AutismKB 2.0

Annotation Detail for UCHL1


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Basic Information Top
Gene Symbol:UCHL1 ( PARK5,PGP 9.5,PGP9.5,PGP95,Uch-L1 )
Gene Full Name: ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Band: 4p13
Quick LinksEntrez ID:7345; OMIM: 191342; Uniprot ID:UCHL1_HUMAN; ENSEMBL ID: ENSG00000154277; HGNC ID: 12513
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05012Parkinson's disease
No data
Pathway IDPathway Name
200187Alpha-synuclein signaling
Pathway IDPathway Name
P00049Parkinson disease
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Nervous system diseases
Neurodegenerative diseases
H00057Parkinson's disease
Desease IDDesease Name
1709Parkinson disease
1712Yersinia infection
1740Alzheimer's disease
1766Renal Cell cancer
1848Embryoma
2053Colon cancer
2066Lung cancer
2086Lysosomal storage disease
Desease Name
Parkinson's disease
Huntington's disease
Alzheimer's disease
NEUROLOGICAL
No data
Desease Name
Parkinson disease, resistance to
Parkinson disease 5, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C017906 3-dinitrobenzene 3-dinitrobenzene affects the expression of UCHL1 mRNAaffects expression 16988215
C018599 4-methylcatechol 4-methylcatechol inhibits the reaction [resiniferatoxin results in decreased expression of UCHL1 protein]decreases expression|decreases reaction 18219259
D000082 Acetaminophen Acetaminophen affects the expression of UCHL1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of UCHL1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of UCHL1 mRNAincreases expression 15725085
C006780 bisphenol A bisphenol A results in decreased expression of UCHL1 mRNAdecreases expression 12075121
C004742 daidzein [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of UCHL1 mRNAaffects cotreatment|decreases expression 16963248
C014347 decitabine [[decitabine co-treated with trichostatin A] affects the methylation of UCHL1 promoter] which affects the expression of UCHL1 mRNAaffects cotreatment|affects expression|affects methylation 18666234
C014347 decitabine decitabine results in increased expression of UCHL1 mRNAincreases expression 19194470
D004041 Dietary Fats Dietary Fats results in increased expression of UCHL1 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of UCHL1 mRNAdecreases expression 12075121
D005419 Flavonoids Flavonoids results in increased expression of UCHL1 mRNAincreases expression 18035473
D005472 Fluorouracil UCHL1 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D019833 Genistein [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of UCHL1 mRNAaffects cotreatment|decreases expression 16963248
D019833 Genistein Genistein results in decreased expression of UCHL1 mRNAdecreases expression 12075121
C086566 glycitein [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of UCHL1 mRNAaffects cotreatment|decreases expression 16963248
D007657 Ketone Bodies Ketone Bodies results in increased expression of UCHL1 mRNAincreases expression 16807920
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of UCHL1 mRNAincreases expression 12634122
D016685 Mitomycin UCHL1 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D008942 Mitoxantrone UCHL1 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C041786 palm oil palm oil results in increased expression of UCHL1 mRNAincreases expression 18042831
D010656 Phenylephrine Phenylephrine results in increased expression of UCHL1 mRNAincreases expression 18158353
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of UCHL1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of UCHL1 mRNAdecreases expression 16985257
C024353 resiniferatoxin 4-methylcatechol inhibits the reaction [resiniferatoxin results in decreased expression of UCHL1 protein]decreases expression|decreases reaction 18219259
C024353 resiniferatoxin resiniferatoxin results in decreased expression of UCHL1 proteindecreases expression 18219259
C017947 sodium arsenite sodium arsenite results in increased expression of UCHL1 mRNAincreases expression 16014739
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of UCHL1 mRNAincreases expression 18495758
D013806 Theophylline Theophylline affects the expression of UCHL1 mRNAaffects expression 16988215
C024746 tobacco tar tobacco tar results in increased expression of UCHL1 mRNAincreases expression 19559774
D019772 Topotecan UCHL1 protein affects the susceptibility to Topotecanaffects response to substance 16217747
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in increased expression of UCHL1 mRNAincreases expression 17951470
C012589 trichostatin A [[decitabine co-treated with trichostatin A] affects the methylation of UCHL1 promoter] which affects the expression of UCHL1 mRNAaffects cotreatment|affects expression|affects methylation 18666234
D014810 Vitamin E Vitamin E results in increased expression of UCHL1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5711752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.2818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6617505938
MESH:D058186 Acute Kidney Injury resiniferatoxin 5.4118460982
MESH:D055371 Acute Lung Injury pirinixic acid 2.8618653653
MESH:D000230 Adenocarcinoma arsenic trioxide 12.7711798837 19825857
MESH:D000230 Adenocarcinoma daidzein 12.7711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.7714692618
MESH:D000230 Adenocarcinoma Fluorouracil 12.7717638652
MESH:D000230 Adenocarcinoma Genistein 12.7711473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.9716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6217306315 16712894
MESH:D000740 Anemia Fluorouracil 7.8815504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.8811748828
MESH:D000799 Angioedema Acetaminophen 3.5610982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.8717460149
MESH:D001161 Arteriosclerosis Dietary Fats 9.0015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.0011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4915885639
MESH:D001249 Asthma Theophylline 3.7812113382 9701106
