycholic Acid [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of UBE2I mRNAaffects cotreatment|increases expression 16556975
D004958 Estradiol Estradiol promotes the reaction [UBE2I protein binds to ESR1 protein]affects binding|increases reaction 15666801
D005419 Flavonoids Flavonoids results in decreased expression of UBE2I mRNAdecreases expression 18035473
C030691 gluconic acid [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of UBE2I mRNAaffects cotreatment|increases expression 16556975
D008713 Methimazole Methimazole results in decreased expression of UBE2I mRNAdecreases expression 17403546
D009538 Nicotine Nicotine results in decreased expression of UBE2I mRNAdecreases expression 18247414
C494474 perchlorate perchlorate results in decreased expression of UBE2I mRNAdecreases expression 17403546
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of UBE2I mRNAaffects binding|decreases expression|increases activity 19710929
D011441 Propylthiouracil Propylthiouracil results in decreased expression of UBE2I mRNAdecreases expression 17403546
C031280 pyrazole pyrazole results in increased expression of UBE2I mRNAincreases expression 17945193
D013974 Thyroxine Thyroxine affects the expression of UBE2I mRNAaffects expression 17403546
D019772 Topotecan UBE2I protein affects the susceptibility to Topotecanaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.0318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2120464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 4.2111473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.606695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4016434500
MESH:D000544 Alzheimer Disease Nicotine 3.2616627626
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.9419483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 8.9419483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0720146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.0716675129 17289903 14630087 17018787 18497071 19861407 17261762 12948864
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3816111702
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.4316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.433084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.4316924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0320419170
MESH:D006332 Cardiomegaly Thyroxine 4.0518093424
MESH:D002386 Cataract Acetaminophen 2.5310977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.7118566989
MESH:D002779 Cholestasis pirinixic acid 2.7619176532
MESH:D003110 Colonic Neoplasms Deoxycholic Acid 3.5516213893
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.3319279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.1618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.1616109766 11529661 11834606 19739265 15619225 18713872 19420014 12705907 16227642 10915739 17522070 17562736 14986274 19416960 15968718 16781746 10774834 11287661 16081117 10663392 16177239 19164858 19085960 17906064 12958197 18071297 11421492 11739529 16485898 11743745 16393943 11461765 12153990 19923254 2444490 12540782 12594235 14550746 12392966 19370779 14725611
MESH:D056486 Drug-Induced Liver Injury pyrazole 6.1612499123
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:D020821 Dystonic Disorders Nicotine 5.8417881519
MESH:D004487 Edema pirinixic acid 2.4012083418
MESH:D016889 Endometrial Neoplasms Estradiol 2.9211473722 18566989 19148513
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9916530937
MESH:D005234 Fatty Liver pirinixic acid 2.6819236843 20131406
MESH:D005756 Gastritis Acetaminophen 3.5916983495
MESH:D006042 Goiter perchlorate 5.2218801409
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6120471113
MESH:D006333 Heart Failure pirinixic acid 2.4820558911
MESH:D006529 Hepatomegaly pirinixic acid 2.9116221962 18467677 19772884 19176532
MESH:D006558 Herpes Genitalis Estradiol 4.9515709030
MESH:D019584 Hot Flashes Estradiol 3.6717088409
MESH:D006930 Hyperalgesia Acetaminophen 2.6316870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1020558911
MESH:D006980 Hyperthyroidism Methimazole 5.5314678291
MESH:D007037 Hypothyroidism Methimazole 11.6618031379
MESH:D007037 Hypothyroidism Propylthiouracil 11.6618031379 8137927
MESH:D007249 Inflammation Flavonoids 2.6017296493
MESH:D007333 Insulin Resistance Estradiol 7.0016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.0016306350
MESH:D007674 Kidney Diseases Acetaminophen 5.7215629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.7215618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.1216705839
MESH:D007680 Kidney Neoplasms Estradiol 7.1215610895
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.9616316344
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.2714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2715474484
MESH:D008107 Liver Diseases Acetaminophen 1.6116610002 12969438 12587719 16611625 11587558 19014921 19784758 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1617185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.2621137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 4.2615890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental Deoxycholic Acid 4.156150874
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5620464547 18569708 18816296 18520028 17053015 20869020 20064080 6695378 20135361
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5016891317 17203775 11807958 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.4019453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.0216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.0216411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.7718551238
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0911141357
MESH:D009369 Neoplasms Nicotine 8.0916365874
MESH:D009369 Neoplasms pirinixic acid 8.0917405874
MESH:D009389 Neovascularization, Pathologic Estradiol 10.0817289903
MESH:D009389 Neovascularization, Pathologic Nicotine 10.0816365874
MESH:D009421 Nervous System Malformations Estradiol 3.5616427766 11399458
MESH:D009447 Neuroblastoma Topotecan 3.8015176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8018514411
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.3516049721 12819281
MESH:D010024 Osteoporosis Calcium 3.7317882678
MESH:D010051 Ovarian Neoplasms Estradiol 2.1919401270
MESH:D010146 Pain Acetaminophen 2.3216870215
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8020887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1417292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.1416740699
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1318551238
MESH:D012640 Seizures Nicotine 6.1317873105
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3310029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5520155912 2093021
MESH:D013733 Testicular Diseases pyrazole 4.736499806
MESH:D013959 Thyroid Diseases Thyroxine 5.5619910387
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.6115710170
MESH:D013978 Tibial Fractures Estradiol 4.6019048282
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.6616720336 11259349 16785264
MESH:D014029 Tobacco Use Disorder Nicotine 5.3618305452 18041664 15735609 17979512
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.2616049721
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 8.2611144890
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.2617053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2310091137
MESH:D014581 Urticaria Acetaminophen 2.8910982225
Pathway ID Pathway Name
KEGG:03013 RNA transport
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37134
    • No data
    Releated disease ID Related disease Name
    PA443622Carcinoma, Non-Small-Cell Lung
    Releated drug ID Related drug Name
    PA164744376adenosine monophosphate
    PA164743471adenosine triphosphate
    PA449014cisplatin
    PA450085irinotecan
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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