AutismKB 2.0

Annotation Detail for VARS


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Basic Information Top
Gene Symbol:VARS ( G7A,VARS1,VARS2 )
Gene Full Name: valyl-tRNA synthetase
Band: 6p21.33
Quick LinksEntrez ID:7407; OMIM: 192150; Uniprot ID:SYVC_HUMAN; ENSEMBL ID: ENSG00000204394; HGNC ID: 12651
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
TRNA-CHARGING-PWYtRNA charging pathway
Pathway IDPathway Name
hsa00970Aminoacyl-tRNA biosynthesis
hsa00290Valine, leucine and isoleucine biosynthesis
Pathway IDPathway Name
Gene Expression
No data
No data
Pathway IDPathway Name
500660Cytosolic tRNA aminoacylation
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of VARS mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of VARS mRNAaffects expression 16483693
D004958 Estradiol Estradiol affects the expression of VARS mRNAaffects expression 15598610
D016226 Phosphorus, Dietary Phosphorus, Dietary affects the expression of VARS mRNAaffects expression 17651324
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of VARS mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001943 Breast Neoplasms Estradiol 2.1118497071 16675129 17261762 12948864 17289903 19861407 14630087 17018787
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0016111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.953084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.9516924424
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0018566989
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.7419279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6616393943 11529661 14986274 11743745 11421492 19416960 10663392 14725611 15619225 11287661 19085960 17906064 16227642 12540782 15968718 11739529 2444490 14550746 12958197 18071297 12392966 19739265 17522070 16781746 11834606 12705907 16109766 11461765 19923254 10915739 19370779 10774834 18713872 16485898 19420014 19164858 17562736 12153990 16081117 12594235 16177239
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D016889 Endometrial Neoplasms Estradiol 3.2011473722 18566989 19148513
MESH:D005234 Fatty Liver pirinixic acid 3.1420131406 19236843
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4816221962 19176532 19772884 18467677
MESH:D006558 Herpes Genitalis Estradiol 5.6415709030
MESH:D019584 Hot Flashes Estradiol 4.3617088409
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007333 Insulin Resistance Estradiol 7.9216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.9216306350
MESH:D007674 Kidney Diseases Acetaminophen 6.5015629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.5015618244
MESH:D007680 Kidney Neoplasms Estradiol 3.2815610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3815474484
MESH:D008107 Liver Diseases Acetaminophen 1.6919784758 12969438 19014921 11587558 19460945 16611625 16610002 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.9216377806 15890375 20007298
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7717203775 16891317 11408345 11807958
MESH:D020149 Manganese Poisoning Estradiol 5.0919453300
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.1716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.1716411023
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009389 Neovascularization, Pathologic Estradiol 4.2717289903
MESH:D009421 Nervous System Malformations Estradiol 4.0911399458 16427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.3019401270
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2620887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0316740699
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D013978 Tibial Fractures Estradiol 5.3019048282
MESH:D014581 Urticaria Acetaminophen 3.3810982225
Pathway ID Pathway Name
KEGG:00970 Aminoacyl-tRNA biosynthesis
REACT:71 Gene Expression
KEGG:00290 Valine, leucine and isoleucine biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37275
    • No data
    No data
    Releated drug ID Related drug Name
    PA449789glycine
    PA448055l-alanine
    PA448478l-arginine
    PA449173l-cysteine
    PA10090l-glutamine
    PA449882l-histidine
    PA450197l-leucine
    PA450280l-lysine
    PA450423l-methionine
    PA450931l-phenylalanine
    PA451125l-proline
    PA451330l-serine
    PA451673l-threonine
    PA10323l-tryptophan
    PA451822l-tyrosine
    PA451843l-valine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00161 - L-Valine Dietary supplements;Essential Amino Acids;Micronutrients
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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