AutismKB 2.0

Annotation Detail for UGP2


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Basic Information Top
Gene Symbol:UGP2 ( UDPG,UDPGP2,UGPP2,pHC379 )
Gene Full Name: UDP-glucose pyrophosphorylase 2
Band: 2p15
Quick LinksEntrez ID:7360; OMIM: 191760; Uniprot ID:UGPA_HUMAN; ENSEMBL ID: ENSG00000169764; HGNC ID: 12527
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5067glycogen biosynthesis II (from UDP-D-Glucose)
COLANSYN-PWYcolanic acid building blocks biosynthesis
Pathway IDPathway Name
hsa00520Amino sugar and nucleotide sugar metabolism
hsa00040Pentose and glucuronate interconversions
hsa01100Metabolic pathways
hsa00052Galactose metabolism
hsa00500Starch and sucrose metabolism
Pathway IDPathway Name
Metabolism of carbohydrates
Biological oxidations
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of UGP2 mRNAdecreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of UGP2 mRNAaffects expression 21346803
D015081 2-Naphthylamine 2-Naphthylamine results in increased expression of UGP2 mRNAincreases expression 18247414
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of UGP2 mRNAincreases expression 18247414
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of UGP2 mRNAaffects expression 17484886
D002995 Clofibric Acid Clofibric Acid affects the expression of UGP2 mRNAaffects expression 17602206
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of UGP2 mRNAincreases expression 17654400
D004052 Diethylnitrosamine [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of UGP2 proteinaffects cotreatment|increases expression 20935162
D004610 Ellagic Acid Ellagic Acid results in decreased expression of UGP2 mRNAdecreases expression 12002526
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of UGP2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UGP2 mRNAaffects cotreatment|increases expression 17942748
C002950 methylformamide methylformamide analog results in increased expression of UGP2 mRNAincreases expression 17040096
C002950 methylformamide methylformamide results in increased expression of UGP2 mRNAincreases expression 17040096
D009151 Mustard Gas Mustard Gas results in increased expression of UGP2 mRNAincreases expression 18988085
D009538 Nicotine Nicotine results in increased expression of UGP2 mRNAincreases expression 18247414
D010634 Phenobarbital [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of UGP2 proteinaffects cotreatment|increases expression 20935162
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of UGP2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of UGP2 mRNAdecreases expression 18445702
C059514 resveratrol resveratrol results in decreased expression of UGP2 mRNAdecreases expression 12002526
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UGP2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of UGP2 mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 14.227525203
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 14.226195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 14.2215322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D058186 Acute Kidney Injury resveratrol 3.8316538975
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1620464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1614692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 15.883712494
MESH:D000236 Adenoma Benzo(a)pyrene 15.886695378
MESH:D000236 Adenoma Diethylnitrosamine 15.8810737359 6695378
MESH:D000236 Adenoma resveratrol 15.8815688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 24.8217620307 16434500 17162532 19052882 18056438 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 24.8217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 24.8216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 24.8216835633
MESH:D000544 Alzheimer Disease Nicotine 4.6816627626
MESH:D000544 Alzheimer Disease resveratrol 4.6816162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0619183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3215885639
MESH:D001169 Arthritis, Experimental resveratrol 7.3217115116
MESH:D001249 Asthma Mustard Gas 2.7010378619
MESH:D050197 Atherosclerosis resveratrol 3.2616873680 17967414
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.021440618 11289319
MESH:D001768 Blister Mustard Gas 5.1519167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D002545 Brain Ischemia resveratrol 4.2717600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9420146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9417474063
MESH:D001943 Breast Neoplasms resveratrol 1.9417534123 16393696 17651959
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.1515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.9817687719 10378619
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7716097048 15673190 16011737 16192424 18705752 15721981 16124888 16227642 16050911 15700767 10355542 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.857296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.8518788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.8520727157 19822196 19208518 19701751 18665156 17978847 18506893 17173139 20524982 3581430 19107877 19052882 19383236 18210153 18494052 17138121 10672840 19335982 20007298 21159647 16502159 18393292 18056438 17761372 18978308 16779866 20101231 16288022 17162532 19539802 20514400 19171122 17055752 3084413 18785209 18691550 16681979 16878318 16328049 11831363 20084675 19394651 20432363 20935162 18788625 19519916 18971187 16935385 20214788 16569478 20512989 16830150 16540662 16807293 19919837 19418558 17428255 10737359 16698587
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.8517173139 6705139 20007298 20935162 1701930
MESH:D006528 Carcinoma, Hepatocellular resveratrol 8.8519321006 16227395
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.5816675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.667296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7020419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.7016227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases resveratrol 3.4615458977
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.6214694615
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.647505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.642727394 17174075 21159647 7505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.244080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.289022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.2817110522 15861022 17333356 16919318 11677210 16105132 17681005
MESH:D002779 Cholestasis pirinixic acid 13.2819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0915668235 8697196 12621046 16354765 15340226
