AutismKB 2.0

Annotation Detail for UGT2B7


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:UGT2B7 ( UDPGT 2B9,UDPGT2B7,UDPGTH2,UGT2B9 )
Gene Full Name: UDP glucuronosyltransferase 2 family, polypeptide B7
Band: 4q13.2
Quick LinksEntrez ID:7364; OMIM: 600068; Uniprot ID:UD2B7_HUMAN; ENSEMBL ID: ENSG00000171234; HGNC ID: 12554
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00140Steroid hormone biosynthesis
hsa00860Porphyrin and chlorophyll metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00040Pentose and glucuronate interconversions
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
hsa00053Ascorbate and aldarate metabolism
hsa00500Starch and sucrose metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
AIDS-Related Opportunistic Infections
tuberculosis
PHARMACOGENOMIC
carvedilol pharmacokinetics
NNAL-glucuronidating activities
mycophenolic acid pharmacokinetics
acyl-mycophenolic acid-glucuronide
sex steroids
METABOLIC
HIV Infections
hepatotoxicity, diclofenac-induced
INFECTION
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C025984 15-hydroxy-5,8,11,13-eicosatetraenoic acid UGT2B7 protein results in increased glucuronidation of 15-hydroxy-5,8,11,13-eicosatetraenoic acidincreases glucuronidation 15231852
C055987 20-hydroxy-5,8,11,14-eicosatetraenoic acid UGT2B7 protein results in increased glucuronidation of 20-hydroxy-5,8,11,14-eicosatetraenoic acidincreases glucuronidation 15231852
C060080 2,2-bis(bromomethyl)-1,3-propanediol UGT2B7 protein results in increased glucuronidation of 2,2-bis(bromomethyl)-1,3-propanediolincreases glucuronidation 20200232
C008012 2-hydroxyestriol UGT2B7 protein results in increased glucuronidation of 2-hydroxyestriolincreases glucuronidation 8517101
C026418 4-hydroxyestrone UGT2B7 protein results in increased glucuronidation of 4-hydroxyestroneincreases glucuronidation 8517101
C475721 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol UGT2B7 protein results in increased glucuronidation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-olincreases glucuronidation 11038164
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone UGT2B7 gene polymorphism results in decreased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanonedecreases glucuronidation 14871856
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone UGT2B7 protein results in increased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneincreases glucuronidation 14871856
C070058 4-trifluoromethylumbelliferyl iduronide UGT2B7 protein results in increased glucuronidation of 4-trifluoromethylumbelliferyl iduronideincreases glucuronidation 15357915
C084236 7-hydroxy-4-trifluoromethylcoumarin silybin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin]decreases reaction|increases glucuronidation 15155549
C084236 7-hydroxy-4-trifluoromethylcoumarin UGT2B7 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarinincreases glucuronidation 15155549
C084615 alclofenac alclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C084615 alclofenac alclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D000450 Aldosterone alclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D000450 Aldosterone Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D000450 Aldosterone cicloprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D000450 Aldosterone Diclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D000450 Aldosterone Diflunisal inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D000450 Aldosterone Fenoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D000450 Aldosterone Ibuprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D000450 Aldosterone Indomethacin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D000450 Aldosterone Ketoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D000450 Aldosterone Ketorolac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D000450 Aldosterone Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D000450 Aldosterone Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D000450 Aldosterone Naproxen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D000450 Aldosterone pirprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D000450 Aldosterone tiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D000450 Aldosterone UGT2B7 protein results in increased glucuronidation of Aldosteroneincreases glucuronidation 19740398
C018447 aldosterone 18-glucuronide alclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C018447 aldosterone 18-glucuronide Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C018447 aldosterone 18-glucuronide cicloprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C018447 aldosterone 18-glucuronide Diclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C018447 aldosterone 18-glucuronide Diflunisal inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C018447 aldosterone 18-glucuronide Fenoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C018447 aldosterone 18-glucuronide Ibuprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C018447 aldosterone 18-glucuronide Indomethacin inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C018447 aldosterone 18-glucuronide Ketoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C018447 aldosterone 18-glucuronide Ketorolac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C018447 aldosterone 18-glucuronide Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C018447 aldosterone 18-glucuronide Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C018447 aldosterone 18-glucuronide Naproxen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C018447 aldosterone 18-glucuronide pirprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C018447 aldosterone 18-glucuronide tiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C018447 aldosterone 18-glucuronide UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronideincreases chemical synthesis 19740398
D000643 Ammonium Chloride Ammonium Chloride affects the expression of UGT2B7 mRNAaffects expression 16483693
D000654 Amobarbital UGT2B7 protein results in increased glycosylation of Amobarbitalincreases glycosylation 15013842
D000894 Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
D000894 Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D000738 Androsterone UGT2B7 protein results in increased glucuronidation of Androsteroneincreases glucuronidation 11186130
C526219 apple polyphenol extract apple polyphenol extract results in increased expression of UGT2B7 mRNAincreases expression 18351577
