AutismKB 2.0

Annotation Detail for UBE2N


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:UBE2N ( MGC131857,MGC8489,UBC13,UbcH-ben )
Gene Full Name: ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
Band: 12q22
Quick LinksEntrez ID:7334; OMIM: 603679; Uniprot ID:UBE2N_HUMAN; ENSEMBL ID: ENSG00000177889; HGNC ID: 12492
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200075IL1-mediated signaling events
Pathway IDPathway Name
P00060Ubiquitin proteasome pathway
P00054Toll receptor signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of UBE2N mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of UBE2N mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone affects the expression of UBE2N mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of UBE2N mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of UBE2N mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of UBE2N mRNAdecreases expression 20064835
C099555 CD 437 CD 437 results in decreased expression of UBE2N mRNAdecreases expression 12958071
D002994 Clofibrate Clofibrate affects the expression of UBE2N mRNAaffects expression 19483382
D000431 Ethanol Ethanol results in increased expression of UBE2N mRNAincreases expression 15513904
D005001 Ethionine Ethionine affects the expression of UBE2N mRNAaffects expression 19483382
C056933 fumonisin B1 fumonisin B1 results in increased expression of UBE2N mRNAincreases expression 16221962
D008628 Mercury Mercury results in decreased expression of UBE2N mRNAdecreases expression 16823088
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of UBE2N mRNAincreases expression 17616710
D009853 Omeprazole Omeprazole affects the expression of UBE2N mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid results in increased expression of UBE2N mRNAincreases expression 16221962
18301758
C006253 pirinixic acid pirinixic acid affects the expression of UBE2N mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of UBE2N mRNAaffects expression 19483382
D012402 Rotenone Rotenone results in increased expression of UBE2N mRNAincreases expression 18191903
C017947 sodium arsenite TP53 protein affects the reaction [sodium arsenite results in increased expression of UBE2N mRNA]affects reaction|increases expression 16966095
D013853 Thioacetamide Thioacetamide affects the expression of UBE2N mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 3.8618926900 17676605
MESH:D000138 Acidosis Ammonium Chloride 10.2718287403
MESH:D000138 Acidosis Ethanol 10.2711192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9720464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.616695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4216434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8516712894 17306315
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.2615451040 15451039
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D000853 Anophthalmos Ethanol 4.7615513904
MESH:D001008 Anxiety Disorders Ethanol 3.9511141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0119183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7420041841 18218290 18057881
MESH:D001281 Atrial Fibrillation Amiodarone 3.8518651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Mercury 2.1417497416
MESH:D001327 Autoimmune Diseases Mercury 4.8116634805
MESH:D001778 Blood Coagulation Disorders Amiodarone 49.6819483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 49.6819483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 49.6819483382
MESH:D001778 Blood Coagulation Disorders Ethionine 49.6819483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 49.6819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 49.6819483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 49.6819483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 49.6819483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0517474063 20146248
MESH:D002056 Burns Ethanol 4.5916374292
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.2716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.273084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 11.271701930
MESH:D006528 Carcinoma, Hepatocellular Ethanol 11.2715289165 18788625 15763234
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.2717306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 11.2717997003
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5420419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.5418572023
MESH:D006332 Cardiomegaly Ethanol 3.4019332462
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 6.0919225199 15710769
MESH:D002311 Cardiomyopathy, Dilated Mercury 6.0910334427
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.0218974383
MESH:D002386 Cataract Acetaminophen 2.5410977129
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 6.871399818
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.8719524636 20056578
MESH:D002637 Chest Pain Omeprazole 5.0515447763
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.2318291259
MESH:D002779 Cholestasis pirinixic acid 2.7719176532
MESH:D002971 Cleft Lip Ethanol 3.5515513904
MESH:D002972 Cleft Palate Ethanol 3.1515513904
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3211198716 15513904 15451040 19302082 15451039 11873399 10194807
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9518551238
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.7316823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.0318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.0319085960 17906064 11834606 2444490 10774834 19164858 16109766 10915739 12958197 19923254 11421492 12392966 19420014 17562736 15619225 18071297 16177239 10663392 17522070 11743745 15968718 11529661 16227642 11461765 14986274 18713872 16485898 19739265 19370779 11287661 11739529 14725611 16781746 14550746 19416960 12705907 12594235 12540782 16081117 12153990 16393943
MESH:D056486 Drug-Induced Liver Injury Amiodarone 15.0315265979 18218290
MESH:D056486 Drug-Induced Liver Injury Ethanol 15.0311566570
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 15.0316221962
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 15.0312963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004381 Duodenal Ulcer Omeprazole 4.2617151854 21218061 15991576 16613094
MESH:D050171 Dyslipidemias Clofibrate 4.0216707586
MESH:D004487 Edema pirinixic acid 2.4212083418
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.2716530937
MESH:D004938 Esophageal Neoplasms Ethanol 7.2716704527
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.2716510608 16805852 15264214 15878914 15547733 16704527 15547721 15623463 15150132
MESH:D005218 Fat Necrosis Thioacetamide 5.6616456712
MESH:D005234 Fatty Liver Amiodarone 18.3414986274
MESH:D005234 Fatty Liver Clofibrate 18.3419224547
MESH:D005234 Fatty Liver Ethanol 18.3416409862 19236843 18620774
MESH:D005234 Fatty Liver pirinixic acid 18.3419236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.6117920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.2415513904 16946407 15451040 10194807
MESH:D005756 Gastritis Acetaminophen 10.9416983495
MESH:D005756 Gastritis Ethanol 10.9415046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6216452187
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6220471113
MESH:D006333 Heart Failure pirinixic acid 2.5020558911
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.5115929193 18665440 17276928
MESH:D006505 Hepatitis Thioacetamide 4.1516456712
MESH:D006529 Hepatomegaly Amiodarone 14.2415265979
MESH:D006529 Hepatomegaly fumonisin B1 14.2416221962
MESH:D006529 Hepatomegaly pirinixic acid 14.2418467677 19772884 16221962 19176532
MESH:D006689 Hodgkin Disease sodium arsenite 3.1012676792
MESH:D006930 Hyperalgesia Acetaminophen 7.6316870215
MESH:D006930 Hyperalgesia Ethanol 7.6318783367
MESH:D006937 Hypercholesterolemia Amiodarone 3.819751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D007037 Hypothyroidism Amiodarone 11.4018020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 11.4018031379 8137927
MESH:D007248 Infertility, Male sodium arsenite 2.9415346721 12646999
MESH:D007333 Insulin Resistance pirinixic acid 2.5916306350
MESH:D007569 Jaw Abnormalities Ethanol 4.3415513904
MESH:D007674 Kidney Diseases Acetaminophen 9.9512587719 15629191
MESH:D007674 Kidney Diseases Mercury 9.9517934191
MESH:D007674 Kidney Diseases sodium arsenite 9.9520008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 2.9216705839
MESH:D007859 Learning Disorders Ethanol 4.1515451040
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.0419248655
MESH:D017880 Limb Deformities, Congenital Ethanol 3.7617676605
MESH:D008064 Lipidoses Amiodarone 3.4617567588 15342952
MESH:D008103 Liver Cirrhosis Ethanol 3.3415289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.0418295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.5718166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5715474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 3.5712891558 18395095 11172339 16098781 15474484 12679928 16248980 17050028 18295389 15075984 16511523 18416461 17292413 18263696 15288472 15334695 17629604 17127702 18615449 14739098 16343077 11682029 15465738 12531686 18458672 11481614 15158331 16126171 15316131 15288473 16097051 10677585 15716488 18380797 18032466 18606216 12557150 16489207 17355460 12085344 12175628 15362042 15095483 18031379 15078482
MESH:D008107 Liver Diseases Acetaminophen 4.0712969438 11587558 19460945 12587719 16611625 16610002 19784758 19014921
MESH:D008107 Liver Diseases Thioacetamide 4.0716337175 15158337 18374380
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.5917347304 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 9.4417185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 9.4415313186 15633222 12479984 17276928
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.2521137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 7.2516377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 7.2516712894 15276417
MESH:D008133 Long QT Syndrome Amiodarone 3.5317391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 7.3712587719
MESH:D008171 Lung Diseases sodium arsenite 7.3719095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.4218516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4020464547 18816296 20135361 6695378 18569708 17053015 18520028 20064080 20869020
MESH:D008175 Lung Neoplasms sodium arsenite 2.4016712894 17306315 19931552 17077188 15276417
MESH:D008545 Melanoma sodium arsenite 2.0219082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008569 Memory Disorders Ethanol 4.1215451040 18411066
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1416381670
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009181 Mycoses Amiodarone 4.8512754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8018551238
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0111141357
MESH:D009369 Neoplasms pirinixic acid 8.0117405874
MESH:D009369 Neoplasms sodium arsenite 8.0111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6020056578
MESH:D009410 Nerve Degeneration Rotenone 3.8318619942 17356569 15790535
MESH:D009436 Neural Tube Defects sodium arsenite 3.1012854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8118514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.879802331
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.3712819281 16049721
MESH:D010051 Ovarian Neoplasms CD 437 5.1717474084
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.1717306315 15276417
MESH:D010146 Pain Acetaminophen 2.3416870215
MESH:D010190 Pancreatic Neoplasms Ethanol 2.9512384795
MESH:D010300 Parkinson Disease Rotenone 2.9516412576 11445065 19232380 15451049 18619942 16140633 18191903 11535288 19114014
MESH:D020734 Parkinsonian Disorders Rotenone 4.0218197244 15927086 15795934 15574749
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2117292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2116039940
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8312832656 11597910 12490602
MESH:D015427 Reperfusion Injury pirinixic acid 2.3519058328
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9518551238
MESH:D012640 Seizures Ethanol 5.959754883
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.0218724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6110029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 5.6119524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7412854658
MESH:D013272 Stomach Diseases Omeprazole 4.5518545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.4420155912 2093021
MESH:D013274 Stomach Neoplasms Ethanol 3.4418456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.4417575124 12958204
MESH:D013276 Stomach Ulcer Amiodarone 11.8518087811
MESH:D013276 Stomach Ulcer Ethanol 11.8516755016 17918041 9562338 11906479 17189318 9211565
MESH:D013276 Stomach Ulcer Omeprazole 11.8510750652 15991576 18237397 11906479 16755016 17977527
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.199754883
MESH:D013610 Tachycardia Amiodarone 4.2211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.1319225199
MESH:D013959 Thyroid Diseases Amiodarone 4.7019731979
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.6315710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.8018020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.1317467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.7616049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.7617053015
MESH:D001749 Urinary Bladder Neoplasms CD 437 11.7616720286
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.7617306315 16452187 11723127 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2510091137
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7111813266
MESH:D014652 Vascular Diseases sodium arsenite 4.3617056641
Pathway ID Pathway Name
REACT:25035 Innate immune response mediated by toll like receptors
REACT:6900 Signaling in Immune system
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved