AutismKB 2.0

Annotation Detail for UQCRB


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Basic Information Top
Gene Symbol:UQCRB ( FLJ92016,FLJ97033,QCR7,QP-C,QPC,UQBC,UQBP,UQCR6,UQPC )
Gene Full Name: ubiquinol-cytochrome c reductase binding protein
Band: 8q22.1
Quick LinksEntrez ID:7381; OMIM: 191330; Uniprot ID:QCR7_HUMAN; ENSEMBL ID: ENSG00000156467; HGNC ID: 12582
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa04260Cardiac muscle contraction
Pathway IDPathway Name
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncou
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Mitochondrial complex III deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of UQCRB mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of UQCRB mRNAdecreases expression 12958071
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA]decreases reaction|increases expression 16964424
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of UQCRB mRNAaffects cotreatment|increases expression 18313992
D004317 Doxorubicin Doxorubicin results in increased expression of UQCRB proteinincreases expression 16144979
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of UQCRB mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of UQCRB mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UQCRB mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of UQCRB mRNA]affects reaction|decreases expression 15016801
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of UQCRB mRNAaffects cotreatment|increases expression 17183730
D008628 Mercury Mercury results in increased expression of UQCRB mRNAincreases expression 16823088
D015735 Mifepristone Mifepristone results in increased expression of UQCRB mRNAincreases expression 17584828
D012402 Rotenone Rotenone results in increased expression of UQCRB mRNAincreases expression 18191903
D012643 Selenium Selenium results in decreased expression of UQCRB mRNAdecreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of UQCRB mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of UQCRB mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UQCRB mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of UQCRB mRNAdecreases expression 20399798
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of UQCRB mRNAaffects cotreatment|increases expression 17183730
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of UQCRB mRNAaffects cotreatment|increases expression 18313992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2811752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.288875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9119490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.819612607
MESH:D000230 Adenocarcinoma Doxorubicin 7.1017418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1014692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.1017638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3716835633
MESH:D000419 Albuminuria Doxorubicin 4.5321441931
MESH:D000550 Amblyopia Valproic Acid 5.2317688650
MESH:D000740 Anemia Fluorouracil 8.6216511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.6211748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.5517497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D001321 Autistic Disorder Mercury 2.3517497416
MESH:D001321 Autistic Disorder Valproic Acid 2.3518177632 17688650 19460635 17157402 15238991 18940202 18396377 18775368 19232924 17507914 18316065 16609825 18985861 20603192 18558336
MESH:D001327 Autoimmune Diseases Mercury 4.8616634805
MESH:D001714 Bipolar Disorder Valproic Acid 3.0617594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.9815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.988888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.7014601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.7917150277
MESH:D001943 Breast Neoplasms Doxorubicin 1.9615939500 15567936 18382427 19526202 18695136 17983394 16264153 16322301 15136595 11325840 16935488 15668708 15994142 18628466 16595493 17426702 15634643 18234424 15993339 16826403 17369602 16096432 16115903 15692762
MESH:D001943 Breast Neoplasms Fluorouracil 1.9619217205 16110121 15136595 16595493 18608205 18357371 16557594
MESH:D001943 Breast Neoplasms Tamoxifen 1.9619155303 15668708 17242785 17261762 11161223 19011961 19103187 17893378 18984771 20859285 19244106 18815881 20065188 16873071 18351453 20544844 18821012 18855134 20005174 19221464 18425577 18629630 19066611 21138602 20135344 19115204 18997820 15565566 16818667 16202921 16273361 21152245 19059307 17049068 19142967 19487384 19288272 19084267 19200415 19410462 19289846 19189212 20390343 17440819 19189210
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002276 Carcinoid Tumor Doxorubicin 12.3516051944
MESH:D002276 Carcinoid Tumor Fluorouracil 12.3516051944
MESH:D002277 Carcinoma Fluorouracil 8.1317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.1316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4919066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.5816705839
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.5816234567 18059187 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.5817971768 17088986 16332177 18930000 17045692 16799960
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.5816924424
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.6416201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.6418695887
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.846189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8418986760 17066447 16280240 16757204
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518850075 16120746 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.5117924179 16364871 18627295 16612575 15811867 17519947 16731534 17131338 17351982 16242529 17928571 16455267 17382496 17007740 15505089 16109756 15792986 17329180 15476868 17974986 16952015 16278810 17308081 16269455 16651473
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 6.1616243910 17334414
MESH:D002311 Cardiomyopathy, Dilated Mercury 6.1610334427
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.756135515
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7020734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8617110522 16105132 15861022 17681005 17333356 16919318 11677210
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7415894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0915340226 15668235 8697196 12621046 16354765
MESH:D003092 Colitis Selenium 3.7717936198
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2317725105 17287894 18772588 17018589 17172411 15001691 16510598 16340194 17169374 17016597