MESH:D003092 Colitis resveratrol 4.1116474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4516338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.1315095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.1314669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.7416507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 15322242 10048152
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.792524372 11298694 14531868 8970840 11906362 8156756 12868966 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.472952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.7516873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2017107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.9416286809
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.219022650 16192314 6482804 18648102 11289319 6679447 18692083 1440618 18289764 9328219 8291058 7440962 9653073
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 15.2121346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.217179309 11566570 6884620 3786805 10915739 2869522 15027814 19085960 10092053 15968718 16177239 3732212 16227642 4309450 17522070 15998439 21278145 6623471 7120509 9327722 19336974 7440962
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 15.2117654400
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.2119107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.2120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004421 Dystonia Phenobarbital 3.991851702
MESH:D020821 Dystonic Disorders Nicotine 5.9217881519
MESH:D004487 Edema Mustard Gas 16.3011428631 9260866 11402378 11428647
MESH:D004487 Edema pirinixic acid 16.3012083418
MESH:D004487 Edema resveratrol 16.308985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.3012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9018230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 9.0717872969
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0010568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.8317923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.093659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.8711558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.8820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.526401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.247750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.013659116
MESH:D004890 Erythema Mustard Gas 5.159357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1216302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.343581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.6115959796 16045604 12631006 19224547 17595544 61145 16239168 12795759
MESH:D005234 Fatty Liver Diethylnitrosamine 18.6120387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.6115345470
MESH:D005234 Fatty Liver pirinixic acid 18.6119236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.026705139
MESH:D005355 Fibrosis Carbon Tetrachloride 8.5518705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.5520067830
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.027505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4111294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.176705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.1719900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 14.3116109766
MESH:D006529 Hepatomegaly pirinixic acid 14.3118467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.3116120746 12621046 15340226
MESH:D006561 Herpes Simplex resveratrol 4.1716876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0516354765 15340226 8697196 18606429 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5216899240
MESH:D006937 Hypercholesterolemia resveratrol 3.9917188708
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006949 Hyperlipidemias resveratrol 4.0116873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9215034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0715338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.2817488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.6317600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4717937319
MESH:D007249 Inflammation Diethylnitrosamine 11.9018785209
MESH:D007249 Inflammation Mustard Gas 11.909260866 11428631 11428620 9357497 11402378 8975870 17524151 11428647 16001271
MESH:D007249 Inflammation resveratrol 11.9016366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.9012200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.5416624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6216306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.029022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.956582329
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.5616087638
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.9511903743 17174718 17157831 16221502 16943688 17334410 21278145 16239168 11408273
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.9518407596 20032147 19638242 18665156 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 10.9521047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.3718006644 15730626 12649538 16033810 18395095 18418968 14512876 18395914 15370692 12958196 18705752 17805973 18472332 17766677 17698563 16097048 18481824 12632512 20821823 17900296 15057751 18251166 17481882 12586293 12609069 15650968 17823541 18205269 18420326 15893842 18054572 12898905 12389079 13678700 15931870 16638106 17869086 15338365 14716496 15996030 16136751 18279442 14716833 17721639 11481614 10355542 16015684 15123356 17944888 18339082 18472094 17714472 14748882 16192424 12445418 18210741 15925388 15052691 18166357 15959796 18277467 12741479 12666154 17565644 14724832 15362042 14620537 17557913 18429990 17922224 18156304 18317297 18263696 18187930 16248980 15673190 17976157 12546737 16027843 16116963 17631135 17761835 15876570 16011737 17708605 18412020 18376398 15818738 12445421 17640975 17525996 12632514 12667390
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3712878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.5216246199 15830285 16964402 17285989 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 6.5217034775
MESH:D008107 Liver Diseases Phenobarbital 6.5219363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6714706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 25.8820195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 25.8819294768
MESH:D008113 Liver Neoplasms Clofibric Acid 25.8817602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 25.8820434301 20137499 19256749 12112319 19255062 19812893 20118626 18644402 18978307 19690152 16942905 20452335 19426721 19638242 21167192 19499222 20501860 12771043 15175105 18754104 19642983 21047994 15885732 19833225 19427195 19073162 19294768 19996281 2862719 21278145 19090486 20101389 2422723 20405173 18648771 20492335 20583210 19254457 10737359 19551842 21071580 9163691 18977376 19850985