D016718 Arachidonic Acid UGT2B7 protein results in increased glucuronidation of Arachidonic Acidincreases glucuronidation 15231852
C029876 benzidine UGT2B7 protein results in increased metabolism of benzidineincreases metabolic processing 15615884
C043211 carvedilol UGT2B7 protein results in increased glucuronidation of carvedilolincreases glucuronidation 14744946
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of UGT2B7 mRNAincreases expression 17851650
C025618 cicloprofen cicloprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C025618 cicloprofen cicloprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D002995 Clofibric Acid UGT2B7 protein results in increased glucuronidation of Clofibric Acidincreases glucuronidation 8517101
C031071 decanoic acid UGT2B7 protein results in increased glucuronidation of decanoic acidincreases glucuronidation 16051554
C037293 denopamine Diclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of denopamine]decreases reaction|increases glucuronidation 15608137
C037293 denopamine UGT2B7 protein results in increased glucuronidation of denopamineincreases glucuronidation 15608137
D004008 Diclofenac Diclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
D004008 Diclofenac Diclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D004008 Diclofenac Diclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of denopamine]decreases reaction|increases glucuronidation 15608137
D004008 Diclofenac UGT2B7 protein results in increased glucuronidation of Diclofenacincreases glucuronidation 15988124
15843492
15608137
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of UGT2B7 mRNAincreases expression 19638242
D004061 Diflunisal Diflunisal inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
D004061 Diflunisal Diflunisal inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D004061 Diflunisal UGT2B7 protein results in increased glucuronidation of Diflunisalincreases glucuronidation 8517101
D004958 Estradiol UGT2B7 protein results in increased glucuronidation of Estradiolincreases glucuronidation 15472229
16051636
D004958 Estradiol UGT2B7 protein results in increased glucuronidation of Estradiol analogincreases glucuronidation 17898154
15472229
D004964 Estriol UGT2B7 protein results in increased glucuronidation of Estriolincreases glucuronidation 8517101
D004970 Estrone UGT2B7 protein results in increased glucuronidation of Estroneincreases glucuronidation 15472229
D004970 Estrone UGT2B7 protein results in increased glucuronidation of Estrone analogincreases glucuronidation 15472229
D004997 Ethinyl Estradiol UGT2B7 protein results in increased glucuronidation of Ethinyl Estradiol analogincreases glucuronidation 17898154
C052488 ethyl 2-(4-chlorophenyl)-5-(2-furyl)-4-oxzoleacetate UGT2B7 protein results in increased glucuronidation of ethyl 2-(4-chlorophenyl)-5-(2-furyl)-4-oxzoleacetateincreases glucuronidation 15988124
D017308 Etodolac UGT2B7 protein results in increased glucuronidation of Etodolacincreases glucuronidation 15535975
C108606 ezetimibe UGT2B7 protein results in increased glucuronidation of ezetimibeincreases glucuronidation 14977865
D005204 Farnesol UGT2B7 protein results in increased glucuronidation of Farnesolincreases glucuronidation 15320866
D005279 Fenoprofen Fenoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
D005279 Fenoprofen Fenoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D005279 Fenoprofen UGT2B7 protein results in increased glucuronidation of Fenoprofenincreases glucuronidation 8517101
D015725 Fluconazole Fluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol]affects cotreatment|decreases reaction|increases glucuronidation 18098064
D005480 Flurbiprofen UGT2B7 protein results in increased glucuronidation of Flurbiprofenincreases glucuronidation 15843492
C001381 hydroxycotinine UGT2B7 protein results in increased glucuronidation of hydroxycotinineincreases glucuronidation 16141602
C010471 hyodeoxycholic acid UGT2B7 protein results in increased glucuronidation of hyodeoxycholic acidincreases glucuronidation 8517101
D007052 Ibuprofen Ibuprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
D007052 Ibuprofen Ibuprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D007052 Ibuprofen UGT2B7 protein results in increased glucuronidation of Ibuprofenincreases glucuronidation 8517101
15843492
C093581 indene UGT2B7 protein results in increased glucuronidation of indeneincreases glucuronidation 15843492
D007213 Indomethacin Indomethacin inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
D007213 Indomethacin Indomethacin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D007213 Indomethacin UGT2B7 protein results in increased glucuronidation of Indomethacinincreases glucuronidation 8517101
15843492
D007660 Ketoprofen Ketoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
D007660 Ketoprofen Ketoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D007660 Ketoprofen UGT2B7 protein results in increased glucuronidation of Ketoprofenincreases glucuronidation 15843492
15535975
8517101
D020910 Ketorolac Ketorolac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
D020910 Ketorolac Ketorolac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D007741 Labetalol Fluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol]affects cotreatment|decreases reaction|increases glucuronidation 18098064
D007741 Labetalol [Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalolaffects cotreatment|increases glucuronidation 18098064
C030358 lauric acid UGT2B7 protein results in increased glucuronidation of lauric acidincreases glucuronidation 16051554
D008469 Meclofenamic Acid Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
D008469 Meclofenamic Acid Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D008528 Mefenamic Acid Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
D008528 Mefenamic Acid Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D008610 Menthol UGT2B7 protein results in increased glucuronidation of Mentholincreases glucuronidation 11186130
D009020 Morphine UGT2B7 protein affects the metabolism of Morphineaffects metabolic processing 15286053
D009020 Morphine UGT2B7 protein results in increased glucuronidation of Morphineincreases glucuronidation 12756209
15611481
12920162
11186130
D009270 Naloxone UGT2B7 protein affects the metabolism of Naloxoneaffects metabolic processing 15286053
D009288 Naproxen Naproxen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
