AutismKB 2.0

Annotation Detail for UPK3A


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Basic Information Top
Gene Symbol:UPK3A ( MGC119178,UP3A,UPIII,UPIIIA,UPK3 )
Gene Full Name: uroplakin 3A
Band: 22q13.31
Quick LinksEntrez ID:7380; OMIM: 611559; Uniprot ID:UPK3A_HUMAN; ENSEMBL ID: ENSG00000100373; HGNC ID: 12580
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of UPK3A mRNAincreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of UPK3A proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of UPK3A mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of UPK3A mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of UPK3A mRNAdecreases expression 20106945
D013629 Tamoxifen Tamoxifen results in decreased expression of UPK3A mRNAdecreases expression 15590111
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5020464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 4.5011473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.153712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.156695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8520146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 1.8516675129 18497071 17018787 17261762 12948864 19861407 14630087 17289903
MESH:D001943 Breast Neoplasms Tamoxifen 1.8520135344 21152245 19155303 19221464 18629630 20859285 11161223 19289846 18855134 19189212 16202921 18821012 19142967 18997820 16273361 20544844 19059307 19487384 19103187 19200415 18351453 16818667 17440819 19189210 19066611 18425577 18815881 19244106 17242785 17261762 18984771 15668708 16873071 20005174 19115204 17893378 19084267 15565566 17049068 21138602 19288272 20390343 19011961 19410462 20065188
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.9316111702
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.913581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.9121507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.9116924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.9116924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9217572228
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.387505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.3812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 12.3818566989
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.6519486331 9022650
MESH:D002779 Cholestasis Cyclosporine 8.6519486331
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2112868966 14531868 11906362 2524372 8156756 18759878 11298694 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D003928 Diabetic Nephropathies Estradiol 9.8119279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.8119279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.036482804 7440962 18289764 1440618 18648102 16192314 9653073 9022650 11289319 9328219 8291058 18692083 6679447
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.9219031437
MESH:D016889 Endometrial Neoplasms Estradiol 8.0419148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 8.0416202921 20544844 19155303 17893378
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.583581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5816530937
MESH:D005234 Fatty Liver Cyclosporine 8.8119224547
MESH:D005234 Fatty Liver Tamoxifen 8.8119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D005355 Fibrosis Cyclosporine 3.5612639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006558 Herpes Genitalis Estradiol 5.5515709030
MESH:D019584 Hot Flashes Estradiol 4.2717088409
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007249 Inflammation Tamoxifen 2.4919457130
MESH:D007333 Insulin Resistance Estradiol 3.1616627594 16393666
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.549022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.4918776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 6.4915618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 20.066582329
MESH:D007680 Kidney Neoplasms Cyclosporine 20.0612371664
MESH:D007680 Kidney Neoplasms Estradiol 20.0615610895
MESH:D007680 Kidney Neoplasms Tamoxifen 20.0618625569
MESH:D008064 Lipidoses Tamoxifen 3.3717567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.5218564211
MESH:D008113 Liver Neoplasms Aflatoxin B1 8.0415890375 2125692 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.0421137059 20195826
MESH:D008113 Liver Neoplasms Tamoxifen 8.0416684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.571399818 3712494 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.578603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5814755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5818816296 20464547 20135361 17053015 18520028 20064080 18569708 6695378 20869020
MESH:D008175 Lung Neoplasms Tamoxifen 3.5818625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6116891317 11408345 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.6116827153 11731420 19196722 14580682 19196723
MESH:D020149 Manganese Poisoning Estradiol 14.4519453300
MESH:D020149 Manganese Poisoning Tamoxifen 14.4519453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5216810080
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.053581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.0519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3011141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 4.0311399458 16427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.724026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2120887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4517292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.4516740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4515067354
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
OMIM:191830 RENAL ADYSPLASIA marker/mechanism
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4919755658 10029692
MESH:D013088 Spermatocele Tamoxifen 4.8116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5019457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.126587162 6582329 3712494 1399818 7505956
MESH:D013978 Tibial Fractures Estradiol 5.2119048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.888074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.8817053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.8816712894 17572228 8653321
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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