MESH:D008113 Liver Neoplasms Phenobarbital 25.8819812893 15975961 19073162 19482888 21047994 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 25.8816377806 15890375 20007298
MESH:D008113 Liver Neoplasms resveratrol 25.8819812893 20405173 19073162 19321006
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 25.8816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 18.513712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 18.5112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.5117854601 18093689 17174075 18544905 21159647 3124819 19539802 18775883 19004024 18079962 16842330 18164116 18253720 19009564 18282651 18308698 16267830 17942915 9362446 2563599 19519916 19126423
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 18.516150874 17172636 2563599 1399818 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.5112151625
MESH:D008171 Lung Diseases Mustard Gas 3.4318161513 18702808
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8220464547 20869020 17053015 20135361 18520028 6695378 18569708 18816296 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.8221163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Mustard Gas 4.823148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8219555203 11884234
MESH:D016393 Lymphoma, B-Cell resveratrol 4.2817088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8514749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.2415688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.108985016 11606380
MESH:D008545 Melanoma resveratrol 2.3617992120
MESH:D008659 Metabolic Diseases resveratrol 4.3617112576
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1716381670
MESH:D009101 Multiple Myeloma resveratrol 3.4514749477 16267019 17049120 17164350 16490592 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.8617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.7119151258
MESH:D009203 Myocardial Infarction resveratrol 5.7117188708 16456233 16525036 16317513 17125593 17015251
MESH:D017202 Myocardial Ischemia resveratrol 8.9517125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.9512213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9316411023
MESH:D009205 Myocarditis resveratrol 4.7517322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4717484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.673581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.679029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 8.2811141357
MESH:D009369 Neoplasms Nicotine 8.2816365874
MESH:D009369 Neoplasms pirinixic acid 8.2817405874
MESH:D009374 Neoplasms, Experimental resveratrol 3.998985016
MESH:D009389 Neovascularization, Pathologic Nicotine 4.9816365874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2014600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.906679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4720387270
MESH:D019636 Neurodegenerative Diseases resveratrol 8.4717652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.3817929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1220387270
MESH:D009503 Neutropenia Mustard Gas 3.957688884 16761898
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.076482804 4026338
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.0714694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.023988306
MESH:D010018 Osteomalacia Phenobarbital 4.3617016548
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.2417513867
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.2416540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.2416965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.477296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.476228378
MESH:D011041 Poisoning Mustard Gas 3.7815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.032563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.032563599
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.5616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5611222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3217292933
MESH:D011471 Prostatic Neoplasms resveratrol 3.3217636462 17675339 17804756 15767336 17718901 16731767
MESH:D011537 Pruritus Ethinyl Estradiol 9.5016919318 15861022
MESH:D011537 Pruritus Mustard Gas 9.5018058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.5012752131
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9210334151 17894541 17620002 17720292 17266442
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.5816325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.5419058328
MESH:D015427 Reperfusion Injury resveratrol 6.5417520802 15827377 16314181 17058453 16317513
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.363692021
MESH:D012640 Seizures Nicotine 6.3417873105
MESH:D012640 Seizures Phenobarbital 6.3411442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.816407741
MESH:D012871 Skin Diseases Mustard Gas 2.7115451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.3910029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 9.398985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.3916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9416709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.332093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3318456281
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.4616321402
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.867505956 3712494 6587162 6582329 1399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.867505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.861399818
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.7111259349 16785264 16720336
MESH:D014029 Tobacco Use Disorder Nicotine 5.4315735609 18305452 18041664 17979512
MESH:D014062 Tongue Neoplasms resveratrol 4.1916227395
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 8.4111144890
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.418074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.4117053015
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.0817473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.4414692618
MESH:D014594 Uterine Neoplasms resveratrol 9.4417044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.2917488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
Pathway ID Pathway Name
KEGG:00520 Amino sugar and nucleotide sugar metabolism
REACT:13433 Biological oxidations
KEGG:00052 Galactose metabolism
KEGG:01100 Metabolic pathways
REACT:474 Metabolism of carbohydrates
KEGG:00040 Pentose and glucuronate interconversions
KEGG:00500 Starch and sucrose metabolism
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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