AutismKB 2.0

Annotation Detail for UPP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:UPP1 ( UDRPASE,UP,UPASE,UPP )
Gene Full Name: uridine phosphorylase 1
Band: 7p12.3
Quick LinksEntrez ID:7378; OMIM: 191730; Uniprot ID:UPP1_HUMAN; ENSEMBL ID: ENSG00000183696; HGNC ID: 12576
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY0-163salvage pathways of pyrimidine ribonucleotides
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of nucleotides
No data
Pathway IDPathway Name
P02775Salvage pyrimidine ribonucleotides
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of UPP1 mRNAincreases expression 20713471
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of UPP1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of UPP1 mRNAdecreases expression 18648102
C034753 5-benzylacyclouridine 5-benzylacyclouridine inhibits the reaction [[TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridine]decreases reaction|increases activity|increases response to substance 16397116
D000241 Adenosine UPP1 protein results in increased metabolism of Adenosineincreases metabolic processing 15772079
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of UPP1 proteinaffects expression 20106945
C053541 bicalutamide bicalutamide results in increased expression of UPP1 mRNAincreases expression 15638997
C006780 bisphenol A bisphenol A affects the expression of UPP1 mRNAaffects expression 20170705
C006780 bisphenol A bisphenol A results in decreased expression of UPP1 mRNAdecreases expression 20678512
C400082 bortezomib bortezomib inhibits the reaction [TNF protein results in increased activity of UPP1 protein]decreases reaction|increases activity 16397116
C400082 bortezomib bortezomib inhibits the reaction [TNF protein results in increased expression of UPP1 mRNA]decreases reaction|increases expression 16397116
C400082 bortezomib bortezomib results in decreased activity of UPP1 proteindecreases activity 16397116
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of UPP1 mRNAincreases expression 15336504
D002104 Cadmium Cadmium results in increased expression of UPP1 mRNAincreases expression 21172416
D016572 Cyclosporine Cyclosporine results in increased expression of UPP1 mRNAincreases expression 20106945
D003562 Cytidine UPP1 protein results in increased metabolism of Cytidineincreases metabolic processing 15772079
D004178 Diquat Diquat results in increased expression of UPP1 mRNAincreases expression 21172416
C025034 doxifluridine 5-benzylacyclouridine inhibits the reaction [[TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridine]decreases reaction|increases activity|increases response to substance 16397116
C025034 doxifluridine [TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridineincreases activity|increases response to substance 16397116
C025034 doxifluridine [TNF protein results in increased expression of UPP1 mRNA] which results in increased susceptibility to doxifluridineincreases expression|increases response to substance 16397116
D004317 Doxorubicin Doxorubicin results in decreased expression of UPP1 mRNAdecreases expression 18510171
D004958 Estradiol Estradiol results in increased expression of UPP1 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of UPP1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UPP1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of UPP1 mRNAincreases expression 17557909
D005472 Fluorouracil Fluorouracil results in increased expression of UPP1 mRNAincreases expression 15109396
D005472 Fluorouracil Fluorouracil results in increased expression of UPP1 proteinincreases expression 15331170
D005472 Fluorouracil UPP1 affects the susceptibility to Fluorouracilaffects response to substance 15067352
D005472 Fluorouracil UPP1 protein affects the susceptibility to Fluorouracilaffects response to substance 15772079
D005472 Fluorouracil [UPP1 protein results in increased metabolism of Uridine] which affects the susceptibility to Fluorouracilaffects response to substance|increases metabolic processing 15772079
D006151 Guanosine UPP1 protein results in increased metabolism of Guanosineincreases metabolic processing 15772079
D007213 Indomethacin Indomethacin results in increased expression of UPP1 mRNAincreases expression 16984733
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of UPP1 mRNAincreases expression 20713471
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of UPP1 mRNAincreases expression 17412507
D010424 Pentobarbital UPP1 protein affects the susceptibility to Pentobarbitalaffects response to substance 15772079
D010424 Pentobarbital [UPP1 protein results in increased metabolism of Uridine] which affects the susceptibility to Pentobarbitalaffects response to substance|increases metabolic processing 15772079
C006253 pirinixic acid pirinixic acid results in decreased expression of UPP1 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of UPP1 mRNAincreases expression 18301758
C030986 pyrimidine UPP1 protein results in increased metabolism of pyrimidineincreases metabolic processing 15772079
C009277 sodium arsenate sodium arsenate results in increased expression of UPP1 mRNAincreases expression 12727804