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.8316206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.8319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.8312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5915746008
MESH:D001862 Bone Resorption bisphenol A 3.6111985600
MESH:D001919 Bradycardia Phenylephrine 4.2615306635
MESH:D001943 Breast Neoplasms bisphenol A 2.8217123778
MESH:D001943 Breast Neoplasms decitabine 2.8219208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 2.8220435547
MESH:D001943 Breast Neoplasms Fluorouracil 2.8218357371 19217205 18608205 16110121 16595493 16557594 15136595
MESH:D001943 Breast Neoplasms Genistein 2.8216873071 16541309 17200150
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8220435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0711589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.6616050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.3816051944
MESH:D002277 Carcinoma Fluorouracil 7.4617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.4616835633
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 18666234
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.353084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.3514691202 16217749 11135700 15073043 15553829
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.3516799960 16332177 18930000 17971768 17045692 17088986
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.3516924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.3516507464 17306315 15276417
MESH:D002278 Carcinoma in Situ bisphenol A 4.7117123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5919014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8918695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8812490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.1119215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.1117066447 18986760 16757204 16280240
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.1118572023
MESH:D006332 Cardiomegaly Phenylephrine 6.3717287366 15728586 11179087 17124262 16170337 11754973
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3718850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases daidzein 7.1616332659
MESH:D002318 Cardiovascular Diseases Genistein 7.1616332659
MESH:D002386 Cataract Acetaminophen 2.4210977129
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 10.432727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.4320056578 19524636
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 10.4319559774
MESH:D002637 Chest Pain Theophylline 5.5915238202
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.0611677210 17681005 17110522 15861022 16919318 17333356 16105132
MESH:D002779 Cholestasis pirinixic acid 7.0619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9916354765 15668235 12621046 8697196 15340226
MESH:D003110 Colonic Neoplasms decitabine 5.5517616700
MESH:D003110 Colonic Neoplasms Fluorouracil 5.5517018589 18772588 17169374 17287894 17172411 16510598 16340194 17725105 17016597 15001691
MESH:D003110 Colonic Neoplasms Genistein 5.5517182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.3220501625
MESH:D015179 Colorectal Neoplasms decitabine 3.3218981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.3218802399 18288408 17695437 14970324 16282729 18949393 20501625 17454858 16524972 18509181 17094418 18383874 15148649 18448328 16391804 17255274 16303861 17401013 17016601 15289873 16331619 17594712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8314669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.5910525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5920055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.5919769572
MESH:D007644 Darier Disease Fluorouracil 4.5116733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8415213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 6.8416647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.8416647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8417107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.2812705907 19739265 17906064 16781746 12153990 12392966 11743745 17522070 10663392 2444490 11739529 11834606 11529661 16109766 12540782 10774834 18713872 17562736 18071297 16227642 14550746 16081117 19420014 11461765 10915739 16393943 19923254 11287661 16177239 19370779 19085960 15968718 16485898 15619225 12594235 12958197 19416960 11421492 14725611 14986274 19164858
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.2820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2618367378
MESH:C538011 Eales disease Vitamin E 4.429068938
MESH:D004487 Edema pirinixic acid 5.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.7212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9212538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.0819294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.0819294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.3116402032
MESH:D016889 Endometrial Neoplasms daidzein 7.3911473722
MESH:D016889 Endometrial Neoplasms Genistein 7.3911473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7810568697 9294722
MESH:D007172 Erectile Dysfunction daidzein 4.7514972507
MESH:D004938 Esophageal Neoplasms marker/mechanism 15930319
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.3512903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.3516481741 15173087 16785472 17638652 16337965
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8111564622
MESH:D005234 Fatty Liver arsenic trioxide 16.7115073043
MESH:D005234 Fatty Liver Dietary Fats 16.7118296743 19551842 19004024 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.7115345470
MESH:D005234 Fatty Liver pirinixic acid 16.7119236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D005355 Fibrosis Dietary Fats 7.7118296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.7120067830
MESH:D005706 Gallbladder Neoplasms marker/mechanism 16965602
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0016904648
MESH:D005756 Gastritis Acetaminophen 3.3916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4016452187
