AutismKB 2.0

Annotation Detail for VCP


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Basic Information Top
Gene Symbol:VCP ( IBMPFD,MGC131997,MGC148092,MGC8560,TERA,p97 )
Gene Full Name: valosin-containing protein
Band: 9p13.3
Quick LinksEntrez ID:7415; OMIM: 601023; Uniprot ID:TERA_HUMAN; ENSEMBL ID: ENSG00000165280; HGNC ID: 12666
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00078Pick's disease
Nervous system diseases
Neurodegenerative diseases
No data
No data
No data
Desease Name
Inclusion body myopathy with early-onset Paget disease and frontotemporal dementia
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of VCP mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of VCP mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of VCP proteindecreases expression 16538041
C006632 arsenic trioxide arsenic trioxide promotes the reaction [CREBBP protein results in increased expression of VCP mRNA]increases expression|increases reaction 18822310
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of VCP mRNAaffects cotreatment|decreases expression 18636392
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of VCP mRNAincreases expression 17942748
17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VCP mRNAaffects cotreatment|increases expression 17942748
C029424 hydrazine hydrazine results in increased expression of VCP proteinincreases expression 15370871
D007657 Ketone Bodies Ketone Bodies results in increased expression of VCP mRNAincreases expression 16807920
C015329 lycopene lycopene results in increased expression of VCP mRNAincreases expression 16886892
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to VCP protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone results in increased expression of VCP proteinincreases expression 17152098
C031721 naphthalene naphthalene metabolite binds to VCP proteinaffects binding 16206326
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of VCP mRNAincreases expression 17616710
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of VCP mRNAaffects cotreatment|decreases expression 18636392
C031280 pyrazole pyrazole results in increased expression of VCP mRNAincreases expression 17945193
D013629 Tamoxifen Tamoxifen affects the expression of VCP mRNAaffects expression 17555576
D013654 Taurine Taurine results in decreased expression of VCP mRNAdecreases expression 16579726
C004648 testosterone enanthate testosterone enanthate affects the expression of VCP mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VCP mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of VCP proteindecreases expression 16548065
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of VCP proteinincreases expression 19201780
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8411752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D055371 Acute Lung Injury Chlorine 4.3120601635
MESH:D000230 Adenocarcinoma arsenic trioxide 4.2719825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2714692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3716835633
MESH:D000544 Alzheimer Disease Ozone 2.4315513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5515570426
MESH:D001249 Asthma Ozone 2.6317854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.9016206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.9721138602 15565566 18815881 18821012 19115204 17242785 19189212 19289846 19288272 18351453 19189210 19155303 21152245 18629630 20390343 19142967 19410462 19084267 20859285 19059307 19200415 16818667 17261762 18997820 17049068 20544844 19487384 18855134 19221464 19066611 16873071 16273361 17893378 18425577 17440819 11161223 20065188 20005174 16202921 19011961 19244106 19103187 15668708 20135344 18984771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6616777450 15516495 17626835 19059883 18315731 14754758 18417511
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3111589617
MESH:D002100 Cachexia Ozone 4.7316183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4919066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.5316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.533084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.5311135700 16217749 14691202 15073043 15553829
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.5316924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8719014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1012490120
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.756135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8611677210 17110522 16919318 16105132 17681005 15861022 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0916354765 12621046 8697196 15340226 15668235
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0417141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4610525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4620055451 10048152 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0018551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0815213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3519031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D058065 Diabetic Cardiomyopathies Taurine 6.0416025228
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4619279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.9918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.9919416960 12705907 19164858 17906064 16227642 18071297 11834606 14550746 19739265 18713872 12392966 12153990 19370779 11743745 12594235 12540782 15968718 10915739 14986274 11529661 19923254 11739529 2444490 10663392 19085960 11287661 16485898 15619225 12958197 16109766 16081117 16393943 17562736 16781746 16177239 14725611 11421492 10774834 17522070 11461765 19420014
MESH:D056486 Drug-Induced Liver Injury pyrazole 11.9912499123
MESH:D056486 Drug-Induced Liver Injury Taurine 11.999328219
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.9920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004417 Dyspnea Chlorine 4.6220016425
