AutismKB 2.0

Annotation Detail for UBTF


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Basic Information Top
Gene Symbol:UBTF ( NOR-90,UBF )
Gene Full Name: upstream binding transcription factor, RNA polymerase I
Band: 17q21.31
Quick LinksEntrez ID:7343; OMIM: 600673; Uniprot ID:UBF1_HUMAN; ENSEMBL ID: ENSG00000108312; HGNC ID: 12511
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
Transcription
Pathway IDPathway Name
200045Validated targets of C-MYC transcriptional activation
200191Regulation of retinoblastoma protein
Pathway IDPathway Name
P00022General transcription by RNA polymerase I
Pathway IDPathway Name
500575RNA Polymerase I Transcription Initiation
500574RNA Polymerase I Promoter Opening
500573RNA Polymerase I Promoter Clearance
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of UBTF mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of UBTF mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of UBTF mRNAaffects expression 16483693
D002118 Calcium Calcium affects the expression of UBTF mRNA alternative formaffects expression 15913539
D004958 Estradiol Estradiol affects the expression of UBTF mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of UBTF mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of UBTF mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UBTF mRNAaffects cotreatment|increases expression 17942748
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of UBTF mRNAdecreases expression 17616710
D011374 Progesterone Progesterone affects the expression of UBTF mRNAaffects expression 17251523
D013629 Tamoxifen Tamoxifen affects the expression of UBTF mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UBTF mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0815322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Estradiol 4.3411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3414692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6017868700
MESH:D001930 Brain Injuries Progesterone 4.4715665606 15380490 15845082
MESH:D001943 Breast Neoplasms Estradiol 1.9612948864 18497071 19861407 17289903 17261762 16675129 14630087 17018787
MESH:D001943 Breast Neoplasms Progesterone 1.9616175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tamoxifen 1.9619289846 20135344 18821012 19189210 16818667 19288272 18984771 15668708 19155303 20390343 17242785 17261762 18997820 20859285 19059307 18855134 20065188 19115204 18425577 19142967 18351453 19189212 19066611 17440819 19244106 18815881 20005174 19084267 19103187 11161223 21152245 19410462 19221464 18629630 16202921 16873071 19011961 20544844 16273361 19200415 17049068 21138602 17893378 19487384 15565566
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.743084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7416924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.7416924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8818566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0016919318 17333356 16105132 17110522 17681005 15861022 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 8697196 12621046 15340226 16354765
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6920423518
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.3519279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.3519279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.7117187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.3821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3816393943 19416960 16227642 18071297 14986274 11461765 12594235 11287661 19370779 16781746 19085960 12153990 15619225 19739265 16109766 14725611 19923254 15968718 16081117 11421492 12392966 17906064 19420014 17522070 19164858 14550746 16485898 12958197 17562736 10663392 2444490 10915739 16177239 12705907 11834606 11529661 10774834 18713872 11739529 11743745 12540782
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 16.5212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 16.5217692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.5219031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.7519148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.7517893378 16202921 19155303 20544844
MESH:D004715 Endometriosis Progesterone 9.4716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.479294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.2715345470
MESH:D005234 Fatty Liver Tamoxifen 8.2719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1116120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116959395 18606429 16354765 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6215869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Progesterone 8.7815869954
MESH:D007249 Inflammation Tamoxifen 8.7819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.7812878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.0716627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 6.1912587719 15629191
MESH:D007674 Kidney Diseases Estradiol 6.1915618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2616705839
MESH:D007680 Kidney Neoplasms Estradiol 13.2615610895
MESH:D007680 Kidney Neoplasms Tamoxifen 13.2618625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.3116316344
MESH:D008064 Lipidoses Tamoxifen 3.2715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008107 Liver Diseases Acetaminophen 1.6619460945 12969438 19784758 16610002 12587719 11587558 16611625 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms Tamoxifen 4.5816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2012151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.2918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2919555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.6011807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.6011408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 10.6019196722 11731420 19196723 14580682 16827153
MESH:D020149 Manganese Poisoning Estradiol 13.5519453300
MESH:D020149 Manganese Poisoning Tamoxifen 13.5519453300
MESH:D008545 Melanoma Tamoxifen 1.9012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4116810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009421 Nervous System Malformations Estradiol 10.1411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5912819281 16049721
MESH:D010024 Osteoporosis Calcium 3.8817882678
MESH:D010051 Ovarian Neoplasms Estradiol 5.0319401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.0317393432 16525653
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311399792 11222880 11896295 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1316740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1315067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6418551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4616709447
MESH:D013088 Spermatocele Tamoxifen 12.4616709447
MESH:D013119 Spinal Cord Injuries Progesterone 11.6816503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 11.6819457130
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 5.1815864552
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2316049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.2316712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
Pathway ID Pathway Name
REACT:1788 Transcription
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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