Annotation Detail for UGT2B10
Basic Information
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| Pathway ID | Pathway Name |
|---|
| hsa00830 | Retinol metabolism |
| hsa00140 | Steroid hormone biosynthesis |
| hsa00860 | Porphyrin and chlorophyll metabolism |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450 |
| hsa00982 | Drug metabolism - cytochrome P450 |
| hsa00040 | Pentose and glucuronate interconversions |
| hsa00983 | Drug metabolism - other enzymes |
| hsa01100 | Metabolic pathways |
| hsa00053 | Ascorbate and aldarate metabolism |
| hsa00500 | Starch and sucrose metabolism |
| Pathway ID | Pathway Name |
|---|
| Biological oxidations |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C016403 |
2,4-dinitrotoluene |
2,4-dinitrotoluene affects the expression of UGT2B10 mRNA | affects expression | 21346803
|
| D019324 |
beta-Naphthoflavone |
beta-Naphthoflavone results in decreased expression of UGT2B10 mRNA | decreases expression | 19737606
|
| D004391 |
Dust |
Dust results in increased expression of UGT2B10 mRNA | increases expression | 17805423
|
| C010257 |
N'-nitrosoanabasine |
UGT2B10 protein results in increased glucuronidation of N'-nitrosoanabasine | increases glucuronidation | 18238858
|
| C032978 |
N'-nitrosoanatabine |
UGT2B10 protein results in increased glucuronidation of N'-nitrosoanatabine | increases glucuronidation | 18238858
|
| C008655 |
N'-nitrosonornicotine |
UGT2B10 protein results in increased glucuronidation of N'-nitrosonornicotine | increases glucuronidation | 18238858
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000236 |
Adenoma |
|
beta-Naphthoflavone |
3.50 | 19389873 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,4-dinitrotoluene |
1.78 | 16705839 |
| MESH:D003490 |
Cyanosis |
|
2,4-dinitrotoluene |
4.43 | 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,4-dinitrotoluene |
2.03 | 21346803 18551238 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,4-dinitrotoluene |
3.24 | 16705839 |
| MESH:D008113 |
Liver Neoplasms |
|
beta-Naphthoflavone |
2.81 | 19389873 21295105 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
beta-Naphthoflavone |
3.29 | 18164116 |
| MESH:D008545 |
Melanoma |
marker/mechanism |
|
| 21499247 |
| MESH:D009336 |
Necrosis |
|
2,4-dinitrotoluene |
4.32 | 18551238 |
| MESH:D009784 |
Occupational Diseases |
|
2,4-dinitrotoluene |
3.73 | 16049721 12819281 |
| MESH:D012640 |
Seizures |
|
2,4-dinitrotoluene |
2.73 | 18551238 |
| MESH:D013274 |
Stomach Neoplasms |
|
N'-nitrosonornicotine |
3.96 | 18456281 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,4-dinitrotoluene |
2.38 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,4-dinitrotoluene |
4.78 | 10091137 |
PharmGKB Accession:PA37186
| Releated disease ID |
Related disease Name |
| PA445062 | Neoplasms |
| Releated drug ID |
Related drug Name |
| PA450626 | nicotine |
Related Diseases/Disorders