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.8919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0319155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0010568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7012903497
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.7015264214 16805852 16510608 16704527 15547721 15150132 15623463 15878914 15547733
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver arsenic trioxide 13.0115073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.0115345470
MESH:D005234 Fatty Liver Tamoxifen 13.0119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9320067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2416904648
MESH:D005739 Gas Poisoning Chlorine 5.0120016425
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3210048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8812621046 15340226 16120746
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.7517440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0518606429 8697196 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9018670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016945680 16569931
OMIM:167320 INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE AND FRONTOTEMPORAL DEMENTIA marker/mechanism
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4717937319
MESH:D007249 Inflammation Tamoxifen 4.8519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8512200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.1915629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.3316705839
MESH:D007680 Kidney Neoplasms Tamoxifen 7.3318625569
MESH:D007938 Leukemia arsenic trioxide 2.8215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1320471514 16968895 17050201 19850784 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2017869043 16112521 15622746 17217047 16823087 19642359 19225113 17712046 11161223 19035177 16966277 12018890 17649720 16331271 17107899 15748426 12712474 15213294 19075265 15336539 11468182 16330433 9834237 16891316 12679006
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3416882451
MESH:D008064 Lipidoses Tamoxifen 3.1417567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.6318564211
MESH:D008106 Liver Cirrhosis, Experimental Taurine 3.6315893842 15931870
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6312878042
MESH:D008107 Liver Diseases Acetaminophen 1.6219784758 12969438 11587558 19014921 16610002 16611625 12587719 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2216871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.637678174
MESH:D008113 Liver Neoplasms arsenic trioxide 10.6314682389
MESH:D008113 Liver Neoplasms Tamoxifen 10.6316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.6316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.726135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.7220377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3315213294
MESH:D008171 Lung Diseases Ozone 3.3619066396 8266340
MESH:D055370 Lung Injury naphthalene 9.576834280
MESH:D055370 Lung Injury Ozone 9.5720417186
MESH:D008175 Lung Neoplasms arsenic trioxide 4.8311798837 19825857
MESH:D008175 Lung Neoplasms Ozone 4.838597069 7614698
MESH:D008175 Lung Neoplasms Tamoxifen 4.8318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8311884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6114580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.5519453300
MESH:D008545 Melanoma Tamoxifen 1.8812393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008679 Metaplasia Ozone 5.1110496685
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0914977855 19549372 15949261 11468182 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1316105982 16882451
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.857678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9416624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5119410462
MESH:D009369 Neoplasms lycopene 3.7217051425
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0019196722 19200415 19189210
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2014600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1010525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4116049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4019769630 12452020 16624393
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5215580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010235 Paraganglioma arsenic trioxide 4.1419927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010538 Peritonitis Ozone 4.1216369182
MESH:D011014 Pneumonia Ozone 4.3918007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1811896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7519131511
MESH:D011471 Prostatic Neoplasms lycopene 2.7515084515 17337101
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.7515067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3016919318 15861022
MESH:D012120 Respiration Disorders Chlorine 5.2118579056
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9416646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5218551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.5616709447
MESH:D013088 Spermatocele Tamoxifen 11.5616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0319457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.6517007042
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.6512958204 17575124
MESH:D013733 Testicular Diseases pyrazole 4.816499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.0719014326
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9515213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.2716049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.2712845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.278653321 17572228 16712894
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3110091137
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
Pathway ID Pathway Name
KEGG:04141 Protein processing in endoplasmic reticulum
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03431 - Adenosine-5'-Diphosphate
DB04395 - Phosphoaminophosphonic Acid-Adenylate Ester
No data
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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