D009288 Naproxen Naproxen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D009288 Naproxen UGT2B7 protein results in increased glucuronidation of Naproxenincreases glucuronidation 15535975
8517101
15843492
D010076 Oxazepam UGT2B7 protein results in increased glucuronidation of Oxazepamincreases glucuronidation 7773302
C026256 oxazepam glucuronide UGT2B7 protein results in increased chemical synthesis of oxazepam glucuronideincreases chemical synthesis 7773302
C008924 pirprofen pirprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C008924 pirprofen pirprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
D010936 Plant Extracts Plant Extracts results in increased expression of UGT2B7 mRNAincreases expression 18351577
C034467 prostaglandin B1 UGT2B7 protein results in increased glucuronidation of prostaglandin B1increases glucuronidation 15231852
C059514 resveratrol resveratrol results in increased expression of UGT2B7 mRNAincreases expression 17287390
C059514 resveratrol resveratrol results in increased expression of UGT2B7 proteinincreases expression 17287390
D020280 Sertraline UGT2B7 protein results in increased glucuronidation of and results in increased metabolism of Sertralineincreases glucuronidation|increases metabolic processing 15547048
C440975 silybin silybin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin]decreases reaction|increases glucuronidation 15155549
D013467 Sulindac UGT2B7 protein results in increased glucuronidation of Sulindacincreases glucuronidation 15843492
C025463 sulindac sulfone UGT2B7 protein results in increased glucuronidation of sulindac sulfoneincreases glucuronidation 15843492
C115070 SX 3030 UGT2B7 protein results in increased glycosylation of SX 3030increases glycosylation 15013842
D013749 Tetrachlorodibenzodioxin UGT2B7 protein results in increased glucuronidation of Tetrachlorodibenzodioxin metaboliteincreases glucuronidation 15258113
C021270 tiaprofenic acid tiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]decreases reaction|increases chemical synthesis 19740398
C021270 tiaprofenic acid tiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]decreases reaction|increases glucuronidation 19740398
C021270 tiaprofenic acid UGT2B7 protein results in increased glucuronidation of tiaprofenic acidincreases glucuronidation 8517101
C052342 topiramate UGT2B7 gene SNP affects the susceptibility to topiramateaffects response to substance 18686368
D014535 Uridine Diphosphate Glucuronic Acid Fluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol]affects cotreatment|decreases reaction|increases glucuronidation 18098064
D014535 Uridine Diphosphate Glucuronic Acid [Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalolaffects cotreatment|increases glucuronidation 18098064
D014635 Valproic Acid UGT2B7 protein results in increased glucuronidation of Valproic Acidincreases glucuronidation 8517101
D015215 Zidovudine UGT2B7 protein results in increased glucuronidation of Zidovudineincreases glucuronidation 10772627
17898154
C020549 zomepirac UGT2B7 protein results in increased glucuronidation of zomepiracincreases glucuronidation 8517101
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 4.7814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.0011752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 6.008875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.2919490988
MESH:D000138 Acidosis Ammonium Chloride 2.8618287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.2217505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.149612607
MESH:D058186 Acute Kidney Injury Diclofenac 30.447897758
MESH:D058186 Acute Kidney Injury Fenoprofen 30.446375363
MESH:D058186 Acute Kidney Injury Ibuprofen 30.446375363
MESH:D058186 Acute Kidney Injury Naproxen 30.447897758
MESH:D058186 Acute Kidney Injury resveratrol 30.4416538975
MESH:D058186 Acute Kidney Injury Sulindac 30.447897758
MESH:D058186 Acute Kidney Injury zomepirac 30.447078269 6375363 3901736
MESH:D000230 Adenocarcinoma Estradiol 10.9411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.9414692618
MESH:D000230 Adenocarcinoma Ibuprofen 10.9410697514
MESH:D000230 Adenocarcinoma Indomethacin 10.9416537180
MESH:D000230 Adenocarcinoma Sulindac 10.9411910360
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 16.2316176798
MESH:D000236 Adenoma Diethylnitrosamine 16.236695378 10737359
MESH:D000236 Adenoma Indomethacin 16.2311497255
MESH:D000236 Adenoma resveratrol 16.2315688382
MESH:D000236 Adenoma Sulindac 16.2310223192
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 7.7217162532 19052882 18056438 19061943 16434500 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 7.7216835633
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 12.9510680582
MESH:D011125 Adenomatous Polyposis Coli Sulindac 12.9511874996 11535846 12394442 19003578 15623613 17611924 16460482
MESH:D011125 Adenomatous Polyposis Coli sulindac sulfone 12.9516150858
MESH:D000380 Agranulocytosis Fenoprofen 5.62156260
MESH:D000437 Alcoholism topiramate 4.4617925516 19331489 18552399
OMIM:607154 ALLERGIC RHINITIS Etodolac 5.1616979129
MESH:D016301 Alveolar Bone Loss Indomethacin 4.6517225004
MESH:D000544 Alzheimer Disease Anti-Inflammatory Agents, Non-Steroidal 10.1716407166 15817521 14586007
MESH:D000544 Alzheimer Disease Ibuprofen 10.1718351690
MESH:D000544 Alzheimer Disease Indomethacin 10.1715579461 17627676
MESH:D000544 Alzheimer Disease Plant Extracts 10.1716962711
MESH:D000544 Alzheimer Disease resveratrol 10.1716183991 16162502
MESH:D000550 Amblyopia Valproic Acid 4.5117688650
MESH:D000707 Anaphylaxis Ibuprofen 4.569532969
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.3311748828
MESH:D001008 Anxiety Disorders Sertraline 7.4718822694
MESH:D001008 Anxiety Disorders Valproic Acid 7.4717497229
MESH:D001014 Aortic Aneurysm Indomethacin 4.1710231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.1810388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.7811256880
MESH:D018771 Arthralgia Indomethacin 4.452160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 9.6215885639
MESH:D001169 Arthritis, Experimental Plant Extracts 9.6214686799
MESH:D001169 Arthritis, Experimental resveratrol 9.6217115116
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.6211248219
MESH:D050197 Atherosclerosis resveratrol 2.8216873680 17967414
MESH:D001321 Autistic Disorder Arachidonic Acid 2.3618582451
MESH:D001321 Autistic Disorder Sertraline 2.3618775368
MESH:D001321 Autistic Disorder Valproic Acid 2.3618316065 15238991 17688650 16609825 17507914 18396377 17157402 20603192 19232924 18558336 18177632 18985861 19460635 18940202 18775368
