AutismKB 2.0

Annotation Detail for UCHL3


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Basic Information Top
Gene Symbol:UCHL3 ( UCH-L3 )
Gene Full Name: ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Band: 13q22.2
Quick LinksEntrez ID:7347; OMIM: 603090; Uniprot ID:UCHL3_HUMAN; ENSEMBL ID: ENSG00000118939; HGNC ID: 12515
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of UCHL3 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of UCHL3 mRNAaffects expression 16483693
C018021 cobaltous chloride cobaltous chloride results in decreased expression of UCHL3 proteindecreases expression 16622835
D016572 Cyclosporine Cyclosporine results in increased expression of UCHL3 mRNAincreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of UCHL3 mRNAdecreases expression 20360939
C006253 pirinixic acid pirinixic acid results in increased expression of UCHL3 mRNAincreases expression 18301758
C031280 pyrazole pyrazole results in increased expression of UCHL3 mRNAincreases expression 17945193
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000236 Adenoma Diethylnitrosamine 2.9910737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.4516434500 18056438 19061943 19052882 17620307 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.4516434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1016705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1016288022 20214788 19335982 18978308 17428255 16830150 19822196 20432363 16878318 16540662 17761372 20101231 18210153 18971187 16681979 16935385 19919837 20512989 19394651 19418558 3084413 17055752 16807293 19208518 18788625 16569478 18506893 18665156 19701751 19107877 3581430 10737359 18056438 18494052 18691550 17162532 19519916 10672840 20935162 16698587 16502159 19383236 18785209 18393292 19052882 20524982 16328049 17978847 20727157 19539802 20514400 20084675 17138121 19171122 16779866 20007298 21159647 11831363 17173139
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.246135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.2412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.247505956 2727394 17174075 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9319052882
MESH:D002779 Cholestasis Cyclosporine 8.4419486331
MESH:D002779 Cholestasis pirinixic acid 8.4419176532
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 4.3816823706 11298694 15059100
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2420387270
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.7821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.7819107877
MESH:D056486 Drug-Induced Liver Injury pyrazole 6.7812499123
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D005234 Fatty Liver Cyclosporine 14.7519224547
MESH:D005234 Fatty Liver Diethylnitrosamine 14.7521071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 14.7519236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.5012639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006529 Hepatomegaly pirinixic acid 3.3519772884 16221962 18467677 19176532
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007249 Inflammation Diethylnitrosamine 2.5018785209
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4818776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 8.0612371664
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9620032147 19638242 18665156 18407596 18522880
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1517034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.927678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.9219642983 16942905 18977376 12771043 21167192 19833225 19090486 20137499 19996281 19073162 18648771 19638242 20118626 10737359 18978307 19427195 19850985 19294768 21071580 19812893 19255062 19256749 20434301 20492335 20583210 21278145 20101389 19499222 2862719 19426721 2422723 9163691 20501860 18754104 19254457 20405173 19551842 21047994 15175105 12112319 15885732 19690152 18644402 20452335
MESH:D008113 Liver Neoplasms pirinixic acid 7.9220007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.462876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.469362446 18093689 18282651 19126423 21159647 16267830 17854601 3124819 19519916 18544905 17174075 18253720 16842330 17942915 2563599 18775883 18308698 19009564 19539802 18164116 19004024 18079962
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7621163286 6695378 20512841 20970405
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2618551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.663581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7016049721
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5016540662
MESH:D011230 Precancerous Conditions Cyclosporine 9.7912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.792563599
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013733 Testicular Diseases pyrazole 5.216499806
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.197505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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