AutismKB 2.0

Annotation Detail for VAV2


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Basic Information Top
Gene Symbol:VAV2 ( - )
Gene Full Name: vav 2 guanine nucleotide exchange factor
Band: 9q34.2
Quick LinksEntrez ID:7410; OMIM: 600428; Uniprot ID:VAV2_HUMAN; ENSEMBL ID: ENSG00000160293; HGNC ID: 12658
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04650Natural killer cell mediated cytotoxicity
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Axon guidance
Hemostasis
Signaling by Rho GTPases
Pathway IDPathway Name
200185EPHA2 forward signaling
200005BCR signaling pathway
200157EPO signaling pathway
200121EPHA forward signaling
200127PDGFR-beta signaling pathway
200165Regulation of RAC1 activity
200113ErbB1 downstream signaling
200105E-cadherin signaling in the nascent adherens junction
200053Nectin adhesion pathway
200050Regulation of RhoA activity
200057CDC42 signaling events
200059Regulation of CDC42 activity
Pathway IDPathway Name
P00053T cell activation
P00010B cell activation
P00047PDGF signaling pathway
Pathway IDPathway Name
500100Signal transduction by L1
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of VAV2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of VAV2 mRNAaffects expression 17562736
C014949 acetylhydrazine acetylhydrazine results in decreased expression of VAV2 mRNAdecreases expression 15282401
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of VAV2 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of VAV2 mRNAdecreases expression 19150397
D017313 Fenretinide Fenretinide results in decreased expression of VAV2 mRNAdecreases expression 16467112
C058346 N-(4-methoxyphenyl)retinamide N-(4-methoxyphenyl)retinamide results in decreased expression of VAV2 mRNAdecreases expression 16467112
C029938 nickel sulfate nickel sulfate results in decreased expression of VAV2 mRNAdecreases expression 16780908
C029938 nickel sulfate nickel sulfate results in increased expression of VAV2 mRNAincreases expression 16780908
C021747 sodium selenate sodium selenate results in decreased expression of VAV2 mRNAdecreases expression 16444006
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury nickel sulfate 4.5312718980 19131640 16100012 11954676
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.8020464547 20127859
MESH:D000230 Adenocarcinoma Fenretinide 4.8010697514
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001932 Brain Neoplasms Fenretinide 4.5416187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4120146248 17474063
MESH:D001943 Breast Neoplasms Fenretinide 2.4116601279
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.803084413
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 4.8016270382 17159502
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 5.0620419170
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 5.0616274795
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8620889678
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.7616154183
MESH:D015179 Colorectal Neoplasms Fenretinide 2.6917273769
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.9316780908 16823706 11298694
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.8921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8910774834 11834606 19370779 16781746 12392966 18713872 12594235 19739265 17562736 14725611 12958197 18071297 15619225 11461765 19923254 12540782 16485898 19416960 2444490 12153990 16081117 11287661 19085960 10663392 16393943 17906064 16109766 11421492 19420014 15968718 16177239 17522070 11739529 14986274 19164858 12705907 11529661 11743745 14550746 10915739 16227642
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5016530937
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005909 Glioblastoma Fenretinide 4.0216187019
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D007674 Kidney Diseases Acetaminophen 2.3012587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.1416705839
MESH:D007972 Leukoplakia, Oral Fenretinide 6.3616707609
MESH:D008107 Liver Diseases Acetaminophen 1.6719014921 16611625 12969438 16610002 12587719 11587558 19460945 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1021137059 20195826
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5620464547 18520028 17053015 18816296 20869020 18569708 20135361 20064080 6695378
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 3.6910697514
MESH:D008545 Melanoma Fenretinide 2.8516270382
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.3116381670
MESH:D009062 Mouth Neoplasms Fenretinide 9.3116274795
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009369 Neoplasms Benzo(a)pyrene 5.6211141357
MESH:D009369 Neoplasms Fenretinide 5.6217353921 15958647
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.9616303764
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6212819281 16049721
MESH:D010051 Ovarian Neoplasms Fenretinide 3.2816133793
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Fenretinide 3.4115580305
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.4317292933
MESH:D011471 Prostatic Neoplasms Fenretinide 3.4317024972
MESH:D012162 Retinal Degeneration Fenretinide 4.5516303925
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6618551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 10.3310029692 19755658
MESH:D012878 Skin Neoplasms Fenretinide 10.3316467112
MESH:D012878 Skin Neoplasms N-(4-methoxyphenyl)retinamide 10.3316467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8216049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.8217053015
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 8.8216720286
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 4.7616154183
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04662 B cell receptor signaling pathway
KEGG:04062 Chemokine signaling pathway
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04510 Focal adhesion
REACT:604 Hemostasis
KEGG:04670 Leukocyte transendothelial migration
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04810 Regulation of actin cytoskeleton
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
KEGG:04660 T cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37281
    • No data
    Releated disease ID Related disease Name
    PA444281Glaucoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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