AutismKB 2.0

Annotation Detail for UQCRC2


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Basic Information Top
Gene Symbol:UQCRC2 ( QCR2,UQCR2 )
Gene Full Name: ubiquinol-cytochrome c reductase core protein II
Band: 16p12.2
Quick LinksEntrez ID:7385; OMIM: 191329; Uniprot ID:QCR2_HUMAN; ENSEMBL ID: ENSG00000140740; HGNC ID: 12586
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa04260Cardiac muscle contraction
Pathway IDPathway Name
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncou
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of UQCRC2 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of UQCRC2 mRNAdecreases expression 12958071
D000082 Acetaminophen Acetaminophen results in decreased expression of UQCRC2 mRNAdecreases expression 11793227
D000082 Acetaminophen Acetaminophen affects the expression of UQCRC2 mRNAaffects expression 17562736
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA]decreases reaction|increases expression 16964424
D002110 Caffeine Caffeine results in decreased expression of UQCRC2 mRNAdecreases expression 11793227
C099555 CD 437 CD 437 results in decreased expression of UQCRC2 mRNAdecreases expression 12958071
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in decreased expression of UQCRC2 mRNAaffects cotreatment|decreases expression 18313992
C009277 sodium arsenate sodium arsenate results in increased expression of UQCRC2 mRNAincreases expression 16882884
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of UQCRC2 mRNAincreases expression 20399798
D013853 Thioacetamide Thioacetamide results in decreased expression of UQCRC2 mRNAdecreases expression 11793227
C066340 tolcapone tolcapone binds to UQCRC2 proteinaffects binding 19783845
C025643 vinclozolin vinclozolin affects the expression of UQCRC2 mRNAaffects expression 19015723
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in decreased expression of UQCRC2 mRNAaffects cotreatment|decreases expression 18313992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9614514962 15322242 11752688
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.939612607
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.4311080934
MESH:D000544 Alzheimer Disease tolcapone 3.2920150427
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7019015723
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4212125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 9.4219483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.673084413
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 4.6717997003
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4116120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.826135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7916835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.7918291259
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315340226 16354765 8697196 15668235 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities sodium arsenate 2.8010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8020055451 10048152 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.4414966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1218551238
MESH:D003866 Depressive Disorder tolcapone 4.367768276 11224284
MESH:D003865 Depressive Disorder, Major tolcapone 4.9710440460
MESH:D003924 Diabetes Mellitus, Type 2 astaxanthine 4.9416964424
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.9417107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.5921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.5916177239 17906064 16393943 14725611 11834606 19416960 19085960 10663392 16227642 14550746 14986274 10774834 11421492 15619225 16109766 2444490 19370779 11529661 16081117 11461765 19164858 19923254 16485898 12705907 12594235 16781746 15968718 18071297 17562736 11287661 17522070 12958197 19739265 12540782 10915739 19420014 11739529 11743745 12392966 18713872 12153990
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 15.5918186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.5920420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 15.5912963478
MESH:D056486 Drug-Induced Liver Injury tolcapone 15.5919783845 16604736
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Lamivudine 14.2315040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 14.2311462148
MESH:D004362 Drug Toxicity Zidovudine 14.2315040536
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.5311455177
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 6.0819578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005218 Fat Necrosis Thioacetamide 5.8516456712
MESH:D005234 Fatty Liver Zidovudine 3.9918299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4316417039
MESH:D018149 Glucose Intolerance sodium arsenate 5.1719446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006402 Hematologic Diseases Zidovudine 4.8012579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.6518665440 15929193 17276928
MESH:D006505 Hepatitis Caffeine 10.3111394713
MESH:D006505 Hepatitis Thioacetamide 10.3116456712
MESH:D006509 Hepatitis B Lamivudine 5.1817703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.1815274664 15631357 16476009 15309715 12044531
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0012621046 15340226 16120746
MESH:D015658 HIV Infections Lamivudine 7.199296927 20032539 11141242 17530837
MESH:D015658 HIV Infections Zidovudine 7.1920032539 11363243 11698656 17358032 11141242
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.188697196 18606429 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D007248 Infertility, Male vinclozolin 3.0916467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8912878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2415629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.8916705839
MESH:D007680 Kidney Neoplasms Zidovudine 7.8912579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.4920370541
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8516417039
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5312878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 2.5316098781 15158331 17050028 18606216 17127702 16097051 15288473 18615449 15075984 17629604 15334695 15465738 11172339 15288472 12531686 16248980 15474484 18458672 18032466 17355460 11481614 16511523 15095483 10677585 12679928 15078482 14739098 16126171 18263696 18295389 18395095 17292413 15316131 15362042 18416461 12085344 11682029 18031379 12891558 16343077 15716488 16489207 18380797 12557150 12175628
MESH:D008107 Liver Diseases Acetaminophen 4.1912969438 12587719 16611625 19460945 19784758 11587558 19014921 16610002
MESH:D008107 Liver Diseases Thioacetamide 4.1916337175 15158337 18374380
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8916871587 17185352
MESH:D017114 Liver Failure, Acute Thioacetamide 9.8917276928 15313186 15633222 12479984
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.467678174
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.902876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9012151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5419555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 2.5418800350
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.9717358032
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.9418186108
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.987678174 18551238
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects sodium arsenate 4.0111749123 10525206 18186108 19446573
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5116049721
MESH:D010051 Ovarian Neoplasms CD 437 3.3417474084
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010300 Parkinson Disease tolcapone 3.629333106 8635184 9708959 9754991 11432539 19783845 17089403 8739811 9305320 18328768 9591521 11586115 10651109 11746615 20216409 7566641 11793426 16758261 20334432 19578428 1977408
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.8811896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.8818042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0518220299
MESH:D011472 Prostatitis vinclozolin 5.0518629315
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.659296927
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5918551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D012893 Sleep Disorders Caffeine 5.4319395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Caffeine 5.2317225163
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 6.0819578428
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.5116049721
MESH:D001749 Urinary Bladder Neoplasms CD 437 5.5116720286
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4310091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014625 Vaginal Neoplasms Zidovudine 4.8612579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D014820 Vitiligo tolcapone 5.2910573327
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:04260 Cardiac muscle contraction
KEGG:05016 Huntington's disease
KEGG:01100 Metabolic pathways
KEGG:00190 Oxidative phosphorylation
KEGG:05012 Parkinson's disease
REACT:6305 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37217
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03122 - B-Octylglucoside Detergents
    DB04141 - 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
    DB04799 - 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole
    DB07401 - METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
    DB07763 - (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE
    DB07778 - FAMOXADONE
    DB08330 - METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
    DB08453 - 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
    DB08690 - UBIQUINONE-2
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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