C025462 sulindac sulfide sulindac sulfide results in increased expression of UPP1 mRNAincreases expression 16184548
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of UPP1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of UPP1 mRNAincreases expression 16704738
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UPP1 mRNAaffects cotreatment|increases expression 17942748
D013849 Thimerosal Thimerosal results in increased expression of UPP1 mRNAincreases expression 16870260
D014529 Uridine UPP1 protein affects the abundance of Uridineaffects abundance 15772079
D014529 Uridine UPP1 protein results in increased metabolism of Uridineincreases metabolic processing 15772079
D014529 Uridine [UPP1 protein results in increased metabolism of Uridine] which affects the susceptibility to Fluorouracilaffects response to substance|increases metabolic processing 15772079
D014529 Uridine [UPP1 protein results in increased metabolism of Uridine] which affects the susceptibility to Pentobarbitalaffects response to substance|increases metabolic processing 15772079
D014635 Valproic Acid Valproic Acid results in increased expression of UPP1 mRNAincreases expression 19101580
D002762 Cholecalciferol Cholecalciferol results in decreased expression of UPP1 mRNAdecreases expression 16508948
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.2315322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.238875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6419490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8218653653
MESH:D000230 Adenocarcinoma Doxorubicin 15.9617418594
MESH:D000230 Adenocarcinoma Estradiol 15.9611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 15.9614692618
MESH:D000230 Adenocarcinoma Fluorouracil 15.9617638652
MESH:D000230 Adenocarcinoma Indomethacin 15.9616537180
MESH:D000230 Adenocarcinoma Methylnitrosourea 15.9615688392 15113128
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.223712494
MESH:D000236 Adenoma Indomethacin 10.2211497255
MESH:D000236 Adenoma Methylcholanthrene 10.226695378 10545420
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.8216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.8216835633
MESH:D000419 Albuminuria Doxorubicin 4.2321441931
MESH:D016301 Alveolar Bone Loss Indomethacin 5.0417225004
MESH:D000544 Alzheimer Disease Indomethacin 4.4017627676 15579461
MESH:D000544 Alzheimer Disease sulindac sulfide 4.4018759972
MESH:D000550 Amblyopia Valproic Acid 4.9017688650
MESH:D000740 Anemia Fluorouracil 7.7515504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.7511748828
MESH:D001008 Anxiety Disorders Pentobarbital 8.4111141031 18313124
MESH:D001008 Anxiety Disorders Valproic Acid 8.4117497229
MESH:D001014 Aortic Aneurysm Indomethacin 4.5410231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.5510388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1511256880
MESH:D018771 Arthralgia Indomethacin 4.842160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4615885639
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.7411248219
MESH:D050197 Atherosclerosis Cadmium 6.4615687053
MESH:D050197 Atherosclerosis Methylcholanthrene 6.4611922910
MESH:D001321 Autistic Disorder Adenosine 2.7520468076
MESH:D001321 Autistic Disorder Valproic Acid 2.7519232924 17157402 19460635 18775368 15238991 18558336 18985861 18396377 20603192 17507914 18316065 18177632 17688650 16609825 18940202
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.7116142846
MESH:D001477 Bartter Syndrome Indomethacin 4.6610684365
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.691440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 2.9120046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.8019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.8012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.3315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.338888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.3714601052
MESH:D001862 Bone Resorption bisphenol A 3.5711985600
MESH:D001929 Brain Edema Indomethacin 4.6911481608
MESH:D002545 Brain Ischemia Indomethacin 4.0912524144
MESH:D001932 Brain Neoplasms Doxorubicin 3.5317150277
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 5.4811921183
MESH:D001943 Breast Neoplasms bisphenol A 5.4817123778
MESH:D001943 Breast Neoplasms Doxorubicin 5.4811325840 15692762 16115903 18382427 18234424 15993339 17369602 18695136 17983394 15136595 19526202 16935488 15668708 17426702 15567936 15939500 16322301 16264153 16826403 15994142 15634643 16595493 18628466 16096432
MESH:D001943 Breast Neoplasms Estradiol 5.4818497071 16675129 17018787 12948864 19861407 17289903 17261762 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 5.4819217205 18357371 16595493 16110121 16557594 15136595 18608205
MESH:D001943 Breast Neoplasms Indomethacin 5.4817401462
MESH:D001943 Breast Neoplasms Methylcholanthrene 5.4817474063
MESH:D001943 Breast Neoplasms Methylnitrosourea 5.4811306469 14633655 16253758
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.4820435547
MESH:D002056 Burns Indomethacin 4.3910459503
MESH:D002100 Cachexia Indomethacin 4.6815141370 16537180 15625704 11239499
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1416111702
MESH:D002276 Carcinoid Tumor Doxorubicin 11.2516051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.2516051944
MESH:D002277 Carcinoma Fluorouracil 12.5117121937
MESH:D002277 Carcinoma Methylcholanthrene 12.5110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 12.5116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.1816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.187296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.1821507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 13.1816023760 16234567 18059187 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.1816924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.1817971768 17045692 17088986 16799960 18930000 16332177
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 13.1816391822
MESH:D002278 Carcinoma in Situ bisphenol A 4.6617123778
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.4011053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.0218791128 14736730 11352223
MESH:D002289 Carcinoma, Non-Small-Cell Lung bortezomib 5.8916052434
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 5.8912391285
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 14.097296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 14.0916201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 14.0918695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 14.0917341418
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.086189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.0818986760 17066447 16757204 16280240
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 7.0815482327 12636206
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1918850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.3215505089 15476868 18627295 16612575 15792986 17131338 16269455 17519947 16731534 16364871 15811867 17308081 16651473 16952015 16109756 16455267 16278810 17382496 17007740 17924179 17928571 17351982 16242529 17329180 17974986
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8317334414 16243910
MESH:D002386 Cataract Methylnitrosourea 3.8012484553
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 23.477505956
MESH:D002471 Cell Transformation, Neoplastic Cadmium 23.4717332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 23.4712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 23.4718566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 23.4716192471
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 23.472727394 7505956
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5920734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D002764 Cholecystitis Indomethacin 4.8411181007
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 17.2519486331 9022650
MESH:D002779 Cholestasis Cyclosporine 17.2519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.2511677210 17333356 16105132 15861022 17681005 17110522 16919318
MESH:D002779 Cholestasis pirinixic acid 17.2519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.978697196 12621046 16354765 15668235 15340226
MESH:D003110 Colonic Neoplasms Fluorouracil 3.7417172411 17016597 17287894 16340194 16510598 17169374 15001691 17725105 17018589 18772588
MESH:D003110 Colonic Neoplasms Indomethacin 3.7415963497 15936596 15625704 11260862 15637740 15786552
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.3618802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.3620501625 16331619 18448328 17016601 18802399 18509181 16391804 15148649 16524972 15289873 17695437 18949393 17594712 17255274 17094418 16282729 14970324 17454858 16303861 17401013 18383874 18288408
MESH:D015179 Colorectal Neoplasms Indomethacin 3.3612606626 11197048 18059344 17054584
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7914669216 17141729
MESH:D018352 Coronavirus Infections Indomethacin 5.3917302372
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.6610525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6615322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.6616575769 17688650 8888407
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7018551238
MESH:D007644 Darier Disease Fluorouracil 4.4716733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.4218759878 11906362 12868966 8156756 11298694 2524372 8970840 14531868
MESH:D017449 Dermatitis, Allergic Contact Thimerosal 6.4215932584 16958921
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.192952479 3621924
MESH:D002658 Developmental Disabilities Thimerosal 4.6215764492
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1419279558
MESH:D003967 Diarrhea Indomethacin 3.497237001 7907874
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 17.0821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 17.088291058 1440618 6482804 7440962 18648102 16192314 9022650 9328219 11289319 6679447 18289764 18692083 9653073
MESH:D056486 Drug-Induced Liver Injury Diquat 17.0818445702 18164269
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 17.0817416283
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 17.0818186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.0820420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 17.0819641884 1733752
MESH:D004362 Drug Toxicity Doxorubicin 7.3218602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.3211462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.8218043480 18446180 16133044 17190690 16326151 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 3.8311991626 17151854 17351913 11595431 11595415 10671773 16699067 11535926 17329845 17202747 17045617
MESH:D004421 Dystonia Valproic Acid 3.751851702
MESH:D004487 Edema Indomethacin 9.7919703484 16100529 8985016 8273558 10653021 7990266 7907874
MESH:D004487 Edema pirinixic acid 9.7912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.7911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.8812538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 6.8317359293
MESH:D016889 Endometrial Neoplasms Estradiol 6.8311473722 19148513 18566989
MESH:D004715 Endometriosis Indomethacin 8.1415652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.1410568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8318037988
MESH:D019446 Endotoxemia Indomethacin 4.1818509659
MESH:D004751 Enteritis Indomethacin 4.4210567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.6617980183
MESH:D004802 Eosinophilia Indomethacin 3.7411298111
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.843659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.593922381 16628512
MESH:D004827 Epilepsy Adenosine 6.8011404469
MESH:D004827 Epilepsy Valproic Acid 6.8020417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.326426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.987750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.743659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.813581430
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.8116481741 16337965 15173087 17638652 16785472
MESH:D004938 Esophageal Neoplasms Indomethacin 6.8111005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7711564622
MESH:D005234 Fatty Liver Cyclosporine 16.3619224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.3615345470
MESH:D005234 Fatty Liver pirinixic acid 16.3620131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 16.3619224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.828888407 18558336
MESH:D005334 Fever Indomethacin 3.8411852909 17627676 10431976
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.696705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.2619069698
MESH:D005354 Fibrosarcoma Indomethacin 18.4210962813
MESH:D005354 Fibrosarcoma Methylcholanthrene 18.4214633661 10962813
MESH:D005354 Fibrosarcoma Methylnitrosourea 18.4211555667
MESH:D005355 Fibrosis Cyclosporine 12.9512639820 12168785
MESH:D005355 Fibrosis Indomethacin 12.9517994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.9520067830
MESH:D005499 Folliculitis Indomethacin 4.8411298111
MESH:D005756 Gastritis Diquat 10.7415046732
MESH:D005756 Gastritis Indomethacin 10.7415046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.898708960
MESH:D005909 Glioblastoma Doxorubicin 6.7417150277
MESH:D005909 Glioblastoma Indomethacin 6.7412870263
MESH:D005910 Glioma Fluorouracil 9.2916145905
MESH:D005910 Glioma Indomethacin 9.2916487511 18371953
MESH:D005910 Glioma Methylnitrosourea 9.299825942
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.0311849393
MESH:D018149 Glucose Intolerance sodium arsenate 4.7819446573
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.747505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D006073 Gout Indomethacin 5.0211248219
MESH:D006258 Head and Neck Neoplasms Doxorubicin 11.7915692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 11.7915162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Indomethacin 11.7915482327
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1610048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.2616707910 16495754 14766674 16244372 18674790 17875725 17888722 16330681 12587719 18006777 16144979 16879835 16244371
MESH:D006333 Heart Failure Doxorubicin 6.3817481944
MESH:D006333 Heart Failure pirinixic acid 6.3820558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6115692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.2815633222
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.216705139
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.3715135802
MESH:D006529 Hepatomegaly pirinixic acid 7.2119772884 19176532 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.2115340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.7015709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.1418501091 17606976 15147373
MESH:D019584 Hot Flashes Estradiol 3.4217088409
MESH:D006849 Hydrocephalus Valproic Acid 4.5417688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7115340226 16959395 18606429 16354765 8697196
MESH:D006930 Hyperalgesia Indomethacin 3.5212727271
MESH:D034321 Hyperamylasemia Indomethacin 5.3917883296
MESH:D006934 Hypercalcemia bortezomib 5.1618089816
MESH:D006940 Hyperemia Indomethacin 4.6812524144
MESH:D006943 Hyperglycemia pirinixic acid 2.9020558911
MESH:D006949 Hyperlipidemias Indomethacin 3.8617546600
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.6215034207
MESH:D006973 Hypertension Cyclosporine 4.5210903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.5218670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4916569931 16945680
MESH:D007077 Ileal Diseases Indomethacin 4.6918306037 10574470
MESH:D007079 Ileitis Indomethacin 5.0210651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.0416133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1612013081
MESH:D007248 Infertility, Male Diquat 10.234850670
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.2317937319
MESH:D007248 Infertility, Male Methylnitrosourea 10.237193160
MESH:D007249 Inflammation Indomethacin 4.557812673 3291741 12568917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.5512878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 11.0916393666
MESH:D007333 Insulin Resistance Estradiol 11.0916393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.0916306350
MESH:D007410 Intestinal Diseases Indomethacin 4.0117329856 15610444 18236018 11686837 11713966 11855677 17994277 15831440 10210152
MESH:D019586 Intracranial Hypertension Indomethacin 5.0415241188
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.698074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0516580747
MESH:D007579 Jejunal Diseases Indomethacin 4.6910574470 18306037 16133968
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1115604871
MESH:D007674 Kidney Diseases Cadmium 17.0716962696 16226777 16322080
MESH:D007674 Kidney Diseases Cyclosporine 17.0718776723 8314463 10903974
MESH:D007674 Kidney Diseases Doxorubicin 17.0715699352 16775033 15369732
MESH:D007674 Kidney Diseases Estradiol 17.0715618244
MESH:D007674 Kidney Diseases Indomethacin 17.0717190690
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.8616707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 20.5516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 20.556582329
MESH:D007680 Kidney Neoplasms Cyclosporine 20.5512371664
MESH:D007680 Kidney Neoplasms Estradiol 20.5515610895
MESH:D007680 Kidney Neoplasms Fluorouracil 20.5516985049
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.6410320625 12228301 11703811
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8316085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell bortezomib 4.8918089816
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.6910785260 15631656 16572323
MESH:D015470 Leukemia, Myeloid, Acute bortezomib 5.9920471514
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 5.9918360721
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 5.9916294345 17596541
MESH:D007964 Leukocytosis Indomethacin 5.0416537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.3917980183
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 3.9715526292
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.3911479899
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.999327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Adenosine 8.1618263696
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.1616439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.1614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 8.1618194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.1615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.1612878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 9.629163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 9.6217045692 18383874 16603448 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 9.6215890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.6216984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 16.491399818 6587162 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 16.498603461
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 16.4916842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 16.491399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.4912151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.1516080182
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.9317228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.0114755239
MESH:D008175 Lung Neoplasms Doxorubicin 10.0117418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 10.0115246190
MESH:D008175 Lung Neoplasms Indomethacin 10.0116537180 11053908 11497255
MESH:D008175 Lung Neoplasms Methylcholanthrene 10.011399818 9230183 10545420 20512841 7750092 6695378 15390079 20970405 16337739 11893704 17909032 16271038 21163286
MESH:D008175 Lung Neoplasms Methylnitrosourea 10.0118062963
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.0111884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4715086387
MESH:D008223 Lymphoma bortezomib 11.5316098063
MESH:D008223 Lymphoma Doxorubicin 11.5316098063
MESH:D008223 Lymphoma Methylnitrosourea 11.5311418001 16257854
MESH:D016393 Lymphoma, B-Cell bortezomib 9.9116675587
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 9.9114633661
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2515621674
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 12.6411921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 12.6415458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.6417203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 12.6414999141 16619500 15688392 17131329 16944150 14633655 19196723 17020996 11751437 12931682 10767621 16051031 11807958 10838139 15113128 16827153 15313902
