AutismKB 2.0

Annotation Detail for UQCRC1


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Basic Information Top
Gene Symbol:UQCRC1 ( D3S3191,QCR1,UQCR1 )
Gene Full Name: ubiquinol-cytochrome c reductase core protein I
Band: 3p21.31
Quick LinksEntrez ID:7384; OMIM: 191328; Uniprot ID:QCR1_HUMAN; ENSEMBL ID: ENSG00000010256; HGNC ID: 12585
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa04260Cardiac muscle contraction
Pathway IDPathway Name
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncou
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016572 Cyclosporine Cyclosporine results in decreased expression of UQCRC1 mRNAdecreases expression 20106945
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of UQCRC1 mRNAaffects cotreatment|increases expression 18313992
17526437
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of UQCRC1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of UQCRC1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UQCRC1 mRNAaffects cotreatment|increases expression 17942748
D012402 Rotenone Rotenone results in increased expression of UQCRC1 mRNAincreases expression 18191903
D012643 Selenium Selenium results in increased expression of UQCRC1 mRNAincreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of UQCRC1 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of UQCRC1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UQCRC1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of UQCRC1 mRNAincreases expression 20399798
D014810 Vitamin E Vitamin E results in increased expression of UQCRC1 mRNAincreases expression 19244175
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of UQCRC1 mRNAaffects cotreatment|increases expression 17526437
18313992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.049612607
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.9416873071 16273361 19115204 18855134 19221464 19155303 19487384 19103187 18984771 18629630 17049068 19142967 18425577 16202921 16818667 18351453 19189212 20135344 19244106 11161223 19011961 19059307 17440819 15565566 18815881 17261762 21152245 18997820 19189210 19289846 20065188 17893378 15668708 19288272 17242785 19410462 20390343 20859285 21138602 19084267 19200415 18821012 20544844 20005174 19066611
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8416924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 8.2019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2017333356 16919318 11677210 15861022 17110522 17681005 16105132
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9715894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 15340226 12621046 8697196 16354765
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5215322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5219769572
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9316285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6319279558
MESH:D056486 Drug-Induced Liver Injury Selenium 6.5015131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.5015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5020420201
MESH:D004362 Drug Toxicity Lamivudine 14.6215040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 14.6211462148
MESH:D004362 Drug Toxicity Zidovudine 14.6215040536
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.6212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.6219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1520544844 19155303 17893378 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 20.2819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.2815345470
MESH:D005234 Fatty Liver Tamoxifen 20.2814986274 19224547
MESH:D005234 Fatty Liver Zidovudine 20.2818299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005355 Fibrosis Cyclosporine 9.2112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8510048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.8516080930
MESH:D006333 Heart Failure Selenium 3.1717162251
MESH:D006402 Hematologic Diseases Zidovudine 4.9012579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006509 Hepatitis B Lamivudine 5.2717703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.2716476009 15631357 15274664 12044531 15309715
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1116120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516490937 16863852
MESH:D015658 HIV Infections Lamivudine 7.339296927 20032539 17530837 11141242
MESH:D015658 HIV Infections Zidovudine 7.3320032539 11141242 11698656 11363243 17358032
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 18606429 16959395 15340226 16354765
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Tamoxifen 5.1619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1612878042 12200463
MESH:D007251 Influenza, Human Selenium 11.8616624496
MESH:D007251 Influenza, Human Vitamin E 11.8616624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.3814714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 6.338314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 6.3312488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms Cyclosporine 13.3412371664
MESH:D007680 Kidney Neoplasms Tamoxifen 13.3418625569
MESH:D007680 Kidney Neoplasms Zidovudine 13.3412579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.5820370541
MESH:D008064 Lipidoses Tamoxifen 3.2717567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5512878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5516169303
MESH:D008113 Liver Neoplasms Tamoxifen 4.5816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2012151625
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D008175 Lung Neoplasms Tamoxifen 5.0118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0111884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 5.0111062179
MESH:D008175 Lung Neoplasms Zidovudine 5.0118800350
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2414737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.4015318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.4019196723 11731420 19196722 14580682 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.8119453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.1017358032
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619189210 19200415 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009410 Nerve Degeneration Rotenone 4.0115790535 17356569 18619942
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010300 Parkinson Disease Rotenone 3.0316412576 11535288 19232380 11445065 15451049 19114014 18191903 16140633 18619942
MESH:D020734 Parkinsonian Disorders Rotenone 4.2418197244 15927086 15795934 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5618760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5615067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5615084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.779296927
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4616709447
MESH:D013088 Spermatocele Tamoxifen 12.4616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2819457130
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4117572228 8653321 16712894
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.9712579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:04260 Cardiac muscle contraction
KEGG:05016 Huntington's disease
KEGG:01100 Metabolic pathways
KEGG:00190 Oxidative phosphorylation
KEGG:05012 Parkinson's disease
REACT:6305 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03122 - B-Octylglucoside Detergents
DB04141 - 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
DB04741 - Myxothiazol Antifungal Agents;Antibiotics, Antifungal;Antibacterial Agents
DB04799 - 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole
DB07401 - METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
DB07763 - (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE
DB07778 - FAMOXADONE
DB08330 - METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
DB08453 - 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
DB08690 - UBIQUINONE-2
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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