Annotation Detail for OSGIN2
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000082 |
Acetaminophen |
Acetaminophen affects the expression of OSGIN2 mRNA | affects expression | 17562736
|
| D016572 |
Cyclosporine |
Cyclosporine results in increased expression of OSGIN2 mRNA | increases expression | 20106945
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of OSGIN2 mRNA | affects binding|increases activity|increases expression | 19710929
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.64 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.22 | 16434500 |
| MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.71 | 10982225 |
| MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.39 | 18445737 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.63 | 19483382 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
1.41 | 3084413 |
| MESH:D002386 |
Cataract |
|
Acetaminophen |
2.81 | 10977129 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
Cyclosporine |
2.82 | 12371664 |
| MESH:D002779 |
Cholestasis |
|
Cyclosporine |
8.86 | 19486331 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
8.86 | 19176532 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.59 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
1.68 | 12594235 19739265 16393943 16177239 15619225 10915739 12540782 15968718 19923254 12705907 19370779 12958197 12392966 18713872 11739529 16781746 10774834 19085960 2444490 12153990 11743745 11421492 14550746 18071297 16485898 11834606 11529661 10663392 19420014 16227642 19164858 17906064 16081117 11287661 17562736 14725611 16109766 19416960 11461765 17522070 14986274 |
| MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.96 | 19426721 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.96 | 12083418 |
| MESH:D005234 |
Fatty Liver |
|
Cyclosporine |
9.21 | 19224547 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
9.21 | 20131406 19236843 |
| MESH:D005355 |
Fibrosis |
|
Cyclosporine |
3.79 | 12168785 12639820 |
| MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.54 | 16983495 |
| MESH:D005885 |
Gingival Hyperplasia |
|
Cyclosporine |
4.96 | 8708960 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.78 | 20558911 |
| MESH:D006457 |
Hemoglobinuria, Paroxysmal |
|
Cyclosporine |
5.16 | 15720958 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.64 | 18467677 19176532 19772884 16221962 |
| MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
3.06 | 16870215 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.63 | 20558911 |
| MESH:D006973 |
Hypertension |
|
Cyclosporine |
2.23 | 10903974 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.90 | 16306350 |
| MESH:D007638 |
Keratoconjunctivitis Sicca |
|
Cyclosporine |
5.31 | 15604871 |
| MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
6.55 | 12587719 15629191 |
| MESH:D007674 |
Kidney Diseases |
|
Cyclosporine |
6.55 | 8314463 10903974 18776723 |
| MESH:D007680 |
Kidney Neoplasms |
|
Cyclosporine |
3.12 | 12371664 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.71 | 12587719 19460945 11587558 19014921 16611625 19784758 16610002 12969438 |
| MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.68 | 17185352 16871587 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
1.94 | 15890375 20007298 16377806 |
| MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
4.22 | 19513568 |
| MESH:D008664 |
Metal Metabolism, Inborn Errors |
|
Cyclosporine |
5.65 | 16801185 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
4.16 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.29 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.29 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.12 | 17405874 |
| MESH:D009402 |
Nephrosis, Lipoid |
|
Cyclosporine |
5.31 | 17954296 |
| MESH:D009404 |
Nephrotic Syndrome |
|
Cyclosporine |
3.70 | 18481113 19348381 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.26 | 18514411 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.89 | 20558911 |
| MESH:D010146 |
Pain |
|
Acetaminophen |
2.77 | 16870215 |
| MESH:D011230 |
Precancerous Conditions |
|
Cyclosporine |
3.64 | 12371664 |
| MESH:D011565 |
Psoriasis |
|
Cyclosporine |
2.34 | 16882103 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.56 | 19058328 |
| MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.50 | 10982225 |
| MESH:D014605 |
Uveitis |
|
Cyclosporine |
4.85 | 1336536 |
| MESH:D014985 |
Xerophthalmia |
|
Cyclosporine |
5.31 | 17120751 |
Related Pathway Information