AutismKB 2.0

Annotation Detail for COL14A1


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Basic Information Top
Gene Symbol:COL14A1 ( UND )
Gene Full Name: collagen, type XIV, alpha 1
Band: 8q24.12
Quick LinksEntrez ID:7373; OMIM: 120324; Uniprot ID:COEA1_HUMAN; ENSEMBL ID: ENSG00000187955; HGNC ID: 2191
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04974Protein digestion and absorption
No data
No data
Pathway IDPathway Name
P00034Integrin signalling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in increased expression of COL14A1 mRNAincreases expression 20458559
D001374 Azacitidine Azacitidine results in increased expression of COL14A1 mRNAincreases expression 19194470
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of COL14A1 mRNAdecreases expression 17484886
C014347 decitabine decitabine results in increased expression of COL14A1 mRNAincreases expression 19194470
C116926 rofecoxib rofecoxib results in decreased expression of COL14A1 mRNAdecreases expression 17070997
D012643 Selenium Selenium results in decreased expression of COL14A1 mRNAdecreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of COL14A1 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of COL14A1 mRNAaffects expression 16962184
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1815322242 14514962 11752688
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3319825857 11798837
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001169 Arthritis, Experimental rofecoxib 4.4816690336
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.7816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms decitabine 2.0718320071 19208741
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0720435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0815721981 15700767 16011737 3786805 16124888 10355542 16097048 18705752 15673190 16192424 16227642 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1516217749 15073043 14691202 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1518788625
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6519215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 16120746 18670907
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915340226 8697196 12621046 16354765 15668235
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D003110 Colonic Neoplasms decitabine 4.3817616700
MESH:D003110 Colonic Neoplasms rofecoxib 4.3812902858
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.6720501625
MESH:D015179 Colorectal Neoplasms Azacitidine 3.6719934284
MESH:D015179 Colorectal Neoplasms decitabine 3.6718981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5310048152 15322242 20055451
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.5621278145 3786805 2869522 15027814 7440962 9327722 16227642 10092053 10915739 15998439 16177239 3732212 19085960 6884620 15968718 11566570 6623471 4309450 19336974 7120509 7179309 17522070
MESH:D056486 Drug-Induced Liver Injury Selenium 6.5615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2816714409 15322242 18230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.4919294695
MESH:D004715 Endometriosis rofecoxib 10.1015652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 10.109294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver arsenic trioxide 8.6915073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.6912795759 61145 15959796 19224547 12631006 17595544 16045604 16239168
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.6418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6420067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.6419215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006333 Heart Failure Selenium 3.2117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2012621046 15340226 16120746
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.1217440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 16354765 16959395 18606429 15340226
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007248 Infertility, Male decitabine 3.3517581917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612200463 12878042
MESH:D007251 Influenza, Human Selenium 4.5716624496
MESH:D007410 Intestinal Diseases rofecoxib 5.3415831440
MESH:D007417 Intestinal Polyps rofecoxib 5.6311245490
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007938 Leukemia arsenic trioxide 11.2515070760
MESH:D007938 Leukemia Azacitidine 11.2519148494
MESH:D007938 Leukemia decitabine 11.2518980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0417077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 17.5919077051
MESH:D007951 Leukemia, Myeloid Azacitidine 17.5919077051
MESH:D007951 Leukemia, Myeloid decitabine 17.5919117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.5016968895 16467208 20471514 17050201 19850784
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 6.5017596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.5019010910 18206229 17679729 19387464 18704418 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.8418055864
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.4519299654
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3616330433 12018890 17712046 11161223 15336539 17217047 12712474 17649720 16331271 17869043 17107899 19225113 15748426 12679006 16112521 16823087 19035177 15622746 19642359 16966277 11468182 16891316 15213294 19075265 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9216221502 11408273 17174718 16943688 21278145 17157831 11903743 16239168 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.7518317297 15673190 14716496 18472094 15052691 16136751 15370692 12741479 15893842 17557913 16116963 16638106 17565644 18412020 18054572 17761835 14620537 18251166 15650968 18376398 15925388 17714472 16015684 17922224 12389079 12958196 17698563 12586293 12445418 15996030 14512876 17766677 12666154 15123356 17823541 15931870 18006644 18339082 10355542 12649538 18279442 17708605 16027843 18210741 15959796 15730626 14716833 15338365 18263696 12898905 18156304 18277467 18429990 17481882 14724832 16248980 18418968 17869086 12667390 17805973 17525996 18187930 16011737 14748882 17640975 15818738 12445421 12632514 17900296 15362042 16097048 18472332 17976157 12546737 15876570 18395914 16192424 12632512 17631135 12609069 18395095 16033810 17944888 18420326 18205269 13678700 15057751 18705752 20821823 18166357 11481614 17721639 18481824
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 3.7517565644
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.7512878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1315720792 16964402 15830285 16246199 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9216899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 7.8714682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.8719294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8716984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.6420377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.6415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.6412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5315213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.6419825857 11798837
MESH:D008175 Lung Neoplasms Azacitidine 3.6421224363
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6419555203 11884234
MESH:D008223 Lymphoma decitabine 3.5819470736
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9015318939
MESH:D008545 Melanoma decitabine 2.2717785578 16505122
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D009006 Monosomy Azacitidine 6.4619299654
MESH:D009101 Multiple Myeloma arsenic trioxide 13.2419417148 11468182 14977855 19549372 15949261
MESH:D009101 Multiple Myeloma Azacitidine 13.2418443271 19549372
MESH:D009101 Multiple Myeloma decitabine 13.2418172295
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 13.2016882451 16105982
MESH:D009190 Myelodysplastic Syndromes Azacitidine 13.2017611569 17596541 18720364 19805378
MESH:D009190 Myelodysplastic Syndromes decitabine 13.2018608210 19010910 16882708 19157545
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009369 Neoplasms decitabine 2.8117925555 19116145 19470736
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2610525206
MESH:D010003 Osteoarthritis rofecoxib 4.5116690336
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.2012452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms decitabine 5.2019259094 19331143
MESH:D010149 Pain, Postoperative rofecoxib 5.7616678543 18165598
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.6415580305
MESH:D010190 Pancreatic Neoplasms decitabine 5.6419294695
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311118676 11399792 11896295 11222880
MESH:D055728 Primary Myelofibrosis decitabine 5.0317616702
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.5519131511
MESH:D011471 Prostatic Neoplasms Azacitidine 3.5518324645
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.6619155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2416646077
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.6217007042
MESH:D013274 Stomach Neoplasms decitabine 2.6219037991
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.9319014326
MESH:D013964 Thyroid Neoplasms decitabine 7.9317967635
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.5111780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.5119087683 17616700
MESH:D014604 Uveal Neoplasms decitabine 5.2917785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
Pathway ID Pathway Name
KEGG:04974 Protein digestion and absorption
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018