AutismKB 2.0

Annotation Detail for UGT2B4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:UGT2B4 ( HLUG25,UDPGT2B4,UDPGTH1,UGT2B11 )
Gene Full Name: UDP glucuronosyltransferase 2 family, polypeptide B4
Band: 4q13.3
Quick LinksEntrez ID:7363; OMIM: 600067; Uniprot ID:UD2B4_HUMAN; ENSEMBL ID: ENSG00000156096; HGNC ID: 12553
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00140Steroid hormone biosynthesis
hsa00860Porphyrin and chlorophyll metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00040Pentose and glucuronate interconversions
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
hsa00053Ascorbate and aldarate metabolism
hsa00500Starch and sucrose metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of UGT2B4 proteinaffects expression 20106945
D000654 Amobarbital UGT2B4 protein results in increased glycosylation of Amobarbitalincreases glycosylation 15013842
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of UGT2B4 mRNAdecreases expression 20106945
C043211 carvedilol UGT2B4 protein results in increased glucuronidation of carvedilolincreases glucuronidation 14744946
D002635 Chenodeoxycholic Acid Chenodeoxycholic Acid results in increased expression of UGT2B4 mRNAincreases expression 17058234
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of UGT2B4 mRNAincreases expression 17851650
D016572 Cyclosporine Cyclosporine affects the expression of UGT2B4 mRNAaffects expression 20106945
D004317 Doxorubicin Doxorubicin results in decreased expression of UGT2B4 mRNAdecreases expression 16404146
D004391 Dust Dust results in increased expression of UGT2B4 mRNAincreases expression 17805423
D004958 Estradiol Estradiol results in decreased expression of UGT2B4 mRNAdecreases expression 20106945
D005204 Farnesol UGT2B4 protein results in increased glucuronidation of Farnesolincreases glucuronidation 15320866
D011345 Fenofibrate Fenofibrate results in increased expression of UGT2B4 mRNAincreases expression 17058234
D005480 Flurbiprofen UGT2B4 protein results in increased glucuronidation of Flurbiprofenincreases glucuronidation 15843492
D005978 Glutathione Glutathione deficiency results in increased expression of UGT2B4 mRNAincreases expression 15345336
D007052 Ibuprofen UGT2B4 protein results in increased glucuronidation of Ibuprofenincreases glucuronidation 15843492
D007657 Ketone Bodies Ketone Bodies results in decreased expression of UGT2B4 mRNAdecreases expression 16807920
D007660 Ketoprofen UGT2B4 protein results in increased glucuronidation of Ketoprofenincreases glucuronidation 15843492
D009288 Naproxen UGT2B4 protein results in increased glucuronidation of Naproxenincreases glucuronidation 15843492
C115070 SX 3030 UGT2B4 protein results in increased glycosylation of SX 3030increases glycosylation 15013842
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of UGT2B4 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7611752688 15322242 14514962
MESH:D058186 Acute Kidney Injury Ibuprofen 9.296375363
MESH:D058186 Acute Kidney Injury Naproxen 9.297897758
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.0620127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 10.0617418594
MESH:D000230 Adenocarcinoma Estradiol 10.0611473722
MESH:D000230 Adenocarcinoma Ibuprofen 10.0610697514
MESH:D000236 Adenoma Benzo(a)pyrene 2.606695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2916835633
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 4.9910680582
MESH:D000419 Albuminuria Doxorubicin 4.4621441931
MESH:D000544 Alzheimer Disease Ibuprofen 3.1518351690
MESH:D000707 Anaphylaxis Ibuprofen 5.169532969
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8711748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001321 Autistic Disorder Glutathione 3.0218929414 16917939 19056591 19267885
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.6214601052
MESH:D002545 Brain Ischemia Ibuprofen 4.8015837124
MESH:D001932 Brain Neoplasms Doxorubicin 3.7317150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9217474063 20146248
MESH:D001943 Breast Neoplasms Doxorubicin 1.9215634643 16322301 16935488 17426702 18695136 16595493 18628466 15692762 16264153 16826403 11325840 15993339 18234424 15994142 19526202 18382427 17369602 15567936 16096432 15136595 15668708 17983394 15939500 16115903
MESH:D001943 Breast Neoplasms Estradiol 1.9216675129 14630087 17261762 17289903 19861407 18497071 12948864 17018787
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D002100 Cachexia Ibuprofen 5.3815141370
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3816111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.7316051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7316835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.5712619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.5716234567 16023760 17876044 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5716924424
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.1216201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.5420419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.546189445
MESH:D002294 Carcinoma, Squamous Cell Glutathione 7.5417015178