MESH:D005909 Glioblastoma Genistein 6.9116598420
MESH:D005909 Glioblastoma trichostatin A 6.9118801729
MESH:D005910 Glioma Fluorouracil 2.7616145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.2819215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.2818337622 15102660 15162350
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0810048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.0816080930
MESH:D006331 Heart Diseases Mitoxantrone 3.9616019553
MESH:D006333 Heart Failure pirinixic acid 2.3720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006529 Hepatomegaly pirinixic acid 7.3516221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.3515340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic marker/mechanism 18958481
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6016863852 16490937
MESH:D006689 Hodgkin Disease sodium arsenite 2.9312676792
MESH:D019584 Hot Flashes Vitamin E 3.6914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7618606429 16354765 15340226 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.4816870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3421332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.3621332399
MESH:D006973 Hypertension daidzein 8.1917169123
MESH:D006973 Hypertension Phenylephrine 8.198949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1918670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.3018502941 12791704
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5416569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2012013081
MESH:D007248 Infertility, Male 3-dinitrobenzene 19.2116988215
MESH:D007248 Infertility, Male decitabine 19.2117581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 19.2117937319
MESH:D007248 Infertility, Male sodium arsenite 19.2112646999 15346721
MESH:D007248 Infertility, Male Theophylline 19.2116988215
MESH:D007249 Inflammation Dietary Fats 7.4620412841
MESH:D007249 Inflammation Flavonoids 7.4617296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.4612200463 12878042
MESH:D007251 Influenza, Human Vitamin E 3.9316624496
MESH:D007333 Insulin Resistance bisphenol A 11.2916393666
MESH:D007333 Insulin Resistance Dietary Fats 11.2918457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 11.2916306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0916580747
MESH:D007674 Kidney Diseases Acetaminophen 9.1315629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 9.1320008137
MESH:D007674 Kidney Diseases Vitamin E 9.1312488133
MESH:D007680 Kidney Neoplasms Fluorouracil 3.0916985049
MESH:D007938 Leukemia arsenic trioxide 9.7315070760
MESH:D007938 Leukemia decitabine 9.7319235587 18980019
MESH:D007938 Leukemia Genistein 9.7318980019 17468513
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.6718172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5517077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.7619077051
MESH:D007951 Leukemia, Myeloid decitabine 8.7619117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.9317050201 19850784 20471514 16968895 16467208
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.9318206229 17679729 19010910 18460780 19387464 18704418
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 5.9318206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1818055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0316330433 12679006 19075265 19225113 17649720 16966277 11468182 16823087 12712474 17869043 12018890 11161223 17712046 15622746 16112521 17107899 19642359 16331271 16891316 15213294 17217047 15336539 9834237 19035177 15748426
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0916882451
MESH:D008103 Liver Cirrhosis Dietary Fats 2.7318296743
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.6417823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.6415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.6412878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.6416169303
MESH:D008107 Liver Diseases Acetaminophen 1.5616610002 19014921 19784758 12969438 12587719 16611625 11587558 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9917185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 16.5714682389
MESH:D008113 Liver Neoplasms Fluorouracil 16.5715113037 16603448 18383874 17045692
MESH:D008113 Liver Neoplasms Mitomycin 16.5715113037
MESH:D008113 Liver Neoplasms pirinixic acid 16.5715890375 16377806 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 16.5716712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.5716984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.2320377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.2312151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1415213294
MESH:D008171 Lung Diseases sodium arsenite 6.8219095001
MESH:D008171 Lung Diseases Vitamin E 6.8216863852
MESH:D008175 Lung Neoplasms arsenic trioxide 6.2011798837 19825857
MESH:D008175 Lung Neoplasms Fluorouracil 6.2015246190
MESH:D008175 Lung Neoplasms sodium arsenite 6.2016712894 17306315 19931552 15276417 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.2019555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 6.2011062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5115086387
MESH:D008223 Lymphoma decitabine 3.2219470736
MESH:D008325 Mammary Neoplasms, Experimental Genistein 2.7714578162 12929590
MESH:D008545 Melanoma decitabine 4.9516505122 17785578
MESH:D008545 Melanoma sodium arsenite 4.9516487513 19082730
MESH:D008545 Melanoma trichostatin A 4.9516505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2919513568
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.6117671175
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4216757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 11.0914977855 19417148 15949261 11468182 19549372
MESH:D009101 Multiple Myeloma decitabine 11.0918172295
MESH:D009101 Multiple Myeloma trichostatin A 11.0918172295
MESH:D009135 Muscular Diseases pirinixic acid 3.2316239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.9716882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 6.9719157545 16882708 19010910 18608210
MESH:D009203 Myocardial Infarction Genistein 5.2817141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.2819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8012213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.6917141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.6916411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6916624393
MESH:D009369 Neoplasms decitabine 14.2619116145 17925555 19470736
MESH:D009369 Neoplasms Fluorouracil 14.2618239605 18600527 16928823
MESH:D009369 Neoplasms Mitoxantrone 14.2616640825
MESH:D009369 Neoplasms pirinixic acid 14.2617405874
MESH:D009369 Neoplasms sodium arsenite 14.2611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3920056578
MESH:D009410 Nerve Degeneration 3-dinitrobenzene 5.1811301198
MESH:D009421 Nervous System Malformations bisphenol A 14.8711399458 16427766
MESH:D009421 Nervous System Malformations Genistein 14.8716427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.8714600291
MESH:D009436 Neural Tube Defects arsenic trioxide 6.7310525206
MESH:D009436 Neural Tube Defects sodium arsenite 6.7312854658
MESH:D009447 Neuroblastoma Topotecan 3.7115176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6518514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2516436463
MESH:D009765 Obesity Dietary Fats 4.1920132043 21332399 11836018 20518802 17217161 19632207 18457598 16723640 18674790
MESH:D009765 Obesity pirinixic acid 4.1920558911
MESH:D010024 Osteoporosis Genistein 3.0819401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8316169203
MESH:D010049 Ovarian Diseases bisphenol A 4.7111985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 14.0216624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms decitabine 14.0219259094 19331143
MESH:D010051 Ovarian Neoplasms Genistein 14.0219005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 14.0215276417 17306315
MESH:D010051 Ovarian Neoplasms trichostatin A 14.0219331143
MESH:D010146 Pain Acetaminophen 2.1716870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 15.2515580305
MESH:D010190 Pancreatic Neoplasms decitabine 15.2519294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.2515113037 16929163 19003803 16500647
MESH:D010190 Pancreatic Neoplasms Mitomycin 15.2515113037
MESH:D010190 Pancreatic Neoplasms trichostatin A 15.2519294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4311578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9019927285
MESH:D010300 Parkinson Disease marker/mechanism
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D010523 Peripheral Nervous System Diseases 4-methylcatechol 10.5718219259
MESH:D010523 Peripheral Nervous System Diseases resiniferatoxin 10.5718219259
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.5810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.5811118676 11222880 11896295 11399792
MESH:D055728 Primary Myelofibrosis decitabine 11.5117616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.5117616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.9620887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0619131511
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0619082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 2.0615378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0616039940
MESH:D011471 Prostatic Neoplasms trichostatin A 2.0619789329 18798265
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0615084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.0315861022 16919318
MESH:D011629 Puberty, Precocious bisphenol A 4.5110548101
MESH:D029424 Pulmonary Disease, Chronic Obstructive Theophylline 4.9218983928
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7815538739 16160472 18722050 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 6.7819058328
MESH:D015427 Reperfusion Injury resiniferatoxin 6.7818460982
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.1419155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6916646077
MESH:D012852 Sinusitis Phenylephrine 4.427327846
MESH:D012871 Skin Diseases Vitamin E 2.3718709164
MESH:D012878 Skin Neoplasms sodium arsenite 5.1519524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6616709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5812854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.2817007042
MESH:D013274 Stomach Neoplasms decitabine 3.2819037991
MESH:D013274 Stomach Neoplasms Fluorouracil 3.2816951190 18567086 18396642 17172411 17498489 17522103 19084572 15786421 16424979 19015929
MESH:D020521 Stroke Vitamin E 3.3016517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.7116045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.6219014326
MESH:D013964 Thyroid Neoplasms decitabine 6.6217967635
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7516280240
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6815213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.7412845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms decitabine 7.7419087683 17616700
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.7416712894 16452187 11723127 17306315
MESH:D014581 Urticaria Acetaminophen 2.7210982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.6816803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.6811813266
MESH:D014591 Uterine Diseases bisphenol A 4.7214652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0314692618
MESH:D014604 Uveal Neoplasms decitabine 4.6317785578
MESH:D014652 Vascular Diseases sodium arsenite 4.1417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2914671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
MESH:D015430 Weight Gain Dietary Fats 3.5016723640
Pathway ID Pathway Name
KEGG:05012 Parkinson's disease
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37160
    • No data
    No data
    Releated drug ID Related drug Name
    PA449092colchicine
    PA449396dopamine
    PA451578tacrolimus
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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