MESH:D020149 Manganese Poisoning Estradiol 4.1519453300
MESH:D008527 Medulloblastoma bortezomib 4.1019213072
MESH:D008545 Melanoma Doxorubicin 2.2416827129
MESH:D008654 Mesothelioma Doxorubicin 2.9317638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4616801185
MESH:D008881 Migraine Disorders Indomethacin 6.9511903285
MESH:D008881 Migraine Disorders Valproic Acid 6.9518803445 18765137
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2115792986
MESH:D009062 Mouth Neoplasms Fluorouracil 8.0016757204 18986760
MESH:D009062 Mouth Neoplasms Indomethacin 8.0012636206
MESH:D052016 Mucositis Doxorubicin 4.4617415656
MESH:D009101 Multiple Myeloma bortezomib 4.2619112201 19112817 19372569
MESH:D009135 Muscular Diseases pirinixic acid 3.1916239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 9.7118186108
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 9.718888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.9717596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.2419429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 5.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.4316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.4316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.5318551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.813581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 8.8118259882
MESH:D009362 Neoplasm Metastasis Indomethacin 8.8116537180 11053908 11239499
MESH:D009369 Neoplasms Fluorouracil 7.4218600527 16928823 18239605
MESH:D009369 Neoplasms Methylnitrosourea 7.4215533788
MESH:D009369 Neoplasms pirinixic acid 7.4217405874
MESH:D009374 Neoplasms, Experimental Indomethacin 8.5210663608 15625704
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 8.5212696579
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4117289903
MESH:D009401 Nephrosis Doxorubicin 4.4516636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.3919348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.3916889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 14.5611399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 14.5611399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.5614600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.026679447
MESH:D009436 Neural Tube Defects sodium arsenate 11.0211749123 18186108 19446573 10525206
MESH:D009436 Neural Tube Defects Valproic Acid 11.028888407 16359493
MESH:D009442 Neurilemmoma Methylnitrosourea 5.1611555667
MESH:D009447 Neuroblastoma Doxorubicin 3.0915555623
MESH:D019636 Neurodegenerative Diseases Indomethacin 3.6812349958
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2216436463
MESH:D009765 Obesity pirinixic acid 1.7320558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.846374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.9516049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 7.954026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.693988306
MESH:D010003 Osteoarthritis Indomethacin 3.477009135
MESH:D012516 Osteosarcoma Doxorubicin 3.8615930896
MESH:D010049 Ovarian Diseases bisphenol A 4.6611985600
MESH:D010051 Ovarian Neoplasms Estradiol 2.1219401270
MESH:D010146 Pain Indomethacin 3.2117627676 13679232 17440234 3291741
MESH:D010149 Pain, Postoperative Indomethacin 4.3518702446 12538197
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.2619003803 16500647 16929163 15113037
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 5.2616965848
MESH:D010195 Pancreatitis Indomethacin 3.6317883296 15028970
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.177296757
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.3916537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.8412349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.3911903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D010437 Peptic Ulcer Indomethacin 4.8211148446
MESH:D010518 Periodontitis Indomethacin 4.5817225004
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.0615687053
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.146228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8317638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9512371664
MESH:D047928 Premature Birth Indomethacin 4.8117000239
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 14.3510548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.3511118676 11222880 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 14.3520603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.5820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.5820887781
MESH:D011471 Prostatic Neoplasms bicalutamide 2.3818487222 15638997 19240160 19011039 17914592
MESH:D011471 Prostatic Neoplasms bisphenol A 2.3816740699
MESH:D011471 Prostatic Neoplasms Cadmium 2.3817075824
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.3817024972
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.3816888761 16729912 18437689 15897917 16868541 15749863