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3216120746 18850075 18670907
MESH:D009202 Cardiomyopathies carvedilol 8.3715476868
MESH:D009202 Cardiomyopathies Doxorubicin 8.3716364871 15811867 17329180 17974986 17308081 16242529 15476868 17924179 17131338 16612575 17519947 16109756 17928571 16455267 16651473 15505089 17382496 16731534 17007740 17351982 16269455 18627295 15792986 16278810 16952015
MESH:D002311 Cardiomyopathy, Dilated carvedilol 6.4819477965
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 6.4816243910 17334414
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.3712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.3718566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0816835633
MESH:D002779 Cholestasis Cyclosporine 2.8519486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0712621046 8697196 15668235 16354765 15340226
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D003550 Cystic Fibrosis Glutathione 4.4119747007
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3319279558
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 6.2117851650
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.2117416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2120420201
MESH:D004362 Drug Toxicity Doxorubicin 7.8918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.8911462148
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.5318446180 16133044 18450898
MESH:D050171 Dyslipidemias Fenofibrate 4.3616707586
MESH:D004487 Edema Ketoprofen 7.147990266
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8218230668 16714409 15322242
MESH:D016889 Endometrial Neoplasms Doxorubicin 12.2817359293
MESH:D016889 Endometrial Neoplasms Estradiol 12.2811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Fenofibrate 12.2816569247
MESH:D004715 Endometriosis Ibuprofen 15.1215652904
MESH:D004715 Endometriosis Naproxen 15.1215652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 15.129294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0818037988
MESH:D019446 Endotoxemia Ibuprofen 4.8811545620
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9511564622
MESH:D005234 Fatty Liver Cyclosporine 2.7719224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005334 Fever Ibuprofen 4.5016997862
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.5019069698
MESH:D005355 Fibrosis Cyclosporine 8.1912639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1920067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D005909 Glioblastoma Doxorubicin 3.2917150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.4715692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2911294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.4214766674 16330681 18674790 18006777 16879835 17888722 16144979 17875725 16495754 12587719 16244372 16707910 16244371
MESH:D006333 Heart Failure Doxorubicin 3.2917481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8215692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8116120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.9515709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.3318501091 15147373 17606976
MESH:D019584 Hot Flashes Estradiol 3.6717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.968697196 15340226 16354765 18606429 16959395
MESH:D006973 Hypertension carvedilol 8.6016640825
MESH:D006973 Hypertension Cyclosporine 8.6010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.6018670907 18850075
MESH:D006984 Hypertrophy Ibuprofen 4.8916672835
MESH:D007235 Infant, Premature, Diseases Ibuprofen 5.7516133044
MESH:D007249 Inflammation Flurbiprofen 11.7811099482
MESH:D007249 Inflammation Ibuprofen 11.783291741
MESH:D007249 Inflammation Naproxen 11.783291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.7812878042 12200463
MESH:D007333 Insulin Resistance Estradiol 2.9116393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007674 Kidney Diseases Cyclosporine 9.808314463 18776723 10903974
MESH:D007674 Kidney Diseases Doxorubicin 9.8015369732 16775033 15699352
MESH:D007674 Kidney Diseases Estradiol 9.8015618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0716707910
MESH:D007680 Kidney Neoplasms Cyclosporine 7.0312371664
MESH:D007680 Kidney Neoplasms Estradiol 7.0315610895
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0816085563
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.9216595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 4.9215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9212878042
MESH:D008107 Liver Diseases Naproxen 3.8916867024
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.4615890375 18177683 9163691 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.4620195826 21137059
MESH:D008113 Liver Neoplasms Fenofibrate 10.4618978307
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.4616984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 13.738603461
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 13.7317085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 13.7318253720 18775883
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.7312151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.7614755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.7620464547 18816296 18520028 17053015 20869020 6695378 18569708 20135361 20064080
MESH:D008175 Lung Neoplasms Doxorubicin 4.766189445 17418594
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7611884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.4016098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4815621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.8115458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.8111408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 9.8110697514
MESH:D020149 Manganese Poisoning Estradiol 4.4019453300
MESH:D008545 Melanoma Doxorubicin 2.2816827129
MESH:D008654 Mesothelioma Doxorubicin 3.0217638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D008881 Migraine Disorders Naproxen 4.8218803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4215792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D052016 Mucositis Doxorubicin 4.7017415656
MESH:D009203 Myocardial Infarction Doxorubicin 2.9119429709 15857846
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2116810080
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.9218259882
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1311141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6517289903
MESH:D009395 Nephritis, Interstitial Ibuprofen 4.906375363
MESH:D009401 Nephrosis Doxorubicin 4.6816636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.0419348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.0416889571 15640375
MESH:D009410 Nerve Degeneration Ibuprofen 4.3210961664
MESH:D009421 Nervous System Malformations Estradiol 9.1816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.1814600291
MESH:D009447 Neuroblastoma Doxorubicin 3.2215555623
MESH:D010003 Osteoarthritis Ibuprofen 4.087009135
MESH:D012516 Osteosarcoma Doxorubicin 4.0415930896
MESH:D010051 Ovarian Neoplasms Estradiol 2.1919401270
MESH:D010146 Pain Ibuprofen 7.563291741
MESH:D010146 Pain Naproxen 7.563291741
MESH:D010149 Pain, Postoperative Ibuprofen 5.0616678543
MESH:D010190 Pancreatic Neoplasms Ibuprofen 3.4612384795
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0817638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1111896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8020887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9017292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9018437689 15897917 16729912 16868541 16888761 15749863
MESH:D011471 Prostatic Neoplasms Estradiol 1.9016740699
MESH:D011471 Prostatic Neoplasms Flurbiprofen 1.9017409433
MESH:D011471 Prostatic Neoplasms Ibuprofen 1.9017409433
MESH:D011507 Proteinuria Ibuprofen 4.546375363
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D051437 Renal Insufficiency Doxorubicin 4.1317922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012509 Sarcoma Doxorubicin 3.9117203757 17710206 15675481 18313854 16767912 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.1616326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7017846226
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.1919755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 9.1915692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.1916192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4817203757 15625365 16767912
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5520155912 2093021
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.3017909728 16010429
MESH:D013978 Tibial Fractures Estradiol 4.6019048282
MESH:D014376 Tuberculosis Chenodeoxycholic Acid 4.9816040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.0317053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.0317653716
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D020301 Vasospasm, Intracranial Ibuprofen 5.1019057314
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1317678736 17638931 17334414 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
Pathway ID Pathway Name
KEGG:00053 Ascorbate and aldarate metabolism
KEGG:04976 Bile secretion
REACT:13433 Biological oxidations
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00983 Drug metabolism - other enzymes
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00514 Other types of O-glycan biosynthesis
KEGG:00040 Pentose and glucuronate interconversions
KEGG:00860 Porphyrin and chlorophyll metabolism
KEGG:00830 Retinol metabolism
KEGG:00500 Starch and sucrose metabolism
KEGG:00140 Steroid hormone biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA360
    • Releated gene ID Related gene Name
    PA360UGT2B4
    No data
    Releated drug ID Related drug Name
    PA449088codeine
    PA449683flurbiprofen
    PA449957ibuprofen
    PA450149ketoprofen
    Drug Bank Top
    No data
    Drugbank ID Action Drug Name Description
    DB00712 substrate Flurbiprofen Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Analgesics;Analgesics, Non-Narcotic;Antipyretics;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB01050 substrate Vicoprofen® Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Analgesics;Analgesics, Non-Narcotic;Antipyretics;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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