MESH:D001477 Bartter Syndrome Indomethacin 4.2910684365
MESH:D001714 Bipolar Disorder Valproic Acid 2.6720046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.4112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.0715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.3815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.388888407
MESH:D001913 Bowen's Disease Sulindac 4.6311207687
MESH:D001929 Brain Edema Indomethacin 4.3111481608
MESH:D002545 Brain Ischemia Ibuprofen 24.3215837124
MESH:D002545 Brain Ischemia Indomethacin 24.3212524144
MESH:D002545 Brain Ischemia Morphine 24.3219211983
MESH:D002545 Brain Ischemia Plant Extracts 24.3216041641
MESH:D002545 Brain Ischemia resveratrol 24.3217600658
MESH:D001943 Breast Neoplasms 2,2-bis(bromomethyl)-1,3-propanediol 3.8611921183
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 3.8620146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.8617474063
MESH:D001943 Breast Neoplasms Estradiol 3.8616675129 12948864 17018787 18497071 17261762 14630087 19861407 17289903
MESH:D001943 Breast Neoplasms Indomethacin 3.8617401462
MESH:D001943 Breast Neoplasms resveratrol 3.8617651959 16393696 17534123
MESH:D001943 Breast Neoplasms Sulindac 3.8616642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.8620435547
MESH:D002056 Burns Indomethacin 4.0110459503
MESH:D002057 Burns, Chemical Plant Extracts 4.629625245
MESH:D002100 Cachexia Ibuprofen 10.3215141370
MESH:D002100 Cachexia Indomethacin 10.3216537180 15625704 11239499 15141370
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.7616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.2316835633
MESH:D006528 Carcinoma, Hepatocellular 2,2-bis(bromomethyl)-1,3-propanediol 9.2116362062
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.2120432363 19394651 16681979 20007298 16569478 16779866 18665156 16288022 19539802 19822196 19701751 18785209 16698587 17978847 20727157 20084675 18210153 3581430 16878318 16807293 18056438 11831363 10672840 20524982 20214788 18506893 16935385 21159647 18788625 17761372 20935162 19171122 18691550 19519916 19418558 19335982 17162532 17138121 3084413 17428255 19107877 17173139 18971187 19919837 20512989 16540662 19208518 18393292 10737359 16328049 20101231 18494052 16830150 18978308 20514400 16502159 17055752 19383236 19052882
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.2116924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 9.2116391822
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 9.2118834353
MESH:D006528 Carcinoma, Hepatocellular resveratrol 9.2119321006 16227395
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 9.0811053908
MESH:D018827 Carcinoma, Lewis Lung resveratrol 9.0816675471
MESH:D018276 Carcinoma, Medullary Indomethacin 4.6418791128 11352223 14736730
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfone 3.7918758305
MESH:D002292 Carcinoma, Renal Cell Indomethacin 2.9917341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 4.1315482327 12636206
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.1316227395
MESH:D006332 Cardiomegaly Plant Extracts 5.5117645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.5116120746 18850075 18670907
MESH:D009202 Cardiomyopathies carvedilol 4.6315476868
MESH:D002311 Cardiomyopathy, Dilated carvedilol 4.2519477965
MESH:D002318 Cardiovascular Diseases Aldosterone 6.3111230374
MESH:D002318 Cardiovascular Diseases resveratrol 6.3115458977
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 4.9917174075 21159647 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 4.9918566989
MESH:D002659 Child Development Disorders, Pervasive topiramate 5.3615650499
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 5.3620734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.3119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.3116835633
MESH:D002764 Cholecystitis Indomethacin 4.4511181007
MESH:D002779 Cholestasis Ethinyl Estradiol 2.3315861022 11677210 17110522 17333356 16105132 16919318 17681005
MESH:D002972 Cleft Palate Fluconazole 5.2216781842
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.2216354765 15340226 8697196 15668235 12621046
MESH:D003092 Colitis resveratrol 3.4516474422
MESH:D003110 Colonic Neoplasms Etodolac 6.8516004971
MESH:D003110 Colonic Neoplasms Indomethacin 6.8515936596 15786552 15963497 15625704 11260862 15637740
MESH:D003110 Colonic Neoplasms resveratrol 6.8516338953
MESH:D003110 Colonic Neoplasms Sulindac 6.8512902858 12458338
MESH:D015179 Colorectal Neoplasms Anti-Inflammatory Agents, Non-Steroidal 7.0212837940 18059344
MESH:D015179 Colorectal Neoplasms Etodolac 7.0211076880
MESH:D015179 Colorectal Neoplasms Indomethacin 7.0211197048 17054584 18059344 12606626
MESH:D015179 Colorectal Neoplasms resveratrol 7.0216550006
MESH:D015179 Colorectal Neoplasms Sulindac 7.0211197048 10666051 11076880 18059344
MESH:D015179 Colorectal Neoplasms sulindac sulfone 7.0210416599 10666051 11197048 18059344
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.4614669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.2616507316
MESH:D003328 Coronary Thrombosis Oxazepam 9.0916048847
MESH:D003328 Coronary Thrombosis zomepirac 9.096188907
MESH:D003329 Coronary Vasospasm zomepirac 5.936610944
MESH:D018352 Coronavirus Infections Indomethacin 5.0017302372
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.1815322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.188888407 16575769 17688650
MESH:D003866 Depressive Disorder Sertraline 4.2420305041 18822694 15014590
MESH:D003865 Depressive Disorder, Major Sertraline 4.7616968574
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.1916873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 5.8720387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 5.8717107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 5.8716979414
MESH:D003928 Diabetic Nephropathies Estradiol 11.6519279558
MESH:D003928 Diabetic Nephropathies Plant Extracts 11.6519706694
MESH:D003928 Diabetic Nephropathies resveratrol 11.6516286809
MESH:D003930 Diabetic Retinopathy Sulindac 4.5012861449 17621415
MESH:D003967 Diarrhea Indomethacin 6.387907874 7237001
MESH:D003967 Diarrhea Morphine 6.382540324
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 6.7517851650
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.7519107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.7520420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.7519641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.4111462148
MESH:D004362 Drug Toxicity Zidovudine 6.4115040536
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 10.8816133044 18450898 18446180
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 10.8817190690 16133044 16326151 18446180 12774134 18043480
MESH:D004381 Duodenal Ulcer Anti-Inflammatory Agents, Non-Steroidal 7.7517157122
MESH:D004381 Duodenal Ulcer Indomethacin 7.7516699067 10671773 11595431 17045617 11991626 17202747 11595415 11535926 17329845 17351913 17151854
MESH:D004412 Dysmenorrhea Fenoprofen 6.443908675
MESH:D004421 Dystonia Valproic Acid 3.391851702
MESH:D004487 Edema Arachidonic Acid 27.2615177302 9831321 7990266 16716910 11698051 9599246
MESH:D004487 Edema Diclofenac 27.2616273134
MESH:D004487 Edema Indomethacin 27.268985016 16100529 8273558 19703484 10653021 7907874 7990266
MESH:D004487 Edema Ketoprofen 27.267990266
MESH:D004487 Edema Meclofenamic Acid 27.268273558
MESH:D004487 Edema Plant Extracts 27.2612787963
MESH:D004487 Edema resveratrol 27.268985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 27.2611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.1818230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 6.9012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 6.9017872969
MESH:D004714 Endometrial Hyperplasia Estriol 5.3716402032
MESH:D016889 Endometrial Neoplasms Estradiol 2.4919148513 11473722 18566989
MESH:D004715 Endometriosis Ibuprofen 22.1015652904
MESH:D004715 Endometriosis Indomethacin 22.1015652904
MESH:D004715 Endometriosis Naproxen 22.1015652904
MESH:D004715 Endometriosis Sulindac 22.1015652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 22.109294722 10568697
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 4.9615268973
MESH:D019446 Endotoxemia Ibuprofen 8.5211545620
MESH:D019446 Endotoxemia Indomethacin 8.5218509659
MESH:D004751 Enteritis Indomethacin 4.0316328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 10.0817980183
MESH:D020345 Enterocolitis, Necrotizing resveratrol 10.0817923197
MESH:D004802 Eosinophilia Indomethacin 3.3811298111
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.4617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.203922381 16628512
MESH:D004827 Epilepsy Plant Extracts 8.9019700373 19439326
MESH:D004827 Epilepsy topiramate 8.9019148780
MESH:D004827 Epilepsy Valproic Acid 8.9018234410 20417680
MESH:D004832 Epilepsy, Absence Naloxone 7.486254150
MESH:D004832 Epilepsy, Absence Valproic Acid 7.487562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.617750514
MESH:D004833 Epilepsy, Temporal Lobe topiramate 5.5516499746
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.363659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.4016302075
MESH:D004938 Esophageal Neoplasms Indomethacin 4.2311005569
MESH:D004938 Esophageal Neoplasms Sulindac 4.2312235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.4611564622
MESH:D005128 Eye Diseases Ketorolac 6.3611084241
MESH:D005234 Fatty Liver Diethylnitrosamine 17.9921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 17.9915345470
MESH:D005234 Fatty Liver Plant Extracts 17.9915975614
MESH:D005234 Fatty Liver Valproic Acid 17.9914986274 19224547
MESH:D005234 Fatty Liver Zidovudine 17.9918299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.7711858732
MESH:D005315 Fetal Diseases Valproic Acid 4.1716575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.468888407 18558336
MESH:D005334 Fever Arachidonic Acid 11.8911852909
MESH:D005334 Fever Ibuprofen 11.8916997862
MESH:D005334 Fever Indomethacin 11.8910431976 17627676 11852909
MESH:D018221 Fibromatosis, Abdominal Sulindac 4.7714745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 4.4319069698
MESH:D005354 Fibrosarcoma Indomethacin 4.1910962813
MESH:D005355 Fibrosis Indomethacin 6.5517994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 6.5520067830
MESH:D005499 Folliculitis Indomethacin 4.4511298111
MESH:D005756 Gastritis Indomethacin 4.0315046732
MESH:D005764 Gastroesophageal Reflux Sulindac 4.3411910360
MESH:D005767 Gastrointestinal Diseases Anti-Inflammatory Agents, Non-Steroidal 5.7217021222
MESH:D005909 Glioblastoma Indomethacin 3.0812870263
MESH:D005910 Glioma Anti-Inflammatory Agents, Non-Steroidal 5.7616487511
MESH:D005910 Glioma Indomethacin 5.7616487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.7111849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.8710696789
MESH:D006073 Gout Indomethacin 4.6411248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.2415482327
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 1.9210048152 11294989
MESH:D006333 Heart Failure Plant Extracts 3.4018097624
MESH:D006402 Hematologic Diseases Zidovudine 4.0612579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.7011000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 3.9315633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.0115135802
MESH:D006521 Hepatitis, Chronic Diclofenac 4.9614986274
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.2215340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.3115709030
MESH:D006561 Herpes Simplex Plant Extracts 7.7910715843
MESH:D006561 Herpes Simplex resveratrol 7.7916876885
MESH:D015658 HIV Infections Plant Extracts 5.6312878215
MESH:D015658 HIV Infections Zidovudine 5.6311698656 11141242 20032539 17358032 11363243
MESH:D019584 Hot Flashes Estradiol 7.9517088409
MESH:D019584 Hot Flashes Plant Extracts 7.9517454163 16566672 14716179
MESH:D006816 Huntington Disease Sertraline 5.3318403212
MESH:D006849 Hydrocephalus Valproic Acid 4.1617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.338697196 15340226 16959395 18606429 16354765
MESH:D006930 Hyperalgesia Indomethacin 3.2112727271
MESH:D034321 Hyperamylasemia Indomethacin 5.0017883296
MESH:D006937 Hypercholesterolemia ezetimibe 7.8917076980 15374793
MESH:D006937 Hypercholesterolemia resveratrol 7.8917188708
MESH:D006940 Hyperemia Indomethacin 4.3012524144
MESH:D020138 Hyperhomocysteinemia Plant Extracts 3.8616484555
MESH:D006949 Hyperlipidemias Indomethacin 11.8617546600
MESH:D006949 Hyperlipidemias Plant Extracts 11.8615268973 15975614
MESH:D006949 Hyperlipidemias resveratrol 11.8616873680
MESH:D006973 Hypertension carvedilol 4.7016640825
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7018850075 18670907
MESH:D006984 Hypertrophy Ibuprofen 4.3416672835
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.6817488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.1216945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 4.3118306037 10574470
MESH:D007079 Ileitis Indomethacin 4.6416133968 10651667 10647630
MESH:D007235 Infant, Premature, Diseases Ibuprofen 11.8016133044
MESH:D007235 Infant, Premature, Diseases Indomethacin 11.8016133044
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 3.9617600658
MESH:D007246 Infertility 2,2-bis(bromomethyl)-1,3-propanediol 5.522792593
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.0017937319
MESH:D007249 Inflammation Anti-Inflammatory Agents, Non-Steroidal 40.3114586007 3291741 16684565
MESH:D007249 Inflammation Arachidonic Acid 40.319831321 15177302 17371808
MESH:D007249 Inflammation Diclofenac 40.3116273134
MESH:D007249 Inflammation Diethylnitrosamine 40.3118785209
MESH:D007249 Inflammation Fenoprofen 40.317009135 3291741
MESH:D007249 Inflammation Flurbiprofen 40.3111099482
MESH:D007249 Inflammation Ibuprofen 40.313291741
MESH:D007249 Inflammation Indomethacin 40.313291741 12568917 7812673
MESH:D007249 Inflammation Naproxen 40.313291741
MESH:D007249 Inflammation Plant Extracts 40.3119332304 15997105 16366677 12787963
MESH:D007249 Inflammation resveratrol 40.3116366677
MESH:D007249 Inflammation Sulindac 40.313291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 40.3112878042 12200463
MESH:D007251 Influenza, Human resveratrol 3.8316624496
MESH:D007333 Insulin Resistance Estradiol 2.4816627594 16393666
MESH:D007410 Intestinal Diseases Indomethacin 3.6411855677 10210152 15831440 17329856 18236018 11713966 17994277 11686837 15610444
MESH:D007414 Intestinal Neoplasms Plant Extracts 8.2012351151 12584176 12628509
MESH:D007414 Intestinal Neoplasms Sulindac 8.2012351151 10223192 12584176 10213222 12663524 12628509
MESH:D007417 Intestinal Polyps Sulindac 4.3312394442 11245490
MESH:D019586 Intracranial Hypertension Indomethacin 4.6515241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.7016580747
MESH:D007579 Jejunal Diseases Indomethacin 4.3110574470 16133968 18306037
MESH:D007674 Kidney Diseases Estradiol 4.7915618244
MESH:D007674 Kidney Diseases Indomethacin 4.7917190690
MESH:D007680 Kidney Neoplasms 2,2-bis(bromomethyl)-1,3-propanediol 13.202731663 12594523 9437797
MESH:D007680 Kidney Neoplasms Estradiol 13.2015610895
MESH:D007680 Kidney Neoplasms Estrone 13.2015610895
MESH:D007680 Kidney Neoplasms Zidovudine 13.2012579204
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.3211703811 12228301 10320625
MESH:D007938 Leukemia 2,2-bis(bromomethyl)-1,3-propanediol 4.5712594523
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 3.7820370541
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.3810785260 16572323 15631656
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.4918360721
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.4916294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.0816087638
MESH:D007964 Leukocytosis Indomethacin 4.6516537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.0017980183
MESH:D008064 Lipidoses Sertraline 4.2917567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.0011479899
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.4920032147 18665156 19638242 18407596 18522880
MESH:D008103 Liver Cirrhosis Plant Extracts 5.4917157831
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 3.7412468960
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.4014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 5.4018194892
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 5.4015479170
MESH:D008106 Liver Cirrhosis, Experimental silybin 5.4016169303
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.4012878042
MESH:D008107 Liver Diseases Diclofenac 12.6316867024 14566034
MESH:D008107 Liver Diseases Diethylnitrosamine 12.6317034775
MESH:D008107 Liver Diseases Fluconazole 12.6314966256
MESH:D008107 Liver Diseases Naproxen 12.6316867024
MESH:D008107 Liver Diseases Plant Extracts 12.6317034775
MESH:D008107 Liver Diseases Sulindac 12.6316867024 14986274
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 13.6715890375
MESH:D008113 Liver Neoplasms Clofibric Acid 13.6717602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.6712771043 18754104 19427195 18648771 21278145 19996281 19833225 20434301 10737359 18978307 19073162 18977376 20452335 19294768 19499222 18644402 19638242 2422723 9163691 20501860 20137499 20583210 20492335 2862719 21047994 19551842 19812893 21167192 16942905 21071580 12112319 20118626 20405173 19256749 19426721 15175105 15885732 19254457 19690152 19255062 20101389 19850985 19642983 19090486
MESH:D008113 Liver Neoplasms Plant Extracts 13.6719168119
MESH:D008113 Liver Neoplasms resveratrol 13.6720405173 19812893 19321006 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.6716984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 4.2017942915 19539802 18253720 19004024 19126423 9362446 3124819 19009564 18164116 18775883 18079962 18282651 18093689 17854601 18544905 17174075 16842330 2563599 21159647 16267830 19519916 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 4.2012151625
MESH:D008171 Lung Diseases Fluconazole 4.3214966256
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.5417228818
MESH:D008175 Lung Neoplasms 2,2-bis(bromomethyl)-1,3-propanediol 12.709437797 12594523
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 12.7019931552 15893417 18813816 18508827 16061637 16401635 14755239 12438228 9255578 17139156 15172992
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.7021163286 20512841 20970405 6695378
MESH:D008175 Lung Neoplasms Indomethacin 12.7016537180 11053908 11497255
MESH:D008175 Lung Neoplasms Plant Extracts 12.7020869020
MESH:D008175 Lung Neoplasms silybin 12.7016788158
MESH:D008175 Lung Neoplasms Sulindac 12.7019359593 15713900
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.7011884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 12.7018800350
MESH:D016393 Lymphoma, B-Cell resveratrol 3.6417088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.2814749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.5515688416
MESH:D008325 Mammary Neoplasms, Experimental 2,2-bis(bromomethyl)-1,3-propanediol 10.4211921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.4216891317 17203775 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 10.4210697514
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 10.4211606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 3.7619453300
MESH:D008545 Melanoma resveratrol 3.2517992120
MESH:D008545 Melanoma Sulindac 3.2516642371
MESH:D001523 Mental Disorders Sertraline 4.1316856516
MESH:D008659 Metabolic Diseases resveratrol 3.7417112576
