AutismKB 2.0

Annotation Detail for UTRN


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:UTRN ( DMDL,DRP,DRP1,FLJ23678 )
Gene Full Name: utrophin
Band: 6q24.2
Quick LinksEntrez ID:7402; OMIM: 128240; Uniprot ID:UTRO_HUMAN; ENSEMBL ID: ENSG00000152818; HGNC ID: 12635
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of UTRN mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of UTRN mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of UTRN mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of UTRN mRNAdecreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of UTRN mRNAdecreases expression 20382639
19150397
D016572 Cyclosporine Cyclosporine results in increased expression of UTRN mRNAincreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of UTRN mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of UTRN mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of UTRN mRNAaffects cotreatment|increases expression 18164116
C008493 methylselenic acid methylselenic acid results in decreased expression of UTRN mRNAdecreases expression 18548127
D008942 Mitoxantrone UTRN protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of UTRN mRNAdecreases expression 20106945
C016837 zinc chloride zinc chloride binds to UTRN proteinaffects binding 17009962
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0414514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 11.666695378
MESH:D000236 Adenoma beta-Naphthoflavone 11.6619389873
MESH:D000236 Adenoma Diethylnitrosamine 11.6610737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.7117620307 18056438 16434500 19052882 19061943 17162532
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8017474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8017474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 2.9118210153 16807293 16288022 18056438 11831363 19335982 20935162 19418558 17173139 18785209 20524982 10672840 17978847 20007298 18393292 20432363 19539802 16569478 17428255 21159647 3084413 17162532 19701751 3581430 19052882 18978308 17761372 19394651 18506893 17055752 17138121 18691550 19171122 20101231 19822196 19208518 10737359 16328049 19383236 20084675 19519916 16502159 18971187 16698587 18665156 20512989 16878318 19919837 20214788 16935385 19107877 16681979 18788625 20727157 16779866 20514400 16830150 18494052 16540662
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.7120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.7112371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.712727394 7505956 17174075 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7416835633
MESH:D002779 Cholestasis Cyclosporine 3.0219486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1512621046 16354765 15668235 15340226 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3217107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3415968718 11529661 19420014 10915739 2444490 12705907 10774834 10663392 19923254 19416960 19164858 19370779 16485898 16109766 15619225 18071297 12594235 11743745 11421492 14725611 12392966 16781746 16393943 16081117 17522070 16177239 12958197 11461765 19739265 17562736 18713872 14550746 11287661 12540782 16227642 11739529 12153990 19085960 11834606 17906064 14986274
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.3419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Cyclosporine 8.1819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 8.1821071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Cyclosporine 9.0712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0720067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6710048152 11294989
MESH:D006331 Heart Diseases Mitoxantrone 4.2416019553
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0716120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616354765 8697196 16959395 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D007249 Inflammation Diethylnitrosamine 5.1218785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1212200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.0512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.058314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.8418172266
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8918665156 18522880 18407596 20032147 19638242
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 4.0111587558 16611625 19014921 19460945 12587719 12969438 19784758 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0117034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1120195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 11.1121295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.1121278145 10737359 19499222 20101389 19812893 2422723 12771043 20492335 18754104 21071580 20452335 21047994 18644402 21167192 19690152 20118626 19426721 15175105 20137499 19642983 19638242 18977376 12112319 20434301 19256749 16942905 9163691 2862719 19090486 18648771 20405173 19551842 18978307 19850985 20501860 19294768 19833225 15885732 20583210 19255062 19427195 19254457 19996281 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1116984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.3618164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.3619519916 18253720 19126423 18079962 16267830 18164116 18308698 18775883 3124819 18544905 9362446 21159647 19004024 19009564 2563599 18093689 17854601 17174075 17942915 18282651 19539802 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3612151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4218520028 18569708 17053015 20869020 6695378 20064080 18816296 20464547 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4220970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4219555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.613581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 5.5711141357
MESH:D009369 Neoplasms Mitoxantrone 5.5716640825
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.5818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.5820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4616540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.3612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.362563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3717292933
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.3716205645
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.362093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.097505956
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2217053015
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:05414 Dilated cardiomyopathy
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved