AutismKB 2.0

Annotation Detail for VCL


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Basic Information Top
Gene Symbol:VCL ( CMD1W,CMH15,MVCL )
Gene Full Name: vinculin
Band: 10q22.2
Quick LinksEntrez ID:7414; OMIM: 193065; Uniprot ID:VINC_HUMAN; ENSEMBL ID: ENSG00000035403; HGNC ID: 12665
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa05146Amoebiasis
hsa05131Shigellosis
hsa05100Bacterial invasion of epithelial cells
hsa04520Adherens junction
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion
Pathway IDPathway Name
Hemostasis
Muscle contraction
Pathway IDPathway Name
200007RhoA signaling pathway
200155Stabilization and expansion of the E-cadherin adherens junction
200161Signaling events mediated by VEGFR1 and VEGFR2
200109Integrins in angiogenesis
200192Signaling events mediated by focal adhesion kinase
Pathway IDPathway Name
P00034Integrin signalling pathway
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Cardiomyopathy, familial hypertrophic, 15
Cardiomyopathy, dilated, 1W
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of VCL mRNAaffects expression 21346803
C024709 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone binds to VCL proteinaffects binding 16533022
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of VCL mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of VCL proteindecreases expression 16483693
D000968 Antimycin A Antimycin A results in decreased expression of VCL proteindecreases expression 12490576
D000968 Antimycin A PD 150606 inhibits the reaction [Antimycin A results in decreased expression of VCL protein]decreases expression|decreases reaction 12490576
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of VCL mRNAaffects cotreatment|increases expression 18585445
D001241 Aspirin Aspirin results in decreased expression of VCL mRNAdecreases expression 11906190
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of VCL mRNAaffects cotreatment|increases expression 18585445
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of VCL mRNAdecreases expression 19150397
D004041 Dietary Fats Dietary Fats results in decreased expression of VCL mRNAdecreases expression 18042831
D005472 Fluorouracil VCL protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C056933 fumonisin B1 fumonisin B1 results in increased expression of VCL mRNAincreases expression 16221962
D015741 Metribolone Metribolone results in increased expression of VCL proteinincreases expression 17152098
D010100 Oxygen Oxygen deficiency results in increased expression of VCL mRNAincreases expression 17914565
C041786 palm oil palm oil results in decreased expression of VCL mRNAdecreases expression 18042831
C100442 PD 150606 PD 150606 inhibits the reaction [Antimycin A results in decreased expression of VCL protein]decreases expression|decreases reaction 12490576
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of VCL mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of VCL mRNAincreases expression 18301758
16221962
C017947 sodium arsenite sodium arsenite results in decreased expression of VCL mRNAdecreases expression 20308225
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of VCL mRNAincreases expression 15667827
D014212 Tretinoin Tretinoin results in increased expression of VCL mRNAincreases expression 16236135
D014635 Valproic Acid Valproic Acid results in increased expression of VCL mRNAincreases expression 15345369
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.9511752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.958875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8319490988
MESH:D000138 Acidosis Ammonium Chloride 3.4518287403
MESH:D055371 Acute Lung Injury Oxygen 8.8816759491
MESH:D055371 Acute Lung Injury pirinixic acid 8.8818653653
MESH:D000230 Adenocarcinoma Fluorouracil 2.4017638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.693712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.5416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.5416835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5915276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8017306315 16712894
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.1211874814
MESH:D000505 Alopecia Tretinoin 3.5315955085
MESH:D000550 Amblyopia Valproic Acid 5.1317688650
MESH:D000740 Anemia Fluorouracil 8.3515504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.3511748828
MESH:D000860 Anoxia Oxygen 4.9520872349
MESH:D001008 Anxiety Disorders Valproic Acid 3.4817497229
MESH:D001161 Arteriosclerosis Dietary Fats 3.7815238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.0116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2416292516
MESH:D001249 Asthma Tretinoin 2.3116456186
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.6020485159 12372130
MESH:D050197 Atherosclerosis Oxygen 3.7416391483
MESH:D001321 Autistic Disorder Valproic Acid 2.0115238991 17157402 20603192 17507914 18558336 18396377 18985861 18177632 19460635 18940202 19232924 18316065 17688650 16609825 18775368
MESH:D001471 Barrett Esophagus Tretinoin 4.2916935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.911440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.0220046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.6819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.6812125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.6816206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.7915746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.798888407
MESH:D001932 Brain Neoplasms Aspirin 4.3215481559
MESH:D001943 Breast Neoplasms Aspirin 2.9215161893
MESH:D001943 Breast Neoplasms Dietary Fats 2.9220435547
MESH:D001943 Breast Neoplasms Fluorouracil 2.9218357371 16557594 16110121 19217205 16595493 15136595 18608205
MESH:D001943 Breast Neoplasms Oxygen 2.9217263869
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9220435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9216166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4816813970
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5616051944
MESH:D002277 Carcinoma Fluorouracil 7.8917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0516168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.6916705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.693581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.6916799960 17045692 17971768 16332177 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.6917306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.691917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.337296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.3318695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.3818986760 16757204 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.3818572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.3816051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3118850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated marker/mechanism
OMIM:613255 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 15 marker/mechanism
MESH:D002386 Cataract Tretinoin 3.0317460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.406135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.407505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.4020889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.4020056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4816129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6720734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.579022650 19486331
MESH:D002779 Cholestasis pirinixic acid 7.5719176532
MESH:D002822 Choriocarcinoma Tretinoin 5.0516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6115340226 8697196 12621046 16354765 15668235
MESH:D002972 Cleft Palate Tretinoin 5.619407595
MESH:D003092 Colitis Tretinoin 3.6017035595
MESH:D003110 Colonic Neoplasms Aspirin 4.0412411196
MESH:D003110 Colonic Neoplasms Fluorouracil 4.0417018589 17287894 18772588 17172411 16340194 17725105 16510598 15001691 17016597 17169374
MESH:D015179 Colorectal Neoplasms Aspirin 2.8517047198
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.8520501625 17094418 16391804 18383874 18448328 18949393 18802399 17016601 16282729 17594712 18509181 18288408 15289873 16524972 17695437 17454858 16303861 15148649 17255274 16331619 14970324 17401013
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6915322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.699224671 9125849 17551590 14991402 9211117 8800419 10589399 9664655 9142499 16925845
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.6917688650 16575769 8888407
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9118551238
MESH:D007644 Darier Disease Fluorouracil 4.6816733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7018759878 11298694 8970840 14531868 12868966 8156756 11906362 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.393621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.6821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.686482804 6679447 18692083 9328219 18289764 7440962 9022650 16192314 18648102 1440618 11289319 9653073 8291058
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 11.6816221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.6820420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.6819641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3718367378
MESH:D004417 Dyspnea Oxygen 4.7320016425
MESH:D004421 Dystonia Valproic Acid 3.941851702
MESH:D004487 Edema Aspirin 10.9217259670
MESH:D004487 Edema pirinixic acid 10.9212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.9211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.5915322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.5918230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.043659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.813922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.8820417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.496426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.197750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.963659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.083581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0820426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.0816337965 17638652 16481741 15173087 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.5611564622
MESH:D005124 Eye Abnormalities Tretinoin 8.5616938888 9664655
MESH:D005234 Fatty Liver Dietary Fats 12.5318296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver pirinixic acid 12.5320131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 12.5319224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.7816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.028888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.916705139
MESH:D005355 Fibrosis Dietary Fats 14.1418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.1420067830
MESH:D005355 Fibrosis Tretinoin 14.1417994277
MESH:D005739 Gas Poisoning Oxygen 5.1120016425
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5716452187
MESH:D005909 Glioblastoma Aspirin 7.2312870263
MESH:D005909 Glioblastoma Tretinoin 7.2317312396
MESH:D005910 Glioma Fluorouracil 2.8316145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.937505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006261 Headache Aspirin 4.8515240983
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.5518337622 15102660 15162350
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.5516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0516084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.3414991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.4720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.416705139
MESH:D006529 Hepatomegaly fumonisin B1 13.8616221962
MESH:D006529 Hepatomegaly pirinixic acid 13.8619772884 19176532 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.8616120746 12621046 15340226
MESH:D006689 Hodgkin Disease sodium arsenite 3.0612676792
MESH:D006849 Hydrocephalus Valproic Acid 4.7617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9415340226 8697196 18606429 16959395 16354765
MESH:D012001 Hyperacusis Aspirin 5.6615240983
MESH:D006930 Hyperalgesia Tretinoin 3.1216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4921332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4616778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.5121332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8315034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8718850075 18670907
MESH:D007248 Infertility, Male Atrazine 6.8512948887
MESH:D007248 Infertility, Male sodium arsenite 6.8512646999 15346721
MESH:D007249 Inflammation Dietary Fats 4.7320412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.7312200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.0118457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.0116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.6617994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.919022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.5916580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.5917551590 15992940
MESH:D007674 Kidney Diseases sodium arsenite 2.7420008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.9116705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.916582329
MESH:D007680 Kidney Neoplasms Fluorouracil 11.9116985049
MESH:D007938 Leukemia Tretinoin 2.7217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6019285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8216294345 19850784 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8216294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0817506722 16331271 17294898 17649720 16891316 15748426 19029980 16140955 19225113 17368321 12679006 19035177 16823087 17107899 16788101 19642359 17361223 17339181 19075265 17301526 9834237 16935935 16766008 17712046 17217047
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.239224671
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8218296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.3216248980 18397230
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.797678174
MESH:D008113 Liver Neoplasms Fluorouracil 13.7917045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 13.7920007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 13.7916712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.7916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.372876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.37598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.3712151625
MESH:D008171 Lung Diseases sodium arsenite 3.1019095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1617228818
MESH:D055370 Lung Injury Oxygen 4.4018339021
MESH:D008175 Lung Neoplasms Fluorouracil 3.3515246190
MESH:D008175 Lung Neoplasms sodium arsenite 3.3519931552 17306315 15276417 17077188 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3511884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6815086387
MESH:D008527 Medulloblastoma Tretinoin 2.7417453147
MESH:D008545 Melanoma sodium arsenite 3.2819082730 16487513
MESH:D008545 Melanoma Tretinoin 3.2816752155
MESH:D008591 Meningomyelocele Tretinoin 4.3216940565
MESH:D008654 Mesothelioma Atrazine 3.481916698
MESH:D008881 Migraine Disorders Aspirin 7.6015240983
MESH:D008881 Migraine Disorders Valproic Acid 7.6018803445 18765137
MESH:D009062 Mouth Neoplasms Fluorouracil 3.5516757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.4016239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.928888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.1917596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.1917596541
MESH:D009203 Myocardial Infarction Aspirin 5.7812692751
MESH:D009203 Myocardial Infarction pirinixic acid 5.7819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8616411023
MESH:D009325 Nausea Aspirin 5.1115240983
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.7518551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.433581430
MESH:D009369 Neoplasms Fluorouracil 11.4218600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 11.4217405874
MESH:D009369 Neoplasms sodium arsenite 11.4211559025
MESH:D009369 Neoplasms Tretinoin 11.4216594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5620056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.1514600291
MESH:D009421 Nervous System Malformations Tretinoin 9.159125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 16.746679447
MESH:D009436 Neural Tube Defects sodium arsenite 16.7412854658
MESH:D009436 Neural Tube Defects Tretinoin 16.749142499
MESH:D009436 Neural Tube Defects Valproic Acid 16.7416359493 8888407
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3616436463
MESH:D009765 Obesity Dietary Fats 4.3420518802 19632207 16723640 21332399 18457598 18674790 20132043 17217161 11836018
MESH:D009765 Obesity pirinixic acid 4.3420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.5516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.556482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.913988306
MESH:D010003 Osteoarthritis Aspirin 3.997009135
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.7715276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 4.7716936753
MESH:D010146 Pain Aspirin 6.826995502 6363464
MESH:D010146 Pain Tretinoin 6.8216870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.2119003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2115976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.387296757
MESH:D010300 Parkinson Disease Atrazine 3.2317218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.4311156591
MESH:D020795 Photophobia Aspirin 5.6615240983
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.366228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.1011896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.1020603192
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3919082440 18626508
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3916039940
MESH:D011507 Proteinuria Tretinoin 3.5016636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.4412752131 11422049
MESH:D011625 Pterygium Tretinoin 4.6816723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9218722050 15538739 18286688 16160472
MESH:D015427 Reperfusion Injury pirinixic acid 2.3319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.4017627322 18339021
MESH:D012135 Respiratory Sounds Atrazine 4.4111874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.293692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.5116116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.5119155313
MESH:D012220 Rhinitis Aspirin 4.2812372130
MESH:D012559 Schizophrenia Valproic Acid 2.0515737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 5.6918551238
MESH:D012640 Seizures Valproic Acid 5.6915475178 11044598 17978042 14763951 11738929 16876388 3137016 1511512
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.1512269725
MESH:D012878 Skin Neoplasms sodium arsenite 9.1318572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.1316192470
MESH:D012878 Skin Neoplasms Tretinoin 9.1316467112
MESH:D016135 Spinal Dysraphism sodium arsenite 9.2612854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.2619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4412833885
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4818567086 16424979 16951190 18396642 19015929 17172411 17522103 15786421 19084572 17498489
MESH:D013274 Stomach Neoplasms Tretinoin 2.4817261132
MESH:D020521 Stroke Aspirin 4.2916403987
MESH:D013398 Sudden Infant Death Oxygen 5.4312563064
MESH:D013927 Thrombosis Aspirin 4.4217672075
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.851399818 3712494 7505956 6587162 6582329
MESH:D013964 Thyroid Neoplasms Tretinoin 6.8517045167 16026305
MESH:D014062 Tongue Neoplasms Fluorouracil 9.5016280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.5016051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.1317262798
MESH:D014376 Tuberculosis Tretinoin 3.1616040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.413119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.0616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.068074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.0611723127 16712894 17306315 16452187
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.538888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2110091137
MESH:D014581 Urticaria Aspirin 4.3320485159 10982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 15.2916803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 15.2911813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 15.2916129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.5016752155
MESH:D014652 Vascular Diseases sodium arsenite 4.3217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D014820 Vitiligo Tretinoin 3.9516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D015430 Weight Gain Dietary Fats 3.6416723640
MESH:D009396 Wilms Tumor Tretinoin 3.8716287080
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:05146 Amoebiasis
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04510 Focal adhesion
REACT:604 Hemostasis
KEGG:04670 Leukocyte transendothelial migration
REACT:17044 Muscle contraction
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05131 Shigellosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37288
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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