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.1217358032
MESH:D008881 Migraine Disorders Indomethacin 13.6711903285
MESH:D008881 Migraine Disorders Naproxen 13.6718803445
MESH:D008881 Migraine Disorders topiramate 13.6716942474 18803445 18759728 18765137
MESH:D008881 Migraine Disorders Valproic Acid 13.6718765137 18803445
MESH:D009062 Mouth Neoplasms Anti-Inflammatory Agents, Non-Steroidal 7.6115555568
MESH:D009062 Mouth Neoplasms Indomethacin 7.6112636206
MESH:D009101 Multiple Myeloma resveratrol 2.9517049120 17164350 17935668 14749477 16490592 16267019
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.1617962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.398888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.7117596541
MESH:D009203 Myocardial Infarction resveratrol 2.6916317513 16456233 17188708 17015251 16525036 17125593
MESH:D017202 Myocardial Ischemia resveratrol 7.0917125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.0912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.7216810080
MESH:D009205 Myocarditis resveratrol 4.0517322642
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 4.813581430 9029167
MESH:D009362 Neoplasm Metastasis Indomethacin 4.8116537180 11239499 11053908
MESH:D009369 Neoplasms Anti-Inflammatory Agents, Non-Steroidal 4.0416684565
MESH:D009374 Neoplasms, Experimental Indomethacin 7.1310663608 15625704
MESH:D009374 Neoplasms, Experimental resveratrol 7.138985016
MESH:D009389 Neovascularization, Pathologic Estradiol 3.0317289903
MESH:D009395 Nephritis, Interstitial Anti-Inflammatory Agents, Non-Steroidal 19.573291741
MESH:D009395 Nephritis, Interstitial Fenoprofen 19.576375363
MESH:D009395 Nephritis, Interstitial Ibuprofen 19.576375363
MESH:D009395 Nephritis, Interstitial zomepirac 19.576375363
MESH:D009410 Nerve Degeneration Ibuprofen 3.8310961664
MESH:D009421 Nervous System Malformations Estradiol 7.2411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 7.2414600291
MESH:D009436 Neural Tube Defects Valproic Acid 2.6416359493 8888407
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.4917168769
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 15.3520387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 15.3512349958
MESH:D019636 Neurodegenerative Diseases resveratrol 15.3517652729
MESH:D019636 Neurodegenerative Diseases Sulindac 15.3517266991 16850258
MESH:D020078 Neurogenic Inflammation resveratrol 3.7417929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.4020387270
MESH:D009765 Obesity Plant Extracts 2.9319056576 20132043
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.456374098
MESH:D014009 Onychomycosis Fluconazole 5.6314966256
MESH:D010003 Osteoarthritis Diclofenac 14.1818287210
MESH:D010003 Osteoarthritis Fenoprofen 14.187009135
MESH:D010003 Osteoarthritis Ibuprofen 14.187009135
MESH:D010003 Osteoarthritis Indomethacin 14.187009135
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.6017513867
MESH:D010051 Ovarian Neoplasms Estradiol 1.9619401270
MESH:D010146 Pain Anti-Inflammatory Agents, Non-Steroidal 31.703291741 16684565 17440234
MESH:D010146 Pain Diclofenac 31.7013679232
MESH:D010146 Pain Fenoprofen 31.707009135 3291741
MESH:D010146 Pain Ibuprofen 31.703291741
MESH:D010146 Pain Indomethacin 31.703291741 17440234 13679232 17627676
MESH:D010146 Pain Morphine 31.7018699797 15215642 15275824 6776300 20225289 16273134
MESH:D010146 Pain Naproxen 31.703291741
MESH:D010146 Pain Sulindac 31.703291741
MESH:D010146 Pain zomepirac 31.70121342 6995502 20225289 6363464 6776300
MESH:D010149 Pain, Postoperative Ibuprofen 9.0916678543
MESH:D010149 Pain, Postoperative Indomethacin 9.0918702446 12538197
MESH:D010190 Pancreatic Neoplasms 2,2-bis(bromomethyl)-1,3-propanediol 12.999437797
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 12.9912384795
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 12.9916540662
MESH:D010190 Pancreatic Neoplasms Ibuprofen 12.9912384795
MESH:D010190 Pancreatic Neoplasms Sulindac 12.9916820089 11504793
MESH:D010195 Pancreatitis Indomethacin 3.2817883296 15028970
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.0311578682
MESH:D010212 Papilloma Plant Extracts 3.8116517061 15173996
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.0016537180
MESH:D010300 Parkinson Disease Anti-Inflammatory Agents, Non-Steroidal 4.1412925360
MESH:D020734 Parkinsonian Disorders Indomethacin 3.5012349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.0011903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.5312520081
MESH:D010437 Peptic Ulcer Indomethacin 4.4411148446
MESH:D010438 Peptic Ulcer Hemorrhage Anti-Inflammatory Agents, Non-Steroidal 5.8617681167
MESH:D010518 Periodontitis Indomethacin 4.1917225004
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.8918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 2.952563599
MESH:D047928 Premature Birth Indomethacin 4.4317000239
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 12.2216679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 12.2211896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 12.2220603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.2420887781
MESH:D011471 Prostatic Neoplasms Anti-Inflammatory Agents, Non-Steroidal 1.9717609663
MESH:D011471 Prostatic Neoplasms Estradiol 1.9716740699
MESH:D011471 Prostatic Neoplasms Flurbiprofen 1.9717409433
MESH:D011471 Prostatic Neoplasms Ibuprofen 1.9717409433
MESH:D011471 Prostatic Neoplasms Plant Extracts 1.9717804756 14666653
MESH:D011471 Prostatic Neoplasms resveratrol 1.9717636462 16731767 15767336 17675339 17804756 17718901
MESH:D011471 Prostatic Neoplasms sulindac sulfone 1.9717908994 15570007
MESH:D011507 Proteinuria Fenoprofen 16.906375363
MESH:D011507 Proteinuria Ibuprofen 16.906375363
MESH:D011507 Proteinuria Indomethacin 16.9011849393
MESH:D011507 Proteinuria zomepirac 16.906375363
MESH:D011537 Pruritus Ethinyl Estradiol 7.7016919318 15861022
MESH:D011537 Pruritus Naloxone 7.7015861022
MESH:D019310 Pseudolymphoma Valproic Acid 3.8211422049 12752131
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.8616325855
MESH:D015427 Reperfusion Injury Morphine 5.8719211983
MESH:D015427 Reperfusion Injury resveratrol 5.8716317513 15827377 17058453 17520802 16314181
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.1618990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.5219155313
MESH:D012559 Schizophrenia Valproic Acid 1.9615737665 19110320
MESH:D012640 Seizures topiramate 4.8716499746
MESH:D012640 Seizures Valproic Acid 4.873137016 16876388 1511512 11738929 14763951 11044598 15475178 17978042
MESH:D012878 Skin Neoplasms 2,2-bis(bromomethyl)-1,3-propanediol 10.5012594523 9437797
MESH:D012878 Skin Neoplasms Plant Extracts 10.5015173996 16517061
MESH:D012878 Skin Neoplasms resveratrol 10.5015837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.5016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.2216709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.2219490988
MESH:D013226 Status Epilepticus Valproic Acid 3.8212833885
MESH:D013272 Stomach Diseases Indomethacin 3.7216184426 15472012 10215738 15038085 17160473 17638125 18545984 16113693 18209964 17207306 16280098 10192188 10486359
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.9818456281
MESH:D013274 Stomach Neoplasms Indomethacin 2.9815609394
MESH:D013274 Stomach Neoplasms Zidovudine 2.9817696246
MESH:D013276 Stomach Ulcer Anti-Inflammatory Agents, Non-Steroidal 8.8317157122
MESH:D013276 Stomach Ulcer Indomethacin 8.8311145282 16631530 15255614 11595431 16755016 18181030 12498302 18193104 11595415 16150113 16252198 17895592 18087811 16169175 11523592 12077510 18237397 16397915 18431645 17918041 11729361 12787963 17627676 10423059 18543354 15138204 10750652 16934674 14567935 10878458 12467913 17654042 12500499 1323529 18299717 11906479 17135157 17657623 18726076 15104355 18209962 17977527
MESH:D013276 Stomach Ulcer Plant Extracts 8.8318237397 15255614 17135157 12787963 18193104
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.8516321402
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 4.7617997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 2.9611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.5515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.1812697716
MESH:D013964 Thyroid Neoplasms 2,2-bis(bromomethyl)-1,3-propanediol 9.139437797 12594523
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 9.137505956
MESH:D013964 Thyroid Neoplasms Indomethacin 9.1311352223 18791128 14736730
MESH:D013978 Tibial Fractures Estradiol 3.9619048282
MESH:D014062 Tongue Neoplasms resveratrol 3.5916227395
MESH:D014178 Translocation, Genetic Valproic Acid 4.5117262798
MESH:D014456 Ulcer Indomethacin 4.1910574470 17380554
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.813119515
MESH:D001749 Urinary Bladder Neoplasms marker/mechanism 15615884
MESH:D001749 Urinary Bladder Neoplasms 2,2-bis(bromomethyl)-1,3-propanediol 5.669437797 2731663 12594523
MESH:D001749 Urinary Bladder Neoplasms benzidine 5.6611144890 12500666 16003747
MESH:D014564 Urogenital Abnormalities Valproic Acid 3.958888407
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.4817473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 12.2714692618
MESH:D014594 Uterine Neoplasms resveratrol 12.2717044934
MESH:D014594 Uterine Neoplasms Sulindac 12.2718645019
MESH:D014625 Vaginal Neoplasms Zidovudine 4.0712579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.8712125929
MESH:D020301 Vasospasm, Intracranial Ibuprofen 4.4919057314
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.9014671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 8.2518097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 8.2517488730
MESH:D020257 Ventricular Remodeling Plant Extracts 4.6118097624
MESH:D014839 Vomiting Indomethacin 4.0311897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.5315886252
MESH:D014947 Wounds and Injuries Plant Extracts 3.6719894650 20213670
Pathway ID Pathway Name
KEGG:00053 Ascorbate and aldarate metabolism
REACT:13433 Biological oxidations
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00983 Drug metabolism - other enzymes
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00514 Other types of O-glycan biosynthesis
KEGG:00040 Pentose and glucuronate interconversions
KEGG:00860 Porphyrin and chlorophyll metabolism
KEGG:00830 Retinol metabolism
KEGG:00500 Starch and sucrose metabolism
KEGG:00140 Steroid hormone biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA361
    • Releated gene ID Related gene Name
    PA31588NFE2L2
    PA361UGT2B7
    Releated disease ID Related disease Name
    PA443899Diarrhea
    PA443937Drug Toxicity
    PA444773Leukopenia
    PA444065Epilepsy
    PA443560Breast Neoplasms
    PA443334Pain Insensitivity, Congenital
    PA445208Pain
    PA443355Anemia, Sickle Cell
    PA444801Liver Diseases
    PA445876Tobacco Use Disorder
    PA133888799Organ Transplantation
    PA443224Abnormalities, Drug-Induced
    PA164925725Toxic liver disease
    Releated drug ID Related drug Name
    PA451581tamoxifen
    PA165260403arteether
    PA165111696artemisinin
    PA164781320flunitrazepam
    PA131301952gefitinib
    PA450626nicotine
    PA449088codeine
    PA451954zidovudine
    PA450268losartan
    PA448785carbamazepine
    PA452618opioids
    PA449476epirubicin
    PA450401methadone
    PA450496midazolam
    PA450267lorazepam
    PA451846valproic acid
    PA450550morphine
    PA449293diclofenac
    PA450566mycophenolate mofetil
    PA448685buprenorphine
    PA448927chloramphenicol
    PA449167cyclosporine
    PA450731oxazepam
    PA450741oxycodone
    PA451608temazepam
    PA164781343varenicline
    PA164748728mycophenolic acid
    PA165111698artemether
    PA165111697artesunate
    PA449683flurbiprofen
    PA449957ibuprofen
    PA450149ketoprofen
    Drug Bank Top
    No data
    Drugbank ID Action Drug Name Description
    DB00586 substrate Diclofenac Cyclooxygenase Inhibitors;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB00678 substrate Hyzaar Antihypertensive Agents;Angiotensin II Receptor Antagonists;Antiarrhythmic Agents;Angiotensin II Type 1 Receptor Blockers;Anti-Arrhythmia Agents
    DB00712 substrate Flurbiprofen Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Analgesics;Analgesics, Non-Narcotic;Antipyretics;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB00749 substrate Etodolac Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Analgesics;Analgesics, Non-Narcotic;Antipyretics;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB00788 substrate Naproxen Cyclooxygenase Inhibitors;Gout Suppressants
    DB00870 substrate Suprofen Cyclooxygenase Inhibitors
    DB01050 substrate Vicoprofen® Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Analgesics;Analgesics, Non-Narcotic;Antipyretics;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB01252 substrate Mitiglinide Hypoglycemic Agents
    DB01544 inhibitor Flunitrazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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