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.6418259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6417454858 18383874 16303861 17594712 17401013 15289873 14970324 17695437 16331619 17094418 15148649 16282729 18509181 18949393 18802399 17016601 18448328 16391804 20501625 18288408 16524972 17255274
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4720055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.478888407 17688650 16575769
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0018551238
MESH:D007644 Darier Disease Fluorouracil 4.7816733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3519031437
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.7816823706
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7616285004
MESH:D003924 Diabetes Mellitus, Type 2 astaxanthine 4.8616964424
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.8617107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4619279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.2018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 15.2017416283
MESH:D056486 Drug-Induced Liver Injury Selenium 15.2015131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 15.2015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.2020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 15.201733752 19641884
MESH:D004362 Drug Toxicity Doxorubicin 19.5418602426
MESH:D004362 Drug Toxicity Lamivudine 19.5415040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 19.5411462148
MESH:D004362 Drug Toxicity Zidovudine 19.5415040536
MESH:D004421 Dystonia Valproic Acid 4.031851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9018230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.8919031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.5217359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.5220544844 19155303 17893378 16202921
MESH:D004715 Endometriosis Mifepristone 9.0916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.099294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.1618037988
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.1417275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.9216628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9220417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.576426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.287750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.063659116
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4416481741 16337965 15173087 16785472 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.6715345470
MESH:D005234 Fatty Liver Tamoxifen 18.6719224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 18.6714986274 19224547
MESH:D005234 Fatty Liver Zidovudine 18.6718299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8916575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.1118558336 8888407
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5214745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 11.4119069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 11.4119069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9320067830
MESH:D005909 Glioblastoma Doxorubicin 3.3317150277
MESH:D005910 Glioma Fluorouracil 2.8616145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.8715692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.8718337622 15102660 15162350
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3211294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.4716144979 17875725 17888722 16244372 16330681 16879835 14766674 16495754 16244371 18006777 18674790 12587719 16707910
MESH:D006333 Heart Failure Doxorubicin 7.2017481944
MESH:D006333 Heart Failure Selenium 7.2017162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8815692506
MESH:D006402 Hematologic Diseases Zidovudine 4.6912579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006509 Hepatitis B Lamivudine 5.0817703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.0816476009 12044531 15309715 15631357 15274664
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8816120746 12621046 15340226
MESH:D015658 HIV Infections Lamivudine 7.0220032539 11141242 17530837 9296927
MESH:D015658 HIV Infections Zidovudine 7.0220032539 11363243 11141242 17358032 11698656
MESH:D006689 Hodgkin Disease Doxorubicin 3.3917606976 18501091 15147373
MESH:D006849 Hydrocephalus Valproic Acid 4.8617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0515340226 16354765 18606429 16959395 8697196
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9018670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.6116612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4717937319
MESH:D007249 Inflammation Tamoxifen 4.8519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8512200463 12878042
MESH:D007251 Influenza, Human Selenium 4.2016624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.2614714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007674 Kidney Diseases Doxorubicin 6.5215369732 16775033 15699352
MESH:D007674 Kidney Diseases Mercury 6.5217934191
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.9216707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.9216518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.6716705839
MESH:D007680 Kidney Neoplasms Fluorouracil 17.6716985049
MESH:D007680 Kidney Neoplasms Tamoxifen 17.6718625569
MESH:D007680 Kidney Neoplasms Zidovudine 17.6712579204
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1616085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.3920370541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1516294345 17596541
MESH:D008064 Lipidoses Tamoxifen 3.1417567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.4816439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4812878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.647678174
MESH:D008113 Liver Neoplasms Fluorouracil 10.6416603448 18383874 17045692 15113037
MESH:D008113 Liver Neoplasms Tamoxifen 10.6416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.6416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.766135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.7617085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7612151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2617228818
MESH:D008175 Lung Neoplasms Doxorubicin 6.586189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 6.5815246190
MESH:D008175 Lung Neoplasms Tamoxifen 6.5818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5819555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 6.5818800350
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7815086387
MESH:D008223 Lymphoma Doxorubicin 3.4416098063
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0414737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7717654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.5515621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7519428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.9415458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.9415318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.9419196722 11731420 19196723 16827153 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.5519453300
MESH:D008545 Melanoma Doxorubicin 3.4016827129
MESH:D008545 Melanoma Tamoxifen 3.4019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1715990972
MESH:D008654 Mesothelioma Doxorubicin 6.2617638057
MESH:D008654 Mesothelioma Selenium 6.2615107826
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.8417358032
MESH:D008881 Migraine Disorders Valproic Acid 3.1718765137 18803445
OMIM:124000 MITOCHONDRIAL COMPLEX III DEFICIENCY marker/mechanism
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4815792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6116757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.7817415656
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.018888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1417596541
MESH:D009203 Myocardial Infarction Doxorubicin 2.9415857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8518551238 7678174
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.8418259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.8419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5119410462
MESH:D009369 Neoplasms Fluorouracil 2.6016928823 18600527 18239605
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0019200415 19189210 19196722
MESH:D009401 Nephrosis Doxorubicin 4.7516899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.9816889571 15640375
MESH:D009410 Nerve Degeneration Rotenone 3.8617356569 18619942 15790535
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2014600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.118888407 16359493
MESH:D009447 Neuroblastoma Doxorubicin 3.2515555623
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4216436463
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4116049721
MESH:D012516 Osteosarcoma Doxorubicin 4.0915930896
MESH:D010051 Ovarian Neoplasms Mifepristone 3.1216525653
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.6616500647 16929163 15113037 19003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010300 Parkinson Disease Rotenone 2.9716412576 18191903 11535288 19114014 11445065 15451049 16140633 19232380 18619942
MESH:D020734 Parkinsonian Disorders Rotenone 4.0618197244 15795934 15927086 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1617983394
MESH:D010954 Plasmacytoma Selenium 4.8915087411
MESH:D010997 Pleural Neoplasms Doxorubicin 5.1617638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4411118676 11222880 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.4420603192
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.1016729912 16868541 15897917 18437689 15749863 16888761
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1019082440 18626508
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.1018760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3016919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.5411422049 12752131
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9916160472 18286688 15538739 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 4.2117922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.539296927
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.1619155313
MESH:D012509 Sarcoma Doxorubicin 3.9715675481 17203757 15625365 17710206 18313854 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.2316326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7817846226
MESH:D012559 Schizophrenia Valproic Acid 2.0719110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 5.8918551238
MESH:D012640 Seizures Valproic Acid 5.8914763951 1511512 11044598 3137016 16876388 11738929 17978042 15475178
MESH:D012878 Skin Neoplasms Doxorubicin 5.6515692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6516192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5517203757 15625365 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 11.5616709447
MESH:D013088 Spermatocele Tamoxifen 11.5616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0319457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.5412833885
MESH:D013274 Stomach Neoplasms Fluorouracil 2.7517522103 16951190 16424979 18396642 15786421 17498489 18567086 19084572 17172411 19015929
MESH:D013274 Stomach Neoplasms Zidovudine 2.7517696246
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.3517909728 16010429
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9716280240
MESH:D014178 Translocation, Genetic Valproic Acid 5.2317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.513119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.3116049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.3117653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.318653321 16712894 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.638888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3110091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.8616803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2814692618
MESH:D014625 Vaginal Neoplasms Zidovudine 4.7412579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.2117638931 17334414 17678736 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:04260 Cardiac muscle contraction
KEGG:05016 Huntington's disease
KEGG:01100 Metabolic pathways
KEGG:00190 Oxidative phosphorylation
KEGG:05012 Parkinson's disease
REACT:6305 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03122 - B-Octylglucoside Detergents
DB04141 - 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
DB04799 - 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole
DB07401 - METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
DB07636 - 5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE
DB07763 - (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE
DB07778 - FAMOXADONE
DB08330 - METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
DB08453 - 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
DB08690 - UBIQUINONE-2
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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