MESH:D011471 Prostatic Neoplasms Estradiol 2.3816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.3818626508 19082440
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.3815682402 12376480
MESH:D011507 Proteinuria Indomethacin 3.8611849393
MESH:D011537 Pruritus Ethinyl Estradiol 2.9915861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.2112752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.1116882103
MESH:D011629 Puberty, Precocious bisphenol A 4.4610548101
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7415538739 16160472 18286688 18722050
MESH:D012021 Reflex, Abnormal Pentobarbital 5.6910930210
MESH:D051437 Renal Insufficiency Doxorubicin 3.9017922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.313692021
MESH:D012162 Retinal Degeneration Methylnitrosourea 8.3118155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 5.1611555667
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.8719155313
MESH:D012509 Sarcoma Doxorubicin 3.7116767912 17710206 17203757 15625365 15675481 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.9316326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4617846226
MESH:D012559 Schizophrenia Valproic Acid 2.0315737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 8.7218551238
MESH:D012640 Seizures Pentobarbital 8.729754883 10087439
MESH:D012640 Seizures Valproic Acid 8.7211738929 1511512 15475178 11044598 17978042 14763951 16876388 3137016
MESH:D012878 Skin Neoplasms Doxorubicin 8.5615692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.568532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.5616192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2517203757 16767912 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6116709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5319490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2112833885
MESH:D013272 Stomach Diseases Indomethacin 4.0917160473 17207306 10486359 18545984 16280098 10215738 17638125 16113693 10192188 16184426 18209964 15038085 15472012
MESH:D013274 Stomach Neoplasms Fluorouracil 3.4016951190 18567086 19015929 16424979 15786421 17522103 17498489 17172411 18396642 19084572
MESH:D013274 Stomach Neoplasms Indomethacin 3.4015609394
MESH:D013274 Stomach Neoplasms Methylnitrosourea 3.4018593901 15930296 16257854
MESH:D013276 Stomach Ulcer Indomethacin 3.3017135157 17657623 12500499 18726076 16252198 16631530 11906479 18193104 12498302 17654042 11523592 17895592 11595415 16169175 17627676 17977527 11729361 12787963 11595431 10423059 12077510 16934674 15104355 18181030 15138204 14567935 16397915 12467913 11145282 1323529 18087811 16755016 18209962 18543354 18237397 18299717 10750652 10878458 17918041 18431645 16150113 15255614
MESH:D019966 Substance-Related Disorders bisphenol A 3.6616045194 16684133
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 4.709754883 11529278
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8815669648
MESH:D013953 Thymus Neoplasms Methylnitrosourea 4.9111418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 15.171399818 3712494 6587162 7505956 6582329
MESH:D013964 Thyroid Neoplasms Doxorubicin 15.1716010429 17909728
MESH:D013964 Thyroid Neoplasms Indomethacin 15.1718791128 11352223 14736730
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 15.177505956 3078959
MESH:D013978 Tibial Fractures Estradiol 4.3519048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7116280240
MESH:D014178 Translocation, Genetic Valproic Acid 4.9017262798
MESH:D014456 Ulcer Indomethacin 4.5717380554 10574470
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.193119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.5716049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 7.578074119
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 7.5717653716
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.328888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.9910091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.6016803524
MESH:D014591 Uterine Diseases bisphenol A 4.6814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.6614692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 8.6618645019
MESH:D014605 Uveitis Cyclosporine 3.651336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9017334414 17638931 17678736 16364871
MESH:D014839 Vomiting Indomethacin 4.4211897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1117120751
Pathway ID Pathway Name
KEGG:00983 Drug metabolism - other enzymes
KEGG:01100 Metabolic pathways
REACT:1698 Metabolism of nucleotides
KEGG:00240 Pyrimidine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA365
    • No data
    Releated disease ID Related disease Name
    PA446108Colorectal Neoplasms
    Releated drug ID Related drug Name
    PA448771capecitabine
    PA128406956fluorouracil
    PA450626nicotine
    PA130230921uridine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB07437 - 1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4(1H,3H)-DIONE
    Drugbank ID Action Drug Name Description
    DB00544 substrate Fluorouracil Antineoplastic Agents;Antimetabolites;Immunosuppressive Agents;Antimetabolites, Antineoplastic
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved